DCTB - BACSU - GREMLIN Contacts

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DCTB - C4-dicarboxylate-binding protein DctB

UniProt:	P96600	Sequences: MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQIVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGDVQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLAYWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLLENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILTEAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPIFGRELIRELLELRKDS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	350 (308)
Sequences:	9266 (6700)
Seq/√Len:	381.7

ECOLI - YIAO
BACSU - DCTB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
269_P	272_R	3.612	1.00
77_K	271_T	3.597	1.00
268_T	271_T	3.536	1.00
261_E	265_K	3.489	1.00
299_E	303_K	3.186	1.00
73_K	277_E	2.734	1.00
318_Q	322_K	2.700	1.00
157_K	261_E	2.663	1.00
273_R	277_E	2.645	1.00
71_N	79_K	2.530	1.00
46_V	81_E	2.360	1.00
104_Q	263_F	2.353	1.00
234_Y	300_E	2.345	1.00
337_R	341_R	2.329	1.00
299_E	302_K	2.328	1.00
264_W	276_T	2.323	1.00
65_K	68_D	2.290	1.00
74_S	274_I	2.278	1.00
197_D	200_K	2.211	1.00
69_L	281_E	2.164	1.00
50_S	94_E	2.149	1.00
288_T	292_Q	2.132	1.00
157_K	276_T	2.126	1.00
67_A	71_N	2.078	1.00
168_Q	249_S	2.035	1.00
68_D	72_E	1.973	1.00
341_R	345_E	1.969	1.00
263_F	266_A	1.965	1.00
46_V	79_K	1.961	1.00
69_L	73_K	1.912	1.00
197_D	330_Q	1.898	1.00
65_K	69_L	1.825	1.00
69_L	72_E	1.817	1.00
146_Q	342_E	1.795	1.00
65_K	285_W	1.771	1.00
269_P	273_R	1.758	1.00
313_S	316_E	1.752	1.00
64_N	68_D	1.749	1.00
73_K	278_A	1.721	1.00
180_D	183_K	1.704	1.00
69_L	278_A	1.698	1.00
298_L	302_K	1.698	1.00
179_P	319_E	1.684	1.00
45_I	271_T	1.679	1.00
292_Q	296_E	1.673	1.00
119_E	150_S	1.656	1.00
73_K	274_I	1.646	1.00
130_T	134_A	1.619	1.00
148_F	158_G	1.605	1.00
300_E	303_K	1.598	1.00
47_F	263_F	1.584	1.00
244_Y	310_Y	1.566	1.00
296_E	300_E	1.565	1.00
149_D	152_K	1.559	1.00
199_F	204_A	1.558	1.00
74_S	78_I	1.548	1.00
105_F	259_T	1.543	1.00
244_Y	308_H	1.535	1.00
177_K	310_Y	1.535	1.00
175_P	308_H	1.530	1.00
247_I	311_E	1.521	1.00
171_T	225_G	1.514	1.00
66_F	279_M	1.505	1.00
67_A	82_V	1.501	1.00
152_K	261_E	1.482	1.00
201_L	326_P	1.480	1.00
295_K	299_E	1.461	1.00
322_K	325_D	1.453	1.00
293_M	296_E	1.441	1.00
140_N	287_E	1.439	1.00
215_F	241_V	1.430	1.00
142_S	145_T	1.425	1.00
332_E	337_R	1.420	1.00
289_Y	292_Q	1.419	1.00
60_G	64_N	1.413	1.00
68_D	71_N	1.412	1.00
318_Q	321_M	1.411	1.00
45_I	78_I	1.396	1.00
285_W	289_Y	1.390	1.00
239_Y	305_S	1.387	1.00
319_E	322_K	1.385	1.00
73_K	281_E	1.380	1.00
44_Q	77_K	1.378	1.00
45_I	268_T	1.375	1.00
300_E	305_S	1.371	1.00
247_I	298_L	1.371	1.00
48_K	83_F	1.370	1.00
276_T	280_K	1.367	1.00
316_E	319_E	1.366	1.00
317_K	321_M	1.363	1.00
49_F	80_I	1.357	1.00
89_Y	97_A	1.353	1.00
145_T	149_D	1.350	1.00
44_Q	79_K	1.341	1.00
70_V	274_I	1.341	1.00
49_F	63_A	1.335	1.00
90_S	93_E	1.315	1.00
51_H	60_G	1.310	1.00
329_R	332_E	1.306	1.00
144_G	148_F	1.305	1.00
131_D	134_A	1.303	1.00
70_V	275_L	1.282	1.00
249_S	317_K	1.281	1.00
78_I	271_T	1.280	1.00
157_K	264_W	1.279	1.00
264_W	272_R	1.277	1.00
136_K	291_E	1.260	1.00
77_K	270_E	1.251	1.00
66_F	70_V	1.249	1.00
200_K	206_P	1.242	1.00
47_F	104_Q	1.234	1.00
230_I	298_L	1.231	1.00
209_E	223_V	1.230	1.00
170_T	226_E	1.229	1.00
209_E	217_L	1.224	1.00
277_E	281_E	1.221	1.00
70_V	80_I	1.218	1.00
246_T	310_Y	1.197	1.00
48_K	81_E	1.196	1.00
94_E	106_I	1.196	1.00
341_R	344_L	1.195	1.00
237_K	240_N	1.192	1.00
173_Q	185_Q	1.191	1.00
259_T	263_F	1.189	1.00
180_D	319_E	1.187	1.00
214_T	223_V	1.180	1.00
329_R	333_P	1.177	1.00
273_R	276_T	1.175	1.00
117_S	150_S	1.160	1.00
262_H	265_K	1.155	1.00
146_Q	149_D	1.153	1.00
314_D	318_Q	1.153	1.00
326_P	329_R	1.147	1.00
272_R	276_T	1.146	1.00
274_I	278_A	1.143	1.00
338_E	342_E	1.141	1.00
133_N	137_K	1.123	1.00
98_L	106_I	1.110	1.00
177_K	181_D	1.110	1.00
152_K	157_K	1.105	1.00
178_T	181_D	1.104	1.00
170_T	242_Q	1.095	1.00
55_E	64_N	1.092	1.00
98_L	260_D	1.092	1.00
175_P	244_Y	1.089	1.00
234_Y	297_Q	1.077	1.00
278_A	281_E	1.077	1.00
243_D	308_H	1.074	1.00
230_I	247_I	1.071	1.00
177_K	316_E	1.070	1.00
325_D	329_R	1.068	1.00
78_I	275_L	1.060	1.00
51_H	82_V	1.059	1.00
187_L	225_G	1.058	1.00
67_A	80_I	1.057	1.00
162_W	282_T	1.054	1.00
83_F	88_L	1.051	1.00
157_K	265_K	1.048	1.00
302_K	309_I	1.048	1.00
50_S	103_V	1.043	1.00
201_L	330_Q	1.036	1.00
297_Q	300_E	1.033	1.00
47_F	105_F	1.031	1.00
171_T	185_Q	1.026	1.00
69_L	285_W	1.023	1.00
285_W	288_T	1.017	1.00
278_A	282_T	1.015	1.00
284_E	288_T	1.005	1.00
156_L	258_M	1.005	1.00
338_E	341_R	1.005	1.00
150_S	153_K	0.997	1.00
185_Q	225_G	0.996	1.00
62_A	286_N	0.988	1.00
175_P	310_Y	0.986	1.00
170_T	233_I	0.982	1.00
160_A	283_T	0.978	1.00
301_I	307_I	0.972	1.00
312_L	316_E	0.964	1.00
342_E	345_E	0.962	1.00
120_W	151_L	0.957	1.00
340_I	344_L	0.952	1.00
38_Q	42_Q	0.945	1.00
298_L	309_I	0.942	1.00
319_E	323_R	0.941	1.00
159_L	279_M	0.941	1.00
169_I	199_F	0.940	1.00
171_T	176_V	0.938	1.00
259_T	264_W	0.931	1.00
169_I	248_S	0.931	1.00
173_Q	243_D	0.929	1.00
37_D	41_L	0.923	1.00
48_K	104_Q	0.919	1.00
134_A	137_K	0.918	1.00
55_E	85_N	0.918	1.00
171_T	246_T	0.918	1.00
83_F	87_S	0.918	1.00
67_A	70_V	0.913	1.00
179_P	320_W	0.912	1.00
96_E	116_L	0.910	1.00
41_L	44_Q	0.909	1.00
230_I	245_L	0.905	1.00
168_Q	247_I	0.903	1.00
312_L	315_K	0.903	1.00
281_E	285_W	0.900	1.00
197_D	201_L	0.900	1.00
70_V	78_I	0.896	1.00
136_K	140_N	0.894	1.00
74_S	271_T	0.893	1.00
56_N	60_G	0.887	1.00
330_Q	334_I	0.887	1.00
39_E	42_Q	0.881	1.00
61_L	64_N	0.881	1.00
101_G	104_Q	0.881	1.00
330_Q	333_P	0.880	1.00
170_T	245_L	0.870	1.00
129_F	138_G	0.867	1.00
215_F	240_N	0.861	1.00
296_E	299_E	0.860	1.00
339_L	343_L	0.857	1.00
323_R	326_P	0.857	1.00
155_Q	262_H	0.851	1.00
291_E	295_K	0.849	1.00
332_E	340_I	0.848	1.00
211_F	236_K	0.848	1.00
182_L	204_A	0.843	1.00
114_G	121_G	0.841	1.00
77_K	268_T	0.840	1.00
216_Q	220_N	0.840	1.00
136_K	287_E	0.837	1.00
96_E	100_N	0.836	1.00
142_S	342_E	0.825	1.00
280_K	284_E	0.825	1.00
282_T	285_W	0.823	1.00
65_K	281_E	0.822	1.00
47_F	275_L	0.819	1.00
97_A	102_D	0.816	1.00
262_H	266_A	0.805	1.00
64_N	82_V	0.802	1.00
117_S	120_W	0.800	1.00
186_D	205_T	0.796	1.00
42_Q	45_I	0.794	1.00
328_Y	332_E	0.794	1.00
38_Q	41_L	0.793	1.00
49_F	105_F	0.792	1.00
130_T	321_M	0.792	1.00
51_H	84_P	0.783	1.00
66_F	80_I	0.782	1.00
67_A	79_K	0.780	1.00
145_T	148_F	0.777	1.00
202_L	324_L	0.776	1.00
142_S	146_Q	0.775	1.00
178_T	316_E	0.774	1.00
321_M	325_D	0.773	1.00
233_I	245_L	0.772	1.00
36_D	42_Q	0.771	1.00
295_K	298_L	0.763	1.00
39_E	43_D	0.762	1.00
182_L	320_W	0.761	1.00
49_F	257_V	0.761	1.00
66_F	275_L	0.761	1.00
226_E	242_Q	0.760	1.00
280_K	283_T	0.758	1.00
196_E	200_K	0.757	1.00
315_K	318_Q	0.755	1.00
172_N	221_N	0.754	1.00
302_K	311_E	0.753	1.00
40_G	44_Q	0.753	1.00
246_T	312_L	0.753	1.00
187_L	204_A	0.752	1.00
94_E	103_V	0.749	1.00
176_V	181_D	0.748	1.00
47_F	78_I	0.748	1.00
155_Q	261_E	0.741	1.00
328_Y	344_L	0.739	1.00
257_V	279_M	0.735	1.00
167_K	227_E	0.733	1.00
45_I	266_A	0.733	1.00
141_G	144_G	0.732	1.00
65_K	282_T	0.729	1.00
71_N	76_G	0.727	1.00
109_S	253_L	0.725	1.00
78_I	274_I	0.721	1.00
97_A	103_V	0.715	1.00
84_P	87_S	0.715	1.00
47_F	259_T	0.714	1.00
274_I	277_E	0.714	1.00
110_T	256_A	0.713	1.00
245_L	309_I	0.711	1.00
332_E	344_L	0.710	1.00
202_L	323_R	0.709	1.00
332_E	341_R	0.709	1.00
148_F	157_K	0.709	1.00
117_S	154_N	0.708	1.00
92_I	191_Q	0.707	1.00
201_L	327_V	0.707	1.00
176_V	182_L	0.705	1.00
119_E	336_G	0.705	1.00
95_I	156_L	0.705	1.00
197_D	331_Y	0.701	1.00
37_D	40_G	0.694	0.99
105_F	275_L	0.692	0.99
239_Y	307_I	0.685	0.99
175_P	246_T	0.685	0.99
171_T	244_Y	0.684	0.99
71_N	74_S	0.681	0.99
161_Y	257_V	0.680	0.99
61_L	293_M	0.680	0.99
70_V	278_A	0.680	0.99
66_F	282_T	0.678	0.99
271_T	274_I	0.677	0.99
118_P	334_I	0.676	0.99
263_F	267_Q	0.675	0.99
325_D	344_L	0.675	0.99
158_G	256_A	0.675	0.99
55_E	84_P	0.674	0.99
36_D	40_G	0.674	0.99
55_E	60_G	0.674	0.99
339_L	342_E	0.671	0.99
183_K	203_G	0.670	0.99
230_I	297_Q	0.670	0.99
149_D	338_E	0.667	0.99
168_Q	245_L	0.667	0.99
169_I	176_V	0.666	0.99
57_T	60_G	0.666	0.99
50_S	89_Y	0.663	0.99
183_K	323_R	0.662	0.99
187_L	199_F	0.661	0.99
213_S	216_Q	0.660	0.99
89_Y	94_E	0.660	0.99
315_K	319_E	0.660	0.99
322_K	326_P	0.659	0.99
216_Q	219_E	0.656	0.99
61_L	289_Y	0.655	0.99
45_I	263_F	0.654	0.99
98_L	156_L	0.653	0.99
218_L	242_Q	0.652	0.99
40_G	43_D	0.648	0.99
71_N	80_I	0.648	0.99
325_D	328_Y	0.645	0.99
132_Y	291_E	0.643	0.99
234_Y	305_S	0.639	0.99
281_E	284_E	0.637	0.99
133_N	136_K	0.636	0.99
172_N	242_Q	0.636	0.99
78_I	267_Q	0.633	0.99
37_D	42_Q	0.631	0.99
56_N	61_L	0.629	0.99
172_N	243_D	0.629	0.99
41_L	45_I	0.629	0.99
211_F	232_N	0.626	0.99
179_P	313_S	0.625	0.99
261_E	264_W	0.625	0.99
61_L	285_W	0.623	0.99
134_A	138_G	0.622	0.99
36_D	39_E	0.621	0.99
169_I	182_L	0.618	0.99
189_I	195_I	0.616	0.99
312_L	317_K	0.615	0.99
60_G	84_P	0.612	0.99
324_L	328_Y	0.611	0.99
270_E	273_R	0.611	0.99
80_I	105_F	0.611	0.99
227_E	250_H	0.609	0.99
243_D	307_I	0.608	0.99
80_I	275_L	0.607	0.99
263_F	275_L	0.606	0.99
43_D	77_K	0.604	0.99
337_R	340_I	0.602	0.98
63_A	82_V	0.601	0.98
198_Q	324_L	0.601	0.98
331_Y	334_I	0.597	0.98
35_D	38_Q	0.596	0.98
111_S	190_M	0.595	0.98
186_D	224_D	0.595	0.98
169_I	187_L	0.593	0.98
132_Y	136_K	0.592	0.98
77_K	274_I	0.592	0.98
45_I	77_K	0.591	0.98
165_G	294_N	0.590	0.98
47_F	80_I	0.589	0.98
122_V	343_L	0.587	0.98
335_F	338_E	0.584	0.98
211_F	214_T	0.583	0.98
293_M	297_Q	0.582	0.98
213_S	222_V	0.582	0.98
149_D	153_K	0.581	0.98
260_D	266_A	0.579	0.98
234_Y	239_Y	0.578	0.98
167_K	251_G	0.576	0.98
98_L	258_M	0.576	0.98
189_I	196_E	0.574	0.98
214_T	226_E	0.573	0.98
226_E	238_F	0.572	0.98
180_D	323_R	0.572	0.98
160_A	279_M	0.571	0.98
182_L	202_L	0.566	0.98
199_F	227_E	0.566	0.98
138_G	141_G	0.563	0.98
92_I	116_L	0.560	0.98
267_Q	271_T	0.558	0.98
189_I	199_F	0.558	0.98
247_I	309_I	0.555	0.97
267_Q	275_L	0.553	0.97
88_L	103_V	0.553	0.97
66_F	278_A	0.552	0.97
209_E	214_T	0.552	0.97
47_F	267_Q	0.552	0.97
52_V	108_P	0.550	0.97
217_L	222_V	0.549	0.97
292_Q	295_K	0.548	0.97
195_I	251_G	0.547	0.97
242_Q	307_I	0.546	0.97
148_F	152_K	0.546	0.97
35_D	40_G	0.545	0.97
198_Q	327_V	0.545	0.97
217_L	223_V	0.543	0.97
49_F	107_A	0.542	0.97
157_K	272_R	0.537	0.97
193_D	197_D	0.537	0.97
61_L	65_K	0.536	0.97
36_D	41_L	0.534	0.97
144_G	147_L	0.533	0.97
131_D	137_K	0.533	0.97
201_L	323_R	0.532	0.97
245_L	307_I	0.531	0.97
72_E	75_G	0.531	0.97
35_D	42_Q	0.529	0.97
105_F	257_V	0.529	0.97
136_K	163_T	0.528	0.97
178_T	319_E	0.528	0.97
65_K	289_Y	0.527	0.97
121_G	334_I	0.525	0.96
122_V	339_L	0.525	0.96
125_L	328_Y	0.525	0.96
146_Q	150_S	0.524	0.96
74_S	77_K	0.523	0.96
133_N	291_E	0.523	0.96
216_Q	222_V	0.522	0.96
196_E	206_P	0.522	0.96
37_D	44_Q	0.521	0.96
60_G	82_V	0.521	0.96
135_V	252_Y	0.521	0.96
211_F	238_F	0.519	0.96
98_L	105_F	0.518	0.96
162_W	283_T	0.517	0.96
35_D	41_L	0.516	0.96
289_Y	293_M	0.515	0.96
171_T	310_Y	0.514	0.96
277_E	280_K	0.513	0.96
173_Q	244_Y	0.513	0.96
207_H	223_V	0.512	0.96
44_Q	81_E	0.511	0.96
336_G	339_L	0.511	0.96
327_V	330_Q	0.511	0.96
195_I	198_Q	0.508	0.96
312_L	319_E	0.506	0.96
143_I	146_Q	0.506	0.96
166_F	252_Y	0.504	0.96
311_E	314_D	0.503	0.95
170_T	307_I	0.501	0.95
201_L	324_L	0.501	0.95
86_G	90_S	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3u65B	1	0.8657	100	0.194	Contact Map
4nguA	1	0.8743	100	0.215	Contact Map
4pddA	1	0.8629	100	0.217	Contact Map
2xwvA	1	0.8657	100	0.226	Contact Map
2vpnA	1	0.8657	100	0.228	Contact Map
4o94A	1	0.8743	100	0.232	Contact Map
4xeqA	1	0.8629	100	0.241	Contact Map
4oanA	1	0.88	100	0.243	Contact Map
3fxbA	1	0.8657	100	0.243	Contact Map
4ovsA	1	0.8686	100	0.244	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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