GREMLIN Database
FLIW - Flagellar assembly factor FliW
UniProt: P96503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (138)
Sequences: 845 (717)
Seq/√Len: 61.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_D118_K3.7451.00
58_F95_I3.3201.00
4_H10_Q3.2171.00
31_E52_T3.1261.00
33_Q52_T3.0381.00
2_I10_Q3.0101.00
84_I90_V2.9651.00
133_T136_H2.8541.00
19_I115_V2.8351.00
94_T107_A2.7821.00
36_I60_V2.5841.00
75_D78_T2.4401.00
31_E56_L2.4011.00
60_V93_M2.3421.00
83_D121_M2.3131.00
101_P104_K2.0841.00
83_D119_N2.0321.00
21_F25_I1.9661.00
21_F48_L1.9451.00
72_F92_V1.9091.00
22_E121_M1.8911.00
110_L130_S1.8611.00
2_I12_N1.8001.00
24_G122_A1.7690.99
111_A134_T1.6790.99
72_F127_L1.6250.99
96_L107_A1.6070.99
32_K52_T1.5930.99
31_E53_S1.5860.99
99_A105_S1.5730.99
92_V114_I1.5710.99
96_L105_S1.5240.98
31_E50_S1.4270.98
13_I35_V1.4180.97
47_A57_A1.3880.97
60_V95_I1.3600.97
23_S81_L1.3580.97
20_L33_Q1.3470.96
46_V93_M1.3350.96
101_P105_S1.3230.96
45_F96_L1.2780.95
22_E82_L1.2720.95
35_V51_V1.2700.95
39_L47_A1.2570.95
8_H57_A1.2550.95
91_E117_R1.2510.95
62_S93_M1.1720.92
3_I51_V1.1650.92
4_H54_E1.1020.90
8_H47_A1.0910.89
34_F50_S1.0880.89
5_T8_H1.0840.89
67_F136_H1.0820.89
86_N89_D1.0780.89
102_F105_S1.0640.88
5_T57_A1.0570.88
30_E53_S1.0510.88
98_M105_S1.0500.88
26_P111_A1.0430.87
113_I135_K1.0390.87
106_T137_P1.0320.87
47_A99_A1.0300.87
36_I46_V1.0130.86
81_L123_K1.0090.85
111_A131_S0.9850.84
104_K137_P0.9700.83
25_I58_F0.9610.83
45_F139_G0.9600.82
18_I33_Q0.9570.82
99_A135_K0.9420.81
21_F26_P0.9360.81
67_F138_I0.9150.79
61_V107_A0.9140.79
115_V122_A0.9130.79
99_A102_F0.9040.79
38_P46_V0.9040.79
61_V66_F0.9030.78
31_E34_F0.8920.78
61_V96_L0.8890.77
110_L128_H0.8890.77
5_T49_Q0.8790.77
95_I126_V0.8650.75
22_E78_T0.8630.75
87_I90_V0.8430.73
61_V94_T0.8420.73
72_F90_V0.8420.73
17_Q35_V0.8230.72
29_L137_P0.8180.71
95_I135_K0.8170.71
27_G126_V0.8140.71
23_S32_K0.8110.71
37_L49_Q0.8060.70
60_V78_T0.7960.69
61_V138_I0.7700.67
85_D118_K0.7650.66
78_T123_K0.7620.66
67_F107_A0.7560.65
67_F109_L0.7550.65
21_F24_G0.7530.65
3_I66_F0.7410.64
45_F59_I0.7380.63
53_S101_P0.7300.62
62_S91_E0.7300.62
25_I95_I0.7260.62
53_S56_L0.7190.61
99_A104_K0.7190.61
64_F74_L0.7110.60
74_L79_A0.7100.60
72_F114_I0.7100.60
19_I30_E0.7090.60
29_L78_T0.7060.60
13_I37_L0.7020.59
97_T134_T0.7010.59
28_F58_F0.7010.59
129_D132_Y0.7000.59
22_E81_L0.6980.59
62_S107_A0.6980.59
34_F75_D0.6930.58
39_L59_I0.6880.58
72_F79_A0.6850.58
8_H39_L0.6770.57
26_P127_L0.6760.57
41_E44_P0.6730.56
17_Q93_M0.6730.56
78_T87_I0.6720.56
38_P138_I0.6720.56
97_T135_K0.6700.56
16_E120_M0.6700.56
36_I93_M0.6660.55
95_I107_A0.6660.55
18_I117_R0.6600.55
96_L111_A0.6590.55
17_Q120_M0.6580.55
47_A59_I0.6580.55
76_E79_A0.6580.55
8_H11_M0.6570.54
96_L134_T0.6570.54
21_F122_A0.6550.54
36_I48_L0.6520.54
47_A122_A0.6510.54
45_F72_F0.6510.54
23_S95_I0.6450.53
27_G139_G0.6450.53
70_Y132_Y0.6350.52
29_L129_D0.6340.52
8_H126_V0.6340.52
63_P92_V0.6330.52
59_I67_F0.6270.51
40_S43_S0.6270.51
97_T106_T0.6240.51
34_F58_F0.6180.50
74_L114_I0.6130.49
26_P58_F0.6110.49
24_G57_A0.6090.49
7_Y11_M0.6080.49
17_Q113_I0.6060.49
8_H128_H0.5970.48
13_I17_Q0.5950.47
67_F137_P0.5940.47
48_L96_L0.5920.47
68_K133_T0.5920.47
76_E87_I0.5920.47
42_D111_A0.5880.47
40_S45_F0.5860.46
26_P34_F0.5840.46
31_E101_P0.5840.46
62_S94_T0.5770.45
63_P66_F0.5770.45
73_D87_I0.5760.45
110_L134_T0.5750.45
68_K118_K0.5720.45
54_E120_M0.5710.45
6_K98_M0.5690.44
66_F109_L0.5680.44
92_V116_N0.5640.44
68_K92_V0.5580.43
33_Q100_E0.5530.43
57_A128_H0.5470.42
45_F138_I0.5460.42
40_S107_A0.5460.42
77_S89_D0.5430.42
5_T77_S0.5400.41
25_I30_E0.5400.41
130_S138_I0.5370.41
18_I131_S0.5330.40
58_F64_F0.5310.40
26_P126_V0.5310.40
15_E33_Q0.5310.40
22_E34_F0.5230.39
3_I69_N0.5230.39
34_F54_E0.5210.39
4_H113_I0.5180.39
34_F40_S0.5180.39
11_M93_M0.5160.39
21_F34_F0.5130.38
26_P123_K0.5120.38
74_L102_F0.5120.38
61_V121_M0.5120.38
59_I106_T0.5110.38
43_S113_I0.5090.38
11_M86_N0.5080.38
45_F98_M0.5060.38
75_D122_A0.5050.37
73_D84_I0.5010.37
90_V104_K0.5000.37
110_L126_V0.5000.37
42_D82_L0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aj7A 4 1 100 0.084 Contact Map
3fz3A 5 0.5734 5.4 0.955 Contact Map
2l66A 2 0.3217 4.1 0.957 Contact Map
4cr2X 1 0.5524 3.3 0.959 Contact Map
4bifA 4 0.3986 2.9 0.96 Contact Map
2y69G 1 0.2238 2.8 0.961 Contact Map
2rh0A 2 0.6713 2.6 0.961 Contact Map
3wa2X 2 0.7063 2.3 0.963 Contact Map
1mkyA 1 0.8322 2.3 0.963 Contact Map
3rt3C 2 0.2098 2.2 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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