GREMLIN Database
ENDAI - Antitoxin EndoAI
UniProt: P96621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (86)
Sequences: 168 (110)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_C86_V2.4640.88
54_R65_A2.3360.85
38_S41_V2.2570.83
74_E82_A1.9750.73
10_M48_R1.9510.72
51_R74_E1.9250.71
8_T13_S1.8850.69
66_K70_N1.8780.69
9_E38_S1.8560.68
31_R83_E1.7460.63
22_L39_Q1.6910.61
10_M23_D1.6840.60
8_T34_N1.6730.60
83_E86_V1.6720.60
30_K50_T1.6170.57
14_L36_L1.5800.55
26_A33_R1.5770.55
42_R46_S1.5710.55
78_A81_E1.5680.55
19_V23_D1.5500.54
73_S90_V1.5500.54
73_S79_E1.5000.51
44_Y49_T1.4400.48
27_M37_I1.4020.46
79_E82_A1.3900.46
65_A82_A1.3710.45
35_E48_R1.3640.44
9_E13_S1.3430.43
85_T89_L1.3350.43
49_T67_I1.3080.42
54_R81_E1.2580.39
80_C88_R1.2470.39
44_Y47_E1.2450.39
32_S50_T1.1780.36
30_K52_H1.1580.35
57_M81_E1.1560.35
21_E49_T1.1550.35
80_C87_E1.1470.34
46_S52_H1.1420.34
19_V34_N1.1330.34
48_R55_D1.1310.33
9_E41_V1.1150.33
58_R90_V1.1120.33
66_K85_T1.0910.32
13_S43_A1.0820.31
23_D33_R1.0790.31
14_L35_E1.0580.30
22_L36_L1.0390.30
73_S82_A1.0380.29
66_K79_E1.0320.29
7_R37_I1.0250.29
14_L21_E1.0200.29
71_I81_E0.9640.27
62_M66_K0.9630.26
50_T53_N0.9540.26
74_E81_E0.9490.26
5_S26_A0.9450.26
73_S76_H0.9450.26
71_I82_A0.9150.25
13_S41_V0.9130.25
15_P69_L0.8790.23
11_K69_L0.8670.23
16_E27_M0.8660.23
21_E26_A0.8400.22
75_A90_V0.8290.22
26_A38_S0.8270.22
11_K22_L0.8260.22
19_V44_Y0.8260.22
47_E50_T0.8230.21
63_E69_L0.8080.21
53_N80_C0.8080.21
20_A86_V0.8070.21
10_M65_A0.8000.21
56_L85_T0.7990.21
16_E65_A0.7890.20
20_A41_V0.7820.20
10_M16_E0.7810.20
51_R73_S0.7770.20
18_L47_E0.7760.20
11_K24_G0.7580.19
85_T88_R0.7310.18
21_E57_M0.7130.18
21_E47_E0.7120.18
7_R50_T0.7120.18
58_R87_E0.7100.18
13_S38_S0.7060.18
19_V58_R0.6970.17
30_K56_L0.6970.17
47_E54_R0.6900.17
28_R35_E0.6840.17
22_L41_V0.6710.17
35_E62_M0.6690.17
48_R65_A0.6690.17
32_S43_A0.6670.17
8_T33_R0.6660.17
54_R62_M0.6520.16
33_R37_I0.6510.16
34_N37_I0.6470.16
74_E79_E0.6450.16
19_V22_L0.6440.16
75_A79_E0.6410.16
5_S20_A0.6410.16
19_V38_S0.6330.16
42_R47_E0.6230.15
36_L55_D0.6230.15
75_A82_A0.6200.15
28_R71_I0.6170.15
29_E72_S0.5870.15
34_N39_Q0.5850.14
35_E38_S0.5840.14
25_V28_R0.5790.14
34_N47_E0.5790.14
11_K34_N0.5700.14
29_E59_R0.5690.14
75_A88_R0.5680.14
7_R84_T0.5640.14
13_S20_A0.5570.14
29_E48_R0.5540.14
37_I56_L0.5440.14
13_S27_M0.5390.13
23_D72_S0.5380.13
19_V41_V0.5330.13
12_I58_R0.5300.13
36_L53_N0.5290.13
12_I51_R0.5270.13
6_A86_V0.5090.13
7_R55_D0.5020.13
79_E83_E0.5020.13
5_S28_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4me7E 2 0.8602 99.9 0.401 Contact Map
2hzaA 3 0.9032 98.1 0.779 Contact Map
2bj7A 3 0.9247 98.1 0.779 Contact Map
2cpgA 2 0.4839 97.9 0.79 Contact Map
3kxeC 2 0.7849 97.9 0.791 Contact Map
2wvfA 2 0.9247 97.7 0.797 Contact Map
2k5jA 2 0.7204 97.6 0.803 Contact Map
2mdvA 2 0.4086 97.5 0.806 Contact Map
2gpeA 2 0.5161 96.9 0.822 Contact Map
2ay0A 2 0.4946 96.9 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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