GREMLIN Database
FLGL - Flagellar hook-associated protein 3
UniProt: P96501 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (284)
Sequences: 6388 (4835)
Seq/√Len: 286.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_R218_D4.5271.00
111_G115_K3.6711.00
83_G121_L3.5601.00
90_V114_V3.3391.00
257_S261_D2.9491.00
89_K113_E2.9231.00
29_Q267_V2.8601.00
63_K246_S2.7131.00
60_Q249_E2.6511.00
103_G106_E2.6151.00
35_K42_D2.5371.00
53_N256_L2.4941.00
266_E270_E2.4821.00
19_S281_T2.4421.00
116_Q119_E2.4161.00
61_Q64_S2.3841.00
256_L260_E2.3761.00
120_Q123_N2.3621.00
262_V267_V2.3441.00
34_K260_E2.3311.00
86_I121_L2.3281.00
86_I117_L2.3051.00
66_A242_N2.2761.00
36_I45_V2.2461.00
57_S92_E2.1461.00
26_L274_Q2.1411.00
89_K93_L2.1161.00
25_K29_Q2.0461.00
77_E228_R2.0261.00
87_L217_I2.0101.00
104_E108_Q1.9981.00
73_L231_L1.9731.00
28_S38_K1.9631.00
227_E230_D1.8771.00
108_Q112_V1.8361.00
90_V117_L1.8341.00
49_S260_E1.8311.00
142_K145_V1.8141.00
93_L113_E1.7741.00
53_N260_E1.7571.00
94_A214_L1.7481.00
115_K203_N1.7341.00
218_D222_D1.7291.00
82_E85_D1.6921.00
89_K92_E1.6721.00
83_G224_M1.6501.00
87_L224_M1.6351.00
100_D107_R1.5911.00
87_L221_S1.5441.00
100_D207_L1.5381.00
143_P146_T1.5361.00
139_N142_K1.5221.00
42_D45_V1.5211.00
110_I114_V1.5181.00
86_I124_I1.5121.00
109_A112_V1.4881.00
111_G114_V1.4631.00
93_L110_I1.4591.00
110_I204_S1.4581.00
59_V245_L1.4531.00
45_V259_N1.4531.00
115_K119_E1.4461.00
90_V217_I1.4461.00
83_G86_I1.4281.00
26_L270_E1.4261.00
115_K118_K1.4201.00
112_V230_D1.4041.00
86_I120_Q1.3941.00
97_A110_I1.3911.00
118_K122_L1.3821.00
102_N106_E1.3811.00
157_D163_V1.3641.00
70_F239_E1.3411.00
106_E109_A1.3361.00
26_L267_V1.3251.00
204_S210_M1.3231.00
98_Q211_D1.3221.00
36_I49_S1.3101.00
79_N128_Q1.3071.00
249_E253_T1.2991.00
122_L126_N1.2961.00
105_P222_D1.2901.00
79_N124_I1.2861.00
14_R18_S1.2761.00
105_P108_Q1.2691.00
272_I275_Q1.2681.00
56_L253_T1.2631.00
206_S209_G1.2621.00
193_E197_S1.2551.00
268_I272_I1.2431.00
123_N127_T1.2391.00
80_I83_G1.2331.00
91_R95_V1.2291.00
88_S91_R1.2151.00
118_K199_E1.2141.00
208_D212_S1.2121.00
243_T246_S1.2061.00
18_S22_K1.2051.00
84_I221_S1.2001.00
102_N110_I1.1891.00
215_N219_H1.1871.00
84_I225_S1.1871.00
81_T85_D1.1861.00
30_I267_V1.1811.00
67_S242_N1.1751.00
205_G209_G1.1721.00
66_A245_L1.1561.00
56_L252_A1.1491.00
282_L292_T1.1461.00
22_K274_Q1.1401.00
230_D234_R1.1311.00
8_I24_D1.1291.00
116_Q234_R1.1261.00
80_I224_M1.1241.00
96_E110_I1.1221.00
112_V226_A1.1201.00
62_Y245_L1.1201.00
51_K106_E1.1131.00
207_L211_D1.1091.00
50_L53_N1.1081.00
126_N136_N1.1051.00
64_S68_Q1.1041.00
36_I41_D1.1021.00
133_Y136_N1.0981.00
61_Q92_E1.0931.00
203_N209_G1.0921.00
268_I271_F1.0881.00
254_K258_D1.0861.00
157_D160_D1.0831.00
95_V214_L1.0801.00
7_M11_N1.0631.00
63_K249_E1.0601.00
82_E124_I1.0461.00
90_V118_K1.0451.00
271_F275_Q1.0441.00
28_S37_S1.0431.00
70_F242_N1.0421.00
66_A238_L1.0411.00
264_L268_I1.0341.00
84_I88_S1.0231.00
283_A287_Q1.0221.00
153_Y156_S1.0171.00
195_L198_F1.0091.00
83_G124_I1.0011.00
28_S32_S0.9861.00
60_Q63_K0.9851.00
270_E273_A0.9821.00
219_H223_G0.9811.00
59_V249_E0.9761.00
141_D144_P0.9731.00
9_Q13_L0.9701.00
141_D146_T0.9701.00
23_L27_Q0.9611.00
34_K262_V0.9611.00
53_N57_S0.9561.00
20_Y278_H0.9551.00
11_N14_R0.9511.00
88_S221_S0.9431.00
19_S23_L0.9421.00
27_Q271_F0.9381.00
219_H222_D0.9371.00
61_Q65_N0.9341.00
13_L17_G0.9341.00
114_V118_K0.9251.00
120_Q237_R0.9221.00
25_K28_S0.9221.00
94_A210_M0.9211.00
179_S182_G0.9201.00
63_K245_L0.9171.00
95_V98_Q0.9151.00
59_V63_K0.9141.00
49_S256_L0.9131.00
14_R250_E0.9121.00
84_I224_M0.9121.00
115_K199_E0.9061.00
99_N102_N0.9051.00
95_V218_D0.9051.00
26_L262_V0.9051.00
70_F74_E0.9041.00
94_A198_F0.9021.00
71_T129_V0.8931.00
70_F235_Y0.8921.00
94_A213_V0.8891.00
94_A98_Q0.8881.00
212_S216_D0.8861.00
161_V164_N0.8841.00
91_R214_L0.8801.00
160_D163_V0.8791.00
278_H282_L0.8721.00
184_T189_Q0.8701.00
202_L205_G0.8691.00
133_Y144_P0.8601.00
267_V270_E0.8591.00
114_V202_L0.8581.00
199_E202_L0.8561.00
125_A135_F0.8531.00
89_K117_L0.8521.00
190_N193_E0.8511.00
13_L269_T0.8511.00
215_N218_D0.8501.00
199_E203_N0.8501.00
93_L96_E0.8501.00
19_S22_K0.8481.00
94_A217_I0.8481.00
82_E240_L0.8471.00
270_E274_Q0.8471.00
4_T7_M0.8451.00
176_D179_S0.8401.00
192_F195_L0.8391.00
15_Y32_S0.8391.00
4_T34_K0.8381.00
159_A164_N0.8341.00
16_I278_H0.8301.00
85_D88_S0.8261.00
74_E235_Y0.8241.00
32_S37_S0.8241.00
22_K25_K0.8171.00
18_S21_S0.8121.00
16_I282_L0.8100.99
141_D145_V0.8050.99
161_V167_N0.8020.99
241_V245_L0.8020.99
56_L256_L0.7940.99
193_E196_D0.7930.99
24_D27_Q0.7920.99
226_A230_D0.7910.99
157_D161_V0.7890.99
291_P295_D0.7890.99
222_D226_A0.7870.99
98_Q214_L0.7860.99
177_P181_F0.7830.99
29_Q262_V0.7830.99
81_T228_R0.7780.99
275_Q279_R0.7770.99
73_L238_L0.7760.99
175_S178_K0.7750.99
114_V204_S0.7740.99
122_L125_A0.7700.99
292_T295_D0.7680.99
235_Y239_E0.7640.99
138_T157_D0.7630.99
69_A238_L0.7630.99
283_A295_D0.7600.99
63_K67_S0.7570.99
210_M213_V0.7510.99
142_K146_T0.7500.99
111_G118_K0.7500.99
47_M109_A0.7470.99
88_S92_E0.7450.99
196_D200_K0.7400.99
118_K196_D0.7360.99
19_S274_Q0.7360.99
37_S41_D0.7300.99
158_T161_V0.7300.99
90_V195_L0.7260.99
22_K270_E0.7250.99
179_S183_G0.7240.99
98_Q210_M0.7210.99
248_Q252_A0.7210.99
102_N109_A0.7190.99
189_Q193_E0.7180.99
98_Q102_N0.7140.99
151_G154_T0.7130.99
50_L225_S0.7130.99
117_L120_Q0.7130.99
23_L275_Q0.7040.99
93_L117_L0.7010.99
158_T163_V0.7010.99
166_S169_M0.7000.99
282_L285_N0.6990.99
151_G156_S0.6980.99
151_G157_D0.6940.98
178_K182_G0.6890.98
44_V48_K0.6880.98
206_S210_M0.6820.98
111_G203_N0.6820.98
103_G109_A0.6790.98
136_N139_N0.6790.98
155_I161_V0.6780.98
9_Q269_T0.6750.98
111_G205_G0.6750.98
242_N246_S0.6740.98
16_I281_T0.6710.98
139_N157_D0.6710.98
57_S60_Q0.6700.98
159_A165_I0.6700.98
246_S249_E0.6690.98
250_E254_K0.6690.98
21_S25_K0.6690.98
112_V115_K0.6690.98
79_N135_F0.6670.98
102_N107_R0.6670.98
94_A114_V0.6650.98
9_Q12_S0.6610.98
107_R210_M0.6590.98
19_S278_H0.6580.98
77_E231_L0.6570.98
79_N127_T0.6560.98
213_V217_I0.6550.98
76_T175_S0.6540.98
271_F278_H0.6520.98
66_A241_V0.6520.98
221_S225_S0.6520.98
113_E233_A0.6510.98
97_A107_R0.6470.98
23_L26_L0.6460.98
216_D219_H0.6460.98
223_G226_A0.6440.97
279_R283_A0.6430.97
273_A277_V0.6420.97
175_S181_F0.6420.97
60_Q266_E0.6420.97
76_T231_L0.6350.97
63_K242_N0.6340.97
73_L234_R0.6330.97
118_K121_L0.6330.97
137_G144_P0.6320.97
8_I27_Q0.6310.97
137_G141_D0.6310.97
150_D155_I0.6300.97
103_G131_G0.6300.97
21_S24_D0.6290.97
165_I241_V0.6280.97
209_G213_V0.6260.97
139_N144_P0.6250.97
281_T284_V0.6230.97
153_Y157_D0.6220.97
113_E117_L0.6220.97
146_T151_G0.6200.97
8_I12_S0.6170.97
275_Q287_Q0.6150.97
26_L29_Q0.6150.97
239_E243_T0.6090.96
175_S180_A0.6070.96
192_F197_S0.6070.96
191_V195_L0.6040.96
136_N142_K0.6010.96
55_Q58_Q0.5990.96
7_M10_Q0.5990.96
84_I228_R0.5940.96
90_V121_L0.5930.96
10_Q14_R0.5930.96
112_V229_S0.5910.96
213_V216_D0.5910.96
280_A283_A0.5900.96
71_T74_E0.5890.96
81_T84_I0.5890.96
97_A210_M0.5880.96
158_T178_K0.5870.96
212_S215_N0.5850.96
35_K64_S0.5830.96
78_T251_T0.5820.95
23_L278_H0.5800.95
247_A251_T0.5790.95
247_A250_E0.5780.95
57_S88_S0.5770.95
83_G135_F0.5770.95
47_M130_N0.5770.95
15_Y28_S0.5770.95
203_N206_S0.5730.95
68_Q71_T0.5720.95
133_Y143_P0.5720.95
284_V287_Q0.5690.95
160_D165_I0.5690.95
116_Q237_R0.5670.95
119_E123_N0.5660.95
76_T134_I0.5650.95
233_A236_N0.5630.95
35_K45_V0.5620.95
30_I268_I0.5610.94
155_I163_V0.5610.94
283_A286_A0.5600.94
177_P182_G0.5590.94
202_L213_V0.5570.94
176_D182_G0.5560.94
94_A97_A0.5560.94
257_S260_E0.5550.94
157_D165_I0.5550.94
204_S207_L0.5540.94
178_K183_G0.5540.94
111_G202_L0.5530.94
214_L218_D0.5500.94
146_T156_S0.5490.94
161_V166_S0.5480.94
72_W134_I0.5430.93
25_K40_S0.5400.93
204_S213_V0.5400.93
50_L260_E0.5400.93
194_M198_F0.5400.93
285_N289_V0.5380.93
12_S15_Y0.5380.93
161_V168_N0.5360.93
125_A192_F0.5360.93
278_H281_T0.5340.93
96_E102_N0.5340.93
264_L293_L0.5330.93
150_D154_T0.5320.93
79_N83_G0.5310.93
8_I16_I0.5290.93
80_I228_R0.5280.93
229_S237_R0.5270.92
128_Q131_G0.5250.92
117_L240_L0.5250.92
175_S179_S0.5220.92
194_M197_S0.5210.92
73_L235_Y0.5210.92
165_I168_N0.5210.92
196_D199_E0.5200.92
163_V167_N0.5190.92
25_K38_K0.5180.92
143_P154_T0.5160.92
17_G20_Y0.5100.91
244_R248_Q0.5100.91
151_G155_I0.5090.91
111_G204_S0.5090.91
151_G160_D0.5080.91
54_T131_G0.5080.91
136_N144_P0.5060.91
46_A50_L0.5050.91
151_G161_V0.5040.91
164_N168_N0.5030.91
75_N129_V0.5030.91
208_D211_D0.5030.91
158_T162_V0.5020.91
36_I260_E0.5020.91
271_F287_Q0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ucuA 1 1 100 0.262 Contact Map
3pwxA 2 0.7349 100 0.367 Contact Map
2d4xA 1 0.6477 100 0.39 Contact Map
3k8wA 1 0.7181 100 0.45 Contact Map
4nx9A 1 0.6409 100 0.57 Contact Map
3v47C 1 0.5604 99.9 0.611 Contact Map
4cfiA 1 0.5705 99.9 0.658 Contact Map
1io1A 1 0.6711 99.8 0.666 Contact Map
3k1iC 1 0.3993 99.4 0.775 Contact Map
1oryB 2 0.1275 97.3 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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