GREMLIN Database
SPRTL - Protein SprT-like
UniProt: P96628 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (145)
Sequences: 464 (362)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_K77_E7.0021.00
7_Q11_E3.9441.00
48_L61_L2.9571.00
40_L47_E2.9151.00
80_G85_D2.8761.00
52_Y101_C2.8381.00
12_D16_T2.7531.00
10_T26_A2.6151.00
14_S73_H2.5080.99
44_H76_L2.4580.99
9_L62_I2.4340.99
39_Y75_H2.4030.99
27_L45_N2.3910.99
41_L44_H2.2110.98
62_I66_K2.1400.98
13_I65_I2.0550.98
79_K87_D2.0420.97
84_R89_R1.9960.97
131_M145_I1.9770.97
40_L43_S1.9200.96
86_R90_M1.8390.95
2_D95_V1.7450.94
30_D50_R1.7010.93
24_H44_H1.6980.93
117_I122_G1.6750.92
2_D5_E1.6500.92
10_T46_I1.5970.90
81_Y85_D1.4720.86
58_R62_I1.4710.86
82_K85_D1.4490.85
13_I66_K1.4100.84
80_G87_D1.3960.83
92_L97_A1.3880.83
25_Q45_N1.3660.82
119_T146_K1.3520.81
60_E98_P1.3320.80
7_Q44_H1.3240.79
39_Y44_H1.3210.79
40_L45_N1.2900.78
39_Y76_L1.2760.77
117_I124_Q1.2670.76
44_H75_H1.2290.74
1_M28_F1.1880.71
92_L136_Y1.1700.70
60_E104_L1.1600.70
78_G87_D1.1400.68
10_T65_I1.1180.67
3_N27_L1.1140.66
52_Y105_K1.1050.66
60_E101_C1.1030.66
98_P101_C1.0970.65
66_K96_N1.0880.65
6_L50_R1.0830.64
34_T49_N1.0730.63
125_Y145_I1.0690.63
115_M124_Q1.0610.63
53_L61_L1.0470.62
55_E106_K1.0400.61
46_I61_L1.0360.61
9_L65_I1.0210.60
55_E104_L1.0150.59
28_F32_L0.9960.58
98_P102_T0.9830.57
56_H104_L0.9830.57
11_E44_H0.9760.56
46_I101_C0.9760.56
97_A102_T0.9750.56
10_T15_E0.9750.56
52_Y60_E0.9720.56
64_I101_C0.9660.55
94_Q113_T0.9630.55
9_L116_Y0.9480.54
25_Q129_R0.9420.53
7_Q39_Y0.9390.53
5_E28_F0.9370.53
53_L56_H0.9360.53
81_Y87_D0.9340.53
123_Q140_K0.9320.53
125_Y142_R0.9310.53
52_Y64_I0.9230.52
40_L101_C0.9200.52
125_Y139_G0.9190.52
30_D54_I0.9180.51
139_G145_I0.9180.51
53_L57_G0.9170.51
52_Y98_P0.8970.50
61_L64_I0.8960.50
47_E101_C0.8840.49
60_E102_T0.8800.48
20_K78_G0.8700.48
20_K23_R0.8680.48
113_T128_K0.8610.47
24_H41_L0.8320.45
24_H73_H0.8260.44
41_L75_H0.8250.44
47_E64_I0.8220.44
3_N25_Q0.8220.44
56_H105_K0.8100.43
115_M126_I0.8080.43
3_N134_D0.8080.43
30_D51_K0.8030.42
41_L76_L0.7850.41
33_K131_M0.7830.41
60_E64_I0.7800.41
119_T123_Q0.7750.40
87_D90_M0.7740.40
7_Q75_H0.7730.40
12_D137_R0.7660.40
97_A101_C0.7650.39
93_Q117_I0.7620.39
62_I65_I0.7500.38
4_K8_K0.7500.38
34_T78_G0.7470.38
56_H130_A0.7440.38
57_G100_F0.7430.38
10_T48_L0.7420.38
19_K117_I0.7390.38
52_Y102_T0.7370.37
52_Y57_G0.7360.37
4_K132_N0.7360.37
11_E76_L0.7320.37
121_C143_G0.7320.37
16_T146_K0.7300.37
23_R120_T0.7250.36
57_G70_C0.7250.36
125_Y140_K0.7240.36
9_L41_L0.7210.36
70_C121_C0.7160.36
32_L50_R0.7130.36
13_I63_G0.7100.35
26_A73_H0.7090.35
40_L98_P0.7090.35
49_N116_Y0.7080.35
50_R97_A0.7050.35
61_L78_G0.7040.35
13_I17_Y0.7020.35
2_D8_K0.6950.34
41_L61_L0.6950.34
52_Y104_L0.6850.34
116_Y133_P0.6850.34
113_T136_Y0.6760.33
17_Y66_K0.6750.33
1_M5_E0.6730.33
117_I146_K0.6720.33
91_L95_V0.6710.33
137_R144_K0.6690.32
93_Q115_M0.6660.32
15_E109_E0.6600.32
74_L89_R0.6560.32
24_H43_S0.6550.31
122_G126_I0.6540.31
7_Q24_H0.6450.31
91_L94_Q0.6450.31
34_T41_L0.6370.30
7_Q76_L0.6350.30
23_R86_R0.6350.30
55_E95_V0.6340.30
30_D142_R0.6340.30
26_A56_H0.6300.30
52_Y56_H0.6250.29
32_L57_G0.6240.29
58_R93_Q0.6240.29
111_K128_K0.6230.29
11_E137_R0.6220.29
63_G92_L0.6180.29
111_K131_M0.6180.29
94_Q109_E0.6100.28
110_N146_K0.6080.28
119_T144_K0.6020.28
63_G66_K0.5970.28
33_K40_L0.5920.27
3_N26_A0.5900.27
115_M133_P0.5880.27
89_R100_F0.5870.27
41_L49_N0.5860.27
27_L47_E0.5850.27
8_K12_D0.5840.27
8_K87_D0.5830.27
8_K21_P0.5820.27
76_L82_K0.5820.27
7_Q41_L0.5810.27
56_H103_P0.5810.27
46_I85_D0.5800.27
28_F39_Y0.5790.27
12_D15_E0.5760.26
7_Q10_T0.5750.26
24_H95_V0.5720.26
15_E144_K0.5720.26
34_T122_G0.5710.26
112_K130_A0.5700.26
9_L61_L0.5630.26
115_M140_K0.5620.25
43_S102_T0.5580.25
48_L97_A0.5580.25
63_G97_A0.5570.25
43_S101_C0.5560.25
82_K100_F0.5470.25
19_K120_T0.5460.25
3_N15_E0.5440.24
11_E39_Y0.5400.24
6_L48_L0.5360.24
92_L108_A0.5310.24
19_K94_Q0.5310.24
24_H45_N0.5290.24
46_I125_Y0.5290.24
115_M122_G0.5280.23
27_L40_L0.5270.23
43_S57_G0.5260.23
3_N46_I0.5260.23
94_Q124_Q0.5240.23
114_Y131_M0.5150.23
12_D144_K0.5110.23
25_Q93_Q0.5110.23
90_M94_Q0.5080.22
19_K86_R0.5070.22
114_Y133_P0.5060.22
90_M134_D0.5020.22
74_L83_H0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jixA 2 0.7067 99.3 0.815 Contact Map
4qhjA 2 0.7 96.3 0.912 Contact Map
4jiuA 1 0.6933 95.1 0.919 Contact Map
3cqbA 4 0.5467 91.3 0.93 Contact Map
4aybP 1 0.22 89.2 0.933 Contact Map
2lcqA 1 0.7467 87.9 0.935 Contact Map
4il3A 1 0.8667 86.6 0.936 Contact Map
4qiwP 1 0.2133 83 0.939 Contact Map
1vd4A 1 0.32 72.8 0.944 Contact Map
2dulA 2 0.88 56.3 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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