GREMLIN Database
LRPC - HTH-type transcriptional regulator LrpC
UniProt: P96582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (135)
Sequences: 13482 (8853)
Seq/√Len: 761.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_E28_K2.8951.00
44_E52_Y2.8441.00
72_T127_Q2.6051.00
100_A129_V2.5671.00
93_F106_K2.3901.00
110_E114_A2.2671.00
22_M40_V2.2191.00
59_K113_E2.0811.00
7_D39_R2.0571.00
42_Q46_F2.0381.00
13_E20_L1.9571.00
50_K57_D1.9441.00
74_K126_A1.8331.00
66_S106_K1.8311.00
20_L28_K1.7811.00
92_E108_N1.7521.00
68_I95_Y1.7431.00
50_K55_E1.7391.00
6_I31_L1.7371.00
41_R45_S1.6701.00
70_E131_H1.6481.00
88_L118_F1.6261.00
23_R27_R1.6201.00
13_E16_K1.6121.00
31_L35_S1.5951.00
114_A117_D1.5041.00
24_E27_R1.4971.00
111_S114_A1.4831.00
31_L36_V1.4761.00
88_L121_K1.4751.00
23_R33_P1.4521.00
32_S35_S1.4471.00
84_Y87_T1.4281.00
81_F85_I1.4071.00
82_K86_Q1.3871.00
10_I25_L1.3781.00
19_R52_Y1.3661.00
71_A105_L1.3661.00
90_N114_A1.3631.00
22_M37_T1.3531.00
72_T100_A1.3231.00
117_D121_K1.2951.00
116_E135_S1.2881.00
70_E101_A1.2811.00
69_V107_I1.2801.00
79_E83_S1.2741.00
29_I36_V1.2711.00
77_D80_R1.2681.00
5_Q9_N1.2631.00
72_T126_A1.2601.00
65_V112_L1.2601.00
20_L25_L1.2251.00
24_E28_K1.2201.00
63_L110_E1.2111.00
73_V81_F1.2071.00
6_I9_N1.2031.00
14_L40_V1.1991.00
82_K135_S1.1741.00
16_K28_K1.1691.00
41_R44_E1.1631.00
17_D28_K1.1631.00
20_L24_E1.1461.00
70_E129_V1.1381.00
21_S24_E1.0971.00
13_E25_L1.0881.00
51_Q55_E1.0831.00
4_D39_R1.0701.00
6_I29_I1.0641.00
66_S108_N1.0511.00
22_M26_G1.0451.00
9_N13_E1.0431.00
18_S52_Y1.0141.00
26_G36_V1.0101.00
9_N12_E1.0031.00
109_A114_A1.0021.00
17_D20_L0.9991.00
80_R84_Y0.9901.00
91_I107_I0.9691.00
94_C105_L0.9651.00
82_K103_Y0.9641.00
12_E16_K0.9611.00
83_S86_Q0.9611.00
37_T41_R0.9571.00
9_N29_I0.9401.00
33_P37_T0.9391.00
57_D60_K0.9381.00
97_I104_M0.9371.00
95_Y106_K0.9361.00
68_I104_M0.9311.00
19_R44_E0.9211.00
3_L8_L0.9171.00
68_I106_K0.9121.00
109_A115_V0.8951.00
109_A118_F0.8911.00
26_G31_L0.8751.00
22_M33_P0.8671.00
23_R37_T0.8551.00
74_K77_D0.8521.00
58_Q108_N0.8521.00
83_S87_T0.8491.00
64_P111_S0.8471.00
107_I118_F0.8461.00
43_L48_I0.8451.00
7_D42_Q0.8451.00
95_Y133_I0.8271.00
116_E120_N0.8211.00
119_I130_T0.8201.00
68_I133_I0.8181.00
84_Y88_L0.8171.00
18_S54_L0.8141.00
91_I94_C0.8121.00
8_L12_E0.8041.00
95_Y136_E0.7981.00
74_K124_P0.7911.00
79_E82_K0.7891.00
100_A127_Q0.7731.00
70_E104_M0.7651.00
85_I94_C0.7601.00
4_D7_D0.7581.00
98_A132_V0.7561.00
91_I105_L0.7541.00
101_A129_V0.7541.00
10_I39_R0.7521.00
34_P38_E0.7471.00
25_L40_V0.7321.00
90_N121_K0.7321.00
82_K137_I0.7311.00
112_L132_V0.7301.00
71_A81_F0.7271.00
72_T101_A0.7231.00
10_I36_V0.7091.00
66_S133_I0.7091.00
80_R83_S0.7061.00
78_Y103_Y0.7051.00
13_E17_D0.6991.00
25_L36_V0.6961.00
3_L48_I0.6941.00
63_L90_N0.6931.00
90_N118_F0.6931.00
70_E100_A0.6851.00
69_V105_L0.6801.00
71_A125_Y0.6781.00
117_D120_N0.6721.00
119_I128_T0.6721.00
5_Q8_L0.6691.00
48_I60_K0.6671.00
80_R124_P0.6601.00
118_F122_T0.6481.00
81_F103_Y0.6401.00
10_I40_V0.6331.00
84_Y124_P0.6321.00
38_E42_Q0.6311.00
96_R103_Y0.6291.00
63_L108_N0.6281.00
39_R43_L0.6221.00
85_I105_L0.6211.00
113_E116_E0.6191.00
26_G33_P0.6161.00
34_P37_T0.6151.00
11_I43_L0.6151.00
114_A118_F0.6091.00
16_K20_L0.6081.00
90_N110_E0.6051.00
10_I13_E0.6041.00
38_E41_R0.6041.00
18_S51_Q0.5991.00
66_S136_E0.5991.00
71_A128_T0.5991.00
47_G50_K0.5961.00
97_I101_A0.5871.00
7_D43_L0.5861.00
67_C132_V0.5851.00
69_V128_T0.5811.00
57_D61_L0.5801.00
84_Y123_S0.5791.00
67_C115_V0.5791.00
96_R120_N0.5701.00
112_L134_F0.5691.00
22_M36_V0.5681.00
10_I20_L0.5651.00
56_V61_L0.5631.00
72_T129_V0.5601.00
10_I43_L0.5541.00
97_I133_I0.5471.00
49_I52_Y0.5461.00
42_Q45_S0.5441.00
113_E117_D0.5421.00
70_E97_I0.5271.00
66_S95_Y0.5261.00
23_R26_G0.5241.00
100_A131_H0.5211.00
7_D46_F0.5161.00
15_K53_T0.5151.00
67_C109_A0.5141.00
21_S26_G0.5141.00
6_I35_S0.5091.00
96_R102_C0.5081.00
119_I134_F0.5081.00
12_E15_K0.5071.00
67_C130_T0.5011.00
85_I122_T0.5001.00
17_D24_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9514 100 0.152 Contact Map
4un1B 1 1 100 0.193 Contact Map
4pcqA 2 0.9861 100 0.218 Contact Map
2e1cA 1 0.9931 100 0.226 Contact Map
4un1A 1 0.9653 100 0.226 Contact Map
2p5vA 5 1 100 0.231 Contact Map
2ia0A 2 0.9653 100 0.233 Contact Map
2cfxA 5 0.9722 100 0.238 Contact Map
2cg4A 6 1 100 0.249 Contact Map
3i4pA 5 0.9792 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.