GREMLIN Database
YDCC - Sporulation protein YdcC
UniProt: P96619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (323)
Sequences: 385 (327)
Seq/√Len: 18.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_N171_D6.5461.00
269_L332_M5.4591.00
164_E178_K5.1311.00
259_M271_Q4.0931.00
74_L94_E4.0291.00
68_W76_R3.4641.00
138_V149_E3.2550.99
49_K194_S3.1150.99
100_L212_M3.1130.99
70_K203_K2.9730.99
100_L211_N2.9010.99
297_G304_L2.7610.98
6_K56_T2.6470.97
243_L259_M2.5350.97
49_K66_E2.4860.96
232_K271_Q2.4660.96
201_F205_S2.3810.95
266_S319_D2.3080.94
51_K191_E2.2680.94
240_G264_E2.2080.93
173_S197_F2.1990.93
92_R98_F2.1850.92
278_K309_D2.1520.92
249_I253_D2.1520.92
67_I89_V2.1280.91
243_L246_E2.0910.91
45_S199_K2.0900.91
119_S130_D2.0510.90
189_K198_N1.9830.88
166_T176_S1.9250.87
221_T224_K1.8880.85
181_D185_K1.8720.85
131_V167_F1.8350.84
68_W205_S1.8090.83
201_F204_E1.7870.82
71_K304_L1.7330.80
42_E204_E1.7100.79
199_K243_L1.6940.78
15_L18_V1.6890.78
204_E210_K1.6850.78
220_A223_A1.6770.78
11_L207_D1.6730.77
77_V118_S1.6670.77
70_K297_G1.6620.77
44_T72_P1.6620.77
244_L262_G1.6520.77
168_N175_S1.6310.76
98_F310_G1.6300.76
114_W122_Y1.6190.75
178_K236_E1.6120.75
124_F195_F1.5820.73
263_G269_L1.5790.73
10_L20_I1.5500.72
22_S322_K1.5430.71
127_L177_V1.5360.71
164_E236_E1.5290.71
66_E78_Y1.5220.70
13_T51_K1.5180.70
106_K119_S1.5070.70
256_R272_E1.5040.69
13_T259_M1.5030.69
243_L331_S1.4930.69
54_I77_V1.4720.68
99_V163_Q1.4720.68
185_K313_Y1.4710.68
74_L182_T1.4630.67
88_Q122_Y1.4470.66
45_S200_Q1.4450.66
64_N304_L1.4150.65
248_D255_K1.4130.64
229_F257_I1.4110.64
216_Q219_V1.3990.64
57_G68_W1.3900.63
22_S85_D1.3870.63
254_G311_V1.3820.63
161_P256_R1.3790.62
234_P331_S1.3760.62
304_L325_M1.3740.62
45_S204_E1.3710.62
93_N163_Q1.3560.61
53_T191_E1.3470.61
65_V240_G1.3460.61
236_E327_T1.3150.59
228_T261_Y1.3140.59
150_T183_D1.3130.59
129_K202_D1.3100.58
176_S191_E1.3070.58
18_V219_V1.2970.58
16_L171_D1.2910.57
289_P298_A1.2900.57
53_T328_V1.2880.57
277_A328_V1.2800.57
91_L211_N1.2750.56
160_L179_V1.2670.56
22_S82_P1.2610.55
41_K185_K1.2570.55
93_N110_F1.2540.55
225_P228_T1.2480.55
96_G114_W1.2460.54
48_A180_M1.2450.54
15_L165_I1.2390.54
29_Q178_K1.2310.54
292_L330_K1.2290.53
197_F299_L1.2200.53
88_Q104_L1.2200.53
67_I111_Q1.2170.53
304_L330_K1.2110.52
88_Q102_P1.2080.52
176_S189_K1.2070.52
221_T288_E1.2020.52
20_I252_E1.1770.50
52_M122_Y1.1730.50
148_F165_I1.1580.49
263_G267_F1.1560.49
130_D272_E1.1420.48
130_D150_T1.1410.48
209_K229_F1.1350.48
70_K74_L1.1310.47
39_K322_K1.1260.47
124_F174_P1.1190.47
22_S165_I1.1180.47
262_G266_S1.1150.46
129_K168_N1.1100.46
261_Y311_V1.0980.45
50_A124_F1.0930.45
140_T253_D1.0910.45
209_K247_K1.0890.45
53_T72_P1.0890.45
277_A308_Y1.0870.45
45_S99_V1.0840.44
148_F245_E1.0790.44
143_E175_S1.0770.44
119_S303_S1.0760.44
6_K53_T1.0740.44
96_G122_Y1.0720.44
13_T17_A1.0690.44
24_C106_K1.0640.43
316_S321_S1.0630.43
88_Q114_W1.0590.43
91_L174_P1.0570.43
273_K332_M1.0550.43
239_L309_D1.0490.42
16_L42_E1.0480.42
323_E328_V1.0460.42
50_A125_E1.0400.42
328_V331_S1.0390.42
119_S122_Y1.0320.41
101_T115_P1.0300.41
88_Q263_G1.0290.41
105_N169_K1.0280.41
62_V182_T1.0250.41
167_F179_V1.0250.41
115_P154_Y1.0200.41
11_L232_K1.0190.41
23_A238_P1.0120.40
19_L253_D1.0080.40
88_Q96_G1.0040.40
35_G238_P1.0030.40
80_E87_N0.9990.39
168_N305_S0.9990.39
20_I257_I0.9970.39
292_L332_M0.9960.39
237_L261_Y0.9940.39
128_V293_G0.9900.39
197_F315_L0.9890.39
17_A193_S0.9880.39
155_Q261_Y0.9870.39
19_L323_E0.9860.39
7_S244_L0.9850.39
198_N203_K0.9770.38
91_L154_Y0.9770.38
307_T312_D0.9750.38
101_T110_F0.9730.38
114_W163_Q0.9660.37
139_F167_F0.9630.37
36_L128_V0.9570.37
106_K120_Q0.9570.37
153_N236_E0.9570.37
116_N133_N0.9550.37
234_P329_A0.9550.37
241_V303_S0.9530.37
180_M186_V0.9530.37
168_N199_K0.9530.37
83_K326_V0.9520.37
77_V115_P0.9490.36
70_K129_K0.9440.36
91_L190_V0.9410.36
72_P159_M0.9400.36
267_F270_I0.9400.36
97_V115_P0.9370.36
231_V257_I0.9260.35
48_A197_F0.9230.35
305_S312_D0.9180.35
76_R211_N0.9150.35
100_L208_E0.9150.35
63_Y92_R0.9120.34
108_F236_E0.9090.34
196_E199_K0.9080.34
17_A20_I0.9020.34
219_V222_S0.9010.34
246_E261_Y0.8980.34
144_K203_K0.8950.33
96_G106_K0.8930.33
147_V293_G0.8930.33
322_K326_V0.8910.33
269_L315_L0.8880.33
56_T98_F0.8850.33
112_S115_P0.8840.33
191_E327_T0.8830.33
30_Q225_P0.8830.33
288_E322_K0.8810.33
102_P181_D0.8800.33
58_S197_F0.8780.33
44_T290_V0.8740.32
301_D316_S0.8730.32
214_L220_A0.8730.32
71_K205_S0.8700.32
127_L163_Q0.8670.32
158_K161_P0.8660.32
181_D317_S0.8660.32
188_V195_F0.8650.32
108_F263_G0.8640.32
56_T238_P0.8640.32
36_L139_F0.8610.32
106_K163_Q0.8590.31
30_Q44_T0.8580.31
133_N239_L0.8530.31
13_T16_L0.8420.31
60_P72_P0.8420.31
59_E288_E0.8340.30
33_V208_E0.8330.30
94_E98_F0.8320.30
95_N187_M0.8310.30
51_K82_P0.8280.30
238_P331_S0.8250.30
175_S195_F0.8230.30
66_E209_K0.8220.30
255_K259_M0.8210.29
119_S306_W0.8180.29
145_K168_N0.8180.29
10_L224_K0.8170.29
86_Q103_S0.8160.29
198_N239_L0.8090.29
5_R198_N0.8060.29
31_D136_D0.8010.28
97_V112_S0.8010.28
6_K235_L0.7930.28
15_L286_N0.7910.28
32_I50_A0.7910.28
254_G289_P0.7890.28
46_Y63_Y0.7890.28
34_A204_E0.7870.28
147_V256_R0.7810.27
13_T236_E0.7810.27
52_M114_W0.7800.27
52_M120_Q0.7800.27
7_S257_I0.7780.27
5_R232_K0.7770.27
66_E274_A0.7760.27
213_T261_Y0.7760.27
103_S150_T0.7760.27
306_W329_A0.7760.27
49_K164_E0.7710.27
5_R277_A0.7690.27
53_T95_N0.7670.27
125_E180_M0.7660.27
144_K242_K0.7620.27
131_V165_I0.7570.26
73_S243_L0.7550.26
78_Y195_F0.7510.26
244_L275_Q0.7510.26
82_P327_T0.7500.26
49_K193_S0.7460.26
138_V222_S0.7460.26
13_T37_D0.7460.26
43_Y56_T0.7420.26
57_G297_G0.7420.26
245_E261_Y0.7400.26
40_A128_V0.7400.26
249_I309_D0.7400.26
150_T153_N0.7370.25
77_V265_K0.7370.25
199_K257_I0.7370.25
256_R260_T0.7360.25
202_D307_T0.7310.25
91_L107_S0.7290.25
128_V245_E0.7270.25
258_I261_Y0.7270.25
68_W273_K0.7250.25
91_L208_E0.7250.25
129_K290_V0.7230.25
113_D307_T0.7220.25
77_V233_T0.7210.25
44_T304_L0.7180.24
27_K280_S0.7160.24
295_T329_A0.7150.24
196_E323_E0.7130.24
32_I143_E0.7080.24
160_L270_I0.7060.24
168_N173_S0.7030.24
32_I279_A0.7030.24
149_E162_T0.6980.24
139_F320_L0.6960.23
22_S242_K0.6940.23
158_K244_L0.6930.23
97_V111_Q0.6920.23
253_D301_D0.6910.23
42_E49_K0.6900.23
85_D216_Q0.6900.23
25_G52_M0.6880.23
35_G299_L0.6880.23
67_I141_A0.6860.23
92_R261_Y0.6850.23
76_R205_S0.6840.23
81_N208_E0.6840.23
102_P114_W0.6790.23
217_M221_T0.6780.23
227_D277_A0.6760.23
93_N96_G0.6760.23
286_N309_D0.6740.23
115_P130_D0.6720.22
291_N300_S0.6720.22
142_K145_K0.6720.22
196_E269_L0.6700.22
31_D168_N0.6670.22
194_S315_L0.6670.22
112_S163_Q0.6660.22
149_E164_E0.6650.22
149_E202_D0.6650.22
14_G264_E0.6650.22
24_C329_A0.6650.22
145_K294_Y0.6650.22
81_N120_Q0.6620.22
237_L242_K0.6620.22
178_K315_L0.6600.22
116_N255_K0.6570.22
13_T60_P0.6570.22
96_G104_L0.6570.22
96_G102_P0.6570.22
10_L38_E0.6570.22
119_S163_Q0.6540.22
24_C306_W0.6540.22
106_K114_W0.6530.22
93_N127_L0.6530.22
20_I191_E0.6480.21
263_G271_Q0.6440.21
15_L237_L0.6440.21
107_S210_K0.6430.21
53_T149_E0.6430.21
76_R206_F0.6410.21
159_M309_D0.6400.21
222_S247_K0.6390.21
312_D315_L0.6390.21
17_A73_S0.6390.21
136_D167_F0.6380.21
64_N162_T0.6370.21
151_K161_P0.6340.21
77_V110_F0.6330.21
22_S196_E0.6320.21
250_S253_D0.6290.21
13_T38_E0.6280.21
254_G332_M0.6280.21
75_Y79_L0.6270.21
92_R207_D0.6260.21
5_R302_A0.6250.20
198_N206_F0.6220.20
102_P110_F0.6220.20
194_S237_L0.6210.20
33_V149_E0.6200.20
70_K198_N0.6200.20
97_V287_G0.6200.20
32_I172_M0.6180.20
12_L242_K0.6170.20
268_T297_G0.6140.20
63_Y88_Q0.6140.20
76_R247_K0.6130.20
174_P293_G0.6130.20
150_T317_S0.6090.20
239_L327_T0.6080.20
75_Y110_F0.6070.20
14_G18_V0.6050.20
11_L22_S0.6030.20
104_L114_W0.6010.20
199_K248_D0.5980.19
120_Q127_L0.5980.19
48_A192_F0.5970.19
48_A279_A0.5950.19
19_L35_G0.5950.19
285_L318_K0.5930.19
26_Q242_K0.5920.19
213_T219_V0.5900.19
221_T225_P0.5900.19
82_P269_L0.5900.19
263_G272_E0.5900.19
144_K321_S0.5890.19
114_W177_V0.5890.19
132_Q328_V0.5880.19
60_P294_Y0.5880.19
203_K261_Y0.5860.19
96_G123_L0.5840.19
195_F227_D0.5820.19
73_S305_S0.5800.19
158_K299_L0.5790.19
88_Q101_T0.5760.19
46_Y75_Y0.5740.19
209_K328_V0.5740.19
127_L134_D0.5730.18
97_V154_Y0.5730.18
285_L305_S0.5730.18
124_F207_D0.5700.18
219_V299_L0.5680.18
25_G106_K0.5670.18
175_S203_K0.5660.18
76_R180_M0.5650.18
52_M309_D0.5650.18
59_E326_V0.5650.18
208_E211_N0.5640.18
99_V104_L0.5640.18
54_I294_Y0.5640.18
96_G110_F0.5630.18
29_Q167_F0.5620.18
22_S49_K0.5610.18
150_T165_I0.5600.18
152_T161_P0.5600.18
58_S196_E0.5590.18
11_L235_L0.5590.18
244_L264_E0.5570.18
216_Q225_P0.5570.18
162_T184_R0.5550.18
11_L231_V0.5540.18
94_E261_Y0.5520.18
275_Q288_E0.5510.18
74_L263_G0.5510.18
38_E157_N0.5490.18
35_G78_Y0.5470.18
183_D198_N0.5450.17
193_S261_Y0.5450.17
231_V259_M0.5440.17
94_E325_M0.5430.17
79_L117_N0.5400.17
31_D95_N0.5400.17
18_V188_V0.5390.17
35_G137_A0.5390.17
18_V213_T0.5380.17
52_M94_E0.5380.17
174_P310_G0.5380.17
257_I260_T0.5340.17
38_E273_K0.5320.17
118_S272_E0.5310.17
7_S276_I0.5300.17
43_Y71_K0.5300.17
111_Q120_Q0.5290.17
18_V327_T0.5280.17
107_S254_G0.5270.17
70_K95_N0.5260.17
320_L324_E0.5250.17
101_T154_Y0.5250.17
5_R191_E0.5240.17
101_T122_Y0.5240.17
47_K68_W0.5230.17
215_S219_V0.5210.17
34_A175_S0.5200.17
162_T325_M0.5200.17
123_L293_G0.5200.17
54_I155_Q0.5180.17
245_E274_A0.5180.17
108_F157_N0.5180.17
22_S290_V0.5170.16
141_A200_Q0.5170.16
29_Q164_E0.5160.16
167_F172_M0.5150.16
193_S286_N0.5150.16
7_S326_V0.5140.16
293_G306_W0.5130.16
63_Y170_K0.5120.16
252_E317_S0.5110.16
104_L110_F0.5090.16
22_S188_V0.5090.16
23_A203_K0.5070.16
14_G171_D0.5060.16
59_E224_K0.5050.16
221_T244_L0.5020.16
37_D41_K0.5020.16
50_A96_G0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m4wA 2 0.8195 100 0.661 Contact Map
2yzyA 1 0.4645 99.9 0.737 Contact Map
3buuA 1 0.5503 99.9 0.741 Contact Map
4z48A 1 0.5592 99.9 0.748 Contact Map
4mxtA 2 0.5355 99.9 0.748 Contact Map
2w7qA 1 0.5562 99.9 0.751 Contact Map
3bk5A 1 0.6302 99.8 0.764 Contact Map
1iwlA 1 0.5207 99.8 0.772 Contact Map
4qa8A 1 0.5178 97.5 0.909 Contact Map
3mh9C 1 0.5266 97 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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