GREMLIN Database
TOP3 - DNA topoisomerase 3
UniProt: P96583 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 727 (590)
Sequences: 6166 (3720)
Seq/√Len: 153.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_Q245_S5.5801.00
293_E383_K4.1971.00
207_Q545_K4.1041.00
260_E457_K3.9001.00
204_A549_Q3.8521.00
618_K635_D3.8131.00
274_Y282_D3.5791.00
99_Q128_K3.4071.00
240_N243_V3.3851.00
308_V391_I3.3281.00
570_A575_K3.2001.00
389_D393_K3.1931.00
213_P470_S3.1861.00
259_A413_E3.1791.00
265_A404_E3.0891.00
404_E428_S3.0321.00
267_K404_E2.9761.00
86_N90_S2.9401.00
263_K406_E2.8991.00
382_D386_K2.8031.00
413_E416_G2.7901.00
196_L525_L2.6831.00
410_V455_L2.6521.00
128_K149_S2.6101.00
213_P472_Q2.5761.00
137_D141_K2.5691.00
289_F386_K2.5611.00
255_Q460_T2.5471.00
245_S249_K2.5411.00
142_E146_K2.4811.00
203_E478_R2.4421.00
408_T425_T2.4411.00
300_K384_E2.4141.00
406_E427_Q2.4011.00
456_Q459_D2.3601.00
523_E527_N2.3501.00
199_I531_I2.3431.00
283_A387_L2.3311.00
269_F402_A2.3271.00
265_A427_Q2.3101.00
260_E411_I2.3091.00
4_T99_Q2.3041.00
620_M640_S2.2941.00
39_T88_V2.2901.00
77_V85_F2.2551.00
292_K296_S2.2311.00
298_L308_V2.2211.00
254_K415_G2.2001.00
577_K580_V2.1801.00
62_R65_D2.1271.00
200_A540_I2.1141.00
214_Y471_G2.1061.00
331_E336_K2.0971.00
405_Y426_V2.0621.00
41_A117_I2.0461.00
257_V460_T2.0361.00
613_C616_C2.0261.00
423_G453_P2.0151.00
292_K523_E2.0071.00
429_Q433_A2.0021.00
197_A201_K1.9851.00
39_T87_A1.9851.00
212_V239_F1.9771.00
37_I97_V1.9671.00
288_G536_Q1.9621.00
102_I114_A1.9591.00
403_F426_V1.9401.00
211_P472_Q1.9361.00
567_K584_D1.9151.00
612_A619_M1.9071.00
614_P640_S1.8821.00
150_G157_Y1.8781.00
138_K142_E1.8751.00
104_T114_A1.8681.00
289_F297_V1.8551.00
256_A412_A1.8431.00
249_K252_Q1.8381.00
385_R389_D1.8281.00
265_A406_E1.8251.00
241_Q470_S1.8091.00
411_I418_T1.8011.00
571_I581_F1.7971.00
266_K407_E1.7851.00
377_L385_R1.7711.00
155_N574_G1.7671.00
82_G86_N1.7671.00
4_T101_V1.7611.00
250_N417_E1.7611.00
325_T372_E1.7481.00
5_V92_L1.7371.00
638_C641_R1.7331.00
216_G471_G1.7321.00
217_I244_T1.7301.00
267_K402_A1.7191.00
204_A208_A1.7161.00
154_E158_H1.7041.00
223_G459_D1.7021.00
201_K205_D1.7011.00
239_F243_V1.6821.00
90_S96_D1.6811.00
616_C633_C1.6801.00
256_A414_I1.6671.00
39_T91_Q1.6481.00
411_I420_T1.6401.00
3_K35_Q1.6371.00
613_C633_C1.6321.00
524_K528_S1.6241.00
220_A465_T1.6231.00
282_D285_K1.6151.00
203_E540_I1.6101.00
526_F533_K1.6021.00
289_F383_K1.6021.00
563_E567_K1.5961.00
619_M634_Q1.5951.00
70_P583_K1.5941.00
261_L410_V1.5871.00
258_V412_A1.5841.00
259_A418_T1.5831.00
406_E425_T1.5831.00
583_K587_A1.5771.00
246_R250_N1.5761.00
243_V246_R1.5751.00
590_H594_K1.5591.00
615_E639_G1.5571.00
526_F538_I1.5481.00
397_A435_Y1.5431.00
79_K82_G1.5331.00
85_F120_K1.5281.00
487_A510_G1.5271.00
392_A396_L1.5261.00
257_V413_E1.5231.00
611_T620_M1.5191.00
404_E427_Q1.5041.00
238_T244_T1.5031.00
130_L144_F1.5031.00
287_F386_K1.5011.00
248_L468_E1.4921.00
165_E582_I1.4911.00
238_T247_L1.4881.00
220_A467_T1.4861.00
423_G452_L1.4851.00
409_K422_K1.4751.00
595_E599_S1.4571.00
403_F432_K1.4401.00
155_N158_H1.4391.00
6_V144_F1.4301.00
567_K576_L1.4241.00
338_Y429_Q1.4011.00
111_E115_R1.3961.00
37_I91_Q1.3901.00
487_A490_N1.3901.00
6_V36_Y1.3871.00
263_K408_T1.3801.00
327_K331_E1.3771.00
197_A552_P1.3721.00
245_S248_L1.3721.00
52_E74_K1.3701.00
532_E541_T1.3681.00
47_T78_I1.3641.00
283_A390_L1.3611.00
318_L398_V1.3611.00
18_A37_I1.3551.00
221_V412_A1.3501.00
204_A207_Q1.3461.00
376_V379_S1.3461.00
187_S528_S1.3441.00
297_V383_K1.3421.00
381_S384_E1.3421.00
244_T468_E1.3411.00
478_R540_I1.3401.00
223_G226_L1.3391.00
412_A461_L1.3391.00
580_V583_K1.3281.00
633_C638_C1.3261.00
53_G76_V1.3161.00
242_D246_R1.3151.00
83_K87_A1.3121.00
187_S192_Q1.3101.00
254_K414_I1.3051.00
101_V147_L1.3051.00
112_L160_A1.3051.00
296_S300_K1.3001.00
131_W148_R1.3001.00
300_K304_Q1.2981.00
250_N415_G1.2961.00
638_C643_T1.2951.00
100_I123_V1.2941.00
613_C638_C1.2921.00
46_V120_K1.2891.00
611_T642_K1.2851.00
413_E418_T1.2841.00
3_K98_N1.2811.00
474_K477_A1.2771.00
328_D332_G1.2641.00
203_E207_Q1.2621.00
570_A576_L1.2611.00
107_G364_D1.2601.00
200_A548_L1.2581.00
293_E296_S1.2581.00
118_I127_I1.2541.00
221_V256_A1.2441.00
268_S432_K1.2391.00
42_L81_T1.2371.00
223_G228_W1.2251.00
307_L380_L1.2181.00
218_R229_Q1.2181.00
567_K570_A1.2161.00
226_L229_Q1.2121.00
382_D385_R1.2121.00
401_P428_S1.2041.00
83_K86_N1.2031.00
640_S643_T1.2011.00
640_S644_I1.2001.00
92_L100_I1.1981.00
47_T164_A1.1931.00
405_Y424_K1.1931.00
614_P620_M1.1921.00
320_S359_D1.1911.00
4_T35_Q1.1851.00
251_L466_L1.1831.00
289_F387_L1.1771.00
609_T619_M1.1761.00
531_I538_I1.1761.00
159_S572_A1.1741.00
86_N89_K1.1721.00
222_D464_R1.1711.00
241_Q468_E1.1701.00
17_L38_V1.1691.00
16_D19_R1.1681.00
330_L396_L1.1611.00
534_K539_F1.1591.00
71_E583_K1.1491.00
308_V311_P1.1441.00
42_L84_Q1.1441.00
289_F293_E1.1431.00
204_A545_K1.1431.00
138_K321_D1.1381.00
141_K145_Q1.1371.00
251_L414_I1.1301.00
348_R402_A1.1281.00
620_M631_L1.1281.00
566_Q570_A1.1271.00
412_A421_A1.1251.00
569_S572_A1.1211.00
218_R469_T1.1171.00
618_K634_Q1.1110.99
248_L252_Q1.1050.99
256_A461_L1.1050.99
638_C642_K1.1040.99
219_A256_A1.1030.99
525_L531_I1.0920.99
73_L165_E1.0920.99
215_Y241_Q1.0900.99
407_E422_K1.0870.99
616_C638_C1.0770.99
111_E150_G1.0760.99
162_A578_S1.0750.99
373_E376_V1.0730.99
142_E145_Q1.0730.99
304_Q384_E1.0680.99
341_Y346_K1.0660.99
480_N537_D1.0600.99
282_D390_L1.0590.99
223_G461_L1.0590.99
130_L147_L1.0590.99
12_S16_D1.0520.99
263_K454_A1.0490.99
277_T515_V1.0480.99
217_I247_L1.0470.99
223_G229_Q1.0470.99
158_H578_S1.0460.99
608_I619_M1.0450.99
281_R486_S1.0450.99
485_L522_I1.0430.99
317_F363_S1.0410.99
132_I143_G1.0400.99
219_A414_I1.0370.99
84_Q87_A1.0360.99
245_S468_E1.0340.99
463_V466_L1.0340.99
615_E640_S1.0320.99
622_K644_I1.0310.99
45_L120_K1.0300.99
217_I466_L1.0280.99
115_R150_G1.0260.99
540_I545_K1.0250.99
436_D439_E1.0250.99
204_A552_P1.0230.99
580_V584_D1.0200.99
20_V137_D1.0200.99
216_G469_T1.0150.99
478_R539_F1.0140.99
297_V387_L1.0130.99
196_L544_G1.0070.99
251_L419_F1.0070.99
283_A294_T1.0050.99
282_D286_R1.0040.99
327_K339_A1.0030.99
632_V636_R0.9960.99
217_I248_L0.9960.99
215_Y470_S0.9960.99
631_L644_I0.9950.99
329_R333_M0.9870.99
187_S524_K0.9860.99
624_N629_T0.9850.99
479_F487_A0.9820.99
162_A582_I0.9810.99
274_Y394_R0.9800.99
383_K386_K0.9790.99
65_D70_P0.9790.99
195_T488_M0.9750.99
611_T631_L0.9740.99
198_M487_A0.9730.99
200_A545_K0.9710.99
227_T464_R0.9680.99
591_Q595_E0.9630.99
289_F294_T0.9620.98
255_Q462_A0.9620.98
622_K629_T0.9610.98
636_R639_G0.9600.98
455_L459_D0.9600.98
248_L466_L0.9570.98
488_M521_I0.9570.98
279_L294_T0.9570.98
533_K538_I0.9540.98
256_A463_V0.9540.98
223_G227_T0.9540.98
641_R644_I0.9510.98
293_E297_V0.9480.98
143_G147_L0.9430.98
594_K597_K0.9410.98
205_D479_F0.9400.98
594_K598_N0.9400.98
429_Q436_D0.9370.98
49_A74_K0.9360.98
99_Q126_P0.9360.98
39_T84_Q0.9340.98
338_Y428_S0.9320.98
268_S431_W0.9310.98
206_I478_R0.9290.98
636_R641_R0.9290.98
134_S139_A0.9290.98
49_A76_V0.9290.98
246_R249_K0.9260.98
162_A571_I0.9250.98
282_D394_R0.9250.98
291_A519_A0.9210.98
326_L395_F0.9210.98
192_Q524_K0.9210.98
409_K420_T0.9160.98
222_D462_A0.9140.98
263_K425_T0.9130.98
219_A466_L0.9130.98
158_H577_K0.9120.98
291_A538_I0.9110.98
11_P42_L0.9100.98
77_V120_K0.9090.98
192_Q528_S0.9080.98
408_T423_G0.9080.98
231_K236_T0.9070.98
338_Y389_D0.9070.98
258_V410_V0.9060.98
258_V461_L0.9060.98
526_F531_I0.9060.98
401_P404_E0.9030.98
78_I81_T0.9010.98
563_E566_Q0.9010.98
198_M510_G0.8950.98
100_I125_K0.8950.98
250_N416_G0.8910.98
173_N590_H0.8900.98
257_V458_G0.8890.97
480_N483_T0.8890.97
290_S293_E0.8890.97
335_V339_A0.8850.97
622_K631_L0.8820.97
174_A188_C0.8810.97
328_D331_E0.8810.97
202_R205_D0.8770.97
224_M228_W0.8750.97
632_V635_D0.8740.97
299_Q303_E0.8740.97
33_G36_Y0.8720.97
221_V414_I0.8720.97
405_Y432_K0.8710.97
134_S319_S0.8630.97
126_P149_S0.8580.97
37_I96_D0.8570.97
637_E640_S0.8560.97
106_A140_I0.8510.97
576_L580_V0.8500.97
489_E515_V0.8460.97
148_R153_Y0.8450.97
36_Y101_V0.8450.97
551_V556_K0.8450.97
238_T243_V0.8440.97
70_P579_A0.8440.97
221_V419_F0.8440.97
264_T407_E0.8420.97
286_R437_M0.8400.96
300_K381_S0.8360.96
623_V628_G0.8340.96
182_F550_L0.8330.96
529_F532_E0.8330.96
5_V97_V0.8320.96
279_L298_L0.8320.96
291_A485_L0.8310.96
46_V85_F0.8280.96
180_T597_K0.8270.96
632_V638_C0.8240.96
92_L121_A0.8240.96
115_R157_Y0.8220.96
533_K537_D0.8220.96
302_Y311_P0.8210.96
45_L85_F0.8200.96
283_A287_F0.8200.96
520_D524_K0.8190.96
106_A133_S0.8170.96
275_D316_R0.8130.96
542_S546_Q0.8130.96
220_A229_Q0.8120.96
584_D587_A0.8120.96
115_R154_E0.8090.96
380_L384_E0.8070.96
272_A316_R0.8050.96
614_P642_K0.8040.95
612_A617_G0.8040.95
623_V630_M0.8030.95
266_K405_Y0.8010.95
100_I118_I0.8010.95
564_W581_F0.7990.95
263_K457_K0.7990.95
203_E545_K0.7940.95
280_Q519_A0.7930.95
277_T485_L0.7930.95
46_V119_E0.7910.95
261_L455_L0.7890.95
410_V454_A0.7880.95
209_F473_T0.7840.95
340_Q350_I0.7840.95
587_A590_H0.7830.95
200_A204_A0.7790.95
247_L417_E0.7790.95
219_A419_F0.7750.94
214_Y473_T0.7740.94
323_V327_K0.7720.94
19_R137_D0.7710.94
15_R19_R0.7710.94
620_M633_C0.7700.94
92_L118_I0.7680.94
611_T640_S0.7650.94
259_A411_I0.7640.94
106_A131_W0.7630.94
576_L584_D0.7620.94
326_L396_L0.7620.94
291_A533_K0.7620.94
637_E643_T0.7620.94
638_C644_I0.7610.94
221_V463_V0.7600.94
190_R561_T0.7600.94
600_S604_R0.7580.94
6_V103_A0.7570.94
291_A481_E0.7540.94
271_P285_K0.7520.94
251_L256_A0.7500.93
262_K457_K0.7490.93
91_Q96_D0.7490.93
125_K149_S0.7470.93
426_V429_Q0.7460.93
327_K340_Q0.7440.93
482_G485_L0.7440.93
579_A583_K0.7430.93
61_W165_E0.7420.93
266_K403_F0.7410.93
225_T228_W0.7410.93
54_Y169_I0.7400.93
118_I123_V0.7400.93
75_L161_V0.7400.93
426_V432_K0.7390.93
621_L634_Q0.7390.93
291_A523_E0.7390.93
400_M434_V0.7380.93
393_K436_D0.7380.93
638_C645_A0.7370.93
102_I111_E0.7360.93
222_D225_T0.7340.93
228_W461_L0.7340.93
615_E620_M0.7330.93
221_V461_L0.7330.93
193_T551_V0.7310.93
134_S321_D0.7280.92
101_V144_F0.7270.92
6_V21_L0.7270.92
119_E122_N0.7270.92
262_K409_K0.7260.92
154_E157_Y0.7250.92
403_F429_Q0.7250.92
325_T328_D0.7240.92
349_G352_S0.7220.92
321_D325_T0.7210.92
346_K349_G0.7210.92
212_V237_R0.7200.92
593_V597_K0.7190.92
16_D306_K0.7150.92
236_T417_E0.7150.92
320_S323_V0.7140.92
88_V121_A0.7120.92
629_T633_C0.7110.92
173_N593_V0.7080.91
610_G619_M0.7080.91
12_S302_Y0.7080.91
231_K234_K0.7060.91
608_I612_A0.7050.91
570_A573_A0.7040.91
261_L408_T0.7020.91
387_L391_I0.7020.91
632_V641_R0.7010.91
423_G449_D0.7000.91
587_A591_Q0.6990.91
592_T595_E0.6990.91
247_L250_N0.6980.91
61_W71_E0.6980.91
287_F387_L0.6970.91
408_T452_L0.6960.91
630_M641_R0.6950.91
61_W70_P0.6940.91
532_E539_F0.6940.91
621_L632_V0.6940.91
136_T139_A0.6930.90
279_L387_L0.6920.90
252_Q465_T0.6910.90
635_D639_G0.6910.90
164_A168_W0.6900.90
323_V326_L0.6900.90
177_A593_V0.6890.90
174_A555_L0.6890.90
374_P377_L0.6890.90
85_F89_K0.6880.90
220_A464_R0.6870.90
481_E533_K0.6860.90
244_T466_L0.6850.90
39_T42_L0.6840.90
153_Y156_L0.6840.90
419_F466_L0.6840.90
104_T111_E0.6830.90
108_R565_E0.6770.89
643_T646_R0.6770.89
591_Q594_K0.6770.89
282_D435_Y0.6760.89
51_P172_I0.6740.89
610_G620_M0.6730.89
7_L100_I0.6720.89
17_L140_I0.6720.89
7_L114_A0.6700.89
376_V385_R0.6690.89
613_C632_V0.6680.89
318_L369_I0.6680.89
425_T454_A0.6670.89
298_L387_L0.6660.89
8_A17_L0.6630.88
304_Q307_L0.6620.88
219_A463_V0.6620.88
625_G628_G0.6620.88
165_E578_S0.6610.88
8_A13_V0.6600.88
316_R352_S0.6590.88
525_L529_F0.6590.88
637_E641_R0.6580.88
295_L519_A0.6580.88
10_K13_V0.6570.88
275_D278_E0.6560.88
221_V455_L0.6530.88
87_A91_Q0.6530.88
445_E448_R0.6530.88
639_G643_T0.6530.88
175_T179_T0.6530.88
224_M459_D0.6510.88
8_A160_A0.6500.87
131_W140_I0.6500.87
381_S385_R0.6500.87
158_H161_V0.6500.87
244_T248_L0.6490.87
127_I149_S0.6490.87
180_T183_N0.6480.87
631_L634_Q0.6470.87
318_L395_F0.6460.87
314_D515_V0.6450.87
428_S433_A0.6450.87
274_Y390_L0.6450.87
261_L457_K0.6430.87
297_V384_E0.6420.87
616_C634_Q0.6420.87
232_K416_G0.6420.87
484_L522_I0.6410.87
49_A53_G0.6400.87
169_I173_N0.6400.87
62_R70_P0.6390.87
168_W172_I0.6360.86
85_F121_A0.6360.86
366_H369_I0.6330.86
483_T487_A0.6320.86
228_W412_A0.6320.86
259_A457_K0.6310.86
609_T631_L0.6300.86
217_I468_E0.6300.86
47_T76_V0.6290.86
196_L529_F0.6290.86
268_S424_K0.6290.86
644_I647_K0.6280.86
421_A452_L0.6280.86
408_T453_P0.6270.86
602_T605_H0.6270.86
278_E281_R0.6260.85
247_L251_L0.6250.85
613_C620_M0.6240.85
233_S417_E0.6240.85
608_I611_T0.6240.85
613_C634_Q0.6230.85
559_A563_E0.6220.85
477_A537_D0.6210.85
8_A38_V0.6210.85
373_E379_S0.6200.85
620_M636_R0.6190.85
565_E568_L0.6190.85
290_S296_S0.6170.85
256_A466_L0.6170.85
178_L551_V0.6170.85
636_R644_I0.6160.85
410_V459_D0.6160.85
643_T647_K0.6160.85
616_C632_V0.6150.84
336_K339_A0.6150.84
455_L461_L0.6150.84
394_R435_Y0.6140.84
623_V632_V0.6130.84
5_V91_Q0.6120.84
194_P525_L0.6110.84
76_V79_K0.6090.84
85_F117_I0.6090.84
552_P556_K0.6090.84
358_N361_K0.6080.84
207_Q540_I0.6080.84
166_A564_W0.6080.84
265_A408_T0.6080.84
524_K527_N0.6070.84
341_Y434_V0.6070.84
228_W231_K0.6060.84
617_G635_D0.6060.84
631_L640_S0.6040.83
533_K536_Q0.6040.83
285_K438_A0.6030.83
636_R640_S0.6020.83
432_K436_D0.6020.83
319_S322_I0.6020.83
104_T115_R0.6000.83
607_N622_K0.5980.83
84_Q91_Q0.5980.83
554_D592_T0.5980.83
178_L188_C0.5970.83
41_A45_L0.5970.83
393_K435_Y0.5960.83
386_K389_D0.5960.83
629_T643_T0.5960.83
220_A227_T0.5950.82
111_E114_A0.5940.82
589_A593_V0.5940.82
197_A548_L0.5930.82
251_L254_K0.5930.82
139_A321_D0.5930.82
118_I150_G0.5920.82
106_A130_L0.5920.82
178_L596_I0.5920.82
620_M642_K0.5920.82
639_G642_K0.5910.82
623_V636_R0.5900.82
285_K436_D0.5900.82
268_S405_Y0.5900.82
486_S490_N0.5890.82
3_K96_D0.5890.82
172_I175_T0.5890.82
635_D638_C0.5880.82
354_K358_N0.5880.82
102_I115_R0.5860.82
350_I399_L0.5850.81
144_F147_L0.5850.81
270_A402_A0.5840.81
277_T281_R0.5830.81
196_L548_L0.5830.81
4_T36_Y0.5830.81
77_V80_K0.5820.81
54_Y173_N0.5820.81
241_Q248_L0.5820.81
280_Q295_L0.5820.81
612_A618_K0.5820.81
46_V115_R0.5820.81
104_T150_G0.5810.81
610_G631_L0.5800.81
130_L143_G0.5800.81
186_L543_K0.5800.81
114_A118_I0.5800.81
108_R568_L0.5800.81
203_E206_I0.5800.81
616_C620_M0.5790.81
335_V338_Y0.5780.81
286_R435_Y0.5780.81
86_N95_K0.5780.81
201_K558_P0.5770.81
48_L73_L0.5770.81
14_G18_A0.5770.81
281_R482_G0.5750.80
616_C635_D0.5750.80
284_H290_S0.5750.80
136_T322_I0.5740.80
471_G474_K0.5740.80
224_M229_Q0.5740.80
218_R467_T0.5720.80
329_R332_G0.5720.80
620_M644_I0.5710.80
350_I353_H0.5700.80
63_L71_E0.5700.80
298_L391_I0.5690.80
618_K637_E0.5680.79
630_M638_C0.5670.79
273_L367_A0.5670.79
211_P475_P0.5660.79
139_A143_G0.5650.79
350_I402_A0.5650.79
292_K527_N0.5650.79
630_M633_C0.5640.79
627_R643_T0.5630.79
257_V457_K0.5630.79
199_I538_I0.5630.79
128_K147_L0.5620.79
91_Q97_V0.5620.79
247_L466_L0.5600.79
373_E377_L0.5590.78
349_G354_K0.5580.78
161_V165_E0.5570.78
324_P328_D0.5570.78
637_E644_I0.5570.78
222_D227_T0.5560.78
209_F476_P0.5550.78
6_V33_G0.5550.78
20_V140_I0.5550.78
295_L311_P0.5550.78
410_V452_L0.5540.78
600_S603_F0.5540.78
40_W84_Q0.5530.78
168_W173_N0.5530.78
17_L103_A0.5530.78
577_K583_K0.5530.78
176_R179_T0.5520.78
529_F541_T0.5520.78
78_I82_G0.5510.77
157_Y161_V0.5500.77
166_A585_M0.5490.77
77_V82_G0.5490.77
198_M558_P0.5490.77
329_R396_L0.5480.77
217_I251_L0.5480.77
55_G71_E0.5480.77
61_W175_T0.5460.77
75_L160_A0.5460.77
295_L308_V0.5460.77
92_L123_V0.5450.77
108_R159_S0.5450.77
252_Q463_V0.5450.77
223_G455_L0.5440.77
276_L295_L0.5430.76
218_R227_T0.5420.76
445_E449_D0.5420.76
92_L125_K0.5420.76
71_E586_K0.5410.76
266_K424_K0.5410.76
7_L88_V0.5410.76
414_I466_L0.5410.76
600_S605_H0.5410.76
637_E642_K0.5410.76
238_T417_E0.5400.76
481_E526_F0.5400.76
548_L552_P0.5390.76
7_L104_T0.5390.76
291_A522_I0.5390.76
582_I586_K0.5390.76
118_I149_S0.5380.76
377_L380_L0.5380.76
564_W568_L0.5380.76
583_K586_K0.5380.76
7_L92_L0.5380.76
534_K537_D0.5380.76
286_R436_D0.5380.76
624_N627_R0.5370.76
258_V455_L0.5370.76
45_L84_Q0.5370.76
201_K552_P0.5370.76
607_N629_T0.5360.75
412_A455_L0.5360.75
49_A172_I0.5360.75
569_S573_A0.5360.75
100_I127_I0.5350.75
201_K204_A0.5330.75
130_L139_A0.5330.75
161_V578_S0.5320.75
585_M589_A0.5320.75
11_P299_Q0.5320.75
621_L633_C0.5300.75
199_I291_A0.5300.75
10_K514_T0.5300.75
576_L581_F0.5290.75
360_A363_S0.5290.75
314_D363_S0.5290.75
546_Q549_Q0.5290.75
410_V421_A0.5280.74
101_V128_K0.5280.74
599_S602_T0.5280.74
82_G95_K0.5280.74
332_G396_L0.5270.74
609_T612_A0.5270.74
620_M638_C0.5260.74
630_M643_T0.5260.74
611_T622_K0.5260.74
138_K145_Q0.5260.74
320_S349_G0.5260.74
17_L20_V0.5240.74
340_Q347_K0.5240.74
645_A648_T0.5230.74
46_V116_W0.5230.74
554_D595_E0.5230.74
4_T98_N0.5220.74
275_D489_E0.5220.74
150_G154_E0.5210.73
133_S366_H0.5200.73
272_A317_F0.5190.73
112_L116_W0.5190.73
490_N510_G0.5190.73
156_L572_A0.5190.73
329_R334_E0.5180.73
270_A348_R0.5180.73
421_A453_P0.5180.73
135_V431_W0.5170.73
132_I153_Y0.5170.73
608_I634_Q0.5170.73
613_C640_S0.5160.73
12_S303_E0.5160.73
271_P437_M0.5160.73
588_Y591_Q0.5150.73
79_K86_N0.5140.72
485_L518_R0.5140.72
112_L164_A0.5140.72
601_Q604_R0.5130.72
407_E424_K0.5130.72
642_K646_R0.5130.72
306_K371_T0.5130.72
633_C640_S0.5130.72
89_K95_K0.5110.72
233_S236_T0.5110.72
11_P40_W0.5100.72
451_T454_A0.5100.72
640_S645_A0.5100.72
317_F359_D0.5100.72
5_V39_T0.5100.72
597_K601_Q0.5100.72
132_I298_L0.5090.72
307_L375_L0.5070.71
60_S65_D0.5070.71
532_E542_S0.5070.71
525_L536_Q0.5070.71
520_D523_E0.5070.71
50_D76_V0.5060.71
611_T619_M0.5060.71
255_Q457_K0.5060.71
60_S71_E0.5050.71
199_I540_I0.5050.71
114_A117_I0.5050.71
226_L412_A0.5050.71
42_L83_K0.5050.71
12_S133_S0.5040.71
233_S237_R0.5040.71
178_L547_L0.5030.71
130_L309_T0.5010.71
636_R642_K0.5010.71
20_V133_S0.5010.71
75_L116_W0.5000.70
318_L323_V0.5000.70
632_V639_G0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i7dA 1 0.8129 100 0.158 Contact Map
4cgyA 1 0.7703 100 0.198 Contact Map
2gaiA 1 0.7744 100 0.229 Contact Map
1mw9X 1 0.7428 100 0.255 Contact Map
4dduA 1 0.7125 100 0.302 Contact Map
1gkuB 1 0.6781 100 0.312 Contact Map
1vddA 7 0.1554 99.6 0.92 Contact Map
2fcjA 2 0.1554 98.4 0.952 Contact Map
3vdpA 2 0.1541 98.3 0.954 Contact Map
1r7jA 2 0.1238 85.9 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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