GREMLIN Database
IMMA - Metallopeptidase ImmA
UniProt: P96630 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (142)
Sequences: 794 (706)
Seq/√Len: 59.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K69_Q4.3321.00
83_H105_Q4.0401.00
47_G72_V3.7961.00
49_L80_Y3.4171.00
74_A110_A3.1841.00
135_I146_T3.0501.00
30_C37_I2.5691.00
120_L146_T2.5681.00
117_D121_N2.2361.00
11_K112_E2.1861.00
141_V146_T2.1681.00
123_A139_F2.1451.00
108_L112_E2.1401.00
112_E149_K2.1011.00
82_L105_Q2.0651.00
35_I77_L2.0171.00
41_D64_E1.9281.00
72_V142_P1.8331.00
115_L145_V1.8130.99
27_Y73_I1.7840.99
74_A114_I1.7840.99
13_K16_S1.7780.99
46_N66_L1.7690.99
117_D149_K1.7350.99
26_V30_C1.7280.99
132_K146_T1.6400.99
14_V18_I1.6310.99
48_L61_H1.6310.99
78_G109_F1.6200.99
109_F113_L1.5710.99
110_A114_I1.5440.98
74_A113_L1.5210.98
123_A135_I1.5020.98
139_F146_T1.5010.98
120_L150_L1.4940.98
10_I14_V1.4770.98
30_C60_I1.4650.98
62_I73_I1.4630.98
39_K62_I1.4190.97
123_A138_Y1.3880.97
104_H107_S1.3090.95
35_I80_Y1.2860.95
49_L58_Y1.2840.95
71_F116_T1.2800.95
26_V73_I1.2790.95
135_I139_F1.2730.95
71_F142_P1.2670.95
116_T119_M1.2630.94
72_V149_K1.2600.94
147_D151_S1.2540.94
62_I69_Q1.2380.94
41_D65_N1.2210.93
78_G82_L1.2160.93
27_Y39_K1.2000.93
45_A48_L1.1990.93
71_F145_V1.1850.92
46_N69_Q1.1710.92
104_H108_L1.1610.92
58_Y80_Y1.1270.90
77_L81_F1.1130.90
36_Y59_L1.1060.89
148_Y152_Q1.0990.89
28_E32_I1.0960.89
66_L72_V1.0860.89
10_I108_L1.0560.87
14_V109_F1.0530.87
30_C73_I1.0500.87
116_T142_P1.0490.87
18_I24_N1.0350.86
115_L141_V1.0030.84
26_V77_L0.9900.83
136_A141_V0.9840.83
133_E143_S0.9800.83
18_I23_T0.9650.82
111_S115_L0.9290.79
38_L61_H0.9230.79
101_K105_Q0.9160.78
107_S112_E0.9160.78
46_N145_V0.9040.77
21_H29_I0.8960.77
53_K56_D0.8950.77
146_T150_L0.8950.77
51_H56_D0.8920.76
72_V116_T0.8830.76
35_I60_I0.8700.75
50_Q59_L0.8690.75
47_G120_L0.8690.75
66_L144_F0.8530.73
130_F134_Q0.8470.73
33_Q77_L0.8460.73
47_G63_N0.8400.72
145_V149_K0.8310.71
39_K48_L0.8160.70
41_D125_P0.8100.69
18_I21_H0.8080.69
115_L120_L0.8060.69
78_G136_A0.8040.69
10_I109_F0.8020.69
35_I98_L0.7990.68
70_Q74_A0.7950.68
143_S147_D0.7940.68
40_N48_L0.7940.68
37_I44_Q0.7900.67
71_F110_A0.7890.67
58_Y84_K0.7880.67
21_H33_Q0.7870.67
46_N142_P0.7860.67
46_N78_G0.7840.67
77_L131_S0.7770.66
15_Q18_I0.7750.66
46_N149_K0.7660.65
36_Y52_D0.7620.65
61_H120_L0.7580.64
86_L102_L0.7460.63
41_D68_H0.7210.60
18_I99_K0.7140.60
11_K117_D0.7100.59
26_V29_I0.6950.57
75_H79_H0.6930.57
15_Q19_K0.6900.57
73_I82_L0.6860.56
115_L149_K0.6850.56
142_P149_K0.6830.56
18_I116_T0.6830.56
149_K153_I0.6670.54
63_N66_L0.6650.54
17_V20_T0.6620.54
50_Q61_H0.6620.54
42_L61_H0.6600.54
144_F148_Y0.6590.53
131_S134_Q0.6560.53
136_A146_T0.6530.53
107_S111_S0.6520.53
60_I73_I0.6460.52
98_L141_V0.6410.51
30_C98_L0.6370.51
25_N70_Q0.6340.51
111_S116_T0.6300.50
108_L149_K0.6260.50
34_K113_L0.6120.48
72_V145_V0.6120.48
13_K19_K0.6110.48
90_K93_N0.6090.48
75_H103_E0.6050.47
132_K143_S0.6040.47
116_T135_I0.6030.47
37_I123_A0.6000.47
129_G135_I0.5970.47
83_H110_A0.5960.46
70_Q115_L0.5960.46
26_V94_C0.5940.46
136_A143_S0.5930.46
76_E79_H0.5920.46
42_L85_R0.5920.46
115_L132_K0.5900.46
27_Y70_Q0.5880.46
85_R125_P0.5850.45
23_T122_E0.5840.45
25_N28_E0.5830.45
61_H89_F0.5820.45
42_L73_I0.5800.45
79_H103_E0.5780.44
142_P150_L0.5730.44
62_I127_I0.5700.44
119_M139_F0.5670.43
11_K18_I0.5630.43
46_N72_V0.5630.43
33_Q111_S0.5590.42
142_P145_V0.5590.42
20_T28_E0.5580.42
10_I13_K0.5570.42
51_H85_R0.5550.42
59_L125_P0.5550.42
21_H47_G0.5540.42
17_V81_F0.5540.42
93_N97_V0.5510.42
111_S142_P0.5510.42
27_Y30_C0.5510.42
101_K104_H0.5510.42
74_A141_V0.5490.41
56_D140_N0.5480.41
113_L139_F0.5470.41
50_Q57_Q0.5470.41
56_D117_D0.5460.41
46_N71_F0.5420.41
67_Q132_K0.5380.40
12_H16_S0.5370.40
29_I66_L0.5360.40
136_A139_F0.5360.40
22_G132_K0.5310.39
18_I113_L0.5300.39
47_G66_L0.5270.39
61_H64_E0.5250.39
82_L147_D0.5230.39
63_N69_Q0.5220.38
11_K149_K0.5210.38
107_S151_S0.5200.38
18_I147_D0.5190.38
35_I96_K0.5170.38
31_D101_K0.5140.38
50_Q53_K0.5080.37
29_I63_N0.5070.37
98_L105_Q0.5070.37
39_K92_V0.5060.37
60_I82_L0.5050.37
57_Q85_R0.5050.37
43_G67_Q0.5050.37
13_K108_L0.5030.36
78_G83_H0.5020.36
49_L136_A0.5020.36
76_E103_E0.5020.36
130_F135_I0.5010.36
70_Q116_T0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dteA 2 0.9527 100 0.432 Contact Map
4il3A 1 0.858 97.6 0.827 Contact Map
4aw6A 2 0.8639 97.4 0.834 Contact Map
3c37A 1 0.8876 96.1 0.86 Contact Map
3cqbA 4 0.4911 94.6 0.873 Contact Map
4dv8A 1 0.8166 91 0.887 Contact Map
4qhjA 2 0.5917 89 0.892 Contact Map
5a0rA 1 0.8047 86.1 0.897 Contact Map
1j7nA 2 0.8521 84.7 0.899 Contact Map
4jixA 2 0.5976 81.1 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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