GREMLIN Database
DCTA - C4-dicarboxylate transport protein
UniProt: P96603 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (390)
Sequences: 6280 (3739)
Seq/√Len: 189.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_D144_K4.4641.00
169_K173_D3.7811.00
278_E284_K3.5331.00
166_E169_K3.2721.00
95_N326_Q3.1461.00
93_V226_T3.0921.00
17_I198_F3.0821.00
184_K187_G3.0591.00
133_I152_F3.0091.00
52_F154_S2.8591.00
56_V175_F2.8011.00
74_K399_E2.7581.00
33_K37_D2.7571.00
270_L291_I2.6751.00
10_Q191_R2.6291.00
21_V198_F2.6001.00
38_T134_V2.5781.00
170_S177_K2.5631.00
52_F56_V2.4971.00
98_K101_A2.4471.00
53_F178_V2.4381.00
322_S325_Q2.4301.00
6_N9_V2.4151.00
283_S401_E2.3871.00
35_L199_G2.3611.00
283_S396_A2.3491.00
224_Y379_G2.3071.00
157_F181_V2.2611.00
257_L386_I2.2481.00
82_V238_I2.1641.00
221_M225_I2.1401.00
165_G168_G2.1031.00
78_Y391_A2.0981.00
128_E132_H2.0861.00
136_S140_D2.0361.00
240_K243_G2.0341.00
256_E276_K2.0281.00
93_V229_L1.9791.00
74_K398_S1.9501.00
12_I16_I1.9421.00
20_I24_V1.9381.00
170_S173_D1.9171.00
171_V174_F1.9131.00
92_F96_I1.8831.00
14_A198_F1.8801.00
97_M222_S1.8791.00
61_K176_D1.8631.00
88_I92_F1.8621.00
313_L365_G1.8471.00
229_L233_V1.8441.00
282_C393_I1.8341.00
227_M379_G1.8291.00
94_V311_V1.8141.00
277_M389_G1.8021.00
171_V177_K1.7911.00
275_D279_R1.7791.00
146_D149_Q1.7661.00
161_L181_V1.7511.00
73_G77_I1.7441.00
53_F182_F1.7431.00
214_K218_S1.7341.00
373_D380_R1.7331.00
14_A18_G1.7031.00
46_V189_I1.7021.00
163_A184_K1.6801.00
99_P315_Q1.6751.00
239_C390_I1.6621.00
320_D324_G1.6601.00
290_V392_T1.6511.00
252_F280_Y1.6491.00
171_V181_V1.6321.00
139_V142_F1.6291.00
282_C396_A1.6111.00
253_I389_G1.6101.00
97_M225_I1.5751.00
139_V143_A1.5591.00
377_S381_A1.5321.00
94_V308_M1.5321.00
273_M389_G1.5261.00
167_K180_H1.5251.00
217_A221_M1.5221.00
248_N251_R1.5181.00
93_V222_S1.5091.00
38_T131_T1.5071.00
313_L361_I1.5031.00
138_M153_F1.4911.00
227_M383_V1.4811.00
60_A172_I1.4711.00
278_E287_V1.4651.00
257_L382_I1.4591.00
226_T304_I1.4451.00
70_K399_E1.4371.00
274_M287_V1.4261.00
252_F279_R1.4231.00
37_D41_N1.4211.00
44_K136_S1.4181.00
174_F177_K1.3871.00
163_A188_Y1.3811.00
21_V25_W1.3611.00
176_D180_H1.3541.00
238_I394_I1.3491.00
9_V13_T1.3431.00
267_E342_G1.3421.00
317_F365_G1.3351.00
160_G185_I1.3231.00
134_V152_F1.3191.00
52_F142_F1.3141.00
41_N136_S1.3071.00
237_I241_L1.3061.00
170_S174_F1.3061.00
396_A402_F1.3031.00
57_L175_F1.2971.00
51_I147_I1.2941.00
125_D128_E1.2911.00
222_S308_M1.2691.00
323_I327_I1.2631.00
59_I155_I1.2601.00
104_D318_G1.2591.00
253_I386_I1.2551.00
247_W251_R1.2541.00
75_A290_V1.2541.00
245_S248_N1.2511.00
286_V396_A1.2481.00
320_D325_Q1.2431.00
231_V383_V1.2421.00
91_L326_Q1.2401.00
26_P206_G1.2361.00
273_M291_I1.2311.00
232_F236_N1.2311.00
132_H146_D1.2291.00
283_S286_V1.2241.00
164_L168_G1.2151.00
233_V236_N1.2091.00
310_T329_I1.2071.00
45_M153_F1.2051.00
296_S299_L1.2041.00
15_V201_M1.2001.00
25_W28_V1.1951.00
169_K172_I1.1951.00
161_L171_V1.1941.00
188_Y192_A1.1891.00
160_G188_Y1.1891.00
203_Y207_H1.1851.00
46_V186_I1.1751.00
156_L185_I1.1751.00
218_S221_M1.1631.00
220_M372_V1.1601.00
215_P218_S1.1571.00
92_F95_N1.1551.00
157_F178_V1.1541.00
329_I358_L1.1451.00
260_V381_A1.1401.00
182_F186_I1.1371.00
244_F402_F1.1281.00
155_I159_V1.1221.00
33_K203_Y1.1211.00
240_K245_S1.1191.00
348_F370_L1.1101.00
269_V273_M1.1021.00
164_L177_K1.1021.00
305_Y373_D1.1011.00
48_A150_V1.0961.00
35_L192_A1.0931.00
10_Q14_A1.0921.00
249_Y253_I1.0911.00
140_D143_A1.0891.00
79_F290_V1.0861.00
239_C244_F1.0851.00
38_T42_A1.0831.00
20_I23_L1.0831.00
88_I327_I1.0811.00
230_F234_A1.0711.00
255_D279_R1.0671.00
104_D108_L1.0661.00
165_G169_K1.0651.00
67_K285_S1.0641.00
173_D177_K1.0571.00
187_G275_D1.0511.00
192_A195_I1.0501.00
77_I81_V1.0451.00
82_V300_D1.0401.00
300_D337_S1.0381.00
55_I151_L1.0381.00
270_L295_Y1.0361.00
237_I240_K1.0351.00
236_N250_L1.0351.00
71_V286_V1.0311.00
171_V175_F1.0281.00
164_L181_V1.0281.00
273_M385_L1.0261.00
277_M291_I1.0231.00
88_I330_I1.0171.00
53_F57_L1.0161.00
16_I20_I1.0101.00
86_A230_F1.0041.00
327_I331_L1.0041.00
264_S374_R1.0041.00
243_G397_K1.0010.99
81_V85_L0.9970.99
230_F304_I0.9920.99
211_D214_K0.9910.99
397_K400_N0.9890.99
173_D176_D0.9870.99
100_G315_Q0.9860.99
104_D107_K0.9850.99
27_D30_K0.9830.99
214_K217_A0.9810.99
107_K110_K0.9790.99
184_K188_Y0.9770.99
305_Y380_R0.9710.99
93_V97_M0.9670.99
138_M143_A0.9650.99
277_M282_C0.9630.99
28_V32_M0.9610.99
80_E84_T0.9600.99
302_T347_G0.9590.99
244_F248_N0.9550.99
396_A400_N0.9510.99
282_C287_V0.9510.99
129_F135_P0.9500.99
66_K69_G0.9490.99
90_G307_S0.9480.99
344_T377_S0.9470.99
64_D67_K0.9380.99
323_I326_Q0.9370.99
261_L378_E0.9370.99
278_E288_G0.9360.99
28_V31_E0.9360.99
36_G200_A0.9360.99
152_F156_L0.9350.99
70_K74_K0.9300.99
122_Q125_D0.9270.99
128_E131_T0.9270.99
21_V202_A0.9260.99
84_T88_I0.9240.99
121_G124_I0.9190.99
298_N388_N0.9180.99
218_S315_Q0.9180.99
251_R254_K0.9150.99
252_F256_E0.9110.99
91_L95_N0.9100.99
125_D129_F0.9100.99
220_M375_F0.9040.99
31_E34_P0.9030.99
138_M141_A0.9020.99
225_I228_F0.9010.99
124_I132_H0.9010.99
252_F276_K0.9000.99
311_V326_Q0.8950.99
223_V308_M0.8940.99
256_E269_V0.8910.99
256_E273_M0.8910.99
57_L176_D0.8860.99
336_T354_T0.8850.99
238_I242_Y0.8830.99
269_V272_R0.8820.99
124_I128_E0.8820.99
156_L188_Y0.8820.99
276_K279_R0.8810.99
223_V376_M0.8800.99
266_S384_N0.8790.99
168_G177_K0.8780.99
17_I21_V0.8780.99
132_H135_P0.8780.99
32_M202_A0.8650.99
396_A401_E0.8590.98
235_L239_C0.8570.98
234_A238_I0.8560.98
187_G191_R0.8560.98
224_Y228_F0.8550.98
154_S158_G0.8530.98
161_L175_F0.8520.98
277_M287_V0.8510.98
25_W32_M0.8500.98
220_M376_M0.8500.98
159_V163_A0.8490.98
53_F175_F0.8480.98
254_K258_L0.8470.98
141_A153_F0.8470.98
352_A366_L0.8460.98
168_G172_I0.8450.98
259_I272_R0.8440.98
306_L351_L0.8430.98
249_Y389_G0.8420.98
41_N44_K0.8400.98
202_A206_G0.8400.98
299_L388_N0.8390.98
129_F133_I0.8370.98
131_T135_P0.8360.98
348_F366_L0.8350.98
6_N10_Q0.8340.98
305_Y376_M0.8320.98
235_L238_I0.8310.98
317_F364_E0.8300.98
134_V137_N0.8280.98
56_V161_L0.8280.98
228_F232_F0.8250.98
46_V185_I0.8250.98
104_D110_K0.8250.98
398_S402_F0.8250.98
157_F185_I0.8220.98
71_V395_V0.8170.98
259_I269_V0.8170.98
198_F202_A0.8130.98
259_I263_T0.8000.98
129_F132_H0.7990.98
21_V32_M0.7940.97
93_V96_I0.7920.97
179_S183_F0.7920.97
120_G123_G0.7900.97
220_M224_Y0.7900.97
309_A369_L0.7870.97
127_I131_T0.7840.97
36_G196_G0.7810.97
286_V290_V0.7790.97
99_P102_G0.7790.97
89_I229_L0.7790.97
182_F189_I0.7780.97
219_L376_M0.7740.97
275_D278_E0.7730.97
352_A356_S0.7710.97
32_M199_G0.7680.97
174_F178_V0.7670.97
225_I229_L0.7650.97
21_V28_V0.7640.97
321_L325_Q0.7630.97
295_Y388_N0.7630.97
93_V225_I0.7620.97
219_L308_M0.7600.97
89_I226_T0.7520.96
219_L369_L0.7500.96
223_V227_M0.7500.96
396_A403_D0.7450.96
25_W202_A0.7450.96
18_G202_A0.7440.96
297_F338_K0.7440.96
27_D206_G0.7430.96
90_G308_M0.7430.96
306_L348_F0.7410.96
248_N252_F0.7360.96
39_F193_A0.7320.96
56_V157_F0.7290.96
54_T179_S0.7290.96
56_V154_S0.7260.96
249_Y393_I0.7250.96
62_M71_V0.7250.96
142_F153_F0.7250.96
126_W130_I0.7240.96
256_E272_R0.7230.96
222_S225_I0.7220.96
193_A196_G0.7200.95
31_E35_L0.7160.95
310_T354_T0.7160.95
324_G327_I0.7130.95
11_V193_A0.7130.95
260_V385_L0.7130.95
125_D133_I0.7130.95
264_S377_S0.7120.95
67_K72_G0.7090.95
137_N141_A0.7090.95
153_F157_F0.7080.95
102_G105_Y0.7040.95
273_M388_N0.7010.95
131_T134_V0.6980.95
75_A395_V0.6960.95
302_T340_A0.6960.95
180_H184_K0.6950.94
293_T297_F0.6950.94
41_N132_H0.6940.94
340_A350_V0.6930.94
348_F376_M0.6900.94
77_I80_E0.6890.94
98_K315_Q0.6890.94
60_A162_A0.6890.94
30_K206_G0.6880.94
56_V178_V0.6880.94
137_N153_F0.6870.94
130_I134_V0.6870.94
70_K73_G0.6850.94
233_V237_I0.6840.94
219_L305_Y0.6830.94
84_T334_M0.6820.94
226_T308_M0.6810.94
165_G172_I0.6810.94
399_E402_F0.6810.94
302_T306_L0.6810.94
135_P139_V0.6810.94
242_Y398_S0.6780.94
142_F149_Q0.6770.94
10_Q195_I0.6770.94
29_G206_G0.6720.93
82_V86_A0.6720.93
310_T314_A0.6720.93
168_G181_V0.6680.93
236_N240_K0.6680.93
65_M159_V0.6680.93
90_G304_I0.6670.93
164_L180_H0.6650.93
394_I398_S0.6630.93
240_K246_L0.6610.93
64_D72_G0.6600.93
106_S110_K0.6590.93
397_K402_F0.6570.93
37_D131_T0.6570.93
67_K70_K0.6560.93
28_V206_G0.6560.93
125_D132_H0.6550.93
326_Q330_I0.6530.92
105_Y108_L0.6520.92
353_S359_Q0.6510.92
333_L350_V0.6510.92
171_V178_V0.6460.92
176_D179_S0.6460.92
177_K180_H0.6460.92
230_F300_D0.6430.92
281_G403_D0.6430.92
39_F192_A0.6420.92
193_A263_T0.6410.92
26_P30_K0.6390.92
79_F391_A0.6380.92
141_A145_G0.6380.92
291_I392_T0.6360.91
152_F192_A0.6350.91
197_A344_T0.6340.91
232_F237_I0.6320.91
328_T358_L0.6320.91
295_Y299_L0.6310.91
244_F252_F0.6300.91
324_G328_T0.6290.91
126_W129_F0.6290.91
306_L340_A0.6290.91
186_I261_L0.6280.91
284_K288_G0.6280.91
244_F403_D0.6270.91
231_V236_N0.6240.91
108_L111_G0.6230.91
221_M224_Y0.6200.90
330_I333_L0.6200.90
42_A189_I0.6190.90
314_A319_V0.6180.90
85_L234_A0.6180.90
161_L172_I0.6170.90
89_I234_A0.6160.90
122_Q126_W0.6150.90
80_E338_K0.6150.90
280_Y393_I0.6150.90
93_V221_M0.6140.90
338_K388_N0.6140.90
79_F388_N0.6130.90
42_A134_V0.6130.90
65_M72_G0.6120.90
15_V197_A0.6120.90
43_V259_I0.6090.90
235_L387_G0.6080.90
342_G345_G0.6080.90
42_A156_L0.6070.89
195_I199_G0.6060.89
307_S333_L0.6050.89
253_I273_M0.6000.89
249_Y280_Y0.5990.89
286_V401_E0.5980.89
392_T396_A0.5980.89
42_A192_A0.5960.89
283_S287_V0.5960.89
157_F171_V0.5950.89
91_L330_I0.5920.88
57_L61_K0.5920.88
102_G215_P0.5880.88
251_R255_D0.5880.88
219_L309_A0.5880.88
119_N122_Q0.5880.88
300_D387_G0.5860.88
306_L310_T0.5860.88
106_S109_E0.5860.88
285_S401_E0.5860.88
13_T17_I0.5850.88
362_P365_G0.5840.88
50_I151_L0.5840.88
95_N323_I0.5840.88
151_L317_F0.5810.87
274_M291_I0.5810.87
38_T152_F0.5810.87
242_Y394_I0.5800.87
79_F230_F0.5770.87
329_I333_L0.5760.87
177_K181_V0.5760.87
120_G125_D0.5740.87
299_L340_A0.5740.87
328_T332_V0.5740.87
85_L88_I0.5700.86
232_F247_W0.5680.86
267_E295_Y0.5660.86
184_K191_R0.5660.86
352_A363_L0.5650.86
21_V24_V0.5630.86
7_L10_Q0.5630.86
264_S268_S0.5620.86
219_L227_M0.5590.85
23_L210_L0.5590.85
120_G124_I0.5590.85
347_G354_T0.5570.85
400_N403_D0.5570.85
18_G22_G0.5550.85
169_K174_F0.5550.85
320_D323_I0.5550.85
330_I334_M0.5540.85
85_L89_I0.5540.85
164_L184_K0.5530.85
272_R275_D0.5520.85
90_G305_Y0.5520.85
332_V357_A0.5520.85
21_V29_G0.5520.85
67_K401_E0.5520.85
86_A304_I0.5510.84
169_K177_K0.5500.84
365_G368_L0.5480.84
216_L219_L0.5460.84
35_L195_I0.5460.84
384_N388_N0.5440.84
57_L172_I0.5430.84
15_V378_E0.5420.83
269_V295_Y0.5400.83
325_Q328_T0.5380.83
302_T380_R0.5370.83
269_V385_L0.5370.83
138_M145_G0.5360.83
303_S334_M0.5350.83
196_G200_A0.5350.83
190_M193_A0.5350.83
58_G71_V0.5350.83
160_G164_L0.5350.83
345_G349_I0.5350.83
45_M185_I0.5340.83
161_L177_K0.5340.83
137_N140_D0.5340.83
286_V399_E0.5340.83
126_W131_T0.5320.82
164_L167_K0.5310.82
249_Y386_I0.5310.82
48_A142_F0.5310.82
342_G346_S0.5310.82
358_L361_I0.5310.82
302_T346_S0.5270.82
302_T377_S0.5230.81
310_T313_L0.5230.81
226_T230_F0.5230.81
260_V377_S0.5230.81
316_V368_L0.5220.81
50_I182_F0.5220.81
79_F294_G0.5220.81
321_L329_I0.5210.81
260_V382_I0.5210.81
26_P29_G0.5200.81
30_K207_H0.5180.81
282_C392_T0.5180.81
363_L366_L0.5170.81
218_S222_S0.5160.80
143_A146_D0.5160.80
37_D203_Y0.5160.80
239_C394_I0.5150.80
62_M392_T0.5140.80
277_M388_N0.5130.80
236_N239_C0.5120.80
167_K173_D0.5100.80
131_T137_N0.5090.80
122_Q128_E0.5090.80
253_I257_L0.5080.79
29_G203_Y0.5070.79
309_A373_D0.5070.79
391_A394_I0.5070.79
193_A197_A0.5050.79
313_L317_F0.5050.79
87_L334_M0.5050.79
73_G76_F0.5040.79
129_F134_V0.5040.79
71_V399_E0.5040.79
251_R279_R0.5040.79
340_A347_G0.5040.79
128_E133_I0.5030.79
75_A289_L0.5030.79
47_I368_L0.5030.79
396_A399_E0.5030.79
98_K311_V0.5020.79
240_K247_W0.5000.78
317_F362_P0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.9121 100 0.061 Contact Map
4czbA 2 0.6318 27.3 0.966 Contact Map
4n7wA 2 0.3658 19.5 0.969 Contact Map
3zuxA 1 0.3515 17.2 0.969 Contact Map
4cz8A 2 0.6485 14.5 0.97 Contact Map
4r0cA 3 0.7625 12.9 0.971 Contact Map
4ryoA 1 0.3373 11.1 0.972 Contact Map
3ffvA 1 0.1378 9 0.973 Contact Map
2a65A 2 0.5416 6.7 0.974 Contact Map
4bwzA 2 0.6128 5.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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