GREMLIN Database
YDAC - Uncharacterized methyltransferase YdaC
UniProt: P96576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (148)
Sequences: 23473 (18178)
Seq/√Len: 1494.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_S52_H2.5991.00
60_E79_Q2.5871.00
115_Y156_F2.4891.00
35_F55_G2.3881.00
54_H78_I2.2531.00
54_H92_Y2.1311.00
56_I80_G2.1161.00
118_L122_G2.0471.00
95_V114_I2.0141.00
31_L92_Y2.0091.00
42_Q70_V2.0051.00
41_M53_L1.9601.00
34_G100_N1.9251.00
66_A77_L1.9181.00
28_D94_K1.8871.00
87_L92_Y1.8621.00
95_V118_L1.8141.00
52_H76_R1.8091.00
93_D119_K1.7831.00
25_T28_D1.7821.00
113_Q116_R1.7651.00
63_L77_L1.7521.00
63_L79_Q1.7521.00
114_I124_A1.7491.00
106_D109_K1.6901.00
29_S54_H1.6411.00
108_T150_D1.6291.00
108_T153_A1.6261.00
60_E64_K1.6131.00
33_V114_I1.6111.00
100_N104_W1.5931.00
80_G86_P1.5301.00
33_V82_I1.5301.00
108_T112_K1.5071.00
35_F41_M1.4951.00
54_H76_R1.4741.00
107_Q150_D1.4471.00
70_V77_L1.4401.00
41_M55_G1.4291.00
58_V81_S1.4271.00
148_I152_K1.4131.00
102_T128_M1.3961.00
30_I94_K1.3641.00
30_I44_M1.3621.00
97_S100_N1.3481.00
112_K154_A1.3321.00
24_I28_D1.3271.00
118_L124_A1.3211.00
104_W110_G1.2971.00
82_I104_W1.2921.00
29_S119_K1.2911.00
42_Q69_R1.2791.00
29_S92_Y1.2691.00
99_N102_T1.2691.00
108_T154_A1.2691.00
113_Q117_A1.2641.00
65_L68_R1.2221.00
88_P91_F1.2121.00
78_I87_L1.2021.00
29_S93_D1.1991.00
57_D63_L1.1951.00
82_I100_N1.1921.00
29_S91_F1.1741.00
89_A116_R1.1671.00
111_I151_F1.1661.00
45_L74_G1.1601.00
118_L156_F1.1561.00
32_E35_F1.1501.00
55_G77_L1.1421.00
54_H87_L1.1231.00
85_F117_A1.1121.00
115_Y154_A1.0921.00
103_I128_M1.0831.00
99_N127_T1.0721.00
140_T143_F1.0711.00
59_S62_M1.0681.00
63_L67_A1.0621.00
70_V75_V1.0581.00
110_G114_I1.0551.00
44_M96_I1.0471.00
81_S84_T1.0341.00
40_C98_V1.0331.00
17_W20_N1.0321.00
61_A64_K1.0311.00
149_A153_A1.0211.00
43_Q47_R1.0201.00
85_F113_Q0.9841.00
35_F66_A0.9831.00
21_Q162_Q0.9731.00
42_Q46_K0.9721.00
101_Y104_W0.9641.00
109_K112_K0.9601.00
57_D62_M0.9421.00
43_Q46_K0.9401.00
41_M77_L0.9381.00
40_C96_I0.9361.00
28_D51_V0.9281.00
99_N103_I0.9281.00
98_V127_T0.9261.00
64_K67_A0.8861.00
37_P62_M0.8791.00
27_G51_V0.8721.00
31_L95_V0.8701.00
17_W21_Q0.8631.00
34_G97_S0.8601.00
28_D93_D0.8401.00
149_A152_K0.8341.00
135_A139_K0.8301.00
102_T129_Q0.8251.00
86_P113_Q0.8181.00
18_T125_A0.8131.00
70_V73_K0.8021.00
148_I161_I0.7981.00
37_P69_R0.7981.00
144_G163_F0.7961.00
99_N129_Q0.7941.00
35_F63_L0.7911.00
94_K123_K0.7841.00
24_I27_G0.7811.00
101_Y111_I0.7811.00
55_G66_A0.7801.00
65_L69_R0.7771.00
39_Y43_Q0.7751.00
136_S139_K0.7731.00
109_K113_Q0.7711.00
42_Q45_L0.7631.00
92_Y117_A0.7611.00
95_V117_A0.7601.00
135_A140_T0.7561.00
97_S126_I0.7401.00
87_L117_A0.7381.00
67_A70_V0.7301.00
31_L117_A0.7261.00
134_D137_P0.7251.00
111_I154_A0.7251.00
137_P141_K0.7241.00
33_V95_V0.7241.00
111_I147_M0.7221.00
64_K68_R0.7211.00
39_Y69_R0.7211.00
144_G148_I0.7161.00
101_Y110_G0.7141.00
17_W162_Q0.7131.00
83_E106_D0.7101.00
41_M75_V0.7101.00
16_Q43_Q0.7071.00
83_E104_W0.7021.00
56_I78_I0.7021.00
128_M147_M0.7011.00
38_G66_A0.7001.00
37_P65_L0.7001.00
83_E109_K0.6951.00
97_S114_I0.6891.00
40_C43_Q0.6881.00
84_T109_K0.6871.00
61_A65_L0.6871.00
67_A77_L0.6861.00
146_Q149_A0.6851.00
101_Y126_I0.6841.00
19_I47_R0.6811.00
158_D161_I0.6771.00
67_A71_K0.6731.00
130_P163_F0.6641.00
30_I96_I0.6541.00
137_P140_T0.6531.00
80_G85_F0.6521.00
97_S104_W0.6511.00
139_K142_S0.6491.00
16_Q20_N0.6451.00
91_F119_K0.6451.00
30_I53_L0.6421.00
83_E110_G0.6381.00
29_S51_V0.6331.00
111_I150_D0.6321.00
150_D153_A0.6301.00
114_I118_L0.6261.00
68_R71_K0.6231.00
98_V102_T0.6221.00
33_V56_I0.6181.00
107_Q110_G0.6141.00
138_E141_K0.6131.00
68_R72_P0.6131.00
56_I85_F0.6101.00
130_P144_G0.5991.00
45_L53_L0.5961.00
26_R50_D0.5961.00
138_E142_S0.5951.00
126_I151_F0.5921.00
35_F57_D0.5891.00
84_T113_Q0.5871.00
89_A113_Q0.5851.00
90_S120_P0.5811.00
124_A156_F0.5771.00
137_P143_F0.5701.00
87_L91_F0.5671.00
40_C44_M0.5581.00
73_K76_R0.5551.00
97_S124_A0.5541.00
35_F77_L0.5511.00
31_L56_I0.5501.00
150_D154_A0.5451.00
50_D74_G0.5441.00
132_E137_P0.5421.00
38_G77_L0.5371.00
146_Q150_D0.5361.00
28_D123_K0.5321.00
62_M99_N0.5321.00
139_K143_F0.5291.00
94_K122_G0.5281.00
21_Q160_D0.5231.00
69_R72_P0.5161.00
42_Q77_L0.5151.00
20_N47_R0.5131.00
136_S140_T0.5121.00
132_E135_A0.5091.00
55_G75_V0.5081.00
45_L75_V0.5081.00
82_I110_G0.5071.00
23_G123_K0.5041.00
137_P142_S0.5021.00
90_S119_K0.5011.00
15_N43_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o57A 2 0.9945 100 0.365 Contact Map
3ujcA 1 0.9945 100 0.374 Contact Map
4obxA 2 0.9779 100 0.374 Contact Map
4krgA 1 0.989 100 0.376 Contact Map
4pneA 2 0.989 100 0.377 Contact Map
1vl5A 1 0.9171 100 0.378 Contact Map
4ineA 2 0.9945 100 0.378 Contact Map
4kriA 1 0.9945 100 0.379 Contact Map
3busA 1 0.9945 100 0.384 Contact Map
3bkxA 2 1 100 0.391 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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