GREMLIN Database
DLYKI - Probable D-lyxose ketol-isomerase
UniProt: P96578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 167 (163)
Sequences: 105 (87)
Seq/√Len: 6.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_Y153_S3.7010.93
53_Y81_Q3.3650.89
81_Q153_S3.1890.86
58_L148_V3.1120.85
103_P118_W2.8590.79
90_K122_E2.7450.76
109_Q112_R2.6360.73
90_K124_E2.5160.69
12_Y58_L2.4920.69
156_T159_H2.4720.68
37_E61_F2.2140.59
70_R136_K2.1350.56
53_Y131_I2.1320.56
111_D166_R2.0750.54
15_A19_L1.9890.50
7_E38_R1.9490.49
40_V107_P1.8780.46
107_P111_D1.8690.46
11_Y147_V1.8510.45
74_V159_H1.7910.43
110_E115_Y1.7770.42
14_K48_V1.7680.42
8_V58_L1.7260.41
104_K119_H1.7130.40
36_K39_K1.7040.40
44_L115_Y1.7010.40
29_L43_Q1.6940.39
40_V115_Y1.6670.38
8_V43_Q1.6270.37
97_G120_E1.6070.36
6_E148_V1.5950.36
40_V111_D1.5490.34
13_Q21_D1.5320.34
50_T81_Q1.5100.33
5_K9_N1.4990.33
94_Y120_E1.4870.32
53_Y132_P1.4830.32
65_T94_Y1.4790.32
10_S22_E1.4490.31
88_Y147_V1.4480.31
103_P107_P1.4440.31
100_T107_P1.4360.31
20_T127_G1.4330.31
24_V136_K1.4210.30
50_T53_Y1.4100.30
97_G167_I1.4050.30
97_G117_V1.4030.30
52_R153_S1.3890.29
87_R149_T1.3820.29
35_G50_T1.3420.28
96_E115_Y1.3340.27
36_K40_V1.3290.27
131_I153_S1.3190.27
86_C91_V1.3100.27
8_V12_Y1.3000.26
7_E124_E1.2410.25
58_L73_P1.2270.24
53_Y73_P1.1460.22
13_Q16_G1.1420.22
115_Y131_I1.1320.22
8_V113_E1.1190.21
37_E43_Q1.1100.21
28_Q105_V1.0880.21
117_V153_S1.0730.20
8_V29_L1.0720.20
103_P111_D1.0690.20
24_V43_Q1.0580.20
12_Y134_N1.0580.20
124_E136_K1.0550.20
46_V156_T1.0520.20
22_E26_Q1.0450.20
30_M149_T1.0450.20
94_Y97_G1.0390.19
51_D154_T1.0370.19
84_F150_E1.0300.19
68_E141_A1.0260.19
68_E136_K1.0240.19
10_S14_K1.0210.19
105_V140_Q1.0170.19
43_Q88_Y1.0140.19
28_Q41_G1.0100.19
101_P107_P1.0050.19
86_C125_P1.0020.19
112_R125_P1.0000.19
44_L59_V0.9980.19
97_G119_H0.9840.18
24_V135_T0.9710.18
16_G73_P0.9710.18
29_L37_E0.9670.18
36_K88_Y0.9660.18
19_L45_F0.9660.18
45_F136_K0.9500.17
119_H147_V0.9470.17
36_K43_Q0.9440.17
45_F103_P0.9410.17
24_V166_R0.9270.17
81_Q131_I0.9200.17
105_V158_K0.9180.17
9_N24_V0.9180.17
29_L58_L0.9160.17
117_V125_P0.8970.16
127_G149_T0.8950.16
57_E87_R0.8910.16
87_R151_M0.8900.16
50_T154_T0.8860.16
7_E147_V0.8830.16
46_V77_Q0.8810.16
43_Q61_F0.8710.16
14_K22_E0.8630.16
10_S113_E0.8590.16
35_G165_P0.8580.16
44_L131_I0.8570.16
13_Q24_V0.8500.15
78_E164_D0.8450.15
40_V53_Y0.8450.15
30_M95_V0.8430.15
96_E118_W0.8400.15
6_E102_L0.8380.15
21_D118_W0.8370.15
26_Q90_K0.8310.15
38_R159_H0.8280.15
55_S165_P0.8270.15
54_C150_E0.8190.15
65_T95_V0.8160.15
60_L93_L0.8110.15
60_L110_E0.8100.15
10_S134_N0.8080.15
42_L116_T0.7970.14
15_A24_V0.7950.14
28_Q154_T0.7950.14
35_G58_L0.7910.14
54_C84_F0.7900.14
66_C155_S0.7790.14
15_A135_T0.7710.14
66_C87_R0.7680.14
95_V129_Y0.7630.14
10_S143_E0.7620.14
13_Q70_R0.7620.14
5_K78_E0.7610.14
75_D107_P0.7610.14
40_V164_D0.7550.14
13_Q153_S0.7500.14
92_Y103_P0.7480.13
136_K143_E0.7440.13
35_G45_F0.7440.13
37_E132_P0.7430.13
37_E114_H0.7430.13
90_K125_P0.7350.13
74_V156_T0.7330.13
10_S88_Y0.7290.13
92_Y118_W0.7240.13
104_K167_I0.7190.13
63_G109_Q0.7170.13
5_K122_E0.7130.13
91_V161_I0.7090.13
49_N155_S0.7040.13
113_E154_T0.7020.13
25_D143_E0.6950.13
9_N132_P0.6930.13
14_K88_Y0.6850.12
42_L108_P0.6830.12
153_S165_P0.6780.12
26_Q121_I0.6720.12
29_L166_R0.6690.12
58_L132_P0.6600.12
10_S26_Q0.6600.12
44_L155_S0.6540.12
7_E11_Y0.6530.12
61_F76_G0.6470.12
38_R96_E0.6460.12
105_V113_E0.6460.12
81_Q132_P0.6380.12
63_G140_Q0.6360.12
15_A43_Q0.6360.12
35_G97_G0.6350.12
11_Y18_V0.6310.12
61_F112_R0.6270.11
25_D161_I0.6270.11
66_C150_E0.6230.11
37_E76_G0.6220.11
90_K144_E0.6200.11
96_E132_P0.6200.11
51_D77_Q0.6150.11
93_L129_Y0.6130.11
43_Q103_P0.6120.11
125_P136_K0.6120.11
63_G143_E0.6110.11
70_R134_N0.6090.11
78_E110_E0.6080.11
108_P155_S0.6070.11
7_E61_F0.6050.11
42_L133_P0.6030.11
22_E109_Q0.6000.11
19_L29_L0.5940.11
66_C84_F0.5920.11
54_C66_C0.5910.11
73_P144_E0.5890.11
14_K50_T0.5890.11
51_D166_R0.5860.11
40_V154_T0.5860.11
11_Y59_V0.5840.11
32_Y42_L0.5830.11
10_S31_D0.5810.11
57_E66_C0.5780.11
154_T159_H0.5780.11
74_V97_G0.5770.11
121_I131_I0.5760.11
36_K148_V0.5660.11
93_L135_T0.5640.11
53_Y165_P0.5580.10
27_I51_D0.5530.10
44_L163_T0.5500.10
6_E63_G0.5470.10
40_V81_Q0.5420.10
5_K25_D0.5400.10
52_R76_G0.5390.10
43_Q156_T0.5390.10
73_P165_P0.5380.10
98_E117_V0.5380.10
36_K111_D0.5370.10
27_I37_E0.5370.10
66_C149_T0.5370.10
73_P132_P0.5360.10
21_D70_R0.5340.10
8_V70_R0.5330.10
51_D161_I0.5320.10
21_D48_V0.5320.10
47_Y57_E0.5250.10
18_V164_D0.5240.10
59_V134_N0.5220.10
29_L154_T0.5200.10
27_I30_M0.5200.10
94_Y103_P0.5200.10
21_D25_D0.5190.10
36_K99_K0.5170.10
7_E70_R0.5160.10
73_P148_V0.5140.10
40_V103_P0.5120.10
59_V115_Y0.5080.10
37_E45_F0.5070.10
62_P129_Y0.5050.10
20_T149_T0.5030.10
97_G118_W0.5030.10
40_V63_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0oA 2 0.994 100 0.516 Contact Map
3kmhA 2 0.9581 100 0.522 Contact Map
3h8uA 2 0.7126 98.3 0.899 Contact Map
2oa2A 2 0.6946 98 0.907 Contact Map
4zu4A 4 0.7844 97.9 0.907 Contact Map
1v70A 2 0.6228 97.9 0.909 Contact Map
3fjsA 2 0.6587 97.9 0.909 Contact Map
2pfwA 2 0.6707 97.8 0.91 Contact Map
3d0jA 2 0.7186 97.7 0.913 Contact Map
3l2hA 3 0.7784 97.7 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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