GREMLIN Database
ACPS - Holo-[acyl-carrier-protein] synthase
UniProt: P96618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (113)
Sequences: 2752 (1997)
Seq/√Len: 187.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_G103_I2.4561.00
7_L111_A2.3591.00
5_I113_Q2.3231.00
82_D86_K2.2371.00
100_H117_E2.1981.00
52_G105_H2.1661.00
33_S78_E2.1621.00
31_T78_E2.1081.00
7_L113_Q2.1011.00
56_A101_V2.0711.00
60_F89_I2.0601.00
89_I114_V2.0371.00
56_A79_I2.0031.00
104_T111_A1.9591.00
53_R81_K1.9161.00
11_E108_E1.8811.00
27_E35_L1.8381.00
60_F114_V1.7881.00
26_A35_L1.7861.00
99_V116_I1.7151.00
9_I109_Y1.6651.00
16_A20_G1.6181.00
80_R88_Y1.6111.00
55_A112_A1.5891.00
11_E106_T1.5171.00
61_S68_I1.5091.00
37_Q81_K1.4601.00
38_Y50_L1.4271.00
23_K27_E1.4151.00
60_F77_I1.3911.00
7_L102_S1.3781.00
13_K108_E1.3361.00
48_E105_H1.3301.00
12_L47_N1.3111.00
77_I89_I1.3041.00
80_R90_I1.2651.00
91_C99_V1.2551.00
4_G100_H1.2451.00
78_E92_T1.2111.00
9_I111_A1.2051.00
45_R48_E1.1901.00
39_Y50_L1.1731.00
12_L110_A1.1701.00
35_L39_Y1.1701.00
98_A117_E1.1651.00
10_T15_I1.1621.00
30_L49_F1.1611.00
38_Y49_F1.1581.00
68_I74_F1.1571.00
33_S36_D1.1401.00
9_I104_T1.1211.00
10_T55_A1.1201.00
10_T110_A1.1181.00
60_F64_F1.1151.00
30_L50_L1.1051.00
61_S67_G1.1041.00
82_D88_Y1.1031.00
78_E90_I1.1011.00
18_M25_F1.0861.00
13_K16_A1.0861.00
25_F29_I1.0811.00
61_S72_L1.0801.00
43_E46_K1.0451.00
2_I100_H1.0371.00
11_E107_K1.0020.99
19_A50_L0.9880.99
56_A103_I0.9820.99
7_L104_T0.9820.99
16_A47_N0.9770.99
96_Q116_I0.9730.99
27_E32_R0.9670.99
19_A26_A0.9660.99
19_A47_N0.9660.99
30_L38_Y0.9660.99
63_A116_I0.9440.99
15_I25_F0.9170.99
89_I99_V0.9160.99
73_S76_D0.9140.99
49_F53_R0.9130.99
16_A45_R0.9110.99
106_T109_Y0.9000.99
2_I117_E0.8980.99
33_S80_R0.8850.99
61_S66_T0.8790.99
65_G86_K0.8780.99
60_F99_V0.8680.99
79_I101_V0.8470.98
32_R36_D0.8380.98
35_L50_L0.8190.98
26_A39_Y0.8150.98
72_L77_I0.8140.98
13_K107_K0.8100.98
32_R75_Q0.8010.97
12_L51_A0.7990.97
2_I115_V0.7840.97
10_T106_T0.7820.97
37_Q49_F0.7530.96
94_L97_A0.7500.96
61_S77_I0.7440.96
61_S74_F0.7420.96
39_Y46_K0.7400.96
60_F91_C0.7320.96
48_E52_G0.7210.95
18_M22_Q0.7100.95
26_A30_L0.7040.95
93_K97_A0.6930.94
19_A22_Q0.6890.94
55_A110_A0.6870.94
14_R28_R0.6780.94
86_K100_H0.6740.93
76_D92_T0.6740.93
19_A38_Y0.6700.93
30_L37_Q0.6640.93
12_L106_T0.6570.93
29_I54_F0.6550.92
96_Q99_V0.6500.92
23_K35_L0.6480.92
106_T113_Q0.6430.92
55_A59_A0.6360.91
46_K50_L0.6340.91
109_Y113_Q0.6330.91
79_I89_I0.6330.91
93_K96_Q0.6300.91
38_Y53_R0.6250.91
10_T18_M0.6240.91
106_T111_A0.6200.90
18_M21_R0.6150.90
31_T75_Q0.6140.90
59_A114_V0.6120.90
3_Y97_A0.6110.90
100_H113_Q0.6100.90
49_F52_G0.6070.89
80_R101_V0.6070.89
36_D40_E0.6070.89
9_I106_T0.6060.89
15_I18_M0.6010.89
100_H115_V0.5980.89
11_E109_Y0.5930.88
26_A50_L0.5920.88
3_Y96_Q0.5910.88
24_R27_E0.5890.88
33_S90_I0.5870.88
5_I14_R0.5790.87
54_F74_F0.5760.87
31_T92_T0.5760.87
36_D39_Y0.5740.86
64_F72_L0.5730.86
59_A112_A0.5720.86
5_I102_S0.5670.86
89_I101_V0.5660.86
5_I100_H0.5600.85
4_G63_A0.5540.85
10_T14_R0.5500.84
60_F116_I0.5490.84
37_Q40_E0.5480.84
29_I74_F0.5470.84
14_R54_F0.5400.83
8_D58_E0.5370.83
20_G32_R0.5360.83
65_G68_I0.5360.83
57_K77_I0.5320.82
50_L53_R0.5310.82
4_G117_E0.5220.81
5_I115_V0.5220.81
53_R101_V0.5170.80
31_T79_I0.5140.80
92_T97_A0.5080.79
2_I5_I0.5050.79
3_Y60_F0.5020.78
20_G23_K0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uv9A 5 0 100 0.151 Contact Map
2uv8A 6 0 100 0.152 Contact Map
2qg8A 3 0.8678 100 0.191 Contact Map
2bddA 3 0.8182 100 0.192 Contact Map
3nfdA 3 0.9669 100 0.239 Contact Map
2wdsA 3 0.9421 100 0.258 Contact Map
3hykA 3 0.9504 100 0.262 Contact Map
3qmnA 4 0.9669 100 0.268 Contact Map
3gwmA 3 0.9669 100 0.272 Contact Map
1fthA 3 0.9587 100 0.282 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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