GREMLIN Database
CSHA - DEAD-box ATP-dependent RNA helicase CshA
UniProt: P96614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 494 (400)
Sequences: 22068 (13222)
Seq/√Len: 661.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_G91_L5.6371.00
61_L74_A4.7021.00
78_A87_V3.9421.00
37_G180_L3.9201.00
127_G132_L3.5071.00
286_K291_A3.4731.00
251_K274_D3.4391.00
29_I45_G3.3341.00
269_E292_I3.2431.00
233_T264_R3.0421.00
41_K202_E3.0141.00
57_F150_V2.9551.00
248_G254_V2.9031.00
285_R289_E2.8651.00
48_Q51_T2.7431.00
258_A268_A2.7221.00
88_S102_V2.6811.00
88_S92_Y2.6441.00
266_Y294_V2.6011.00
353_L357_E2.5811.00
329_I341_A2.5741.00
282_V286_K2.5141.00
135_H140_T2.5051.00
23_F55_A2.5011.00
248_G257_L2.4741.00
269_E286_K2.4571.00
255_D270_G2.3701.00
217_Q340_M2.3511.00
318_V343_T2.3501.00
73_Q147_N2.2711.00
248_G296_V2.2161.00
90_E93_K2.2081.00
164_D168_S2.0541.00
301_A305_L2.0471.00
309_G337_K1.9931.00
213_V216_I1.9641.00
237_D264_R1.9581.00
242_E311_T1.9561.00
163_I166_I1.9391.00
88_S104_P1.9391.00
103_L122_P1.9271.00
254_V272_H1.9061.00
267_A293_E1.8881.00
163_I167_E1.8831.00
253_R317_D1.8661.00
312_H340_M1.8641.00
258_A270_G1.8541.00
218_Q329_I1.8531.00
74_A148_T1.8511.00
91_L124_I1.8371.00
297_A301_A1.8361.00
165_D168_S1.8331.00
156_E159_N1.8061.00
219_F340_M1.8041.00
261_L296_V1.7941.00
45_G182_F1.7781.00
37_G43_V1.7771.00
137_N168_S1.7471.00
231_T234_R1.7381.00
61_L150_V1.7261.00
191_K203_H1.7221.00
269_E283_A1.7211.00
110_D113_R1.7201.00
191_K195_E1.7151.00
91_L102_V1.7001.00
258_A262_N1.6981.00
183_S186_M1.6931.00
232_L314_Y1.6781.00
36_L202_E1.6671.00
73_Q123_N1.6621.00
21_M93_K1.6451.00
218_Q325_Y1.6331.00
61_L148_T1.6311.00
244_A312_H1.6201.00
85_I281_M1.6141.00
276_T279_K1.6141.00
244_A314_Y1.6121.00
38_L63_E1.5941.00
201_P204_V1.5891.00
164_D167_E1.5731.00
64_K148_T1.5701.00
281_M285_R1.5671.00
229_F260_A1.5461.00
254_V270_G1.5451.00
36_L39_S1.5381.00
71_N145_N1.5301.00
91_L126_V1.5261.00
133_L168_S1.5251.00
75_I146_V1.5151.00
257_L296_V1.5051.00
190_I193_I1.5021.00
77_I132_L1.4941.00
57_F87_V1.4891.00
122_P125_I1.4721.00
42_D181_L1.4681.00
315_N343_T1.4631.00
89_E93_K1.4621.00
312_H342_M1.4481.00
57_F182_F1.4471.00
371_T374_E1.4251.00
349_E353_L1.4141.00
188_A192_R1.3981.00
244_A294_V1.3971.00
149_V170_L1.3921.00
225_E253_R1.3871.00
246_V294_V1.3831.00
103_L125_I1.3781.00
235_L238_I1.3761.00
260_A264_R1.3691.00
191_K194_A1.3691.00
233_T237_D1.3641.00
189_P192_R1.3531.00
315_N329_I1.3501.00
84_A104_P1.3391.00
412_A415_V1.3381.00
361_K364_M1.3331.00
235_L342_M1.3331.00
112_G116_R1.3281.00
167_E196_R1.3271.00
232_L316_F1.3261.00
370_P374_E1.3211.00
258_A296_V1.3161.00
35_P39_S1.3121.00
354_R357_E1.3071.00
168_S172_N1.3071.00
187_P190_I1.3071.00
241_P244_A1.3051.00
419_A422_M1.3001.00
216_I333_G1.2971.00
411_D415_V1.2871.00
182_F185_T1.2731.00
36_L204_V1.2661.00
62_V95_G1.2641.00
136_I172_N1.2641.00
275_L283_A1.2621.00
190_I194_A1.2601.00
74_A150_V1.2591.00
357_E363_K1.2521.00
55_A59_I1.2511.00
250_T253_R1.2261.00
103_L117_A1.2251.00
189_P193_I1.2131.00
32_Q36_L1.2131.00
378_G381_Q1.2091.00
155_D303_R1.2041.00
149_V179_T1.2041.00
101_K123_N1.2041.00
243_L309_G1.2031.00
78_A84_A1.2021.00
168_S171_S1.1991.00
279_K283_A1.1951.00
46_Q205_K1.1811.00
61_L76_V1.1641.00
279_K282_V1.1601.00
162_F166_I1.1551.00
167_E171_S1.1421.00
350_K354_R1.1421.00
127_G141_I1.1421.00
259_E262_N1.1411.00
253_R256_E1.1301.00
174_P177_H1.1211.00
360_T363_K1.1161.00
28_P32_Q1.1091.00
66_N69_S1.1071.00
229_F316_F1.1041.00
237_D266_Y1.0971.00
33_T56_A1.0941.00
64_K147_N1.0931.00
85_I89_E1.0851.00
232_L246_V1.0821.00
417_A420_I1.0811.00
284_L307_I1.0791.00
40_N64_K1.0781.00
319_P325_Y1.0771.00
65_I100_A1.0771.00
228_K317_D1.0741.00
133_L137_N1.0691.00
247_F328_R1.0621.00
193_I197_F1.0601.00
255_D272_H1.0541.00
371_T375_A1.0531.00
77_I161_G1.0461.00
282_V285_R1.0401.00
257_L316_F1.0291.00
315_N328_R1.0281.00
379_Q383_T1.0261.00
370_P373_D1.0181.00
355_A358_Q1.0181.00
399_Y403_A1.0131.00
406_L409_D1.0111.00
234_R238_I1.0071.00
62_V66_N1.0041.00
353_L363_K1.0031.00
285_R288_K1.0001.00
359_T363_K0.9951.00
254_V258_A0.9941.00
245_I297_A0.9931.00
262_N268_A0.9901.00
254_V296_V0.9881.00
224_Q227_K0.9871.00
321_D324_S0.9861.00
62_V65_I0.9831.00
313_V332_T0.9831.00
403_A406_L0.9821.00
352_M355_A0.9821.00
182_F186_M0.9821.00
283_A292_I0.9811.00
40_N178_Q0.9781.00
88_S126_V0.9711.00
229_F257_L0.9701.00
416_V420_I0.9701.00
271_I301_A0.9681.00
236_L244_A0.9661.00
419_A423_A0.9661.00
420_I423_A0.9631.00
233_T260_A0.9581.00
89_E92_Y0.9571.00
407_L411_D0.9571.00
215_N338_T0.9561.00
154_A181_L0.9541.00
350_K353_L0.9501.00
275_L279_K0.9401.00
383_T387_L0.9371.00
95_G98_K0.9351.00
83_L304_G0.9331.00
372_L376_L0.9301.00
37_G60_P0.9261.00
357_E360_T0.9231.00
408_E411_D0.9231.00
242_E338_T0.9221.00
235_L314_Y0.9191.00
396_L399_Y0.9181.00
404_A408_E0.9111.00
286_K292_I0.9041.00
401_T404_A0.9021.00
403_A407_L0.9011.00
356_I360_T0.9011.00
77_I127_G0.8891.00
158_L161_G0.8881.00
408_E412_A0.8871.00
243_L290_G0.8861.00
410_H413_V0.8841.00
243_L310_V0.8831.00
165_D169_I0.8801.00
409_D412_A0.8781.00
234_R237_D0.8781.00
42_D179_T0.8751.00
235_L312_H0.8661.00
416_V419_A0.8651.00
399_Y402_A0.8631.00
59_I63_E0.8611.00
192_R195_E0.8541.00
287_F295_L0.8531.00
54_T87_V0.8521.00
406_L410_H0.8441.00
36_L43_V0.8431.00
230_D233_T0.8401.00
59_I62_V0.8361.00
42_D201_P0.8351.00
229_F233_T0.8331.00
355_A359_T0.8291.00
76_V91_L0.8281.00
412_A416_V0.8281.00
233_T266_Y0.8261.00
44_I186_M0.8251.00
229_F264_R0.8221.00
411_D417_A0.8191.00
61_L91_L0.8191.00
380_Q383_T0.8181.00
106_Y109_Q0.8181.00
157_M160_M0.8171.00
369_E373_D0.8141.00
414_T417_A0.8091.00
256_E260_A0.8091.00
380_Q384_V0.8091.00
138_R145_N0.8081.00
405_E410_H0.8061.00
404_A410_H0.8041.00
406_L415_V0.8031.00
414_T418_A0.7991.00
265_G268_A0.7991.00
179_T182_F0.7971.00
193_I196_R0.7961.00
385_E389_T0.7931.00
112_G115_I0.7891.00
28_P31_A0.7871.00
369_E372_L0.7861.00
219_F222_E0.7831.00
394_N397_N0.7801.00
220_Y345_I0.7801.00
413_V417_A0.7801.00
364_M367_M0.7781.00
235_L344_F0.7781.00
418_A421_K0.7761.00
170_L173_V0.7731.00
402_A405_E0.7731.00
388_R391_I0.7731.00
34_I38_L0.7731.00
231_T344_F0.7711.00
41_K200_E0.7711.00
105_I114_Q0.7701.00
111_I115_I0.7631.00
203_H206_V0.7621.00
416_V422_M0.7611.00
150_V180_L0.7611.00
362_R365_D0.7601.00
404_A407_L0.7581.00
401_T405_E0.7551.00
411_D414_T0.7551.00
166_I170_L0.7531.00
394_N398_F0.7521.00
402_A406_L0.7491.00
409_D413_V0.7491.00
368_K372_L0.7481.00
372_L377_E0.7451.00
252_R256_E0.7441.00
114_Q118_L0.7431.00
38_L64_K0.7411.00
415_V419_A0.7401.00
368_K371_T0.7351.00
390_T393_E0.7341.00
353_L364_M0.7341.00
406_L412_A0.7331.00
83_L86_Q0.7321.00
393_E396_L0.7311.00
228_K232_L0.7291.00
412_A417_A0.7271.00
212_T216_I0.7271.00
179_T184_A0.7271.00
205_K208_A0.7251.00
179_T185_T0.7251.00
374_E377_E0.7231.00
319_P328_R0.7191.00
413_V416_V0.7171.00
390_T394_N0.7171.00
33_T37_G0.7161.00
190_I196_R0.7131.00
356_I361_K0.7121.00
143_L146_V0.7121.00
162_F169_I0.7111.00
115_I140_T0.7111.00
417_A421_K0.7101.00
360_T367_M0.7101.00
411_D419_A0.7081.00
86_Q306_D0.7081.00
384_V388_R0.7071.00
65_I74_A0.7071.00
386_R390_T0.7071.00
116_R120_K0.7051.00
391_I395_N0.7041.00
412_A419_A0.7011.00
348_R351_S0.7011.00
359_T362_R0.7001.00
351_S355_A0.6991.00
377_E380_Q0.6981.00
162_F167_E0.6971.00
270_G275_L0.6951.00
192_R196_R0.6951.00
413_V418_A0.6941.00
202_E205_K0.6931.00
56_A60_P0.6931.00
299_D324_S0.6921.00
95_G102_V0.6901.00
111_I114_Q0.6851.00
90_E94_I0.6841.00
229_F256_E0.6831.00
410_H416_V0.6821.00
395_N399_Y0.6821.00
219_F367_M0.6801.00
299_D328_R0.6801.00
109_Q114_Q0.6801.00
373_D377_E0.6791.00
391_I394_N0.6781.00
155_D327_H0.6781.00
111_I138_R0.6771.00
374_E378_G0.6771.00
216_I225_E0.6761.00
61_L124_I0.6761.00
413_V419_A0.6751.00
170_L174_P0.6731.00
418_A422_M0.6721.00
398_F408_E0.6721.00
353_L356_I0.6711.00
219_F342_M0.6711.00
288_K308_S0.6711.00
230_D234_R0.6711.00
416_V423_A0.6701.00
360_T364_M0.6671.00
414_T419_A0.6671.00
406_L413_V0.6671.00
406_L411_D0.6661.00
225_E346_T0.6641.00
223_V231_T0.6631.00
405_E408_E0.6631.00
409_D417_A0.6631.00
45_G180_L0.6601.00
284_L287_F0.6601.00
401_T408_E0.6591.00
246_V314_Y0.6561.00
395_N400_M0.6541.00
357_E366_R0.6511.00
133_L165_D0.6491.00
357_E361_K0.6481.00
184_A330_G0.6481.00
201_P206_V0.6481.00
44_I181_L0.6461.00
47_A51_T0.6461.00
402_A412_A0.6451.00
320_Q352_M0.6451.00
352_M357_E0.6441.00
311_T337_K0.6441.00
243_L311_T0.6441.00
201_P205_K0.6401.00
407_L410_H0.6401.00
57_F60_P0.6401.00
363_K367_M0.6391.00
245_I295_L0.6391.00
408_E413_V0.6351.00
410_H414_T0.6331.00
243_L287_F0.6321.00
406_L417_A0.6311.00
65_I123_N0.6301.00
148_T178_Q0.6301.00
374_E381_Q0.6301.00
32_Q35_P0.6281.00
169_I173_V0.6281.00
113_R116_R0.6271.00
55_A94_I0.6261.00
371_T376_L0.6261.00
48_Q208_A0.6251.00
404_A411_D0.6241.00
408_E417_A0.6231.00
245_I310_V0.6231.00
379_Q382_V0.6221.00
211_M214_S0.6211.00
402_A407_L0.6201.00
283_A295_L0.6191.00
134_D138_R0.6181.00
57_F78_A0.6181.00
109_Q113_R0.6181.00
400_M403_A0.6181.00
411_D420_I0.6121.00
178_Q185_T0.6111.00
388_R392_S0.6101.00
407_L413_V0.6091.00
220_Y340_M0.6091.00
331_R334_R0.6081.00
310_V332_T0.6071.00
357_E364_M0.6051.00
25_E31_A0.6051.00
249_R320_Q0.6041.00
271_I300_V0.6041.00
114_Q117_A0.6031.00
388_R393_E0.6031.00
385_E388_R0.6021.00
281_M284_L0.6011.00
116_R119_K0.5991.00
95_G100_A0.5991.00
399_Y406_L0.5971.00
322_P354_R0.5971.00
395_N401_T0.5961.00
236_L294_V0.5921.00
176_E185_T0.5921.00
170_L177_H0.5921.00
44_I194_A0.5921.00
391_I396_L0.5911.00
418_A423_A0.5891.00
200_E204_V0.5881.00
115_I135_H0.5881.00
372_L375_A0.5871.00
404_A409_D0.5871.00
217_Q365_D0.5871.00
166_I169_I0.5871.00
249_R317_D0.5861.00
156_E160_M0.5861.00
369_E376_L0.5861.00
228_K235_L0.5851.00
409_D415_V0.5851.00
204_V208_A0.5841.00
164_D171_S0.5831.00
384_V387_L0.5831.00
376_L380_Q0.5821.00
135_H139_R0.5821.00
163_I170_L0.5811.00
308_S337_K0.5811.00
387_L393_E0.5761.00
162_F165_D0.5751.00
220_Y223_V0.5741.00
72_I125_I0.5731.00
121_N146_V0.5721.00
64_K178_Q0.5691.00
410_H415_V0.5681.00
397_N400_M0.5681.00
389_T392_S0.5671.00
408_E418_A0.5651.00
351_S357_E0.5651.00
217_Q338_T0.5641.00
370_P375_A0.5641.00
414_T422_M0.5641.00
58_G62_V0.5621.00
66_N98_K0.5611.00
396_L403_A0.5601.00
77_I151_M0.5601.00
394_N401_T0.5591.00
232_L257_L0.5591.00
259_E263_L0.5591.00
403_A413_V0.5591.00
32_Q204_V0.5581.00
407_L417_A0.5581.00
217_Q367_M0.5581.00
35_P38_L0.5581.00
376_L379_Q0.5571.00
236_L266_Y0.5571.00
407_L414_T0.5571.00
376_L383_T0.5561.00
34_I59_I0.5561.00
131_R134_D0.5561.00
373_D376_L0.5551.00
277_Q281_M0.5551.00
356_I359_T0.5501.00
399_Y404_A0.5501.00
390_T395_N0.5491.00
392_S398_F0.5491.00
261_L294_V0.5491.00
189_P197_F0.5491.00
28_P59_I0.5491.00
32_Q202_E0.5481.00
72_I146_V0.5481.00
411_D416_V0.5471.00
408_E416_V0.5461.00
163_I174_P0.5441.00
409_D416_V0.5441.00
412_A420_I0.5431.00
400_M404_A0.5421.00
401_T411_D0.5401.00
353_L358_Q0.5401.00
405_E423_A0.5391.00
389_T395_N0.5391.00
416_V421_K0.5391.00
394_N399_Y0.5391.00
72_I147_N0.5381.00
178_Q184_A0.5381.00
84_A126_V0.5371.00
381_Q388_R0.5361.00
400_M407_L0.5361.00
329_I343_T0.5331.00
224_Q347_P0.5321.00
65_I73_Q0.5301.00
405_E412_A0.5301.00
302_A324_S0.5301.00
392_S403_A0.5290.99
400_M405_E0.5280.99
31_A35_P0.5270.99
33_T45_G0.5270.99
345_I353_L0.5270.99
409_D414_T0.5270.99
417_A423_A0.5270.99
36_L41_K0.5270.99
386_R389_T0.5260.99
189_P194_A0.5260.99
370_P378_G0.5260.99
322_P359_T0.5260.99
363_K366_R0.5240.99
191_K196_R0.5240.99
46_Q186_M0.5230.99
375_A383_T0.5220.99
356_I363_K0.5220.99
212_T215_N0.5220.99
315_N319_P0.5210.99
358_Q361_K0.5190.99
241_P311_T0.5180.99
74_A124_I0.5170.99
409_D420_I0.5170.99
111_I140_T0.5150.99
102_V126_V0.5150.99
290_G293_E0.5140.99
415_V421_K0.5140.99
414_T420_I0.5140.99
413_V420_I0.5140.99
382_V385_E0.5130.99
349_E352_M0.5120.99
113_R117_A0.5120.99
179_T183_S0.5120.99
236_L261_L0.5110.99
222_E366_R0.5110.99
77_I157_M0.5110.99
66_N73_Q0.5100.99
405_E414_T0.5100.99
392_S402_A0.5090.99
391_I408_E0.5090.99
260_A263_L0.5080.99
245_I313_V0.5070.99
377_E381_Q0.5070.99
399_Y405_E0.5070.99
388_R394_N0.5050.99
398_F402_A0.5030.99
399_Y407_L0.5030.99
389_T393_E0.5010.99
407_L416_V0.5010.99
272_H275_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.7611 100 0.29 Contact Map
4nhoA 1 0.749 100 0.295 Contact Map
4c9bA 1 0.7551 100 0.302 Contact Map
4ljyA 1 0.7854 100 0.305 Contact Map
4d25A 1 0.753 100 0.305 Contact Map
2db3A 1 0.751 100 0.308 Contact Map
3eiqA 1 0.7166 100 0.312 Contact Map
1s2mA 1 0.7632 100 0.317 Contact Map
4ct4B 1 0.7591 100 0.321 Contact Map
3fmpB 1 0.413 100 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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