GREMLIN Database
INT - ICEBs1 integrase
UniProt: P96629 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (305)
Sequences: 28164 (22996)
Seq/√Len: 1316.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_V337_L4.9731.00
107_T110_E3.3071.00
210_W261_K3.2321.00
245_R338_G3.0611.00
311_R314_D2.8261.00
101_S110_E2.7651.00
199_G319_H2.7581.00
195_A312_L2.7231.00
202_C313_H2.6291.00
319_H336_R2.5471.00
218_L254_L2.4761.00
118_L131_I2.4281.00
221_D246_R2.2321.00
195_A205_M2.2101.00
190_T260_W2.2041.00
317_H351_H2.0321.00
42_L45_K2.0061.00
170_R173_E1.9901.00
67_I90_I1.9871.00
97_Y117_H1.9801.00
36_R40_L1.9581.00
115_R132_M1.9541.00
209_Q280_Y1.9181.00
214_D217_L1.9031.00
329_D332_T1.9011.00
254_L258_E1.8941.00
87_K91_N1.8901.00
197_L250_N1.8821.00
209_Q279_T1.8761.00
141_T145_E1.8671.00
324_I333_I1.8291.00
339_H345_T1.8171.00
89_I134_S1.7931.00
204_E245_R1.7761.00
64_P95_S1.7711.00
111_I153_C1.7681.00
210_W281_I1.7431.00
71_L87_K1.7311.00
319_H323_L1.7151.00
248_S336_R1.7111.00
67_I138_I1.6991.00
200_L205_M1.6921.00
225_S239_K1.6701.00
219_E246_R1.6681.00
93_H131_I1.6531.00
209_Q288_P1.6501.00
126_K130_N1.6501.00
102_D105_K1.6281.00
66_L142_A1.6041.00
243_S340_G1.6001.00
106_I139_F1.5991.00
325_H356_K1.5901.00
343_K347_D1.5871.00
33_A42_L1.5871.00
331_I334_K1.5571.00
82_Y86_Q1.5551.00
35_T38_E1.5311.00
324_I350_G1.5281.00
344_T348_V1.5191.00
46_L49_E1.5181.00
323_L328_E1.5091.00
249_I254_L1.4951.00
190_T259_R1.4901.00
202_C206_L1.4871.00
68_S95_S1.4591.00
191_F294_F1.4571.00
42_L46_L1.4491.00
189_K193_T1.4471.00
140_D154_D1.4361.00
215_K258_E1.4341.00
337_L345_T1.4291.00
171_P322_L1.4291.00
212_D223_H1.4131.00
138_I142_A1.4081.00
188_F297_K1.4081.00
45_K49_E1.4041.00
89_I130_N1.4031.00
64_P68_S1.3981.00
191_F205_M1.3971.00
174_F196_F1.3901.00
240_T243_S1.3771.00
323_L333_I1.3731.00
218_L251_K1.3501.00
209_Q212_D1.3491.00
200_L222_V1.3291.00
173_E176_K1.3241.00
169_W318_S1.3031.00
334_K342_V1.2921.00
66_L141_T1.2891.00
143_V148_L1.2851.00
341_S347_D1.2851.00
71_L83_Y1.2771.00
119_M128_V1.2761.00
66_L103_I1.2691.00
132_M136_S1.2661.00
48_R52_E1.2661.00
146_E150_R1.2651.00
69_I73_S1.2611.00
80_P84_Q1.2601.00
190_T256_L1.2431.00
93_H121_T1.2391.00
174_F322_L1.2391.00
334_K345_T1.2331.00
196_F315_F1.2291.00
182_P189_K1.2261.00
202_C291_K1.2201.00
211_K279_T1.2151.00
331_I335_E1.2141.00
320_V333_I1.2131.00
197_L253_L1.2031.00
295_S299_K1.1871.00
181_I301_F1.1721.00
169_W310_I1.1701.00
62_S65_T1.1661.00
114_F118_L1.1631.00
321_A351_H1.1591.00
114_F131_I1.1551.00
115_R119_M1.1541.00
193_T256_L1.1451.00
223_H244_I1.1381.00
81_N84_Q1.1371.00
176_K180_L1.1361.00
208_L220_I1.1361.00
178_I193_T1.1261.00
112_T145_E1.1221.00
43_E47_R1.1201.00
83_Y87_K1.1171.00
251_K255_K1.1171.00
175_K179_S1.1161.00
85_N88_Y1.1121.00
214_D219_E1.1111.00
64_P100_K1.1061.00
321_A350_G1.1061.00
203_G207_A1.1051.00
359_E363_K1.1041.00
86_Q134_S1.1041.00
332_T360_M1.1021.00
112_T116_K1.0961.00
325_H353_Y1.0801.00
93_H96_D1.0761.00
84_Q88_Y1.0731.00
341_S344_T1.0731.00
75_E83_Y1.0711.00
194_V253_L1.0631.00
129_N159_L1.0631.00
108_H144_H1.0621.00
318_S322_L1.0621.00
139_F152_P1.0581.00
140_D151_N1.0571.00
169_W177_F1.0571.00
250_N253_L1.0571.00
249_I253_L1.0551.00
280_Y288_P1.0421.00
291_K295_S1.0411.00
260_W264_Q1.0391.00
196_F322_L1.0371.00
127_S131_I1.0361.00
70_Y137_K1.0351.00
45_K48_R1.0321.00
298_I302_C1.0211.00
37_K41_E1.0201.00
299_K309_P1.0191.00
79_K82_Y1.0171.00
90_I95_S1.0071.00
168_F318_S1.0061.00
180_L304_D1.0041.00
40_L44_A1.0021.00
180_L305_S0.9981.00
139_F148_L0.9971.00
74_C78_S0.9941.00
208_L213_I0.9921.00
356_K359_E0.9841.00
124_S127_S0.9821.00
97_Y114_F0.9801.00
211_K278_D0.9791.00
91_N95_S0.9751.00
191_F282_F0.9751.00
130_N133_T0.9731.00
44_A51_Q0.9701.00
136_S140_D0.9651.00
206_L291_K0.9641.00
118_L123_L0.9631.00
220_I224_K0.9631.00
78_S86_Q0.9631.00
44_A47_R0.9611.00
197_L252_K0.9601.00
119_M125_N0.9561.00
144_H155_N0.9561.00
202_C295_S0.9531.00
41_E45_K0.9501.00
171_P175_K0.9471.00
101_S105_K0.9471.00
335_E357_Q0.9441.00
78_S83_Y0.9431.00
297_K300_Y0.9391.00
215_K254_L0.9381.00
290_R293_I0.9361.00
322_L325_H0.9311.00
97_Y113_D0.9311.00
193_T252_K0.9301.00
293_I296_R0.9261.00
328_E360_M0.9251.00
358_K362_D0.9211.00
320_V350_G0.9181.00
60_S104_Q0.9151.00
151_N154_D0.9121.00
169_W173_E0.9121.00
320_V345_T0.9121.00
68_S72_A0.9101.00
299_K303_K0.9081.00
210_W264_Q0.9061.00
355_N359_E0.9051.00
194_V205_M0.9051.00
98_F114_F0.9001.00
221_D244_I0.9001.00
139_F153_C0.8971.00
252_K255_K0.8961.00
328_E332_T0.8951.00
118_L128_V0.8921.00
60_S102_D0.8831.00
320_V324_I0.8831.00
38_E42_L0.8751.00
319_H337_L0.8731.00
328_E363_K0.8731.00
171_P325_H0.8711.00
214_D221_D0.8691.00
194_V282_F0.8661.00
194_V220_I0.8651.00
108_H112_T0.8631.00
47_R51_Q0.8611.00
196_F318_S0.8601.00
49_E54_R0.8591.00
284_Y287_T0.8591.00
280_Y283_Q0.8591.00
123_L127_S0.8571.00
336_R357_Q0.8551.00
68_S87_K0.8551.00
109_R145_E0.8511.00
85_N89_I0.8431.00
69_I147_I0.8431.00
123_L131_I0.8391.00
302_C310_I0.8351.00
202_C312_L0.8341.00
126_K129_N0.8301.00
144_H157_K0.8291.00
89_I131_I0.8231.00
171_P326_Q0.8171.00
64_P99_L0.8151.00
81_N85_N0.8091.00
143_V151_N0.8061.00
317_H348_V0.8011.00
189_K256_L0.8011.00
67_I95_S0.8001.00
113_D117_H0.7991.00
40_L43_E0.7971.00
132_M153_C0.7961.00
48_R51_Q0.7951.00
66_L145_E0.7931.00
80_P83_Y0.7931.00
143_V150_R0.7891.00
94_I135_L0.7871.00
41_E44_A0.7861.00
61_V65_T0.7861.00
63_F138_I0.7851.00
66_L138_I0.7841.00
67_I71_L0.7771.00
63_F67_I0.7741.00
181_I192_Y0.7711.00
253_L256_L0.7711.00
293_I297_K0.7701.00
208_L281_I0.7661.00
353_Y356_K0.7651.00
108_H146_E0.7651.00
198_T247_V0.7641.00
123_L128_V0.7631.00
109_R113_D0.7631.00
360_M363_K0.7611.00
110_E113_D0.7611.00
177_F192_Y0.7571.00
33_A39_A0.7561.00
251_K362_D0.7551.00
192_Y315_F0.7511.00
142_A147_I0.7511.00
261_K264_Q0.7491.00
310_I314_D0.7481.00
53_E56_R0.7481.00
210_W257_L0.7461.00
300_Y304_D0.7391.00
143_V155_N0.7371.00
70_Y141_T0.7361.00
201_R313_H0.7291.00
85_N130_N0.7281.00
292_D295_S0.7231.00
129_N133_T0.7211.00
37_K40_L0.7201.00
146_E155_N0.7151.00
38_E41_E0.7121.00
44_A48_R0.7101.00
212_D224_K0.7101.00
167_K314_D0.7101.00
106_I111_I0.7091.00
93_H123_L0.7081.00
111_I135_L0.7071.00
61_V69_I0.7041.00
34_S38_E0.7021.00
143_V154_D0.7011.00
332_T336_R0.7001.00
334_K347_D0.6971.00
49_E52_E0.6951.00
206_L294_F0.6951.00
94_I98_F0.6931.00
258_E261_K0.6921.00
117_H121_T0.6921.00
359_E362_D0.6911.00
299_K302_C0.6901.00
94_I139_F0.6891.00
324_I353_Y0.6891.00
166_M311_R0.6871.00
136_S153_C0.6851.00
261_K265_E0.6841.00
41_E51_Q0.6811.00
136_S154_D0.6801.00
296_R300_Y0.6761.00
295_S312_L0.6761.00
181_I189_K0.6721.00
116_K119_M0.6711.00
330_Y347_D0.6701.00
112_T115_R0.6651.00
325_H355_N0.6651.00
199_G337_L0.6651.00
90_I138_I0.6631.00
69_I141_T0.6611.00
259_R263_A0.6611.00
298_I315_F0.6601.00
180_L301_F0.6601.00
41_E48_R0.6581.00
148_L152_P0.6551.00
190_T282_F0.6541.00
182_P193_T0.6531.00
168_F351_H0.6531.00
74_C77_D0.6511.00
139_F151_N0.6511.00
258_E262_E0.6481.00
135_L153_C0.6481.00
324_I331_I0.6471.00
118_L121_T0.6471.00
186_L189_K0.6451.00
115_R128_V0.6451.00
103_I142_A0.6451.00
330_Y342_V0.6441.00
173_E308_T0.6441.00
139_F143_V0.6431.00
132_M156_V0.6431.00
45_K52_E0.6431.00
324_I330_Y0.6331.00
140_D143_V0.6321.00
329_D360_M0.6291.00
186_L259_R0.6281.00
142_A148_L0.6231.00
39_A43_E0.6211.00
65_T69_I0.6211.00
297_K301_F0.6211.00
103_I139_F0.6181.00
61_V147_I0.6171.00
292_D296_R0.6161.00
320_V339_H0.6151.00
240_T338_G0.6141.00
94_I114_F0.6131.00
88_Y91_N0.6091.00
186_L190_T0.6061.00
355_N358_K0.6051.00
248_S357_Q0.6031.00
172_E176_K0.6031.00
215_K218_L0.6021.00
248_S358_K0.6011.00
354_P357_Q0.6011.00
255_K258_E0.6001.00
172_E175_K0.5991.00
202_C294_F0.5981.00
201_R224_K0.5931.00
98_F110_E0.5931.00
93_H114_F0.5921.00
187_L190_T0.5921.00
294_F312_L0.5901.00
219_E358_K0.5891.00
331_I347_D0.5871.00
98_F106_I0.5851.00
174_F318_S0.5831.00
210_W265_E0.5801.00
114_F135_L0.5791.00
314_D317_H0.5771.00
215_K249_I0.5771.00
114_F117_H0.5761.00
195_A202_C0.5761.00
176_K179_S0.5751.00
200_L220_I0.5741.00
329_D356_K0.5731.00
107_T149_K0.5731.00
205_M312_L0.5731.00
111_I156_V0.5711.00
69_I145_E0.5671.00
200_L208_L0.5661.00
194_V200_L0.5651.00
138_I141_T0.5641.00
62_S102_D0.5611.00
177_F298_I0.5571.00
213_I220_I0.5561.00
214_D218_L0.5561.00
187_L260_W0.5561.00
174_F178_I0.5541.00
78_S82_Y0.5541.00
213_I257_L0.5541.00
137_K141_T0.5541.00
180_L183_Q0.5531.00
125_N129_N0.5511.00
168_F321_A0.5511.00
117_H120_E0.5501.00
198_T250_N0.5491.00
215_K220_I0.5491.00
108_H155_N0.5471.00
63_F135_L0.5401.00
69_I72_A0.5391.00
107_T146_E0.5371.00
301_F304_D0.5341.00
255_K259_R0.5331.00
301_F305_S0.5331.00
90_I134_S0.5311.00
321_A352_L0.5301.00
200_L204_E0.5301.00
72_A75_E0.5291.00
336_R361_A0.5281.00
73_S116_K0.5251.00
204_E222_V0.5231.00
66_L147_I0.5231.00
188_F301_F0.5221.00
334_K344_T0.5191.00
169_W314_D0.5181.00
74_C137_K0.5181.00
328_E333_I0.5181.00
90_I94_I0.5171.00
36_R39_A0.5161.00
47_R50_F0.5151.00
195_A315_F0.5141.00
330_Y334_K0.5131.00
74_C86_Q0.5131.00
295_S298_I0.5121.00
324_I352_L0.5121.00
50_F55_A0.5121.00
342_V347_D0.5111.00
320_V334_K0.5111.00
260_W263_A0.5101.00
171_P318_S0.5101.00
256_L259_R0.5081.00
194_V257_L0.5081.00
109_R146_E0.5071.00
93_H118_L0.5031.00
215_K281_I0.5021.00
298_I312_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.8859 100 0.252 Contact Map
1a0pA 1 0.7092 100 0.308 Contact Map
2a3vA 3 0.7745 100 0.314 Contact Map
1z19A 3 0.7527 100 0.323 Contact Map
4a8eA 2 0.7092 100 0.345 Contact Map
1xo0A 3 0.7745 100 0.368 Contact Map
3nkhA 2 0.5571 100 0.465 Contact Map
1ae9A 4 0.4538 100 0.561 Contact Map
1aihA 2 0.4429 99.9 0.582 Contact Map
4e0gA 2 0.712 99.9 0.616 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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