GREMLIN Database
YVIE - Uncharacterized protein YviE
UniProt: P96502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (179)
Sequences: 305 (259)
Seq/√Len: 19.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K73_E3.6991.00
16_G171_D3.6661.00
49_G136_Y3.5551.00
46_V141_L3.3351.00
8_M178_L3.1860.99
172_M175_Y3.1630.99
63_D70_R3.1090.99
35_I152_I2.8760.99
13_G176_P2.8260.99
90_A94_D2.7490.98
58_A132_V2.7020.98
82_V86_I2.6220.98
57_Q133_K2.5890.98
85_G89_T2.5750.98
61_E131_R2.4690.97
51_L136_Y2.3640.96
17_L170_V2.2820.95
85_G88_R2.2070.94
10_S178_L2.1740.93
13_G172_M2.1640.93
105_P109_Q2.0390.91
59_W62_L1.9830.90
56_T69_K1.9450.89
16_G173_L1.9370.89
27_E160_I1.8620.86
57_Q69_K1.7700.84
75_A78_G1.6890.80
14_K173_L1.6830.80
25_K162_E1.6700.80
40_A145_I1.6480.79
42_M145_I1.6290.78
61_E126_A1.6130.77
15_I172_M1.5900.76
94_D98_K1.5880.76
24_L161_V1.5670.75
19_T22_A1.5620.75
9_H181_D1.5270.73
19_T168_V1.5270.73
95_E112_R1.5070.72
92_E112_R1.4700.70
60_E69_K1.4480.69
44_I143_V1.4280.68
25_K164_T1.4250.68
5_R182_V1.4010.66
6_L181_D1.3960.66
7_I182_V1.3830.65
31_A157_H1.3810.65
66_H69_K1.3710.65
36_E151_V1.3580.64
23_S164_T1.3450.63
52_T137_T1.3420.63
55_Q59_W1.2940.60
62_L126_A1.2460.57
22_A170_V1.2440.57
63_D92_E1.2280.56
171_D175_Y1.2270.56
15_I19_T1.2210.55
163_Y166_G1.2120.55
7_I10_S1.2050.54
60_E73_E1.2010.54
32_D157_H1.1900.54
123_E160_I1.1850.53
8_M182_V1.1820.53
124_N127_P1.1490.51
28_Q159_P1.1390.50
11_V177_D1.1330.50
69_K72_E1.1320.50
33_L154_A1.1270.50
61_E128_S1.1230.49
7_I181_D1.1180.49
61_E70_R1.1120.49
6_L182_V1.1090.48
44_I76_Q1.1080.48
46_V139_S1.1010.48
95_E109_Q1.0960.48
124_N128_S1.0930.47
61_E130_S1.0900.47
57_Q61_E1.0610.45
18_T169_K1.0520.45
26_M159_P1.0470.44
121_L124_N1.0290.43
5_R181_D1.0250.43
14_K175_Y1.0210.43
68_F157_H1.0180.43
119_I137_T1.0150.42
38_P151_V1.0090.42
17_L22_A1.0000.41
42_M158_K0.9990.41
29_P157_H0.9790.40
6_L27_E0.9760.40
29_P159_P0.9760.40
60_E85_G0.9650.39
69_K130_S0.9640.39
63_D69_K0.9580.39
38_P148_R0.9570.39
104_N107_A0.9490.38
38_P88_R0.9380.38
73_E85_G0.9290.37
47_T50_K0.9250.37
57_Q60_E0.9240.37
104_N169_K0.9210.37
79_H83_M0.9200.37
18_T165_P0.9100.36
97_M148_R0.9050.36
72_E90_A0.9030.36
24_L165_P0.9020.36
61_E125_Y0.8810.34
40_A148_R0.8750.34
150_P168_V0.8750.34
58_A97_M0.8700.34
132_V136_Y0.8570.33
28_Q31_A0.8540.33
54_D102_K0.8490.33
57_Q96_L0.8470.32
65_K131_R0.8460.32
56_T66_H0.8180.31
151_V154_A0.8170.31
102_K137_T0.8140.31
159_P168_V0.8080.30
92_E166_G0.8040.30
85_G150_P0.8030.30
34_E82_V0.8010.30
30_Q96_L0.8000.30
42_M116_M0.7940.30
38_P150_P0.7910.29
15_I170_V0.7910.29
87_A91_E0.7910.29
11_V22_A0.7840.29
52_T135_Q0.7790.29
176_P179_N0.7700.28
19_T161_V0.7700.28
47_T138_P0.7690.28
4_P28_Q0.7560.28
92_E109_Q0.7540.27
34_E155_E0.7520.27
75_A90_A0.7500.27
12_Q178_L0.7470.27
14_K168_V0.7460.27
28_Q113_N0.7410.27
65_K70_R0.7400.27
59_W66_H0.7320.26
127_P131_R0.7300.26
46_V145_I0.7280.26
56_T132_V0.7260.26
22_A161_V0.7240.26
85_G166_G0.7240.26
6_L82_V0.7230.26
55_Q132_V0.7080.25
40_A150_P0.6980.25
96_L133_K0.6980.25
92_E113_N0.6940.25
10_S98_K0.6930.24
26_M161_V0.6920.24
56_T67_V0.6920.24
29_P160_I0.6910.24
17_L134_I0.6890.24
43_E144_Q0.6870.24
118_Q134_I0.6850.24
73_E76_Q0.6820.24
69_K73_E0.6810.24
84_E91_E0.6800.24
53_I168_V0.6770.24
9_H182_V0.6740.24
22_A162_E0.6740.24
23_S161_V0.6730.24
67_V72_E0.6700.23
25_K77_Q0.6690.23
58_A136_Y0.6680.23
31_A154_A0.6650.23
37_Q132_V0.6630.23
83_M86_I0.6580.23
82_V98_K0.6580.23
22_A150_P0.6570.23
11_V172_M0.6550.23
37_Q127_P0.6520.23
24_L172_M0.6500.22
54_D96_L0.6480.22
39_S149_K0.6470.22
42_M164_T0.6460.22
96_L129_L0.6400.22
81_D85_G0.6380.22
94_D102_K0.6340.22
46_V138_P0.6330.22
59_W131_R0.6320.22
3_I6_L0.6270.21
55_Q143_V0.6240.21
51_L102_K0.6230.21
161_V172_M0.6210.21
82_V140_Q0.6140.21
50_K57_Q0.6110.21
11_V21_P0.6100.21
28_Q132_V0.6100.21
61_E74_A0.6070.21
25_K45_S0.6040.21
43_E172_M0.6040.21
153_Q156_P0.6010.20
127_P139_S0.6010.20
140_Q167_N0.5970.20
10_S86_I0.5930.20
22_A166_G0.5930.20
55_Q58_A0.5930.20
75_A127_P0.5930.20
24_L163_Y0.5900.20
126_A131_R0.5900.20
3_I7_I0.5880.20
89_T94_D0.5870.20
6_L136_Y0.5870.20
92_E121_L0.5860.20
70_R73_E0.5840.20
42_M63_D0.5840.20
10_S13_G0.5820.20
27_E107_A0.5770.19
38_P50_K0.5760.19
12_Q169_K0.5760.19
103_G106_I0.5750.19
42_M84_E0.5740.19
25_K85_G0.5740.19
91_E175_Y0.5730.19
38_P152_I0.5720.19
32_D144_Q0.5720.19
137_T140_Q0.5720.19
74_A84_E0.5700.19
16_G172_M0.5700.19
123_E141_L0.5690.19
10_S97_M0.5670.19
15_I173_L0.5640.19
45_S50_K0.5640.19
19_T170_V0.5630.19
92_E96_L0.5600.19
93_G97_M0.5510.18
40_A80_E0.5510.18
87_A159_P0.5500.18
95_E132_V0.5480.18
98_K101_N0.5450.18
37_Q40_A0.5440.18
33_L146_T0.5440.18
96_L105_P0.5430.18
29_P32_D0.5420.18
125_Y131_R0.5410.18
114_S120_Q0.5390.18
74_A81_D0.5390.18
36_E149_K0.5390.18
31_A56_T0.5380.18
174_Q180_I0.5380.18
77_Q81_D0.5350.18
20_T135_Q0.5300.18
25_K177_D0.5290.18
10_S109_Q0.5270.17
68_F71_I0.5260.17
21_P161_V0.5250.17
96_L153_Q0.5250.17
155_E176_P0.5250.17
11_V81_D0.5230.17
105_P134_I0.5230.17
71_I105_P0.5210.17
55_Q64_R0.5210.17
11_V164_T0.5210.17
79_H86_I0.5210.17
67_V71_I0.5210.17
144_Q162_E0.5210.17
10_S90_A0.5150.17
94_D97_M0.5140.17
135_Q179_N0.5110.17
104_N108_S0.5110.17
55_Q114_S0.5080.17
94_D100_E0.5050.17
8_M172_M0.5010.17
59_W127_P0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1to2I 1 0.3298 6.7 0.96 Contact Map
2xcmC 1 0.4346 4.3 0.964 Contact Map
1rl1A 1 0.4293 4.2 0.964 Contact Map
1urqA 1 0.3037 3.8 0.965 Contact Map
3oonA 2 0.2565 3.6 0.965 Contact Map
1dwmA 1 0.3613 3.3 0.966 Contact Map
2ejxA 2 0.466 3 0.966 Contact Map
1vbwA 1 0.356 2.8 0.967 Contact Map
2rh0A 2 0.4817 2.7 0.967 Contact Map
3plvC 1 0.1047 2.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.