GREMLIN Database
YDAH - Uncharacterized protein YdaH
UniProt: P96581 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (261)
Sequences: 197 (145)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_T196_A4.3280.99
64_G68_D3.5760.96
178_S246_A3.3350.94
212_V217_S2.9030.89
55_S219_L2.8380.88
38_I89_S2.7740.86
90_T245_V2.7060.85
28_T55_S2.6710.84
45_F96_G2.5760.82
245_V258_G2.5010.80
21_I96_G2.4350.78
43_S217_S2.4270.78
64_G174_I2.3050.74
71_G190_S2.2950.74
191_T194_V2.1980.70
94_I106_L2.1930.70
19_H244_R2.1130.67
180_L244_R2.0870.66
86_I256_I2.0870.66
27_A167_L2.0820.66
183_G190_S2.0390.64
169_T172_Y1.9900.62
95_L167_L1.9760.62
11_I62_F1.9150.59
67_I200_I1.8860.58
103_F107_F1.8590.57
92_G119_G1.8470.56
68_D183_G1.8310.55
33_A258_G1.8280.55
175_G204_A1.7870.54
219_L233_L1.7680.53
35_V196_A1.7500.52
87_F249_L1.7460.52
47_V246_A1.7400.51
115_A219_L1.7370.51
19_H56_N1.7320.51
162_F217_S1.7300.51
50_I54_M1.7250.51
97_I245_V1.7170.50
47_V210_I1.7100.50
36_G262_I1.6890.49
179_A194_V1.6370.47
175_G207_L1.6170.46
31_S111_I1.6060.46
24_L103_F1.6040.46
27_A103_F1.5280.42
86_I174_I1.5250.42
91_V238_V1.5250.42
83_R107_F1.5240.42
119_G172_Y1.5200.42
45_F110_A1.5190.42
253_L256_I1.5150.42
48_M170_S1.5060.41
53_R208_L1.4990.41
46_N96_G1.4950.41
114_L198_G1.4930.41
135_K159_K1.4920.41
60_Q176_V1.4900.41
72_K95_L1.4900.41
49_V90_T1.4600.39
77_I251_A1.4460.39
19_H169_T1.4420.39
36_G159_K1.4250.38
98_I254_M1.4240.38
107_F258_G1.4130.38
222_D228_R1.4130.38
255_F258_G1.4050.37
134_F249_L1.3980.37
9_L167_L1.3940.37
9_L67_I1.3890.37
78_V162_F1.3730.36
38_I170_S1.3350.34
111_I195_M1.3300.34
93_T177_L1.3270.34
11_I25_A1.3230.34
244_R251_A1.3010.33
160_R209_A1.2990.33
15_L50_I1.2950.33
63_T114_L1.2800.32
64_G198_G1.2720.32
123_Q132_Q1.2680.32
196_A209_A1.2660.32
64_G172_Y1.2640.32
141_L178_S1.2610.32
36_G143_L1.2530.31
62_F227_K1.2420.31
33_A220_A1.2420.31
55_S103_F1.2420.31
13_C135_K1.2370.31
21_I45_F1.2360.31
17_L166_M1.2360.31
159_K209_A1.2300.30
183_G196_A1.2060.30
143_L149_V1.2060.30
136_N212_V1.2060.30
142_R146_I1.2010.29
19_H176_V1.1930.29
24_L61_P1.1930.29
114_L186_A1.1870.29
86_I255_F1.1830.29
115_A223_V1.1810.29
34_R221_D1.1750.28
16_L95_L1.1750.28
107_F255_F1.1730.28
33_A39_A1.1730.28
178_S258_G1.1560.28
226_G234_K1.1550.28
71_G217_S1.1540.28
104_V111_I1.1530.28
25_A217_S1.1510.28
10_F129_F1.1500.28
67_I167_L1.1490.28
167_L231_I1.1480.27
106_L253_L1.1470.27
53_R200_I1.1440.27
63_T196_A1.1280.27
83_R252_Q1.1190.27
49_V197_S1.1100.26
94_I108_S1.1060.26
111_I142_R1.0980.26
10_F246_A1.0960.26
85_L121_V1.0920.26
130_S222_D1.0840.25
66_L178_S1.0710.25
28_T48_M1.0690.25
111_I255_F1.0670.25
55_S122_F1.0650.25
34_R152_F1.0580.24
46_N237_S1.0580.24
17_L125_F1.0560.24
71_G243_S1.0520.24
95_L125_F1.0520.24
28_T103_F1.0440.24
174_I255_F1.0380.24
164_I171_I1.0370.24
34_R105_A1.0350.24
82_F178_S1.0170.23
66_L81_Q1.0160.23
161_L251_A1.0160.23
92_G219_L1.0120.23
11_I14_F1.0060.23
161_L215_K1.0020.23
169_T173_T0.9980.23
49_V53_R0.9930.22
80_E163_V0.9920.22
93_T169_T0.9900.22
64_G86_I0.9870.22
27_A37_F0.9830.22
51_V87_F0.9790.22
171_I174_I0.9780.22
70_A111_I0.9740.22
116_G152_F0.9720.22
86_I130_S0.9710.22
95_L207_L0.9680.22
83_R90_T0.9640.22
93_T204_A0.9630.22
48_M57_M0.9630.22
191_T244_R0.9550.21
160_R200_I0.9470.21
68_D172_Y0.9460.21
115_A217_S0.9440.21
16_L170_S0.9440.21
51_V80_E0.9430.21
22_E25_A0.9410.21
206_M213_D0.9390.21
26_Y144_P0.9380.21
53_R205_T0.9340.21
83_R103_F0.9340.21
189_R255_F0.9310.21
37_F218_V0.9300.21
161_L184_L0.9260.20
13_C95_L0.9230.20
12_F62_F0.9190.20
242_T249_L0.9180.20
152_F163_V0.9150.20
86_I89_S0.9140.20
40_S156_L0.9120.20
173_T204_A0.9080.20
180_L251_A0.9050.20
62_F192_T0.9050.20
21_I46_N0.9020.20
155_R238_V0.8960.20
35_V63_T0.8930.20
57_M198_G0.8920.20
21_I110_A0.8870.19
7_Q92_G0.8850.19
248_T259_A0.8840.19
115_A129_F0.8830.19
176_V252_Q0.8820.19
183_G235_W0.8780.19
88_G256_I0.8750.19
14_F58_V0.8740.19
223_V233_L0.8680.19
174_I178_S0.8670.19
157_I207_L0.8500.18
13_C140_Y0.8490.18
35_V266_T0.8480.18
88_G259_A0.8450.18
162_F220_A0.8450.18
28_T107_F0.8400.18
100_L129_F0.8370.18
64_G158_P0.8100.17
58_V104_V0.8060.17
22_E119_G0.8010.17
115_A240_M0.8010.17
230_Y234_K0.7980.17
24_L197_S0.7980.17
27_A139_S0.7920.17
259_A263_A0.7910.17
153_H217_S0.7900.17
197_S204_A0.7840.17
28_T246_A0.7800.17
175_G194_V0.7760.17
182_A187_P0.7740.17
141_L167_L0.7730.17
78_V199_L0.7720.16
14_F102_S0.7720.16
9_L27_A0.7700.16
30_L64_G0.7690.16
86_I157_I0.7680.16
89_S254_M0.7660.16
77_I253_L0.7610.16
90_T250_L0.7610.16
145_S183_G0.7600.16
11_I58_V0.7590.16
107_F121_V0.7560.16
68_D266_T0.7530.16
17_L249_L0.7530.16
59_Q173_T0.7440.16
43_S212_V0.7430.16
193_A221_D0.7420.16
185_L259_A0.7380.16
13_C227_K0.7310.16
27_A238_V0.7290.15
22_E217_S0.7280.15
164_I200_I0.7260.15
102_S144_P0.7220.15
18_I24_L0.7200.15
23_T103_F0.7180.15
104_V145_S0.7180.15
212_V216_V0.7150.15
143_L253_L0.7130.15
28_T158_P0.7100.15
20_S114_L0.7100.15
176_V179_A0.7090.15
130_S170_S0.7090.15
36_G146_I0.7080.15
51_V72_K0.7080.15
69_D188_E0.7070.15
123_Q131_K0.7040.15
78_V246_A0.7020.15
52_S61_P0.7020.15
64_G179_A0.6960.15
161_L192_T0.6940.15
28_T49_V0.6910.15
9_L28_T0.6870.15
184_L212_V0.6830.14
56_N176_V0.6790.14
94_I258_G0.6790.14
111_I148_Y0.6760.14
170_S243_S0.6760.14
245_V249_L0.6730.14
85_L217_S0.6690.14
236_T244_R0.6650.14
83_R255_F0.6620.14
95_L139_S0.6620.14
55_S224_A0.6600.14
19_H89_S0.6570.14
56_N250_L0.6540.14
82_F223_V0.6510.14
34_R113_H0.6500.14
201_N204_A0.6490.14
86_I240_M0.6480.14
95_L131_K0.6470.14
146_I150_K0.6460.14
90_T252_Q0.6460.14
37_F235_W0.6440.14
48_M62_F0.6400.14
9_L146_I0.6380.14
41_A104_V0.6380.14
132_Q183_G0.6360.13
133_G212_V0.6350.13
149_V163_V0.6350.13
164_I207_L0.6310.13
88_G138_L0.6310.13
175_G208_L0.6290.13
51_V95_L0.6280.13
53_R206_M0.6280.13
43_S92_G0.6270.13
125_F229_S0.6270.13
97_I102_S0.6230.13
161_L212_V0.6230.13
41_A225_K0.6220.13
24_L204_A0.6210.13
12_F88_G0.6180.13
94_I170_S0.6180.13
59_Q158_P0.6170.13
11_I32_G0.6160.13
243_S264_W0.6150.13
141_L194_V0.6150.13
47_V138_L0.6150.13
115_A236_T0.6140.13
63_T190_S0.6140.13
85_L233_L0.6090.13
102_S187_P0.6090.13
110_A157_I0.6080.13
123_Q245_V0.6070.13
25_A218_V0.6050.13
67_I87_F0.5990.13
14_F54_M0.5970.13
90_T176_V0.5960.13
176_V249_L0.5960.13
85_L242_T0.5940.13
50_I174_I0.5920.13
9_L95_L0.5880.13
89_S179_A0.5880.13
121_V209_A0.5860.12
22_E111_I0.5850.12
129_F139_S0.5850.12
202_G205_T0.5830.12
10_F123_Q0.5820.12
219_L222_D0.5820.12
161_L243_S0.5820.12
65_H136_N0.5780.12
52_S263_A0.5770.12
150_K265_L0.5760.12
79_G200_I0.5750.12
98_I125_F0.5750.12
96_G110_A0.5750.12
87_F254_M0.5750.12
8_V123_Q0.5730.12
160_R224_A0.5730.12
192_T266_T0.5720.12
160_R196_A0.5720.12
247_G257_P0.5710.12
37_F47_V0.5700.12
43_S115_A0.5680.12
194_V234_K0.5670.12
17_L151_G0.5670.12
11_I66_L0.5660.12
24_L205_T0.5620.12
50_I220_A0.5610.12
11_I191_T0.5600.12
189_R192_T0.5590.12
78_V184_L0.5580.12
84_F124_V0.5570.12
15_L252_Q0.5570.12
35_V265_L0.5570.12
43_S131_K0.5540.12
36_G229_S0.5540.12
147_S254_M0.5530.12
163_V166_M0.5520.12
132_Q145_S0.5470.12
16_L92_G0.5470.12
122_F125_F0.5460.12
60_Q220_A0.5460.12
64_G161_L0.5440.12
43_S216_V0.5430.12
219_L223_V0.5400.12
168_I203_I0.5390.12
68_D190_S0.5380.12
98_I203_I0.5380.12
91_V185_L0.5370.12
172_Y198_G0.5360.12
168_I223_V0.5360.12
83_R88_G0.5350.12
32_G38_I0.5330.12
19_H48_M0.5320.12
178_S182_A0.5310.11
243_S267_K0.5280.11
36_G154_M0.5270.11
180_L252_Q0.5260.11
101_P165_N0.5230.11
43_S177_L0.5210.11
9_L160_R0.5190.11
21_I61_P0.5170.11
38_I41_A0.5170.11
95_L179_A0.5160.11
120_S165_N0.5120.11
24_L51_V0.5090.11
189_R203_I0.5090.11
25_A222_D0.5060.11
46_N100_L0.5060.11
56_N244_R0.5060.11
104_V172_Y0.5050.11
163_V212_V0.5050.11
67_I95_L0.5040.11
41_A63_T0.5040.11
176_V244_R0.5040.11
55_S189_R0.5020.11
28_T218_V0.5020.11
85_L206_M0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4akfA 2 0.4944 6.9 0.977 Contact Map
4jifB 1 0.0706 5.5 0.978 Contact Map
3wdoA 1 0.8401 4.7 0.978 Contact Map
3w4tA 1 0.9257 4.6 0.978 Contact Map
1pw4A 1 0.8253 4.6 0.978 Contact Map
2cfqA 1 0.8476 3.3 0.98 Contact Map
4lz6A 1 0.4461 2.5 0.981 Contact Map
1irzA 1 0.2305 2.1 0.982 Contact Map
3mktA 1 0.4424 2 0.982 Contact Map
3klyA 3 0.4312 2 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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