GREMLIN Database
DCTB - C4-dicarboxylate-binding protein DctB
UniProt: P96600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (308)
Sequences: 9266 (6700)
Seq/√Len: 381.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_P272_R3.6121.00
77_K271_T3.5971.00
268_T271_T3.5361.00
261_E265_K3.4891.00
299_E303_K3.1861.00
73_K277_E2.7341.00
318_Q322_K2.7001.00
157_K261_E2.6631.00
273_R277_E2.6451.00
71_N79_K2.5301.00
46_V81_E2.3601.00
104_Q263_F2.3531.00
234_Y300_E2.3451.00
337_R341_R2.3291.00
299_E302_K2.3281.00
264_W276_T2.3231.00
65_K68_D2.2901.00
74_S274_I2.2781.00
197_D200_K2.2111.00
69_L281_E2.1641.00
50_S94_E2.1491.00
288_T292_Q2.1321.00
157_K276_T2.1261.00
67_A71_N2.0781.00
168_Q249_S2.0351.00
68_D72_E1.9731.00
341_R345_E1.9691.00
263_F266_A1.9651.00
46_V79_K1.9611.00
69_L73_K1.9121.00
197_D330_Q1.8981.00
65_K69_L1.8251.00
69_L72_E1.8171.00
146_Q342_E1.7951.00
65_K285_W1.7711.00
269_P273_R1.7581.00
313_S316_E1.7521.00
64_N68_D1.7491.00
73_K278_A1.7211.00
180_D183_K1.7041.00
69_L278_A1.6981.00
298_L302_K1.6981.00
179_P319_E1.6841.00
45_I271_T1.6791.00
292_Q296_E1.6731.00
119_E150_S1.6561.00
73_K274_I1.6461.00
130_T134_A1.6191.00
148_F158_G1.6051.00
300_E303_K1.5981.00
47_F263_F1.5841.00
244_Y310_Y1.5661.00
296_E300_E1.5651.00
149_D152_K1.5591.00
199_F204_A1.5581.00
74_S78_I1.5481.00
105_F259_T1.5431.00
244_Y308_H1.5351.00
177_K310_Y1.5351.00
175_P308_H1.5301.00
247_I311_E1.5211.00
171_T225_G1.5141.00
66_F279_M1.5051.00
67_A82_V1.5011.00
152_K261_E1.4821.00
201_L326_P1.4801.00
295_K299_E1.4611.00
322_K325_D1.4531.00
293_M296_E1.4411.00
140_N287_E1.4391.00
215_F241_V1.4301.00
142_S145_T1.4251.00
332_E337_R1.4201.00
289_Y292_Q1.4191.00
60_G64_N1.4131.00
68_D71_N1.4121.00
318_Q321_M1.4111.00
45_I78_I1.3961.00
285_W289_Y1.3901.00
239_Y305_S1.3871.00
319_E322_K1.3851.00
73_K281_E1.3801.00
44_Q77_K1.3781.00
45_I268_T1.3751.00
300_E305_S1.3711.00
247_I298_L1.3711.00
48_K83_F1.3701.00
276_T280_K1.3671.00
316_E319_E1.3661.00
317_K321_M1.3631.00
49_F80_I1.3571.00
89_Y97_A1.3531.00
145_T149_D1.3501.00
44_Q79_K1.3411.00
70_V274_I1.3411.00
49_F63_A1.3351.00
90_S93_E1.3151.00
51_H60_G1.3101.00
329_R332_E1.3061.00
144_G148_F1.3051.00
131_D134_A1.3031.00
70_V275_L1.2821.00
249_S317_K1.2811.00
78_I271_T1.2801.00
157_K264_W1.2791.00
264_W272_R1.2771.00
136_K291_E1.2601.00
77_K270_E1.2511.00
66_F70_V1.2491.00
200_K206_P1.2421.00
47_F104_Q1.2341.00
230_I298_L1.2311.00
209_E223_V1.2301.00
170_T226_E1.2291.00
209_E217_L1.2241.00
277_E281_E1.2211.00
70_V80_I1.2181.00
246_T310_Y1.1971.00
48_K81_E1.1961.00
94_E106_I1.1961.00
341_R344_L1.1951.00
237_K240_N1.1921.00
173_Q185_Q1.1911.00
259_T263_F1.1891.00
180_D319_E1.1871.00
214_T223_V1.1801.00
329_R333_P1.1771.00
273_R276_T1.1751.00
117_S150_S1.1601.00
262_H265_K1.1551.00
146_Q149_D1.1531.00
314_D318_Q1.1531.00
326_P329_R1.1471.00
272_R276_T1.1461.00
274_I278_A1.1431.00
338_E342_E1.1411.00
133_N137_K1.1231.00
98_L106_I1.1101.00
177_K181_D1.1101.00
152_K157_K1.1051.00
178_T181_D1.1041.00
170_T242_Q1.0951.00
55_E64_N1.0921.00
98_L260_D1.0921.00
175_P244_Y1.0891.00
234_Y297_Q1.0771.00
278_A281_E1.0771.00
243_D308_H1.0741.00
230_I247_I1.0711.00
177_K316_E1.0701.00
325_D329_R1.0681.00
78_I275_L1.0601.00
51_H82_V1.0591.00
187_L225_G1.0581.00
67_A80_I1.0571.00
162_W282_T1.0541.00
83_F88_L1.0511.00
157_K265_K1.0481.00
302_K309_I1.0481.00
50_S103_V1.0431.00
201_L330_Q1.0361.00
297_Q300_E1.0331.00
47_F105_F1.0311.00
171_T185_Q1.0261.00
69_L285_W1.0231.00
285_W288_T1.0171.00
278_A282_T1.0151.00
284_E288_T1.0051.00
156_L258_M1.0051.00
338_E341_R1.0051.00
150_S153_K0.9971.00
185_Q225_G0.9961.00
62_A286_N0.9881.00
175_P310_Y0.9861.00
170_T233_I0.9821.00
160_A283_T0.9781.00
301_I307_I0.9721.00
312_L316_E0.9641.00
342_E345_E0.9621.00
120_W151_L0.9571.00
340_I344_L0.9521.00
38_Q42_Q0.9451.00
298_L309_I0.9421.00
319_E323_R0.9411.00
159_L279_M0.9411.00
169_I199_F0.9401.00
171_T176_V0.9381.00
259_T264_W0.9311.00
169_I248_S0.9311.00
173_Q243_D0.9291.00
37_D41_L0.9231.00
48_K104_Q0.9191.00
134_A137_K0.9181.00
55_E85_N0.9181.00
171_T246_T0.9181.00
83_F87_S0.9181.00
67_A70_V0.9131.00
179_P320_W0.9121.00
96_E116_L0.9101.00
41_L44_Q0.9091.00
230_I245_L0.9051.00
168_Q247_I0.9031.00
312_L315_K0.9031.00
281_E285_W0.9001.00
197_D201_L0.9001.00
70_V78_I0.8961.00
136_K140_N0.8941.00
74_S271_T0.8931.00
56_N60_G0.8871.00
330_Q334_I0.8871.00
39_E42_Q0.8811.00
61_L64_N0.8811.00
101_G104_Q0.8811.00
330_Q333_P0.8801.00
170_T245_L0.8701.00
129_F138_G0.8671.00
215_F240_N0.8611.00
296_E299_E0.8601.00
339_L343_L0.8571.00
323_R326_P0.8571.00
155_Q262_H0.8511.00
291_E295_K0.8491.00
332_E340_I0.8481.00
211_F236_K0.8481.00
182_L204_A0.8431.00
114_G121_G0.8411.00
77_K268_T0.8401.00
216_Q220_N0.8401.00
136_K287_E0.8371.00
96_E100_N0.8361.00
142_S342_E0.8251.00
280_K284_E0.8251.00
282_T285_W0.8231.00
65_K281_E0.8221.00
47_F275_L0.8191.00
97_A102_D0.8161.00
262_H266_A0.8051.00
64_N82_V0.8021.00
117_S120_W0.8001.00
186_D205_T0.7961.00
42_Q45_I0.7941.00
328_Y332_E0.7941.00
38_Q41_L0.7931.00
49_F105_F0.7921.00
130_T321_M0.7921.00
51_H84_P0.7831.00
66_F80_I0.7821.00
67_A79_K0.7801.00
145_T148_F0.7771.00
202_L324_L0.7761.00
142_S146_Q0.7751.00
178_T316_E0.7741.00
321_M325_D0.7731.00
233_I245_L0.7721.00
36_D42_Q0.7711.00
295_K298_L0.7631.00
39_E43_D0.7621.00
182_L320_W0.7611.00
49_F257_V0.7611.00
66_F275_L0.7611.00
226_E242_Q0.7601.00
280_K283_T0.7581.00
196_E200_K0.7571.00
315_K318_Q0.7551.00
172_N221_N0.7541.00
302_K311_E0.7531.00
40_G44_Q0.7531.00
246_T312_L0.7531.00
187_L204_A0.7521.00
94_E103_V0.7491.00
176_V181_D0.7481.00
47_F78_I0.7481.00
155_Q261_E0.7411.00
328_Y344_L0.7391.00
257_V279_M0.7351.00
167_K227_E0.7331.00
45_I266_A0.7331.00
141_G144_G0.7321.00
65_K282_T0.7291.00
71_N76_G0.7271.00
109_S253_L0.7251.00
78_I274_I0.7211.00
97_A103_V0.7151.00
84_P87_S0.7151.00
47_F259_T0.7141.00
274_I277_E0.7141.00
110_T256_A0.7131.00
245_L309_I0.7111.00
332_E344_L0.7101.00
202_L323_R0.7091.00
332_E341_R0.7091.00
148_F157_K0.7091.00
117_S154_N0.7081.00
92_I191_Q0.7071.00
201_L327_V0.7071.00
176_V182_L0.7051.00
119_E336_G0.7051.00
95_I156_L0.7051.00
197_D331_Y0.7011.00
37_D40_G0.6940.99
105_F275_L0.6920.99
239_Y307_I0.6850.99
175_P246_T0.6850.99
171_T244_Y0.6840.99
71_N74_S0.6810.99
161_Y257_V0.6800.99
61_L293_M0.6800.99
70_V278_A0.6800.99
66_F282_T0.6780.99
271_T274_I0.6770.99
118_P334_I0.6760.99
263_F267_Q0.6750.99
325_D344_L0.6750.99
158_G256_A0.6750.99
55_E84_P0.6740.99
36_D40_G0.6740.99
55_E60_G0.6740.99
339_L342_E0.6710.99
183_K203_G0.6700.99
230_I297_Q0.6700.99
149_D338_E0.6670.99
168_Q245_L0.6670.99
169_I176_V0.6660.99
57_T60_G0.6660.99
50_S89_Y0.6630.99
183_K323_R0.6620.99
187_L199_F0.6610.99
213_S216_Q0.6600.99
89_Y94_E0.6600.99
315_K319_E0.6600.99
322_K326_P0.6590.99
216_Q219_E0.6560.99
61_L289_Y0.6550.99
45_I263_F0.6540.99
98_L156_L0.6530.99
218_L242_Q0.6520.99
40_G43_D0.6480.99
71_N80_I0.6480.99
325_D328_Y0.6450.99
132_Y291_E0.6430.99
234_Y305_S0.6390.99
281_E284_E0.6370.99
133_N136_K0.6360.99
172_N242_Q0.6360.99
78_I267_Q0.6330.99
37_D42_Q0.6310.99
56_N61_L0.6290.99
172_N243_D0.6290.99
41_L45_I0.6290.99
211_F232_N0.6260.99
179_P313_S0.6250.99
261_E264_W0.6250.99
61_L285_W0.6230.99
134_A138_G0.6220.99
36_D39_E0.6210.99
169_I182_L0.6180.99
189_I195_I0.6160.99
312_L317_K0.6150.99
60_G84_P0.6120.99
324_L328_Y0.6110.99
270_E273_R0.6110.99
80_I105_F0.6110.99
227_E250_H0.6090.99
243_D307_I0.6080.99
80_I275_L0.6070.99
263_F275_L0.6060.99
43_D77_K0.6040.99
337_R340_I0.6020.98
63_A82_V0.6010.98
198_Q324_L0.6010.98
331_Y334_I0.5970.98
35_D38_Q0.5960.98
111_S190_M0.5950.98
186_D224_D0.5950.98
169_I187_L0.5930.98
132_Y136_K0.5920.98
77_K274_I0.5920.98
45_I77_K0.5910.98
165_G294_N0.5900.98
47_F80_I0.5890.98
122_V343_L0.5870.98
335_F338_E0.5840.98
211_F214_T0.5830.98
293_M297_Q0.5820.98
213_S222_V0.5820.98
149_D153_K0.5810.98
260_D266_A0.5790.98
234_Y239_Y0.5780.98
167_K251_G0.5760.98
98_L258_M0.5760.98
189_I196_E0.5740.98
214_T226_E0.5730.98
226_E238_F0.5720.98
180_D323_R0.5720.98
160_A279_M0.5710.98
182_L202_L0.5660.98
199_F227_E0.5660.98
138_G141_G0.5630.98
92_I116_L0.5600.98
267_Q271_T0.5580.98
189_I199_F0.5580.98
247_I309_I0.5550.97
267_Q275_L0.5530.97
88_L103_V0.5530.97
66_F278_A0.5520.97
209_E214_T0.5520.97
47_F267_Q0.5520.97
52_V108_P0.5500.97
217_L222_V0.5490.97
292_Q295_K0.5480.97
195_I251_G0.5470.97
242_Q307_I0.5460.97
148_F152_K0.5460.97
35_D40_G0.5450.97
198_Q327_V0.5450.97
217_L223_V0.5430.97
49_F107_A0.5420.97
157_K272_R0.5370.97
193_D197_D0.5370.97
61_L65_K0.5360.97
36_D41_L0.5340.97
144_G147_L0.5330.97
131_D137_K0.5330.97
201_L323_R0.5320.97
245_L307_I0.5310.97
72_E75_G0.5310.97
35_D42_Q0.5290.97
105_F257_V0.5290.97
136_K163_T0.5280.97
178_T319_E0.5280.97
65_K289_Y0.5270.97
121_G334_I0.5250.96
122_V339_L0.5250.96
125_L328_Y0.5250.96
146_Q150_S0.5240.96
74_S77_K0.5230.96
133_N291_E0.5230.96
216_Q222_V0.5220.96
196_E206_P0.5220.96
37_D44_Q0.5210.96
60_G82_V0.5210.96
135_V252_Y0.5210.96
211_F238_F0.5190.96
98_L105_F0.5180.96
162_W283_T0.5170.96
35_D41_L0.5160.96
289_Y293_M0.5150.96
171_T310_Y0.5140.96
277_E280_K0.5130.96
173_Q244_Y0.5130.96
207_H223_V0.5120.96
44_Q81_E0.5110.96
336_G339_L0.5110.96
327_V330_Q0.5110.96
195_I198_Q0.5080.96
312_L319_E0.5060.96
143_I146_Q0.5060.96
166_F252_Y0.5040.96
311_E314_D0.5030.95
170_T307_I0.5010.95
201_L324_L0.5010.95
86_G90_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u65B 1 0.8657 100 0.194 Contact Map
4nguA 1 0.8743 100 0.215 Contact Map
4pddA 1 0.8629 100 0.217 Contact Map
2xwvA 1 0.8657 100 0.226 Contact Map
2vpnA 1 0.8657 100 0.228 Contact Map
4o94A 1 0.8743 100 0.232 Contact Map
4xeqA 1 0.8629 100 0.241 Contact Map
4oanA 1 0.88 100 0.243 Contact Map
3fxbA 1 0.8657 100 0.243 Contact Map
4ovsA 1 0.8686 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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