GREMLIN Database
MUTT - Putative 8-oxo-dGTP diphosphatase
UniProt: P96590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (120)
Sequences: 8981 (6476)
Seq/√Len: 591.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_L56_N4.1741.00
12_N16_Q3.7841.00
21_K96_G3.2681.00
35_V44_A3.0891.00
8_V45_A2.8071.00
16_Q101_S2.7241.00
21_K95_A2.6231.00
40_S43_E2.5911.00
8_V49_I2.1271.00
60_S81_S2.0591.00
19_L100_V1.9671.00
20_V94_T1.9561.00
101_S104_R1.9441.00
8_V80_G1.9371.00
49_I57_A1.8941.00
46_V50_L1.7881.00
23_K95_A1.7261.00
57_A80_G1.6731.00
58_A81_S1.6191.00
55_Y82_I1.5981.00
10_V49_I1.5831.00
114_K118_N1.5691.00
100_V108_F1.5201.00
62_K65_V1.5041.00
11_L79_F1.4811.00
58_A83_T1.4351.00
66_Y119_D1.4021.00
106_P118_N1.3761.00
102_P121_K1.3161.00
20_V97_L1.2941.00
98_K108_F1.2811.00
62_K76_H1.2711.00
56_N84_G1.2491.00
118_N122_N1.2261.00
35_V41_A1.2161.00
65_V76_H1.2131.00
41_A76_H1.2111.00
46_V59_L1.1881.00
64_G119_D1.1771.00
61_A79_F1.1721.00
39_E47_R1.1711.00
46_V58_A1.1681.00
34_R73_D1.1661.00
18_L99_W1.1651.00
31_P53_T1.1621.00
115_R118_N1.1531.00
41_A78_F1.1141.00
6_A45_A1.1051.00
90_D93_E1.1031.00
7_F77_L1.0751.00
22_R94_T1.0741.00
67_Q72_Q1.0641.00
43_E46_V1.0641.00
82_I85_G1.0411.00
4_Q35_V1.0361.00
55_Y87_A1.0301.00
59_L80_G1.0241.00
28_W98_K1.0181.00
115_R119_D0.9901.00
22_R29_D0.9861.00
5_G34_R0.9861.00
11_L120_F0.9731.00
89_A92_T0.9641.00
91_G94_T0.9571.00
49_I80_G0.9421.00
60_S79_F0.9331.00
15_Q101_S0.9331.00
100_V104_R0.9281.00
6_A44_A0.9231.00
56_N83_T0.9141.00
27_L109_M0.9131.00
5_G73_D0.9111.00
46_V56_N0.8911.00
119_D122_N0.8811.00
61_A123_G0.8771.00
18_L97_L0.8761.00
28_W100_V0.8731.00
4_Q76_H0.8731.00
19_L108_F0.8711.00
105_L117_I0.8711.00
15_Q102_P0.8681.00
100_V106_P0.8581.00
77_L116_Q0.8541.00
26_P95_A0.8521.00
9_I120_F0.8521.00
21_K28_W0.8491.00
63_I79_F0.8481.00
50_L54_G0.8471.00
88_M92_T0.8471.00
119_D123_G0.8461.00
46_V57_A0.8451.00
21_K26_P0.8441.00
11_L15_Q0.8411.00
111_P114_K0.8321.00
79_F120_F0.8311.00
7_F30_L0.7901.00
39_E44_A0.7761.00
104_R107_L0.7751.00
80_G83_T0.7591.00
18_L55_Y0.7581.00
9_I30_L0.7551.00
29_D113_R0.7271.00
68_R73_D0.7241.00
35_V74_E0.7241.00
29_D73_D0.7181.00
110_V113_R0.7161.00
10_V53_T0.7151.00
59_L62_K0.7091.00
73_D77_L0.7061.00
29_D32_G0.7031.00
20_V31_P0.7001.00
32_G73_D0.6961.00
7_F75_Q0.6951.00
87_A97_L0.6921.00
88_M91_G0.6901.00
54_G88_M0.6901.00
9_I17_I0.6901.00
84_G87_A0.6901.00
27_L108_F0.6891.00
42_E46_V0.6871.00
29_D112_N0.6851.00
118_N121_K0.6831.00
28_W96_G0.6811.00
98_K104_R0.6791.00
19_L110_V0.6791.00
37_P72_Q0.6761.00
106_P121_K0.6761.00
120_F123_G0.6711.00
32_G77_L0.6631.00
113_R116_Q0.6631.00
45_A80_G0.6611.00
113_R117_I0.6511.00
7_F112_N0.6461.00
11_L102_P0.6401.00
50_L53_T0.6381.00
105_L108_F0.6331.00
45_A78_F0.6331.00
16_Q104_R0.6321.00
45_A49_I0.6281.00
42_E78_F0.6241.00
46_V60_S0.6241.00
29_D34_R0.6121.00
111_P115_R0.6121.00
59_L82_I0.6111.00
46_V49_I0.6091.00
13_E81_S0.6031.00
103_G106_P0.6031.00
61_A64_G0.6011.00
66_Y77_L0.5941.00
4_Q74_E0.5851.00
7_F32_G0.5821.00
41_A67_Q0.5761.00
30_L77_L0.5751.00
112_N116_Q0.5741.00
19_L98_K0.5701.00
20_V29_D0.5651.00
23_K94_T0.5641.00
83_T86_Q0.5580.99
24_D34_R0.5550.99
68_R75_Q0.5530.99
59_L81_S0.5500.99
13_E16_Q0.5480.99
13_E85_G0.5440.99
32_G113_R0.5400.99
11_L81_S0.5330.99
20_V113_R0.5290.99
112_N115_R0.5260.99
10_V97_L0.5220.99
104_R108_F0.5210.99
32_G36_D0.5180.99
105_L109_M0.5160.99
62_K78_F0.5160.99
23_K93_E0.5130.99
29_D117_I0.5100.99
49_I53_T0.5080.99
5_G75_Q0.5070.99
8_V57_A0.5060.99
7_F116_Q0.5050.99
75_Q113_R0.5040.99
48_E51_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cngA 4 0.9262 99.9 0.359 Contact Map
1vk6A 2 0.8523 99.9 0.379 Contact Map
3f6aA 2 0.8322 99.9 0.381 Contact Map
3fk9A 2 0.9463 99.9 0.386 Contact Map
4ickA 1 0.8658 99.9 0.387 Contact Map
2azwA 1 0.8188 99.9 0.387 Contact Map
3i7uA 4 0.8456 99.9 0.388 Contact Map
4dywA 2 0.8054 99.9 0.389 Contact Map
2qjtB 2 0.8322 99.9 0.389 Contact Map
3grnA 2 0.8389 99.9 0.391 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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