GREMLIN Database
YDBT - UPF0699 transmembrane protein YdbT
UniProt: P96616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 493 (465)
Sequences: 996 (856)
Seq/√Len: 39.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_E142_R7.2751.00
368_R473_D6.4741.00
65_I85_L5.3011.00
69_R88_T4.3421.00
135_I139_E4.3061.00
475_G478_D3.9501.00
99_Q290_Q3.8741.00
6_K139_E3.6691.00
256_F277_I3.5781.00
296_E427_R3.5211.00
193_T300_R3.3321.00
103_T115_V3.2951.00
81_I130_A3.2791.00
79_F119_I3.2581.00
448_Q473_D3.2011.00
82_E90_K3.1571.00
115_V137_V2.9601.00
265_K286_L2.9481.00
186_E336_K2.8871.00
294_I306_V2.8691.00
181_R262_Q2.8011.00
47_Y51_A2.7111.00
378_I382_I2.7101.00
455_T473_D2.5601.00
362_L366_L2.5501.00
263_I272_I2.4771.00
301_Q423_R2.4721.00
375_F379_P2.4271.00
203_A397_I2.4201.00
232_I236_A2.4081.00
106_G109_Q2.3711.00
454_Y479_A2.3111.00
62_A85_L2.2931.00
301_Q427_R2.2671.00
121_T187_L2.2511.00
362_L403_Y2.2361.00
123_G438_Q2.2070.99
119_I147_V2.0900.99
122_A438_Q2.0730.99
448_Q455_T2.0680.99
418_L458_T2.0630.99
72_Y139_E2.0590.99
404_L424_F2.0560.99
93_I130_A2.0500.99
5_P73_R2.0190.99
313_A438_Q2.0160.99
95_I147_V2.0030.99
273_S279_K1.9670.99
84_G330_P1.9650.99
392_V396_P1.9550.99
364_R473_D1.9550.99
75_E80_R1.9370.99
26_K30_L1.9290.99
452_R476_E1.9230.99
78_E92_Y1.9100.98
366_L402_G1.9090.98
364_R461_K1.8960.98
83_E89_K1.8700.98
70_F81_I1.8640.98
290_Q438_Q1.8560.98
109_Q134_A1.8290.98
296_E429_T1.8110.98
329_F340_M1.7810.98
296_E334_K1.7750.97
203_A207_L1.7740.97
478_D481_F1.7490.97
99_Q122_A1.7340.97
141_E144_K1.7170.97
421_T427_R1.7090.97
271_V283_T1.6490.96
293_K428_T1.6200.96
245_I375_F1.6130.96
358_P429_T1.6100.95
452_R481_F1.5810.95
99_Q120_E1.5570.95
291_A311_V1.5560.95
91_R261_F1.5510.94
108_V111_I1.5410.94
99_Q121_T1.5380.94
24_T27_N1.5350.94
363_K367_F1.5320.94
268_Q287_R1.5020.93
99_Q436_R1.5010.93
191_A254_M1.4930.93
5_P82_E1.4910.93
421_T429_T1.4880.93
293_K430_A1.4830.93
156_E356_R1.4830.93
66_K69_R1.4820.93
69_R85_L1.4770.93
205_F213_E1.4650.93
46_F50_I1.4610.92
206_A210_Q1.4580.92
290_Q461_K1.4570.92
474_V479_A1.4350.92
365_Y409_A1.4300.92
188_L191_A1.4280.92
91_R139_E1.4180.91
379_P382_I1.4070.91
50_I236_A1.4070.91
122_A129_E1.4010.91
122_A290_Q1.3880.90
22_I27_N1.3870.90
107_L277_I1.3820.90
358_P453_L1.3820.90
364_R453_L1.3810.90
290_Q436_R1.3760.90
103_T117_L1.3550.89
297_N331_M1.3540.89
101_M140_A1.3510.89
360_R453_L1.3500.89
93_I129_E1.3490.89
294_I337_L1.3450.89
99_Q438_Q1.3390.89
157_N204_V1.3380.89
12_A17_L1.3360.89
50_I54_V1.3250.88
144_K148_F1.3190.88
94_S110_Q1.3170.88
185_K460_V1.3130.88
295_K309_S1.3020.87
135_I142_R1.3000.87
70_F99_Q1.2980.87
8_L70_F1.2950.87
358_P475_G1.2940.87
54_V58_W1.2910.87
72_Y140_A1.2880.87
22_I26_K1.2840.86
105_A115_V1.2820.86
187_L344_F1.2810.86
262_Q273_S1.2800.86
149_K237_V1.2730.86
314_G448_Q1.2730.86
154_R173_S1.2680.86
99_Q357_L1.2590.85
235_Y302_L1.2530.85
122_A313_A1.2490.85
454_Y476_E1.2410.85
420_L471_V1.2330.84
190_A254_M1.2280.84
118_Q131_V1.2240.84
401_F425_I1.2230.84
71_T253_G1.2220.84
8_L132_L1.2000.82
263_I364_R1.2000.82
305_F332_I1.1980.82
375_F432_V1.1920.82
238_L392_V1.1900.82
292_I308_V1.1840.82
26_K331_M1.1820.81
127_E239_I1.1770.81
375_F413_I1.1760.81
245_I277_I1.1730.81
145_E239_I1.1670.81
190_A300_R1.1660.81
261_F330_P1.1630.80
357_L411_W1.1630.80
109_Q123_G1.1570.80
270_L329_F1.1510.80
246_A350_L1.1510.80
358_P361_A1.1510.80
197_I252_A1.1510.80
178_E303_F1.1500.80
478_D482_I1.1490.80
33_F237_V1.1370.79
196_G254_M1.1340.79
81_I93_I1.1310.79
58_W455_T1.1310.79
410_A421_T1.1300.78
86_F304_G1.1270.78
362_L406_Y1.1230.78
460_V479_A1.1160.78
366_L370_V1.1120.77
5_P9_H1.1110.77
9_H346_P1.1090.77
103_T140_A1.1050.77
248_I431_I1.1030.77
306_V337_L1.0950.76
190_A331_M1.0910.76
336_K339_H1.0900.76
114_L445_S1.0880.76
274_R280_H1.0790.75
222_D225_S1.0790.75
223_K379_P1.0740.75
399_L437_M1.0730.75
46_F51_A1.0730.75
30_L33_F1.0660.74
284_I313_A1.0620.74
299_I303_F1.0620.74
204_V242_G1.0560.74
70_F122_A1.0560.74
102_N280_H1.0540.73
63_S66_K1.0530.73
46_F49_A1.0510.73
70_F313_A1.0500.73
25_I350_L1.0460.73
6_K72_Y1.0410.72
27_N52_L1.0410.72
142_R146_A1.0370.72
82_E200_I1.0270.71
402_G436_R1.0260.71
232_I241_I1.0230.71
54_V160_D1.0180.71
80_R90_K1.0110.70
123_G134_A1.0060.70
107_L149_K1.0040.70
114_L190_A1.0040.70
129_E438_Q0.9990.69
57_I61_A0.9980.69
25_I240_F0.9960.69
227_L319_E0.9940.69
74_I406_Y0.9900.69
307_T471_V0.9900.69
274_R278_E0.9900.69
192_S462_S0.9820.68
190_A261_F0.9820.68
33_F36_Y0.9790.68
5_P80_R0.9780.68
18_C36_Y0.9710.67
21_I374_L0.9700.67
272_I328_L0.9690.67
70_F120_E0.9660.67
252_A457_S0.9650.67
53_G172_P0.9640.67
420_L469_L0.9620.66
201_I259_A0.9600.66
72_Y91_R0.9590.66
122_A461_K0.9550.66
156_E237_V0.9510.65
242_G403_Y0.9510.65
204_V403_Y0.9510.65
221_F224_F0.9500.65
157_N335_K0.9480.65
185_K251_I0.9480.65
102_N315_G0.9470.65
61_A376_L0.9450.65
8_L98_I0.9430.65
72_Y330_P0.9420.65
76_D185_K0.9400.65
186_E290_Q0.9400.65
39_N437_M0.9380.64
99_Q288_K0.9360.64
314_G473_D0.9360.64
53_G484_K0.9330.64
269_E283_T0.9320.64
266_K271_V0.9320.64
423_R486_Y0.9300.64
289_I483_L0.9300.64
298_I404_L0.9290.64
29_I172_P0.9280.64
235_Y239_I0.9240.63
148_F440_C0.9230.63
350_L375_F0.9160.62
122_A289_I0.9140.62
138_E308_V0.9130.62
267_E286_L0.9120.62
120_E123_G0.9120.62
49_A53_G0.9090.62
440_C486_Y0.9090.62
233_G237_V0.9020.61
76_D452_R0.9020.61
272_I460_V0.9010.61
337_L375_F0.9010.61
195_G300_R0.8990.61
130_A311_V0.8970.61
12_A26_K0.8960.61
155_R386_P0.8960.61
289_I310_I0.8950.61
306_V334_K0.8940.61
136_S391_S0.8930.61
187_L255_M0.8920.60
248_I252_A0.8920.60
234_I240_F0.8910.60
153_Q156_E0.8910.60
67_W324_A0.8880.60
300_R303_F0.8880.60
93_I134_A0.8870.60
80_R91_R0.8830.60
155_R476_E0.8810.59
19_H23_Q0.8790.59
136_S193_T0.8780.59
7_R187_L0.8770.59
207_L378_I0.8710.59
157_N379_P0.8700.58
455_T472_R0.8700.58
199_V254_M0.8690.58
81_I261_F0.8680.58
213_E252_A0.8670.58
225_S239_I0.8650.58
8_L263_I0.8650.58
18_C262_Q0.8610.58
72_Y132_L0.8600.58
205_F212_D0.8590.58
259_A276_I0.8570.57
382_I396_P0.8550.57
136_S308_V0.8540.57
225_S230_A0.8520.57
186_E305_F0.8510.57
110_Q314_G0.8500.57
252_A294_I0.8490.57
100_T120_E0.8480.57
46_F248_I0.8460.56
58_W392_V0.8450.56
247_W423_R0.8450.56
67_W92_Y0.8440.56
143_I279_K0.8430.56
297_N301_Q0.8410.56
31_P36_Y0.8410.56
121_T196_G0.8400.56
450_K453_L0.8400.56
266_K418_L0.8390.56
18_C242_G0.8380.56
99_Q461_K0.8380.56
140_A406_Y0.8360.55
6_K343_T0.8340.55
228_Q437_M0.8340.55
186_E411_W0.8280.55
260_N274_R0.8220.54
109_Q114_L0.8220.54
53_G205_F0.8210.54
85_L302_L0.8210.54
367_F378_I0.8200.54
207_L211_L0.8200.54
76_D375_F0.8190.54
242_G366_L0.8190.54
106_G331_M0.8180.54
258_Y327_I0.8150.54
305_F333_H0.8140.53
189_M333_H0.8140.53
187_L258_Y0.8130.53
92_Y271_V0.8130.53
117_L208_I0.8110.53
145_E231_S0.8100.53
369_S402_G0.8100.53
74_I239_I0.8100.53
474_V481_F0.8090.53
370_V398_E0.8090.53
98_I143_I0.8080.53
253_G256_F0.8040.53
420_L450_K0.8030.52
98_I382_I0.8030.52
204_V246_A0.8010.52
67_W402_G0.8010.52
261_F284_I0.8000.52
200_I245_I0.8000.52
387_W393_I0.7990.52
241_I245_I0.7990.52
98_I290_Q0.7980.52
301_Q365_Y0.7960.52
83_E92_Y0.7950.52
396_P400_L0.7920.51
236_A419_Q0.7910.51
100_T311_V0.7900.51
437_M458_T0.7890.51
26_K29_I0.7880.51
205_F209_S0.7850.51
108_V296_E0.7840.51
77_D142_R0.7830.51
52_L61_A0.7810.50
180_Y290_Q0.7750.50
296_E433_L0.7740.50
297_N300_R0.7740.50
72_Y306_V0.7720.50
90_K272_I0.7710.50
123_G461_K0.7700.49
25_I377_I0.7670.49
47_Y77_D0.7650.49
263_I329_F0.7640.49
72_Y314_G0.7620.49
192_S201_I0.7620.49
244_F374_L0.7620.49
430_A469_L0.7610.49
118_Q447_F0.7590.48
305_F337_L0.7520.48
50_I425_I0.7510.48
14_I24_T0.7510.48
13_V62_A0.7470.47
47_Y393_I0.7460.47
215_L220_L0.7440.47
482_I486_Y0.7430.47
10_P351_E0.7430.47
447_F450_K0.7410.47
354_C410_A0.7400.47
50_I375_F0.7390.47
123_G365_Y0.7380.47
368_R448_Q0.7370.46
307_T331_M0.7350.46
127_E203_A0.7350.46
339_H343_T0.7320.46
284_I444_Q0.7320.46
21_I393_I0.7310.46
376_L477_E0.7300.46
388_G420_L0.7300.46
241_I445_S0.7290.46
5_P11_V0.7280.46
48_G51_A0.7260.45
228_Q471_V0.7260.45
236_A240_F0.7250.45
219_W241_I0.7230.45
152_A176_V0.7230.45
105_A137_V0.7220.45
434_K485_W0.7220.45
107_L481_F0.7190.45
32_F85_L0.7190.45
263_I270_L0.7170.45
157_N185_K0.7170.45
43_T418_L0.7150.44
273_S278_E0.7150.44
418_L474_V0.7140.44
21_I27_N0.7140.44
65_I69_R0.7130.44
65_I245_I0.7110.44
443_S457_S0.7110.44
114_L134_A0.7090.44
267_E299_I0.7090.44
27_N31_P0.7060.44
191_A305_F0.7060.44
294_I475_G0.7060.44
182_M263_I0.7030.43
91_R358_P0.7010.43
112_F479_A0.7000.43
194_S312_S0.6980.43
203_A394_L0.6970.43
296_E306_V0.6940.43
319_E443_S0.6940.43
263_I409_A0.6940.43
61_A248_I0.6920.42
65_I86_F0.6910.42
314_G368_R0.6910.42
136_S139_E0.6910.42
335_K481_F0.6910.42
111_I402_G0.6900.42
190_A312_S0.6900.42
72_Y469_L0.6900.42
54_V236_A0.6900.42
178_E262_Q0.6870.42
156_E397_I0.6860.42
253_G279_K0.6850.42
284_I312_S0.6840.42
196_G200_I0.6840.42
35_V277_I0.6830.42
124_G129_E0.6820.41
271_V461_K0.6810.41
21_I32_F0.6810.41
30_L88_T0.6790.41
100_T282_V0.6790.41
237_V287_R0.6780.41
21_I26_K0.6770.41
116_K133_S0.6750.41
208_I443_S0.6740.41
9_H22_I0.6740.41
157_N225_S0.6730.41
89_K227_L0.6730.41
75_E393_I0.6720.41
195_G290_Q0.6720.41
54_V214_V0.6710.41
85_L401_F0.6710.41
207_L395_L0.6690.40
57_I396_P0.6680.40
103_T278_E0.6670.40
120_E313_A0.6650.40
7_R67_W0.6650.40
185_K356_R0.6640.40
143_I296_E0.6640.40
151_K286_L0.6630.40
14_I347_E0.6630.40
308_V313_A0.6620.40
109_Q190_A0.6610.40
259_A277_I0.6600.40
22_I31_P0.6600.40
364_R406_Y0.6600.40
67_W122_A0.6590.39
220_L396_P0.6580.39
341_L437_M0.6570.39
30_L34_F0.6560.39
128_A139_E0.6550.39
360_R452_R0.6540.39
195_G198_G0.6540.39
371_I375_F0.6530.39
251_I457_S0.6520.39
96_D259_A0.6510.39
10_P13_V0.6500.39
442_F480_A0.6500.39
86_F384_F0.6500.39
135_I336_K0.6500.39
70_F130_A0.6480.38
79_F294_I0.6470.38
72_Y114_L0.6460.38
14_I145_E0.6460.38
24_T60_V0.6460.38
300_R331_M0.6460.38
72_Y97_R0.6430.38
47_Y183_N0.6430.38
344_F465_H0.6430.38
175_E236_A0.6420.38
442_F476_E0.6410.38
5_P71_T0.6400.38
291_A459_S0.6400.38
252_A455_T0.6400.38
242_G303_F0.6400.38
48_G52_L0.6360.37
396_P417_R0.6360.37
153_Q222_D0.6360.37
449_K455_T0.6350.37
29_I112_F0.6350.37
456_I482_I0.6340.37
296_E361_A0.6340.37
119_I483_L0.6340.37
111_I147_V0.6330.37
99_Q411_W0.6300.37
52_L222_D0.6300.37
139_E146_A0.6290.37
137_V371_I0.6290.37
364_R368_R0.6280.37
70_F290_Q0.6280.37
365_Y473_D0.6270.37
443_S455_T0.6260.37
258_Y278_E0.6250.37
47_Y58_W0.6250.37
43_T61_A0.6250.37
307_T327_I0.6240.36
100_T300_R0.6230.36
205_F242_G0.6230.36
122_A312_S0.6230.36
289_I465_H0.6230.36
254_M300_R0.6210.36
181_R214_V0.6210.36
35_V38_V0.6210.36
295_K426_G0.6210.36
73_R80_R0.6190.36
353_N484_K0.6190.36
69_R304_G0.6180.36
152_A155_R0.6170.36
150_K484_K0.6150.36
109_Q116_K0.6150.36
58_W61_A0.6150.36
202_S205_F0.6130.36
30_L36_Y0.6120.35
301_Q460_V0.6110.35
475_G479_A0.6110.35
203_A274_R0.6110.35
71_T82_E0.6100.35
98_I355_R0.6100.35
201_I211_L0.6090.35
123_G486_Y0.6060.35
244_F455_T0.6060.35
366_L391_S0.6050.35
81_I193_T0.6040.35
64_I226_F0.6030.35
55_L177_Q0.6020.35
131_V284_I0.6020.35
159_L383_F0.6020.35
271_V296_E0.6010.35
101_M148_F0.6000.34
15_L135_I0.5990.34
203_A452_R0.5990.34
250_S328_L0.5980.34
21_I31_P0.5980.34
71_T360_R0.5970.34
143_I399_L0.5970.34
119_I269_E0.5970.34
35_V51_A0.5950.34
240_F457_S0.5950.34
193_T313_A0.5930.34
298_I426_G0.5930.34
381_C428_T0.5910.34
101_M263_I0.5900.34
104_S116_K0.5900.34
294_I474_V0.5900.34
15_L108_V0.5900.34
361_A453_L0.5890.34
177_Q343_T0.5890.34
302_L430_A0.5880.33
370_V399_L0.5860.33
192_S207_L0.5850.33
33_F45_R0.5850.33
21_I476_E0.5850.33
76_D335_K0.5830.33
99_Q409_A0.5830.33
14_I338_P0.5820.33
386_P392_V0.5820.33
372_F376_L0.5820.33
375_F453_L0.5800.33
116_K131_V0.5800.33
364_R447_F0.5790.33
172_P240_F0.5780.33
346_P485_W0.5780.33
403_Y406_Y0.5780.33
7_R71_T0.5770.33
147_V259_A0.5770.33
134_A280_H0.5760.32
195_G247_W0.5760.32
18_C25_I0.5750.32
134_A328_L0.5750.32
51_A474_V0.5750.32
117_L278_E0.5700.32
31_P35_V0.5690.32
345_T482_I0.5690.32
448_Q462_S0.5680.32
159_L241_I0.5670.32
59_L206_A0.5640.32
361_A473_D0.5620.31
13_V17_L0.5620.31
218_D241_I0.5610.31
157_N378_I0.5590.31
313_A439_V0.5590.31
56_F416_D0.5580.31
74_I344_F0.5580.31
118_Q202_S0.5580.31
53_G201_I0.5570.31
432_V458_T0.5570.31
104_S236_A0.5560.31
32_F157_N0.5550.31
100_T110_Q0.5550.31
24_T299_I0.5530.31
374_L378_I0.5520.31
52_L55_L0.5510.31
293_K439_V0.5510.31
107_L278_E0.5500.30
47_Y50_I0.5500.30
99_Q433_L0.5480.30
120_E438_Q0.5480.30
312_S409_A0.5480.30
74_I474_V0.5470.30
109_Q313_A0.5470.30
113_K177_Q0.5450.30
114_L401_F0.5450.30
112_F353_N0.5440.30
76_D210_Q0.5440.30
212_D252_A0.5440.30
51_A128_A0.5430.30
261_F277_I0.5430.30
284_I365_Y0.5430.30
14_I199_V0.5420.30
72_Y99_Q0.5410.30
100_T402_G0.5410.30
230_A236_A0.5410.30
236_A277_I0.5390.30
211_L226_F0.5380.30
301_Q408_E0.5370.29
103_T461_K0.5370.29
67_W129_E0.5370.29
14_I149_K0.5370.29
78_E254_M0.5360.29
50_I235_Y0.5360.29
65_I399_L0.5350.29
298_I302_L0.5350.29
51_A55_L0.5350.29
46_F239_I0.5320.29
6_K240_F0.5310.29
108_V135_I0.5310.29
191_A255_M0.5270.29
259_A269_E0.5270.29
147_V423_R0.5270.29
28_I60_V0.5260.29
190_A296_E0.5250.29
149_K375_F0.5250.29
120_E195_G0.5240.28
396_P413_I0.5240.28
360_R475_G0.5240.28
158_E222_D0.5230.28
203_A206_A0.5230.28
143_I425_I0.5220.28
272_I282_V0.5220.28
392_V440_C0.5210.28
173_S239_I0.5200.28
288_K463_S0.5190.28
17_L21_I0.5180.28
415_G481_F0.5180.28
388_G396_P0.5180.28
223_K437_M0.5170.28
401_F404_L0.5170.28
102_N274_R0.5160.28
97_R122_A0.5140.28
180_Y249_F0.5140.28
244_F371_I0.5140.28
10_P456_I0.5130.28
50_I245_I0.5130.28
418_L471_V0.5130.28
143_I413_I0.5130.28
72_Y84_G0.5120.28
18_C54_V0.5090.27
459_S463_S0.5090.27
128_A486_Y0.5090.27
373_S381_C0.5090.27
149_K378_I0.5080.27
243_L317_D0.5070.27
8_L12_A0.5060.27
72_Y218_D0.5060.27
67_W328_L0.5050.27
89_K434_K0.5050.27
135_I446_Y0.5040.27
110_Q273_S0.5040.27
270_L364_R0.5030.27
107_L352_E0.5020.27
144_K147_V0.5020.27
134_A305_F0.5010.27
192_S247_W0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.1278 28.4 0.97 Contact Map
4ev6A 3 0.1318 23.4 0.971 Contact Map
2dzkA 1 0.1014 11.1 0.975 Contact Map
3fssA 1 0.217 10.2 0.975 Contact Map
4f4cA 1 0.6045 6.7 0.977 Contact Map
3c5tB 1 0.0507 6.4 0.977 Contact Map
3hsaA 3 0.211 5.6 0.978 Contact Map
2g7oA 4 0.1379 4.8 0.979 Contact Map
2b4nA 1 0.0669 4.3 0.979 Contact Map
2codA 1 0.2312 3.9 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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