GREMLIN Database
YVHJ - Putative transcriptional regulator YvhJ
UniProt: P96499 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (310)
Sequences: 5486 (4059)
Seq/√Len: 230.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_D208_H5.7971.00
189_D201_Y4.1411.00
116_I135_I4.0341.00
181_D206_E3.9371.00
161_K269_N3.7271.00
210_N213_E3.5201.00
100_I113_M3.3641.00
40_G44_Y3.0121.00
218_A238_I2.9641.00
226_R233_D2.9201.00
187_D203_K2.8841.00
101_V159_I2.8271.00
78_S103_T2.7031.00
102_V113_M2.6921.00
183_D206_E2.6801.00
99_L135_I2.5971.00
187_D204_K2.5751.00
82_M147_T2.3511.00
208_H245_R2.3401.00
116_I151_V2.1701.00
133_T137_A2.1561.00
120_T312_P2.1521.00
101_V157_I2.0891.00
313_D316_N2.0821.00
114_L324_L2.0501.00
203_K207_M2.0421.00
41_Y45_K2.0371.00
123_Q132_K2.0321.00
37_G41_Y2.0271.00
322_K326_E2.0171.00
38_L42_K2.0041.00
142_G146_E1.9901.00
177_V242_L1.9891.00
82_M99_L1.9591.00
171_K212_E1.9371.00
105_D108_N1.9321.00
217_Y234_R1.9281.00
209_L213_E1.8571.00
20_I23_R1.8301.00
99_L147_T1.8201.00
271_R274_E1.8091.00
34_V38_L1.7721.00
124_L138_A1.7611.00
176_E261_K1.7341.00
170_F218_A1.6871.00
80_L151_V1.6751.00
184_V207_M1.6721.00
187_D201_Y1.6621.00
19_K23_R1.6271.00
76_P106_P1.6201.00
123_Q153_N1.6151.00
175_N211_G1.6061.00
152_E158_P1.6011.00
36_V40_G1.5991.00
20_I24_I1.5781.00
135_I151_V1.5651.00
30_L34_V1.5641.00
77_F104_L1.5621.00
134_K309_Y1.5581.00
81_F102_V1.5451.00
21_L24_I1.5341.00
96_S147_T1.5331.00
224_D230_G1.5321.00
170_F215_L1.5011.00
146_E150_T1.4831.00
197_S222_K1.4821.00
124_L133_T1.4811.00
23_R27_L1.4601.00
121_R309_Y1.4551.00
172_D264_E1.4391.00
317_L321_R1.4021.00
133_T141_K1.3911.00
180_I238_I1.3871.00
121_R134_K1.3811.00
121_R132_K1.3501.00
217_Y237_Q1.3491.00
185_P237_Q1.3441.00
220_M223_Q1.3421.00
148_V152_E1.3411.00
229_F310_F1.3411.00
180_I241_A1.3291.00
316_N319_K1.3211.00
280_Q283_S1.3161.00
318_E322_K1.3131.00
177_V246_M1.3131.00
314_A318_E1.3031.00
183_D207_M1.3031.00
154_F317_L1.3031.00
124_L150_T1.3001.00
138_A142_G1.2991.00
43_L47_I1.2861.00
26_L30_L1.2841.00
122_V150_T1.2731.00
184_V203_K1.2621.00
182_V209_L1.2511.00
76_P103_T1.2321.00
172_D265_N1.2301.00
167_F215_L1.2221.00
127_D131_S1.2221.00
276_L280_Q1.2191.00
202_F216_A1.2171.00
125_A146_E1.2151.00
319_K323_T1.2071.00
25_M29_A1.2061.00
179_G211_G1.1971.00
230_G233_D1.1801.00
138_A147_T1.1791.00
321_R325_Q1.1711.00
312_P317_L1.1681.00
306_N309_Y1.1631.00
182_V238_I1.1621.00
113_M292_T1.1601.00
184_V202_F1.1571.00
224_D234_R1.1531.00
112_K291_D1.1511.00
297_G310_F1.1471.00
121_R307_T1.1351.00
188_F202_F1.1331.00
96_S138_A1.1251.00
241_A245_R1.1201.00
156_Q325_Q1.1201.00
245_R248_S1.1171.00
101_V155_L1.1151.00
174_I238_I1.1141.00
82_M144_K1.1121.00
42_K45_K1.1121.00
137_A140_S1.1101.00
33_L36_V1.1081.00
148_V269_N1.1071.00
22_K26_L1.0991.00
181_D245_R1.0981.00
226_R230_G1.0951.00
23_R26_L1.0921.00
100_I239_L1.0851.00
148_V162_Y1.0821.00
19_K22_K1.0801.00
180_I214_A1.0741.00
124_L146_E1.0691.00
110_T291_D1.0631.00
96_S99_L1.0561.00
213_E216_A1.0541.00
116_I120_T1.0521.00
188_F220_M1.0461.00
232_N236_K1.0441.00
223_Q226_R1.0401.00
137_A141_K1.0291.00
182_V217_Y1.0281.00
241_A244_D1.0251.00
49_A263_S1.0211.00
39_G43_L1.0181.00
36_V39_G1.0161.00
76_P105_D1.0141.00
86_D166_D1.0081.00
103_T114_L1.0071.00
150_T154_F1.0061.00
191_K199_R1.0041.00
127_D146_E1.0041.00
39_G42_K0.9931.00
95_R141_K0.9841.00
122_V135_I0.9821.00
79_I102_V0.9821.00
202_F209_L0.9761.00
229_F297_G0.9691.00
119_D134_K0.9641.00
75_K107_K0.9621.00
237_Q241_A0.9601.00
125_A150_T0.9591.00
96_S164_T0.9501.00
95_R137_A0.9451.00
198_K216_A0.9411.00
15_S19_K0.9401.00
78_S160_D0.9391.00
144_K162_Y0.9391.00
175_N210_N0.9391.00
156_Q321_R0.9381.00
182_V241_A0.9361.00
220_M224_D0.9321.00
42_K46_T0.9311.00
101_V116_I0.9251.00
184_V187_D0.9241.00
134_K307_T0.9241.00
236_K292_T0.9191.00
79_I104_L0.9191.00
35_V39_G0.9181.00
165_V169_G0.9171.00
33_L37_G0.9151.00
77_F106_P0.9121.00
300_L311_E0.9081.00
256_D260_E0.9071.00
257_K261_K0.8990.99
124_L127_D0.8970.99
236_K294_S0.8960.99
77_F161_K0.8860.99
37_G40_G0.8840.99
125_A149_E0.8840.99
185_P217_Y0.8830.99
125_A153_N0.8820.99
139_Y164_T0.8820.99
183_D204_K0.8820.99
238_I242_L0.8800.99
202_F207_M0.8790.99
146_E149_E0.8790.99
160_D269_N0.8750.99
45_K49_A0.8740.99
43_L46_T0.8640.99
316_N323_T0.8620.99
254_K257_K0.8610.99
47_I50_A0.8540.99
81_F163_V0.8470.99
190_E223_Q0.8450.99
276_L279_Q0.8430.99
38_L41_Y0.8390.99
134_K308_Y0.8350.99
174_I177_V0.8350.99
18_R22_K0.8330.99
227_G230_G0.8290.99
31_A34_V0.8270.99
44_Y48_N0.8250.99
229_F232_N0.8170.99
274_E277_A0.8160.99
45_K260_E0.8140.99
118_R221_R0.8140.99
87_Y167_F0.8120.99
63_S66_R0.8030.99
249_A254_K0.8020.99
80_L99_L0.8000.99
212_E216_A0.7980.99
81_F169_G0.7970.99
133_T307_T0.7970.99
190_E202_F0.7940.99
318_E321_R0.7940.99
126_G146_E0.7930.99
232_N294_S0.7880.99
183_D237_Q0.7870.99
188_F224_D0.7840.99
85_E95_R0.7840.99
29_A33_L0.7810.99
236_K240_N0.7790.98
79_I270_I0.7780.98
187_D207_M0.7780.98
165_V266_V0.7780.98
317_L320_V0.7770.98
305_N309_Y0.7760.98
22_K25_M0.7730.98
29_A32_L0.7730.98
215_L219_R0.7700.98
95_R140_S0.7680.98
134_K137_A0.7640.98
87_Y90_K0.7610.98
298_S313_D0.7580.98
95_R133_T0.7580.98
75_K106_P0.7580.98
200_I213_E0.7580.98
173_V258_I0.7560.98
174_I210_N0.7550.98
161_K271_R0.7540.98
200_I216_A0.7520.98
299_D308_Y0.7470.98
148_V159_I0.7440.98
154_F312_P0.7440.98
84_I87_Y0.7410.98
27_L31_A0.7410.98
84_I164_T0.7380.98
270_I275_G0.7380.98
200_I207_M0.7360.98
176_E257_K0.7350.98
17_R21_L0.7330.98
259_A263_S0.7320.98
42_K47_I0.7300.98
240_N244_D0.7300.98
23_R30_L0.7280.98
105_D110_T0.7250.98
301_Y308_Y0.7240.98
180_I245_R0.7240.98
223_Q234_R0.7210.97
243_I247_S0.7200.97
253_A257_K0.7190.97
233_D236_K0.7170.97
191_K197_S0.7170.97
121_R302_L0.7170.97
184_V209_L0.7160.97
112_K323_T0.7160.97
171_K215_L0.7160.97
122_V154_F0.7130.97
185_P204_K0.7110.97
41_Y44_Y0.7090.97
25_M32_L0.7040.97
112_K293_L0.7010.97
272_I275_G0.7010.97
111_M285_F0.7010.97
93_K140_S0.6990.97
100_I232_N0.6980.97
21_L25_M0.6960.97
40_G45_K0.6930.97
233_D237_Q0.6920.97
191_K200_I0.6890.97
152_E157_I0.6870.97
173_V177_V0.6790.96
115_S236_K0.6790.96
124_L141_K0.6780.96
18_R21_L0.6770.96
36_V41_Y0.6760.96
190_E220_M0.6760.96
15_S20_I0.6740.96
315_T319_K0.6740.96
80_L101_V0.6740.96
81_F165_V0.6730.96
99_L116_I0.6720.96
104_L278_L0.6710.96
38_L46_T0.6690.96
182_V237_Q0.6670.96
151_V155_L0.6650.96
121_R300_L0.6620.96
127_D141_K0.6620.96
319_K322_K0.6610.96
270_I274_E0.6580.96
232_N292_T0.6570.96
315_T318_E0.6510.95
186_F204_K0.6490.95
229_F294_S0.6480.95
86_D164_T0.6450.95
169_G173_V0.6430.95
24_I27_L0.6400.95
190_E197_S0.6400.95
135_I150_T0.6400.95
202_F213_E0.6390.95
190_E198_K0.6390.95
329_D332_P0.6380.95
260_E263_S0.6370.95
82_M96_S0.6350.95
234_R237_Q0.6340.95
251_N254_K0.6340.95
164_T267_E0.6330.95
184_V237_Q0.6330.95
27_L38_L0.6320.95
190_E200_I0.6310.95
281_I285_F0.6310.95
237_Q240_N0.6300.95
322_K325_Q0.6260.94
116_I155_L0.6250.94
299_D310_F0.6250.94
249_A252_I0.6240.94
144_K164_T0.6240.94
296_T316_N0.6230.94
302_L311_E0.6180.94
37_G44_Y0.6180.94
161_K274_E0.6160.94
169_G265_N0.6150.94
64_N67_N0.6130.94
103_T327_H0.6130.94
109_K284_G0.6130.94
34_V37_G0.6130.94
273_T276_L0.6120.94
321_R324_L0.6120.94
115_S232_N0.6110.94
217_Y238_I0.6110.94
331_T334_T0.6100.94
26_L29_A0.6100.94
13_K17_R0.6090.94
45_K48_N0.6080.93
247_S250_S0.6020.93
46_T50_A0.6010.93
279_Q283_S0.5970.93
97_D221_R0.5930.93
131_S146_E0.5930.93
173_V242_L0.5930.93
184_V206_E0.5930.93
28_F31_A0.5880.92
261_K265_N0.5860.92
94_G139_Y0.5860.92
176_E258_I0.5840.92
240_N292_T0.5820.92
88_A168_D0.5810.92
42_K260_E0.5810.92
325_Q330_Y0.5810.92
179_G208_H0.5800.92
97_D118_R0.5800.92
145_D149_E0.5790.92
120_T295_I0.5780.92
40_G43_L0.5780.92
302_L309_Y0.5770.92
38_L43_L0.5770.92
108_N111_M0.5760.92
92_Q95_R0.5750.91
166_D265_N0.5730.91
174_I242_L0.5730.91
285_F288_K0.5720.91
137_A307_T0.5700.91
173_V176_E0.5700.91
188_F200_I0.5690.91
185_P258_I0.5690.91
120_T162_Y0.5690.91
287_S290_I0.5670.91
22_K27_L0.5640.91
172_D176_E0.5630.91
308_Y311_E0.5630.91
137_A308_Y0.5630.91
181_D207_M0.5610.90
302_L305_N0.5600.90
80_L147_T0.5590.90
139_Y234_R0.5580.90
140_S146_E0.5580.90
17_R22_K0.5580.90
297_G300_L0.5570.90
239_L243_I0.5550.90
98_S218_A0.5540.90
39_G44_Y0.5530.90
166_D170_F0.5530.90
188_F201_Y0.5520.90
28_F35_V0.5510.90
65_L68_E0.5510.90
31_A35_V0.5510.90
79_I161_K0.5500.90
190_E216_A0.5490.90
190_E222_K0.5490.90
320_V323_T0.5470.89
15_S18_R0.5440.89
174_I268_T0.5430.89
65_L70_V0.5400.89
147_T154_F0.5380.89
122_V125_A0.5380.89
186_F225_K0.5370.88
97_D136_N0.5350.88
100_I115_S0.5340.88
36_V44_Y0.5340.88
171_K175_N0.5330.88
293_L323_T0.5320.88
133_T306_N0.5320.88
227_G308_Y0.5310.88
185_P207_M0.5280.88
139_Y144_K0.5280.88
117_P294_S0.5270.88
117_P229_F0.5260.87
133_T138_A0.5260.87
186_F230_G0.5250.87
86_D94_G0.5240.87
330_Y334_T0.5220.87
175_N179_G0.5210.87
17_R23_R0.5200.87
318_E325_Q0.5200.87
120_T310_F0.5200.87
108_N327_H0.5190.87
172_D175_N0.5180.87
120_T154_F0.5180.87
77_F278_L0.5180.87
18_R23_R0.5170.87
117_P232_N0.5140.86
79_I163_V0.5140.86
98_S165_V0.5140.86
57_L148_V0.5120.86
223_Q230_G0.5110.86
53_S56_A0.5100.86
78_S328_L0.5080.86
44_Y47_I0.5070.86
21_L35_V0.5060.85
98_S115_S0.5060.85
22_K46_T0.5060.85
119_D221_R0.5050.85
215_L218_A0.5050.85
168_D172_D0.5040.85
138_A150_T0.5040.85
114_L155_L0.5030.85
112_K327_H0.5020.85
126_G130_G0.5010.85
324_L327_H0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3owqA 1 0.6164 100 0.232 Contact Map
3pe5A 1 0.6931 100 0.237 Contact Map
3nxhA 1 0.555 100 0.277 Contact Map
4de9A 1 0.6113 100 0.297 Contact Map
3qfiA 1 0.665 100 0.302 Contact Map
3okzA 1 0.734 100 0.308 Contact Map
2xxpA 1 0.8286 100 0.318 Contact Map
4obmA 1 0.6471 97.3 0.918 Contact Map
2m8rA 1 0.11 81.9 0.951 Contact Map
2kogA 1 0.11 73.9 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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