GREMLIN Database
MNTH - Divalent metal cation transporter MntH
UniProt: P96593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 425 (389)
Sequences: 4065 (2580)
Seq/√Len: 130.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_K99_E8.1701.00
190_D193_S5.7231.00
387_S402_T4.5581.00
399_K403_V3.6561.00
292_Q295_G3.4051.00
386_T397_N3.3631.00
389_K396_I3.2571.00
380_I413_V3.2051.00
100_E388_N3.1521.00
399_K402_T3.1291.00
383_I405_S3.0451.00
397_N402_T2.9831.00
338_P341_V2.9541.00
107_I111_I2.9411.00
77_L408_I2.8451.00
295_G300_P2.7521.00
88_A395_L2.7231.00
380_I409_A2.6621.00
80_S84_K2.6431.00
267_A271_I2.5481.00
65_L267_A2.5081.00
398_A401_I2.4421.00
55_S59_K2.3921.00
380_I384_M2.3881.00
417_V421_V2.3791.00
230_A327_V2.3521.00
85_L386_T2.3251.00
194_V271_I2.3041.00
101_F384_M2.2791.00
191_A194_V2.2591.00
131_G311_L2.2501.00
104_P108_G2.2111.00
295_G303_A2.1711.00
74_M408_I2.1671.00
52_T214_G2.1451.00
201_P204_H2.0761.00
196_K202_A2.0591.00
198_L267_A2.0491.00
76_L256_L2.0461.00
343_R346_T2.0421.00
204_H208_S2.0301.00
384_M388_N2.0011.00
174_F178_I1.9971.00
102_P105_V1.9851.00
289_V292_Q1.9721.00
139_P142_E1.9621.00
77_L401_I1.9401.00
387_S397_N1.9371.00
132_L136_F1.9211.00
81_L397_N1.9121.00
60_Y205_G1.8591.00
150_G153_A1.8491.00
80_S252_F1.8421.00
147_A311_L1.8351.00
92_N95_E1.8251.00
163_R167_A1.8101.00
249_R253_I1.7271.00
418_F422_D1.7241.00
410_V414_A1.7231.00
111_I115_L1.7171.00
128_A147_A1.7161.00
85_L96_V1.7041.00
91_K96_V1.6891.00
183_Q272_V1.6681.00
210_L366_L1.6651.00
103_K107_I1.6541.00
379_L409_A1.6351.00
60_Y208_S1.6351.00
38_F258_A1.6271.00
339_L342_R1.6081.00
406_W410_V1.6001.00
403_V406_W1.5911.00
260_L264_A1.5751.00
388_N391_I1.5701.00
190_D194_V1.5661.00
175_V308_I1.5621.00
78_I379_L1.5431.00
81_L405_S1.5301.00
196_K200_V1.5071.00
84_K397_N1.5071.00
193_S197_G1.5051.00
30_L253_I1.5011.00
62_Y275_A1.4961.00
88_A248_F1.4871.00
338_P342_R1.4841.00
60_Y207_D1.4701.00
383_I387_S1.4691.00
385_F391_I1.4651.00
83_A251_E1.4571.00
68_I270_L1.4531.00
69_L263_G1.4431.00
91_K100_E1.4291.00
383_I409_A1.4231.00
204_H207_D1.4221.00
387_S406_W1.4131.00
129_A140_M1.3961.00
359_N362_T1.3861.00
44_Y262_A1.3851.00
337_I341_V1.3741.00
94_P328_I1.3741.00
279_K282_L1.3571.00
253_I257_I1.3491.00
396_I399_K1.3441.00
210_L369_V1.3431.00
286_D289_V1.3421.00
281_G284_V1.3391.00
26_G30_L1.3391.00
51_A290_A1.3171.00
132_L311_L1.3131.00
304_A308_I1.3061.00
56_A215_I1.2981.00
43_A320_V1.2961.00
181_A268_S1.2871.00
175_V312_V1.2831.00
112_Q374_G1.2781.00
341_V345_I1.2731.00
112_Q116_V1.2701.00
192_V195_M1.2661.00
191_A195_M1.2621.00
384_M406_W1.2491.00
53_N266_N1.2481.00
185_F189_P1.2431.00
400_W403_V1.2411.00
347_I354_I1.2341.00
71_S219_T1.2321.00
141_L355_A1.2301.00
187_A298_V1.2301.00
98_R106_S1.2191.00
189_P194_V1.2090.99
41_A45_I1.2070.99
97_A109_L1.2050.99
119_A367_S1.2010.99
301_M305_L1.1930.99
358_V363_A1.1910.99
150_G315_L1.1910.99
87_I251_E1.1860.99
173_L316_S1.1850.99
117_I328_I1.1730.99
397_N401_I1.1710.99
352_L355_A1.1630.99
74_M216_L1.1590.99
167_A170_A1.1590.99
270_L274_A1.1550.99
79_Q220_V1.1450.99
300_P303_A1.1450.99
322_T326_D1.1430.99
292_Q296_H1.1420.99
407_L410_V1.1390.99
138_I142_E1.1340.99
339_L343_R1.1250.99
47_P314_G1.1190.99
336_R339_L1.1140.99
389_K394_S1.1120.99
116_V374_G1.1060.99
409_A413_V1.1030.99
224_A320_V1.0970.99
184_T271_I1.0950.99
397_N400_W1.0890.99
379_L408_I1.0880.99
73_I77_L1.0880.99
26_G29_G1.0850.99
29_G32_P1.0830.99
383_I406_W1.0820.99
285_E289_V1.0780.99
273_A276_L1.0710.99
37_A41_A1.0710.99
193_S196_K1.0610.99
138_I143_A1.0580.99
222_P371_L1.0580.99
61_G278_F1.0570.99
393_G396_I1.0570.99
184_T268_S1.0560.99
149_I153_A1.0350.98
27_F31_L1.0330.98
120_T124_E1.0290.98
63_M202_A1.0250.98
336_R340_Y1.0230.98
79_Q94_P1.0220.98
403_V410_V1.0160.98
218_A221_M1.0130.98
403_V407_L1.0110.98
124_E127_G1.0110.98
56_A211_L1.0060.98
39_I320_V1.0050.98
63_M204_H1.0010.98
54_I290_A1.0000.98
363_A367_S1.0000.98
413_V417_V0.9980.98
123_A367_S0.9940.98
94_P226_Y0.9910.98
348_I351_I0.9830.98
269_M272_V0.9830.98
373_F416_N0.9790.98
366_L370_V0.9780.98
138_I146_I0.9770.98
183_Q186_F0.9700.98
185_F188_K0.9690.98
383_I402_T0.9680.98
291_F303_A0.9660.98
187_A275_A0.9620.97
180_F265_I0.9590.97
77_L405_S0.9580.97
102_P388_N0.9560.97
172_M312_V0.9530.97
77_L404_V0.9410.97
124_E218_A0.9400.97
182_L186_F0.9370.97
50_F309_G0.9310.97
394_S398_A0.9310.97
49_N53_N0.9300.97
414_A418_F0.9280.97
141_L145_I0.9240.97
164_S167_A0.9230.97
89_T96_V0.9150.97
272_V275_A0.9070.96
136_F304_A0.9050.96
92_N233_Q0.9020.96
219_T368_Q0.9000.96
89_T391_I0.8990.96
271_I274_A0.8990.96
72_N263_G0.8990.96
133_Y288_D0.8980.96
166_E235_R0.8960.96
91_K95_E0.8940.96
376_A413_V0.8940.96
192_V196_K0.8920.96
145_I149_I0.8920.96
82_S86_G0.8910.96
189_P271_I0.8840.96
117_I325_G0.8810.96
132_L143_A0.8780.96
81_L386_T0.8760.96
145_I351_I0.8680.95
112_Q117_I0.8670.95
123_A364_L0.8600.95
298_V305_L0.8600.95
181_A185_F0.8600.95
46_D49_N0.8530.95
195_M198_L0.8520.95
396_I402_T0.8520.95
44_Y223_H0.8510.95
304_A307_G0.8480.95
398_A402_T0.8470.95
179_A305_L0.8470.95
195_M200_V0.8460.95
53_N269_M0.8460.95
48_G368_Q0.8440.95
148_A351_I0.8390.94
121_D124_E0.8340.94
81_L85_L0.8330.94
76_L260_L0.8310.94
337_I343_R0.8280.94
79_Q226_Y0.8240.94
93_L226_Y0.8200.94
203_F208_S0.8180.94
411_L414_A0.8130.93
347_I350_P0.8110.93
101_F385_F0.8100.93
85_L385_F0.8100.93
45_I316_S0.8000.93
53_N120_T0.8000.93
39_I42_I0.8000.93
182_L305_L0.7970.93
110_W342_R0.7970.93
183_Q187_A0.7930.93
232_T235_R0.7930.93
153_A157_L0.7920.93
245_K394_S0.7920.93
39_I43_A0.7890.92
180_F269_M0.7890.92
190_D410_V0.7870.92
401_I405_S0.7830.92
34_L38_F0.7770.92
35_G254_D0.7770.92
371_L375_I0.7750.92
216_L376_A0.7730.92
45_I265_I0.7720.92
43_A50_F0.7710.92
161_G164_S0.7690.91
47_P364_L0.7680.91
221_M371_L0.7660.91
41_A87_I0.7630.91
256_L260_L0.7610.91
56_A68_I0.7590.91
142_E145_I0.7570.91
197_G202_A0.7570.91
351_I355_A0.7560.91
224_A228_H0.7550.91
147_A151_S0.7540.91
149_I152_F0.7530.91
245_K395_L0.7520.90
386_T392_M0.7520.90
78_I408_I0.7510.90
45_I176_V0.7490.90
120_T123_A0.7470.90
40_A255_I0.7460.90
36_P254_D0.7460.90
299_S302_S0.7430.90
222_P230_A0.7420.90
96_V99_E0.7400.90
248_F252_F0.7400.90
144_S148_A0.7390.90
146_I150_G0.7390.90
228_H232_T0.7380.90
83_A228_H0.7370.90
43_A222_P0.7360.90
203_F212_A0.7340.89
175_V282_L0.7340.89
75_A219_T0.7310.89
126_I354_I0.7300.89
261_I265_I0.7300.89
124_E317_S0.7300.89
202_A205_G0.7300.89
394_S399_K0.7290.89
354_I360_P0.7290.89
347_I355_A0.7280.89
211_L365_V0.7280.89
85_L382_L0.7260.89
54_I287_L0.7260.89
300_P394_S0.7250.89
79_Q222_P0.7250.89
300_P304_A0.7240.89
168_G319_S0.7200.88
221_M225_I0.7200.88
59_K207_D0.7190.88
134_L307_G0.7170.88
372_S416_N0.7170.88
153_A230_A0.7170.88
96_V391_I0.7170.88
247_I250_F0.7170.88
209_V418_F0.7170.88
68_I215_I0.7160.88
66_W204_H0.7160.88
44_Y75_A0.7150.88
125_F148_A0.7150.88
296_H302_S0.7140.88
42_I46_D0.7110.88
269_M309_G0.7110.88
62_Y274_A0.7090.88
284_V289_V0.7090.88
341_V344_F0.7080.88
178_I292_Q0.7080.88
52_T368_Q0.7060.88
337_I340_Y0.7060.88
42_I173_L0.7060.88
83_A87_I0.7060.88
79_Q219_T0.7050.87
49_N218_A0.7040.87
182_L185_F0.7040.87
145_I148_A0.7030.87
125_F143_A0.7020.87
96_V385_F0.7020.87
180_F294_F0.7000.87
75_A259_M0.6980.87
402_T406_W0.6960.87
223_H372_S0.6940.87
59_K178_I0.6910.86
68_I272_V0.6900.86
162_Y234_R0.6900.86
143_A146_I0.6870.86
306_F365_V0.6860.86
179_A298_V0.6860.86
362_T366_L0.6850.86
221_M228_H0.6850.86
69_L198_L0.6850.86
323_L327_V0.6830.86
414_A417_V0.6830.86
51_A364_L0.6820.86
252_F414_A0.6810.86
46_D124_E0.6810.86
326_D330_Q0.6800.86
263_G267_A0.6800.86
220_V310_L0.6780.85
49_N221_M0.6770.85
276_L279_K0.6760.85
148_A347_I0.6750.85
95_E233_Q0.6750.85
127_G189_P0.6750.85
293_Q309_G0.6740.85
44_Y49_N0.6740.85
115_L370_V0.6740.85
55_S361_T0.6650.84
99_E389_K0.6650.84
224_A227_L0.6640.84
340_Y343_R0.6630.84
104_P107_I0.6620.84
184_T272_V0.6610.84
47_P228_H0.6600.84
173_L177_V0.6570.84
205_G208_S0.6570.84
174_F267_A0.6560.83
378_A381_P0.6540.83
152_F156_E0.6540.83
142_E149_I0.6540.83
407_L414_A0.6530.83
39_I224_A0.6520.83
40_A225_I0.6520.83
225_I379_L0.6510.83
101_F105_V0.6500.83
337_I342_R0.6500.83
285_E348_I0.6470.83
100_E390_R0.6470.83
195_M370_V0.6460.82
282_L296_H0.6460.82
88_A233_Q0.6460.82
43_A378_A0.6460.82
184_T191_A0.6460.82
178_I182_L0.6460.82
139_P149_I0.6430.82
62_Y197_G0.6430.82
164_S344_F0.6430.82
348_I355_A0.6420.82
234_R237_V0.6400.82
269_M294_F0.6390.82
45_I53_N0.6390.82
147_A155_L0.6380.82
197_G200_V0.6370.82
94_P331_G0.6360.81
403_V414_A0.6350.81
400_W404_V0.6340.81
75_A262_A0.6340.81
46_D120_T0.6330.81
120_T371_L0.6320.81
223_H229_S0.6320.81
208_S212_A0.6320.81
374_G378_A0.6310.81
348_I352_L0.6260.80
92_N331_G0.6250.80
339_L344_F0.6210.80
237_V247_I0.6200.80
270_L273_A0.6190.80
218_A368_Q0.6190.80
26_G250_F0.6180.80
108_G112_Q0.6170.80
66_W201_P0.6150.79
221_M368_Q0.6150.79
26_G404_V0.6140.79
82_S93_L0.6130.79
41_A254_D0.6130.79
411_L415_L0.6120.79
81_L84_K0.6120.79
59_K283_F0.6110.79
269_M274_A0.6080.79
217_G324_S0.6070.78
40_A224_A0.6050.78
181_A264_A0.6050.78
128_A148_A0.6020.78
195_M245_K0.6010.78
29_G246_K0.5990.78
162_Y231_L0.5990.78
62_Y190_D0.5980.77
46_D317_S0.5980.77
278_F282_L0.5970.77
46_D53_N0.5960.77
270_L275_A0.5930.77
47_P127_G0.5920.77
202_A389_K0.5910.77
200_V203_F0.5890.76
314_G317_S0.5870.76
80_S248_F0.5860.76
40_A43_A0.5860.76
396_I401_I0.5840.76
143_A147_A0.5840.76
266_N270_L0.5830.76
399_K421_V0.5830.76
86_G229_S0.5820.75
146_I149_I0.5810.75
203_F209_V0.5810.75
37_A258_A0.5810.75
39_I247_I0.5800.75
268_S298_V0.5790.75
140_M145_I0.5790.75
50_F320_V0.5790.75
171_G304_A0.5790.75
223_H266_N0.5760.75
142_E195_M0.5750.75
160_R164_S0.5750.75
98_R334_N0.5740.74
227_L230_A0.5740.74
190_D195_M0.5730.74
184_T305_L0.5730.74
218_A222_P0.5730.74
135_L304_A0.5720.74
215_I270_L0.5720.74
153_A282_L0.5720.74
124_E223_H0.5680.74
132_L146_I0.5670.74
97_A332_F0.5660.73
282_L289_V0.5660.73
272_V293_Q0.5640.73
72_N76_L0.5640.73
276_L296_H0.5620.73
95_E331_G0.5620.73
347_I351_I0.5600.73
227_L231_L0.5600.73
117_I321_G0.5600.73
86_G93_L0.5590.73
73_I76_L0.5590.73
109_L381_P0.5590.73
232_T236_V0.5590.73
388_N396_I0.5580.72
30_L34_L0.5570.72
45_I180_F0.5570.72
122_L350_P0.5560.72
196_K389_K0.5550.72
278_F281_G0.5540.72
171_G182_L0.5530.72
88_A392_M0.5510.71
60_Y211_L0.5500.71
111_I175_V0.5470.71
309_G313_A0.5460.71
49_N266_N0.5460.71
69_L384_M0.5450.71
123_A368_Q0.5450.71
116_V130_L0.5430.70
44_Y228_H0.5420.70
133_Y140_M0.5420.70
251_E276_L0.5420.70
388_N402_T0.5420.70
221_M229_S0.5400.70
213_A413_V0.5390.70
280_N285_E0.5390.70
144_S168_G0.5370.70
356_S360_P0.5360.69
113_G116_V0.5360.69
398_A403_V0.5360.69
171_G175_V0.5360.69
357_G360_P0.5350.69
127_G314_G0.5350.69
46_D316_S0.5340.69
43_A223_H0.5270.68
188_K191_A0.5260.68
50_F218_A0.5260.68
322_T329_M0.5250.68
187_A413_V0.5250.68
254_D378_A0.5250.68
28_R32_P0.5250.68
55_S58_S0.5240.68
43_A225_I0.5240.68
149_I192_V0.5230.68
168_G174_F0.5230.68
132_L138_I0.5220.67
228_H231_L0.5210.67
66_W251_E0.5210.67
290_A306_F0.5210.67
151_S154_I0.5210.67
56_A309_G0.5210.67
192_V308_I0.5200.67
342_R346_T0.5190.67
37_A131_G0.5190.67
86_G92_N0.5190.67
336_R341_V0.5180.67
206_T407_L0.5180.67
110_W321_G0.5160.67
83_A90_G0.5160.67
48_G375_I0.5160.67
110_W114_E0.5160.67
118_I121_D0.5150.66
175_V360_P0.5140.66
152_F267_A0.5140.66
113_G117_I0.5130.66
271_I275_A0.5130.66
144_S354_I0.5130.66
406_W409_A0.5120.66
350_P354_I0.5110.66
136_F143_A0.5100.66
131_G307_G0.5090.65
194_V274_A0.5090.65
310_L314_G0.5090.65
274_A277_F0.5080.65
51_A123_A0.5070.65
104_P377_F0.5060.65
74_M277_F0.5060.65
337_I344_F0.5050.65
310_L363_A0.5040.65
267_A270_L0.5040.65
70_F411_L0.5030.65
110_W117_I0.5020.64
82_S229_S0.5020.64
73_I202_A0.5020.64
169_I319_S0.5020.64
63_M67_V0.5000.64
223_H226_Y0.5000.64
148_A152_F0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wgvA 2 0.8847 100 0.206 Contact Map
3dh4A 3 0.8753 99.3 0.853 Contact Map
2jlnA 1 0.9294 99.1 0.865 Contact Map
2xq2A 2 0.8941 98.8 0.878 Contact Map
3l1lA 2 0.8635 98.8 0.881 Contact Map
3giaA 1 0.8776 98.8 0.881 Contact Map
4djkA 2 0.8518 98.4 0.895 Contact Map
4us3A 1 0.88 98.3 0.896 Contact Map
2a65A 2 0.8941 97.7 0.91 Contact Map
4xp4A 1 0.8965 96.6 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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