GREMLIN Database
YDAM - Uncharacterized glycosyltransferase YdaM
UniProt: P96587 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (374)
Sequences: 11361 (8811)
Seq/√Len: 455.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_Y153_Y5.2801.00
61_E93_R5.1171.00
219_R223_E4.8761.00
52_S135_G3.7111.00
139_C216_A3.6481.00
52_S82_E3.6061.00
82_E109_K3.5801.00
137_V156_V3.4441.00
86_V129_G3.2621.00
137_V159_L3.0691.00
65_R100_E2.9571.00
95_G99_N2.9001.00
221_I248_Y2.8911.00
87_N90_S2.8851.00
54_L86_V2.8341.00
93_R96_D2.8091.00
82_E135_G2.7851.00
51_V156_V2.6631.00
96_D100_E2.6601.00
224_K246_L2.6601.00
166_G248_Y2.5241.00
265_T268_V2.4681.00
154_Y255_A2.4591.00
165_A251_R2.4361.00
55_I71_M2.3751.00
158_G253_F2.3461.00
137_V216_A2.3431.00
65_R69_K2.3421.00
150_M154_Y2.2911.00
52_S133_S2.2821.00
50_K136_D2.2521.00
51_V152_V2.2441.00
180_T183_T2.2211.00
159_L216_A2.1401.00
139_C152_V2.1361.00
220_S224_K2.1141.00
50_K135_G2.1001.00
310_Y314_F2.0971.00
52_S84_I2.0771.00
98_V110_M2.0681.00
155_L216_A2.0521.00
75_Y150_M2.0231.00
314_F317_V1.9591.00
238_E242_R1.9581.00
306_F310_Y1.9571.00
164_K249_H1.9381.00
224_K248_Y1.9351.00
272_Q276_W1.9031.00
60_E143_A1.8681.00
210_I215_F1.8671.00
85_V98_V1.8631.00
50_K134_N1.8551.00
69_K101_F1.8501.00
189_E273_R1.8321.00
70_A147_P1.8081.00
385_W388_L1.7891.00
59_N90_S1.7671.00
379_F382_S1.7571.00
49_P76_Y1.7511.00
234_A279_G1.7321.00
130_F138_I1.7171.00
48_L77_P1.6991.00
221_I243_V1.6911.00
49_P156_V1.6891.00
16_M20_H1.6871.00
167_A250_I1.6761.00
82_E134_N1.6431.00
162_D249_H1.6411.00
122_K126_L1.6381.00
68_L101_F1.6221.00
86_V125_A1.6221.00
151_A214_N1.6001.00
300_I303_L1.5881.00
172_F213_T1.5831.00
98_V102_S1.5811.00
76_Y156_V1.5631.00
137_V218_R1.5511.00
20_H23_L1.5161.00
50_K82_E1.4991.00
87_N113_T1.4961.00
114_K117_N1.4701.00
65_R97_I1.4681.00
273_R276_W1.4231.00
307_F310_Y1.4121.00
378_Y382_S1.3991.00
168_V253_F1.3861.00
113_T116_P1.3841.00
110_M115_P1.3801.00
350_L353_T1.3631.00
381_Y385_W1.3621.00
303_L310_Y1.3611.00
348_F352_M1.3421.00
136_D220_S1.3391.00
350_L354_E1.3381.00
81_L152_V1.3241.00
147_P151_A1.3241.00
96_D99_N1.3211.00
145_N258_T1.3111.00
306_F309_T1.3041.00
75_Y149_K1.2981.00
133_S219_R1.2821.00
141_Y147_P1.2651.00
99_N102_S1.2611.00
313_F317_V1.2611.00
57_A94_T1.2601.00
74_L152_V1.2501.00
69_K73_N1.2451.00
303_L307_F1.2371.00
76_Y81_L1.2321.00
317_V320_S1.2281.00
138_I222_I1.2261.00
154_Y157_L1.2191.00
382_S386_I1.2111.00
126_L140_V1.2091.00
97_I101_F1.2051.00
138_I219_R1.2031.00
52_S219_R1.2021.00
113_T117_N1.1861.00
23_L26_G1.1851.00
135_G219_R1.1811.00
123_S126_L1.1801.00
174_V262_E1.1781.00
64_I94_T1.1771.00
70_A146_T1.1731.00
53_V139_C1.1691.00
53_V81_L1.1651.00
272_Q275_R1.1601.00
388_L392_S1.1541.00
176_N183_T1.1541.00
166_G243_V1.1511.00
54_L129_G1.1461.00
351_F354_E1.1441.00
186_I189_E1.1421.00
166_G218_R1.1391.00
13_I16_M1.1291.00
29_R33_T1.1291.00
88_D121_G1.1281.00
94_T98_V1.1231.00
110_M113_T1.1221.00
73_N149_K1.1211.00
302_D306_F1.1191.00
167_A243_V1.1171.00
358_T362_E1.1121.00
145_N260_E1.1101.00
169_V172_F1.1081.00
87_N95_G1.1051.00
98_V101_F1.1041.00
19_Y23_L1.1021.00
167_A210_I1.1011.00
93_R97_I1.0941.00
64_I85_V1.0941.00
48_L153_Y1.0911.00
99_N103_E1.0881.00
45_M48_L1.0811.00
57_A64_I1.0781.00
310_Y313_F1.0781.00
26_G30_H1.0741.00
121_G125_A1.0651.00
128_S132_E1.0571.00
320_S323_I1.0571.00
20_H24_M1.0561.00
370_N374_V1.0531.00
303_L306_F1.0401.00
346_L349_F1.0391.00
87_N114_K1.0371.00
269_W272_Q1.0331.00
12_L16_M1.0221.00
23_L27_G1.0211.00
391_Y395_V1.0171.00
67_T71_M1.0171.00
123_S127_N1.0091.00
71_M83_I1.0091.00
72_V105_Y1.0061.00
122_K212_G1.0031.00
302_D305_Y1.0011.00
59_N91_S0.9981.00
289_A293_K0.9971.00
313_F316_G0.9891.00
84_I109_K0.9871.00
125_A129_G0.9851.00
354_E357_I0.9851.00
90_S94_T0.9831.00
95_G110_M0.9781.00
389_V392_S0.9721.00
87_N144_D0.9721.00
354_E358_T0.9671.00
71_M147_P0.9591.00
382_S388_L0.9561.00
383_Q387_V0.9521.00
126_L228_W0.9491.00
158_G251_R0.9481.00
170_G214_N0.9441.00
111_V132_E0.9351.00
218_R248_Y0.9301.00
17_L21_M0.9261.00
198_Q201_R0.9241.00
120_K124_S0.9201.00
155_L170_G0.9181.00
382_S387_V0.9151.00
53_V152_V0.9141.00
127_N131_A0.9131.00
220_S223_E0.9121.00
214_N258_T0.9081.00
22_F26_G0.9041.00
159_L165_A0.9031.00
155_L168_V0.8991.00
111_V129_G0.8971.00
26_G29_R0.8931.00
305_Y309_T0.8911.00
82_E133_S0.8911.00
128_S131_A0.8901.00
121_G124_S0.8861.00
59_N87_N0.8851.00
182_L186_I0.8811.00
382_S385_W0.8781.00
371_F375_F0.8771.00
17_L20_H0.8761.00
384_A392_S0.8751.00
342_I350_L0.8741.00
376_L379_F0.8731.00
348_F351_F0.8711.00
260_E263_P0.8701.00
64_I98_V0.8691.00
66_Q69_K0.8691.00
213_T272_Q0.8691.00
342_I346_L0.8671.00
279_G282_Y0.8651.00
225_L243_V0.8651.00
97_I100_E0.8631.00
339_L342_I0.8591.00
102_S105_Y0.8581.00
109_K132_E0.8581.00
33_T36_R0.8551.00
186_I190_T0.8541.00
235_E238_E0.8531.00
302_D310_Y0.8451.00
129_G133_S0.8421.00
269_W273_R0.8411.00
16_M23_L0.8401.00
111_V128_S0.8401.00
24_M28_F0.8321.00
30_H33_T0.8321.00
384_A387_V0.8311.00
309_T313_F0.8291.00
21_M28_F0.8261.00
48_L76_Y0.8231.00
347_A350_L0.8221.00
377_M382_S0.8211.00
377_M381_Y0.8201.00
357_I361_I0.8191.00
111_V115_P0.8181.00
19_Y22_F0.8171.00
360_S363_K0.8151.00
25_Q33_T0.8111.00
190_T194_Q0.8111.00
269_W276_W0.8101.00
20_H27_G0.8091.00
191_I194_Q0.8071.00
20_H26_G0.8061.00
60_E272_Q0.8031.00
388_L391_Y0.8011.00
344_W348_F0.7941.00
315_F319_M0.7931.00
88_D144_D0.7921.00
352_M355_V0.7921.00
381_Y386_I0.7921.00
228_W231_K0.7911.00
147_P214_N0.7911.00
84_I129_G0.7901.00
145_N213_T0.7891.00
314_F318_I0.7891.00
299_I303_L0.7891.00
331_D334_L0.7881.00
243_V248_Y0.7881.00
12_L20_H0.7871.00
392_S395_V0.7861.00
159_L218_R0.7831.00
44_N47_E0.7821.00
385_W389_V0.7801.00
260_E272_Q0.7791.00
88_D114_K0.7761.00
344_W347_A0.7731.00
53_V74_L0.7711.00
158_G168_V0.7701.00
354_E361_I0.7701.00
165_A168_V0.7701.00
324_F327_N0.7671.00
121_G144_D0.7671.00
84_I133_S0.7661.00
384_A388_L0.7651.00
359_L363_K0.7641.00
341_M348_F0.7641.00
310_Y317_V0.7621.00
391_Y394_F0.7601.00
343_L350_L0.7591.00
183_T186_I0.7561.00
390_I394_F0.7541.00
312_L316_G0.7531.00
235_E279_G0.7511.00
309_T314_F0.7491.00
213_T260_E0.7461.00
27_G33_T0.7451.00
323_I327_N0.7441.00
127_N130_F0.7431.00
209_T237_T0.7411.00
283_V287_F0.7411.00
14_W18_L0.7401.00
300_I304_F0.7381.00
59_N94_T0.7381.00
318_I321_N0.7351.00
78_K81_L0.7341.00
217_I243_V0.7331.00
171_K252_F0.7291.00
383_Q386_I0.7271.00
139_C151_A0.7261.00
355_V358_T0.7251.00
57_A143_A0.7241.00
101_F105_Y0.7231.00
55_I67_T0.7231.00
267_K271_R0.7231.00
130_F222_I0.7221.00
95_G98_V0.7201.00
378_Y381_Y0.7201.00
227_G231_K0.7191.00
316_G320_S0.7191.00
140_V215_F0.7161.00
387_V390_I0.7141.00
346_L350_L0.7131.00
199_G254_P0.7131.00
22_F30_H0.7131.00
240_T250_I0.7121.00
29_R32_M0.7101.00
148_E259_W0.7061.00
359_L362_E0.7061.00
373_I376_L0.7051.00
233_L279_G0.7051.00
380_T383_Q0.7041.00
32_M36_R0.7021.00
379_F383_Q0.7011.00
18_L22_F0.7001.00
67_T141_Y0.6991.00
370_N373_I0.6981.00
272_Q279_G0.6971.00
212_G236_D0.6941.00
260_E276_W0.6931.00
108_I111_V0.6931.00
263_P272_Q0.6921.00
314_F319_M0.6921.00
379_F386_I0.6911.00
150_M153_Y0.6901.00
349_F353_T0.6901.00
229_D232_A0.6901.00
371_F374_V0.6901.00
15_V19_Y0.6891.00
347_A351_F0.6891.00
367_N370_N0.6861.00
310_Y316_G0.6861.00
146_T175_I0.6831.00
67_T70_A0.6811.00
57_A60_E0.6791.00
306_F314_F0.6781.00
276_W279_G0.6771.00
72_V107_F0.6771.00
67_T72_V0.6761.00
145_N214_N0.6751.00
218_R221_I0.6741.00
301_F305_Y0.6741.00
169_V210_I0.6731.00
346_L353_T0.6691.00
52_S134_N0.6691.00
358_T361_I0.6671.00
213_T273_R0.6641.00
20_H30_H0.6641.00
313_F319_M0.6621.00
155_L214_N0.6601.00
23_L31_Y0.6601.00
234_A237_T0.6591.00
314_F324_F0.6581.00
346_L354_E0.6581.00
59_N92_D0.6571.00
343_L346_L0.6561.00
152_V216_A0.6551.00
95_G113_T0.6541.00
18_L29_R0.6531.00
186_I273_R0.6531.00
339_L350_L0.6521.00
21_M24_M0.6521.00
235_E240_T0.6511.00
144_D260_E0.6511.00
342_I345_I0.6481.00
374_V377_M0.6481.00
381_Y384_A0.6451.00
55_I141_Y0.6421.00
23_L30_H0.6411.00
304_F308_F0.6400.99
319_M323_I0.6400.99
379_F385_W0.6390.99
172_F260_E0.6390.99
166_G221_I0.6380.99
64_I68_L0.6380.99
21_M31_Y0.6340.99
278_R282_Y0.6340.99
386_I390_I0.6330.99
378_Y385_W0.6330.99
339_L344_W0.6320.99
357_I360_S0.6320.99
74_L153_Y0.6300.99
122_K142_D0.6300.99
388_L393_L0.6300.99
130_F133_S0.6290.99
13_I26_G0.6260.99
124_S128_S0.6250.99
60_E142_D0.6250.99
68_L98_V0.6230.99
122_K235_E0.6220.99
229_D286_K0.6210.99
213_T234_A0.6190.99
343_L351_F0.6180.99
307_F314_F0.6160.99
262_E272_Q0.6160.99
13_I20_H0.6150.99
340_A347_A0.6140.99
190_T198_Q0.6140.99
186_I262_E0.6130.99
213_T279_G0.6120.99
305_Y308_F0.6110.99
169_V174_V0.6110.99
50_K78_K0.6090.99
335_S338_F0.6090.99
259_W263_P0.6080.99
380_T384_A0.6080.99
312_L323_I0.6070.99
27_G31_Y0.6070.99
341_M345_I0.6060.99
189_E272_Q0.6060.99
355_V362_E0.6050.99
194_Q211_P0.6040.99
123_S235_E0.6030.99
99_N113_T0.6020.99
155_L256_A0.6020.99
51_V137_V0.6010.99
145_N172_F0.6010.99
356_M360_S0.6010.99
343_L347_A0.6000.99
302_D309_T0.6000.99
307_F311_F0.6000.99
290_Q293_K0.5990.99
378_Y384_A0.5990.99
120_K123_S0.5960.99
349_F352_M0.5950.99
12_L19_Y0.5920.99
238_E241_I0.5870.99
12_L23_L0.5870.99
30_H34_F0.5860.99
344_W358_T0.5860.99
109_K113_T0.5830.99
71_M74_L0.5780.99
60_E94_T0.5780.99
21_M33_T0.5770.99
126_L130_F0.5770.99
353_T357_I0.5770.99
105_Y108_I0.5770.99
211_P234_A0.5760.99
311_F314_F0.5760.99
35_E38_I0.5750.99
72_V108_I0.5740.99
141_Y214_N0.5730.99
16_M27_G0.5720.99
35_E39_P0.5720.99
209_T213_T0.5710.99
102_S108_I0.5710.99
61_E94_T0.5690.99
303_L309_T0.5680.99
354_E363_K0.5680.99
64_I97_I0.5670.99
292_F295_K0.5660.99
377_M384_A0.5660.99
184_R187_N0.5640.99
342_I354_E0.5630.99
242_R245_N0.5630.99
20_H29_R0.5630.99
102_S107_F0.5630.99
88_D145_N0.5620.99
190_T201_R0.5620.99
343_L354_E0.5610.99
302_D307_F0.5570.99
20_H25_Q0.5570.99
16_M19_Y0.5560.99
270_W274_T0.5560.99
181_L184_R0.5550.99
148_E257_I0.5550.99
235_E283_V0.5550.99
374_V378_Y0.5540.99
63_V67_T0.5540.99
341_M344_W0.5530.99
66_Q146_T0.5520.99
15_V18_L0.5500.98
58_H117_N0.5490.98
170_G256_A0.5490.98
356_M359_L0.5490.98
92_D96_D0.5480.98
225_L242_R0.5480.98
60_E64_I0.5480.98
186_I260_E0.5460.98
244_Y250_I0.5460.98
317_V324_F0.5440.98
63_V143_A0.5430.98
172_F211_P0.5410.98
172_F190_T0.5410.98
32_M35_E0.5400.98
213_T235_E0.5370.98
12_L15_V0.5360.98
17_L27_G0.5360.98
355_V359_L0.5360.98
155_L159_L0.5350.98
228_W232_A0.5330.98
226_G229_D0.5330.98
350_L362_E0.5320.98
22_F25_Q0.5320.98
29_R34_F0.5310.98
190_T211_P0.5310.98
12_L21_M0.5300.98
377_M380_T0.5300.98
154_Y253_F0.5280.98
186_I269_W0.5260.98
61_E97_I0.5260.98
339_L354_E0.5260.98
71_M141_Y0.5260.98
21_M26_G0.5240.98
377_M385_W0.5240.98
13_I23_L0.5230.98
21_M25_Q0.5230.98
133_S138_I0.5230.98
308_F313_F0.5220.98
312_L319_M0.5210.98
237_T241_I0.5210.98
367_N374_V0.5210.98
61_E92_D0.5200.98
385_W392_S0.5180.98
139_C155_L0.5170.98
33_T37_N0.5170.98
235_E239_L0.5160.98
367_N373_I0.5160.98
94_T97_I0.5150.98
169_V234_A0.5140.98
305_Y310_Y0.5130.98
211_P260_E0.5130.98
46_K49_P0.5110.98
289_A294_L0.5110.98
123_S238_E0.5100.98
14_W17_L0.5080.97
74_L147_P0.5070.97
25_Q28_F0.5070.97
88_D142_D0.5070.97
122_K125_A0.5070.97
345_I350_L0.5060.97
190_T193_F0.5030.97
352_M363_K0.5030.97
382_S393_L0.5020.97
234_A273_R0.5010.97
377_M393_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9548 100 0.359 Contact Map
2z86A 2 0.6857 100 0.543 Contact Map
3bcvA 2 0.4357 100 0.564 Contact Map
1qg8A 1 0.5238 100 0.567 Contact Map
1xhbA 1 0.8857 100 0.575 Contact Map
2d7iA 1 0.8357 100 0.582 Contact Map
3ckjA 2 0.669 100 0.593 Contact Map
2bo4A 4 0.8024 100 0.596 Contact Map
3l7iA 4 0.1548 100 0.597 Contact Map
5ajoA 1 0.931 100 0.603 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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