GREMLIN Database
YDAK - Uncharacterized membrane protein YdaK
UniProt: P96585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (245)
Sequences: 14272 (12971)
Seq/√Len: 828.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_S134_V3.6221.00
202_R205_D3.5861.00
167_L231_L3.2441.00
141_D145_R3.1481.00
150_L267_A3.1381.00
165_V259_P2.9351.00
146_M216_G2.8771.00
140_F194_G2.7971.00
167_L255_V2.7761.00
171_M193_V2.3921.00
254_H281_N2.3901.00
165_V227_M2.3651.00
210_P216_G2.3081.00
121_M125_Q2.2901.00
146_M208_F2.2151.00
140_F207_K2.1931.00
172_H254_H2.1631.00
196_Q241_Y2.1571.00
232_T235_K2.0991.00
145_R149_E2.0801.00
125_Q128_I2.0661.00
188_R191_Q2.0251.00
129_K133_A2.0221.00
169_L253_F1.9831.00
272_E276_N1.9811.00
153_E156_R1.9701.00
184_K272_E1.9541.00
149_E152_E1.9051.00
197_I207_K1.8661.00
169_L255_V1.8031.00
189_L251_L1.7001.00
200_S237_Q1.6951.00
261_R264_I1.6941.00
138_T190_F1.6901.00
219_L230_V1.6701.00
168_L210_P1.6661.00
223_P226_H1.6561.00
149_E208_F1.6471.00
177_F249_V1.6411.00
114_T117_L1.6121.00
266_T269_Q1.6121.00
238_L253_F1.6091.00
200_S233_K1.6091.00
185_E188_R1.6071.00
264_I273_E1.6011.00
117_L121_M1.5981.00
201_V207_K1.5921.00
193_V238_L1.5851.00
192_Y195_Q1.5761.00
177_F189_L1.5511.00
133_A148_L1.5491.00
164_F270_F1.5371.00
164_F260_Y1.5231.00
210_P271_L1.5091.00
167_L219_L1.4861.00
141_D206_K1.4831.00
192_Y196_Q1.4781.00
201_V217_I1.4681.00
136_R144_Q1.4561.00
149_E206_K1.4551.00
143_K187_D1.4491.00
149_E153_E1.4481.00
235_K239_D1.4391.00
133_A145_R1.4291.00
168_L278_M1.4271.00
213_E252_T1.3951.00
127_E131_Y1.3791.00
162_N221_H1.3771.00
118_R121_M1.3761.00
121_M124_L1.3701.00
230_V233_K1.3681.00
124_L127_E1.3621.00
145_R148_L1.3411.00
188_R192_Y1.3411.00
143_K147_K1.3391.00
260_Y270_F1.3331.00
168_L271_L1.3281.00
228_P232_T1.3231.00
192_Y241_Y1.3211.00
131_Y144_Q1.3151.00
273_E277_E1.2991.00
171_M253_F1.2891.00
173_Y176_E1.2861.00
173_Y213_E1.2801.00
153_E220_T1.2791.00
192_Y242_Q1.2781.00
232_T236_K1.2761.00
175_K179_S1.2671.00
174_F190_F1.2521.00
196_Q242_Q1.2461.00
195_Q198_R1.2361.00
178_K186_T1.2071.00
114_T118_R1.1971.00
193_V197_I1.1921.00
145_R208_F1.1881.00
185_E244_E1.1781.00
194_G207_K1.1701.00
147_K268_D1.1561.00
189_L213_E1.1551.00
235_K255_V1.1441.00
191_Q195_Q1.1431.00
169_L197_I1.1401.00
145_R206_K1.1391.00
265_Q273_E1.1371.00
133_A141_D1.1331.00
277_E281_N1.1321.00
258_L270_F1.1321.00
236_K240_T1.1281.00
141_D208_F1.1271.00
147_K151_S1.1251.00
176_E180_L1.1231.00
258_L274_L1.1151.00
151_S267_A1.1081.00
179_S279_M1.1081.00
146_M150_L1.1031.00
122_T125_Q1.0971.00
227_M231_L1.0971.00
237_Q240_T1.0941.00
231_L255_V1.0861.00
199_T237_Q1.0811.00
201_V205_D1.0571.00
213_E281_N1.0531.00
125_Q129_K1.0481.00
117_L122_T1.0471.00
227_M257_Y1.0311.00
224_A259_P1.0261.00
168_L274_L1.0191.00
201_V234_L1.0161.00
269_Q272_E1.0131.00
169_L217_I1.0131.00
134_V141_D1.0121.00
150_L218_V1.0041.00
214_R275_E1.0021.00
193_V253_F0.9971.00
163_S262_N0.9901.00
267_A271_L0.9871.00
166_F271_L0.9841.00
275_E279_M0.9831.00
231_L257_Y0.9781.00
118_R122_T0.9771.00
151_S155_K0.9771.00
156_R220_T0.9761.00
146_M218_V0.9601.00
54_G58_A0.9561.00
184_K188_R0.9531.00
183_E275_E0.9491.00
222_T226_H0.9461.00
216_G271_L0.9421.00
261_R273_E0.9381.00
258_L273_E0.9351.00
258_L277_E0.9321.00
205_D230_V0.9251.00
201_V230_V0.9241.00
164_F218_V0.9181.00
175_K279_M0.9101.00
212_D279_M0.9101.00
236_K239_D0.9081.00
127_E130_S0.9031.00
196_Q237_Q0.9001.00
191_Q194_G0.8941.00
115_A119_R0.8941.00
167_L257_Y0.8881.00
244_E247_K0.8821.00
153_E164_F0.8791.00
119_R122_T0.8771.00
207_K217_I0.8761.00
54_G57_Y0.8711.00
117_L120_S0.8561.00
273_E276_N0.8541.00
170_H213_E0.8531.00
166_F270_F0.8461.00
183_E279_M0.8441.00
126_S129_K0.8421.00
224_A228_P0.8271.00
165_V257_Y0.8251.00
193_V251_L0.8191.00
167_L217_I0.8111.00
242_Q250_S0.8101.00
178_K212_D0.8081.00
136_R147_K0.8011.00
148_L152_E0.8001.00
231_L235_K0.7981.00
50_G54_G0.7971.00
197_I217_I0.7971.00
211_S279_M0.7941.00
115_A118_R0.7901.00
195_Q199_T0.7881.00
269_Q273_E0.7881.00
160_Y221_H0.7851.00
208_F216_G0.7811.00
137_V190_F0.7761.00
238_L242_Q0.7731.00
188_R245_N0.7721.00
150_L154_I0.7661.00
177_F185_E0.7661.00
211_S214_R0.7651.00
219_L227_M0.7641.00
244_E249_V0.7641.00
265_Q269_Q0.7611.00
192_Y243_L0.7591.00
185_E249_V0.7551.00
181_Y249_V0.7511.00
184_K268_D0.7511.00
179_S275_E0.7481.00
261_R265_Q0.7481.00
125_Q131_Y0.7481.00
278_M281_N0.7441.00
128_I131_Y0.7381.00
133_A144_Q0.7351.00
139_G191_Q0.7341.00
122_T126_S0.7321.00
276_N280_M0.7301.00
176_E213_E0.7281.00
77_Q81_T0.7261.00
132_V142_N0.7161.00
226_H229_A0.7161.00
181_Y185_E0.7141.00
137_V143_K0.7091.00
174_F213_E0.7071.00
124_L128_I0.7051.00
172_H252_T0.7031.00
156_R160_Y0.7021.00
166_F216_G0.7011.00
130_S139_G0.7011.00
137_V191_Q0.7001.00
157_A164_F0.6981.00
171_M252_T0.6971.00
175_K275_E0.6951.00
108_G111_H0.6901.00
202_R233_K0.6851.00
95_V98_I0.6821.00
154_I267_A0.6811.00
194_G197_I0.6801.00
159_R202_R0.6801.00
52_W56_I0.6781.00
153_E218_V0.6781.00
146_M210_P0.6771.00
124_L131_Y0.6761.00
166_F274_L0.6761.00
114_T119_R0.6741.00
104_S108_G0.6711.00
228_P257_Y0.6661.00
205_D219_L0.6641.00
243_L248_Y0.6641.00
109_R113_I0.6641.00
189_L242_Q0.6631.00
120_S123_R0.6591.00
168_L216_G0.6591.00
107_S111_H0.6591.00
170_H282_E0.6571.00
147_K150_L0.6551.00
117_L125_Q0.6531.00
143_K210_P0.6521.00
179_S214_R0.6511.00
238_L251_L0.6481.00
119_R123_R0.6461.00
174_F281_N0.6461.00
170_H178_K0.6441.00
172_H213_E0.6431.00
229_A233_K0.6421.00
235_K281_N0.6411.00
170_H279_M0.6411.00
202_R230_V0.6361.00
196_Q200_S0.6341.00
118_R125_Q0.6331.00
206_K218_V0.6301.00
205_D233_K0.6281.00
268_D272_E0.6271.00
147_K208_F0.6251.00
53_F57_Y0.6241.00
91_R95_V0.6221.00
214_R279_M0.6191.00
158_E260_Y0.6161.00
149_E218_V0.6141.00
175_K214_R0.6131.00
163_S259_P0.6101.00
197_I234_L0.6081.00
134_V198_R0.6071.00
123_R127_E0.6051.00
76_F79_G0.6041.00
169_L207_K0.6031.00
157_A260_Y0.6031.00
171_M174_F0.6031.00
175_K178_K0.6021.00
128_I132_V0.6011.00
144_Q148_L0.5991.00
90_L93_L0.5991.00
170_H183_E0.5991.00
140_F208_F0.5971.00
128_I133_A0.5961.00
172_H278_M0.5951.00
175_K183_E0.5941.00
41_C44_F0.5901.00
277_E280_M0.5901.00
226_H230_V0.5901.00
198_R207_K0.5891.00
114_T121_M0.5891.00
134_V145_R0.5881.00
51_I55_P0.5881.00
211_S275_E0.5841.00
225_E228_P0.5831.00
51_I54_G0.5831.00
165_V219_L0.5831.00
116_E119_R0.5821.00
146_M271_L0.5761.00
173_Y278_M0.5761.00
239_D252_T0.5751.00
197_I215_I0.5741.00
263_D273_E0.5721.00
159_R204_T0.5691.00
131_Y136_R0.5691.00
256_C274_L0.5691.00
197_I201_V0.5671.00
227_M259_P0.5651.00
140_F197_I0.5651.00
147_K271_L0.5581.00
154_I260_Y0.5521.00
77_Q80_Q0.5501.00
102_L106_I0.5501.00
163_S223_P0.5491.00
231_L253_F0.5461.00
67_F71_T0.5451.00
173_Y251_L0.5441.00
147_K267_A0.5401.00
217_I234_L0.5401.00
241_Y244_E0.5371.00
150_L164_F0.5371.00
154_I158_E0.5351.00
213_E279_M0.5341.00
75_F78_T0.5321.00
156_R159_R0.5321.00
172_H281_N0.5301.00
107_S110_I0.5301.00
231_L281_N0.5301.00
181_Y247_K0.5301.00
233_K237_Q0.5291.00
99_A106_I0.5291.00
106_I110_I0.5291.00
95_V99_A0.5271.00
230_V234_L0.5271.00
130_S133_A0.5261.00
155_K158_E0.5261.00
165_V231_L0.5251.00
69_L73_M0.5241.00
171_M190_F0.5231.00
146_M267_A0.5211.00
239_D250_S0.5211.00
105_F109_R0.5211.00
134_V140_F0.5211.00
144_Q147_K0.5211.00
158_E265_Q0.5191.00
105_F108_G0.5181.00
224_A227_M0.5171.00
40_L44_F0.5161.00
200_S205_D0.5151.00
38_L42_I0.5131.00
178_K187_D0.5121.00
174_F189_L0.5101.00
173_Y252_T0.5071.00
210_P213_E0.5071.00
200_S230_V0.5061.00
183_E213_E0.5051.00
96_W99_A0.5031.00
89_G95_V0.5031.00
157_A162_N0.5031.00
89_G92_M0.5021.00
48_A52_W0.5021.00
189_L192_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.7986 100 0.362 Contact Map
4j40A 2 0 100 0.372 Contact Map
3ezuA 2 0.9364 100 0.377 Contact Map
3pjxA 1 0.5901 100 0.386 Contact Map
4rnhA 2 0.5194 100 0.391 Contact Map
4ymeA 1 0.5371 100 0.399 Contact Map
3ignA 1 0.5477 100 0.4 Contact Map
3mtkA 2 0.523 100 0.414 Contact Map
3i5cA 2 0.629 100 0.423 Contact Map
3hvaA 1 0.5406 100 0.428 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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