GREMLIN Database
ENDOA - mRNA interferase EndoA
UniProt: P96622 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 116 (109)
Sequences: 1351 (928)
Seq/√Len: 88.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_A27_V3.5641.00
9_Y88_L2.9811.00
59_H78_E2.7841.00
13_L27_V2.7191.00
28_L103_V2.7051.00
45_A75_I2.6961.00
20_E87_R2.6061.00
7_D94_H2.4281.00
45_A77_L2.3601.00
96_D99_M2.2111.00
11_A83_I2.1911.00
99_M102_K1.9991.00
5_R104_D1.9821.00
43_I110_S1.9641.00
3_V29_V1.8931.00
16_V22_G1.8071.00
31_Q42_A1.7371.00
6_G100_M1.7071.00
13_L81_R1.6931.00
75_I103_V1.6431.00
64_A72_D1.5921.00
10_F92_I1.5891.00
15_P81_R1.5811.00
104_D113_L1.5361.00
12_D24_V1.4540.99
3_V88_L1.4470.99
42_A85_K1.4270.99
27_V83_I1.4060.99
10_F89_T1.3530.99
7_D91_K1.3510.99
66_R99_M1.3400.99
81_R87_R1.3290.99
9_Y91_K1.3080.99
10_F90_D1.2880.99
41_T82_T1.2730.99
16_V81_R1.2580.98
56_L59_H1.2490.98
51_I74_V1.2450.98
67_Y95_L1.2150.98
30_I45_A1.2150.98
15_P20_E1.2060.98
31_Q43_I1.1970.98
68_G93_T1.1890.98
31_Q41_T1.1880.98
5_R100_M1.1860.98
20_E81_R1.1620.97
30_I107_L1.1600.97
8_V92_I1.1570.97
31_Q35_G1.1510.97
28_L45_A1.1490.97
44_V83_I1.1150.97
21_Q76_L1.1090.96
60_V106_A1.0890.96
35_G110_S1.0680.96
49_A71_R1.0470.95
15_P87_R1.0270.95
19_S41_T0.9540.92
28_L95_L0.9500.92
69_F73_S0.9380.91
63_D72_D0.9330.91
17_V86_Q0.9320.91
32_N35_G0.9310.91
100_M103_V0.9300.91
47_I62_I0.9270.91
108_Q111_L0.9240.91
108_Q113_L0.9030.90
35_G39_S0.9000.90
88_L91_K0.8950.89
33_D36_N0.8830.89
51_I61_E0.8530.87
30_I77_L0.8510.87
13_L46_A0.8460.87
104_D111_L0.8450.86
97_D102_K0.8430.86
104_D108_Q0.8050.84
56_L78_E0.8050.84
24_V89_T0.7940.83
3_V9_Y0.7810.82
95_L100_M0.7790.82
14_S87_R0.7600.80
82_T85_K0.7550.80
61_E72_D0.7430.78
17_V87_R0.7400.78
47_I73_S0.7390.78
95_L103_V0.7320.77
21_Q59_H0.7280.77
39_S58_T0.7270.77
42_A88_L0.7200.76
91_K94_H0.7120.75
21_Q78_E0.7090.75
5_R107_L0.7050.75
4_K71_R0.7010.74
28_L112_A0.6980.74
96_D102_K0.6960.74
39_S78_E0.6960.74
6_G104_D0.6910.73
60_V99_M0.6880.73
14_S24_V0.6880.73
35_G41_T0.6870.73
104_D107_L0.6830.72
94_H97_D0.6800.72
29_V67_Y0.6760.72
102_K105_E0.6730.71
12_D89_T0.6700.71
80_I111_L0.6690.71
63_D99_M0.6660.71
10_F73_S0.6620.70
62_I69_F0.6580.70
34_I107_L0.6490.69
20_E84_D0.6490.69
3_V7_D0.6490.69
3_V91_K0.6480.68
52_Q74_V0.6470.68
46_A82_T0.6450.68
43_I80_I0.6420.68
55_K74_V0.6370.67
4_K7_D0.6330.67
94_H99_M0.6310.66
58_T78_E0.6280.66
35_G78_E0.6230.65
98_E102_K0.6220.65
13_L20_E0.6160.65
32_N110_S0.6110.64
49_A52_Q0.6100.64
47_I75_I0.6080.64
27_V88_L0.6070.63
14_S84_D0.5990.62
58_T76_L0.5990.62
39_S76_L0.5960.62
6_G32_N0.5920.62
80_I107_L0.5820.60
19_S40_P0.5790.60
64_A67_Y0.5770.60
8_V94_H0.5770.60
100_M104_D0.5760.59
30_I60_V0.5630.58
88_L92_I0.5600.57
79_Q84_D0.5570.57
8_V93_T0.5560.57
43_I82_T0.5540.56
63_D66_R0.5540.56
45_A80_I0.5540.56
32_N109_I0.5530.56
8_V67_Y0.5520.56
52_Q86_Q0.5460.55
38_F56_L0.5460.55
23_G59_H0.5420.55
41_T79_Q0.5420.55
61_E74_V0.5410.55
29_V69_F0.5380.54
14_S22_G0.5370.54
3_V42_A0.5270.53
41_T84_D0.5270.53
29_V88_L0.5240.52
69_F93_T0.5230.52
31_Q110_S0.5220.52
19_S76_L0.5180.52
35_G38_F0.5170.51
51_I89_T0.5140.51
9_Y89_T0.5070.50
74_V110_S0.5070.50
46_A49_A0.5040.50
91_K101_D0.5030.50
43_I77_L0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mzmA 2 0.9914 100 0.226 Contact Map
4mdxA 2 0.9828 100 0.228 Contact Map
1ub4A 2 0.8534 100 0.302 Contact Map
1m1fA 2 0.9052 100 0.307 Contact Map
2kmtA 2 0.8621 99.5 0.626 Contact Map
3vubA 2 0.8362 99.1 0.686 Contact Map
1h3zA 1 0.8448 21 0.927 Contact Map
2l89A 1 0.8276 12.9 0.933 Contact Map
1ua4A 1 0.7845 11.4 0.935 Contact Map
1dd4C 7 0.2931 10.5 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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