FLIW - BACSU - GREMLIN Contacts

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FLIW - Flagellar assembly factor FliW

UniProt:	P96503	Sequences: MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSPFVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPFEKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	143 (138)
Sequences:	845 (717)
Seq/√Len:	61.0

BACSU - FLIW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
89_D	118_K	3.745	1.00
58_F	95_I	3.320	1.00
4_H	10_Q	3.217	1.00
31_E	52_T	3.126	1.00
33_Q	52_T	3.038	1.00
2_I	10_Q	3.010	1.00
84_I	90_V	2.965	1.00
133_T	136_H	2.854	1.00
19_I	115_V	2.835	1.00
94_T	107_A	2.782	1.00
36_I	60_V	2.584	1.00
75_D	78_T	2.440	1.00
31_E	56_L	2.401	1.00
60_V	93_M	2.342	1.00
83_D	121_M	2.313	1.00
101_P	104_K	2.084	1.00
83_D	119_N	2.032	1.00
21_F	25_I	1.966	1.00
21_F	48_L	1.945	1.00
72_F	92_V	1.909	1.00
22_E	121_M	1.891	1.00
110_L	130_S	1.861	1.00
2_I	12_N	1.800	1.00
24_G	122_A	1.769	0.99
111_A	134_T	1.679	0.99
72_F	127_L	1.625	0.99
96_L	107_A	1.607	0.99
32_K	52_T	1.593	0.99
31_E	53_S	1.586	0.99
99_A	105_S	1.573	0.99
92_V	114_I	1.571	0.99
96_L	105_S	1.524	0.98
31_E	50_S	1.427	0.98
13_I	35_V	1.418	0.97
47_A	57_A	1.388	0.97
60_V	95_I	1.360	0.97
23_S	81_L	1.358	0.97
20_L	33_Q	1.347	0.96
46_V	93_M	1.335	0.96
101_P	105_S	1.323	0.96
45_F	96_L	1.278	0.95
22_E	82_L	1.272	0.95
35_V	51_V	1.270	0.95
39_L	47_A	1.257	0.95
8_H	57_A	1.255	0.95
91_E	117_R	1.251	0.95
62_S	93_M	1.172	0.92
3_I	51_V	1.165	0.92
4_H	54_E	1.102	0.90
8_H	47_A	1.091	0.89
34_F	50_S	1.088	0.89
5_T	8_H	1.084	0.89
67_F	136_H	1.082	0.89
86_N	89_D	1.078	0.89
102_F	105_S	1.064	0.88
5_T	57_A	1.057	0.88
30_E	53_S	1.051	0.88
98_M	105_S	1.050	0.88
26_P	111_A	1.043	0.87
113_I	135_K	1.039	0.87
106_T	137_P	1.032	0.87
47_A	99_A	1.030	0.87
36_I	46_V	1.013	0.86
81_L	123_K	1.009	0.85
111_A	131_S	0.985	0.84
104_K	137_P	0.970	0.83
25_I	58_F	0.961	0.83
45_F	139_G	0.960	0.82
18_I	33_Q	0.957	0.82
99_A	135_K	0.942	0.81
21_F	26_P	0.936	0.81
67_F	138_I	0.915	0.79
61_V	107_A	0.914	0.79
115_V	122_A	0.913	0.79
99_A	102_F	0.904	0.79
38_P	46_V	0.904	0.79
61_V	66_F	0.903	0.78
31_E	34_F	0.892	0.78
61_V	96_L	0.889	0.77
110_L	128_H	0.889	0.77
5_T	49_Q	0.879	0.77
95_I	126_V	0.865	0.75
22_E	78_T	0.863	0.75
87_I	90_V	0.843	0.73
61_V	94_T	0.842	0.73
72_F	90_V	0.842	0.73
17_Q	35_V	0.823	0.72
29_L	137_P	0.818	0.71
95_I	135_K	0.817	0.71
27_G	126_V	0.814	0.71
23_S	32_K	0.811	0.71
37_L	49_Q	0.806	0.70
60_V	78_T	0.796	0.69
61_V	138_I	0.770	0.67
85_D	118_K	0.765	0.66
78_T	123_K	0.762	0.66
67_F	107_A	0.756	0.65
67_F	109_L	0.755	0.65
21_F	24_G	0.753	0.65
3_I	66_F	0.741	0.64
45_F	59_I	0.738	0.63
53_S	101_P	0.730	0.62
62_S	91_E	0.730	0.62
25_I	95_I	0.726	0.62
53_S	56_L	0.719	0.61
99_A	104_K	0.719	0.61
64_F	74_L	0.711	0.60
74_L	79_A	0.710	0.60
72_F	114_I	0.710	0.60
19_I	30_E	0.709	0.60
29_L	78_T	0.706	0.60
13_I	37_L	0.702	0.59
97_T	134_T	0.701	0.59
28_F	58_F	0.701	0.59
129_D	132_Y	0.700	0.59
22_E	81_L	0.698	0.59
62_S	107_A	0.698	0.59
34_F	75_D	0.693	0.58
39_L	59_I	0.688	0.58
72_F	79_A	0.685	0.58
8_H	39_L	0.677	0.57
26_P	127_L	0.676	0.57
41_E	44_P	0.673	0.56
17_Q	93_M	0.673	0.56
78_T	87_I	0.672	0.56
38_P	138_I	0.672	0.56
97_T	135_K	0.670	0.56
16_E	120_M	0.670	0.56
36_I	93_M	0.666	0.55
95_I	107_A	0.666	0.55
18_I	117_R	0.660	0.55
96_L	111_A	0.659	0.55
17_Q	120_M	0.658	0.55
47_A	59_I	0.658	0.55
76_E	79_A	0.658	0.55
8_H	11_M	0.657	0.54
96_L	134_T	0.657	0.54
21_F	122_A	0.655	0.54
36_I	48_L	0.652	0.54
47_A	122_A	0.651	0.54
45_F	72_F	0.651	0.54
23_S	95_I	0.645	0.53
27_G	139_G	0.645	0.53
70_Y	132_Y	0.635	0.52
29_L	129_D	0.634	0.52
8_H	126_V	0.634	0.52
63_P	92_V	0.633	0.52
59_I	67_F	0.627	0.51
40_S	43_S	0.627	0.51
97_T	106_T	0.624	0.51
34_F	58_F	0.618	0.50
74_L	114_I	0.613	0.49
26_P	58_F	0.611	0.49
24_G	57_A	0.609	0.49
7_Y	11_M	0.608	0.49
17_Q	113_I	0.606	0.49
8_H	128_H	0.597	0.48
13_I	17_Q	0.595	0.47
67_F	137_P	0.594	0.47
48_L	96_L	0.592	0.47
68_K	133_T	0.592	0.47
76_E	87_I	0.592	0.47
42_D	111_A	0.588	0.47
40_S	45_F	0.586	0.46
26_P	34_F	0.584	0.46
31_E	101_P	0.584	0.46
62_S	94_T	0.577	0.45
63_P	66_F	0.577	0.45
73_D	87_I	0.576	0.45
110_L	134_T	0.575	0.45
68_K	118_K	0.572	0.45
54_E	120_M	0.571	0.45
6_K	98_M	0.569	0.44
66_F	109_L	0.568	0.44
92_V	116_N	0.564	0.44
68_K	92_V	0.558	0.43
33_Q	100_E	0.553	0.43
57_A	128_H	0.547	0.42
45_F	138_I	0.546	0.42
40_S	107_A	0.546	0.42
77_S	89_D	0.543	0.42
5_T	77_S	0.540	0.41
25_I	30_E	0.540	0.41
130_S	138_I	0.537	0.41
18_I	131_S	0.533	0.40
58_F	64_F	0.531	0.40
26_P	126_V	0.531	0.40
15_E	33_Q	0.531	0.40
22_E	34_F	0.523	0.39
3_I	69_N	0.523	0.39
34_F	54_E	0.521	0.39
4_H	113_I	0.518	0.39
34_F	40_S	0.518	0.39
11_M	93_M	0.516	0.39
21_F	34_F	0.513	0.38
26_P	123_K	0.512	0.38
74_L	102_F	0.512	0.38
61_V	121_M	0.512	0.38
59_I	106_T	0.511	0.38
43_S	113_I	0.509	0.38
11_M	86_N	0.508	0.38
45_F	98_M	0.506	0.38
75_D	122_A	0.505	0.37
73_D	84_I	0.501	0.37
90_V	104_K	0.500	0.37
110_L	126_V	0.500	0.37
42_D	82_L	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2aj7A	4	1	100	0.084	Contact Map
3fz3A	5	0.5734	5.4	0.955	Contact Map
2l66A	2	0.3217	4.1	0.957	Contact Map
4cr2X	1	0.5524	3.3	0.959	Contact Map
4bifA	4	0.3986	2.9	0.96	Contact Map
2y69G	1	0.2238	2.8	0.961	Contact Map
2rh0A	2	0.6713	2.6	0.961	Contact Map
3wa2X	2	0.7063	2.3	0.963	Contact Map
1mkyA	1	0.8322	2.3	0.963	Contact Map
3rt3C	2	0.2098	2.2	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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