GREMLIN Database
YWPJ - Putative phosphatase YwpJ
UniProt: P94592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (253)
Sequences: 10701 (8714)
Seq/√Len: 547.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_L279_H4.1681.00
15_S273_D3.5361.00
234_A248_A3.1371.00
271_T274_E2.9711.00
245_L251_G2.8641.00
20_S275_H2.7141.00
22_E275_H2.5951.00
222_A232_T2.5561.00
259_E263_S2.4651.00
22_E282_K2.4551.00
6_I37_V2.4361.00
14_N18_Q2.4141.00
41_T48_V2.3411.00
246_E264_I2.3401.00
219_K247_A2.3011.00
229_L247_A2.0701.00
2_K231_E2.0461.00
213_S243_S2.0391.00
29_Q32_R1.9251.00
21_L25_N1.9241.00
242_K261_I1.8811.00
239_L260_D1.8811.00
78_H220_R1.8501.00
253_A265_A1.8311.00
251_G266_D1.8301.00
242_K264_I1.8211.00
27_L37_V1.8151.00
29_Q282_K1.8041.00
259_E262_K1.8031.00
30_A35_I1.7731.00
270_L274_E1.7661.00
24_E54_P1.7641.00
239_L258_R1.7631.00
3_L38_V1.7461.00
83_D86_R1.7221.00
228_P231_E1.7141.00
219_K223_K1.7001.00
250_K267_A1.6611.00
29_Q33_D1.6601.00
5_A218_L1.6511.00
250_K266_D1.6171.00
71_D75_R1.6151.00
220_R224_Q1.6041.00
220_R223_K1.5941.00
86_R194_D1.5861.00
252_V280_M1.5761.00
261_I264_I1.5701.00
218_L244_M1.5581.00
215_G247_A1.5461.00
20_S23_N1.5441.00
8_L13_L1.5431.00
216_Q219_K1.5421.00
80_E220_R1.5341.00
6_I235_V1.5171.00
94_L174_G1.5141.00
267_A284_L1.4941.00
36_E225_L1.4711.00
267_A280_M1.4681.00
235_V277_V1.4521.00
23_N275_H1.4491.00
156_S159_E1.4461.00
95_E112_P1.4421.00
25_N29_Q1.4411.00
234_A244_M1.4261.00
230_E249_G1.4151.00
186_W190_E1.4021.00
89_D194_D1.4011.00
22_E279_H1.3981.00
24_E28_R1.3731.00
253_A257_A1.3321.00
31_Q58_K1.3051.00
76_L79_H1.3021.00
255_G271_T1.3001.00
86_R89_D1.2981.00
245_L261_I1.2921.00
235_V280_M1.2891.00
26_A278_A1.2871.00
79_H168_D1.2741.00
242_K246_E1.2631.00
229_L232_T1.2621.00
222_A229_L1.2601.00
5_A40_S1.2571.00
196_T243_S1.2441.00
80_E209_S1.2411.00
93_W97_E1.2331.00
181_K184_A1.2281.00
97_E188_R1.2161.00
28_R32_R1.1991.00
262_K268_V1.1941.00
260_D263_S1.1901.00
68_V76_L1.1891.00
84_K88_Y1.1841.00
4_I281_M1.1831.00
267_A283_H1.1761.00
26_A282_K1.1731.00
86_R195_L1.1721.00
14_N273_D1.1631.00
60_W225_L1.1631.00
3_L227_I1.1521.00
4_I35_I1.1451.00
79_H170_Y1.1401.00
3_L222_A1.1371.00
232_T248_A1.1341.00
183_E199_S1.1281.00
277_V281_M1.1241.00
38_V221_L1.1151.00
38_V60_W1.1111.00
22_E26_A1.1031.00
256_N272_N1.1011.00
269_T280_M1.1001.00
4_I30_A1.0941.00
258_R261_I1.0941.00
183_E187_K1.0941.00
196_T211_K1.0941.00
234_A245_L1.0881.00
233_A284_L1.0871.00
229_L249_G1.0861.00
194_D210_R1.0841.00
69_I220_R1.0781.00
31_Q59_T1.0781.00
5_A232_T1.0691.00
62_I217_A1.0611.00
21_L24_E1.0571.00
28_R31_Q1.0561.00
269_T276_G1.0531.00
254_M276_G1.0501.00
252_V269_T1.0421.00
171_N206_E1.0421.00
233_A250_K1.0421.00
15_S272_N1.0401.00
209_S212_A1.0351.00
248_A251_G1.0301.00
8_L51_I1.0131.00
252_V267_A1.0051.00
238_S258_R1.0041.00
198_V208_S1.0021.00
233_A280_M0.9981.00
213_S216_Q0.9911.00
222_A247_A0.9781.00
278_A282_K0.9781.00
233_A252_V0.9761.00
218_L248_A0.9741.00
222_A227_I0.9721.00
93_W96_S0.9651.00
255_G262_K0.9641.00
12_L23_N0.9591.00
3_L232_T0.9591.00
270_L276_G0.9591.00
92_S96_S0.9591.00
69_I78_H0.9581.00
28_R56_G0.9571.00
12_L27_L0.9521.00
257_A262_K0.9491.00
176_S181_K0.9441.00
219_K229_L0.9431.00
81_T168_D0.9421.00
187_K190_E0.9401.00
79_H106_G0.9371.00
253_A261_I0.9351.00
67_A212_A0.9351.00
35_I233_A0.9291.00
45_H63_S0.9261.00
221_L225_L0.9261.00
215_G243_S0.9251.00
6_I277_V0.9211.00
80_E211_K0.9161.00
280_M284_L0.9151.00
88_Y92_S0.9121.00
184_A188_R0.9031.00
280_M283_H0.9021.00
184_A187_K0.9021.00
239_L242_K0.9001.00
176_S182_L0.8981.00
279_H283_H0.8981.00
70_H76_L0.8961.00
255_G270_L0.8951.00
25_N28_R0.8941.00
254_M269_T0.8851.00
89_D92_S0.8831.00
30_A37_V0.8791.00
49_M74_G0.8751.00
208_S213_S0.8721.00
222_A249_G0.8721.00
232_T249_G0.8691.00
69_I217_A0.8621.00
63_S68_V0.8601.00
116_R120_D0.8571.00
82_I209_S0.8501.00
255_G274_E0.8471.00
41_T63_S0.8461.00
49_M53_E0.8441.00
81_T170_Y0.8431.00
279_H282_K0.8431.00
183_E186_W0.8411.00
70_H74_G0.8391.00
5_A38_V0.8391.00
92_S158_Q0.8321.00
77_Y224_Q0.8321.00
260_D264_I0.8291.00
117_E121_V0.8281.00
4_I233_A0.8271.00
45_H70_H0.8261.00
23_N278_A0.8261.00
154_I157_F0.8251.00
155_N158_Q0.8231.00
62_I221_L0.8191.00
60_W221_L0.8181.00
6_I12_L0.8161.00
8_L39_V0.8101.00
30_A281_M0.8071.00
117_E120_D0.8071.00
155_N159_E0.8061.00
232_T247_A0.8041.00
249_G266_D0.8011.00
245_L264_I0.7971.00
234_A251_G0.7921.00
36_E60_W0.7891.00
85_K89_D0.7871.00
40_S62_I0.7861.00
93_W188_R0.7861.00
14_N20_S0.7831.00
23_N26_A0.7801.00
63_S70_H0.7801.00
197_L207_L0.7801.00
96_S188_R0.7761.00
89_D93_W0.7711.00
116_R119_L0.7711.00
12_L19_V0.7671.00
44_A64_A0.7621.00
16_K273_D0.7601.00
245_L265_A0.7521.00
26_A29_Q0.7521.00
152_A155_N0.7491.00
179_K183_E0.7451.00
178_F181_K0.7421.00
60_W71_D0.7411.00
196_T213_S0.7411.00
270_L283_H0.7381.00
35_I231_E0.7371.00
254_M257_A0.7361.00
91_L95_E0.7361.00
186_W199_S0.7321.00
237_D257_A0.7271.00
257_A261_I0.7261.00
84_K168_D0.7241.00
39_V48_V0.7171.00
218_L234_A0.7161.00
14_N272_N0.7141.00
88_Y158_Q0.7091.00
22_E278_A0.7071.00
97_E184_A0.7071.00
216_Q220_R0.7051.00
75_R224_Q0.7031.00
95_E101_Y0.7001.00
48_V63_S0.6911.00
10_G254_M0.6881.00
67_A209_S0.6831.00
105_T169_F0.6811.00
193_E210_R0.6791.00
65_N206_E0.6761.00
108_A152_A0.6761.00
173_L206_E0.6741.00
231_E249_G0.6731.00
212_A216_Q0.6711.00
251_G261_I0.6701.00
219_K222_A0.6691.00
12_L272_N0.6691.00
267_A279_H0.6681.00
187_K191_H0.6671.00
237_D254_M0.6671.00
48_V61_V0.6631.00
251_G265_A0.6601.00
40_S244_M0.6601.00
235_V252_V0.6601.00
171_N200_S0.6591.00
250_K280_M0.6581.00
243_S246_E0.6561.00
88_Y162_E0.6561.00
22_E25_N0.6511.00
87_A169_F0.6411.00
179_K202_E0.6381.00
267_A270_L0.6371.00
235_V269_T0.6371.00
85_K88_Y0.6331.00
8_L48_V0.6301.00
239_L261_I0.6231.00
68_V170_Y0.6191.00
179_K199_S0.6181.00
256_N262_K0.6181.00
196_T210_R0.6121.00
68_V106_G0.6111.00
201_A238_S0.6111.00
261_I265_A0.6091.00
45_H49_M0.6051.00
91_L103_V0.6051.00
118_L121_V0.6031.00
52_F61_V0.6021.00
159_E162_E0.6011.00
173_L204_N0.6001.00
13_L272_N0.5971.00
95_E158_Q0.5941.00
275_H278_A0.5931.00
188_R191_H0.5931.00
4_I235_V0.5911.00
105_T108_A0.5861.00
197_L205_F0.5841.00
242_K245_L0.5831.00
76_L106_G0.5810.99
84_K162_E0.5780.99
8_L12_L0.5780.99
253_A264_I0.5780.99
58_K72_P0.5770.99
19_V24_E0.5750.99
269_T279_H0.5740.99
20_S278_A0.5730.99
113_Q155_N0.5720.99
31_Q56_G0.5700.99
103_V169_F0.5700.99
26_A30_A0.5700.99
98_N181_K0.5680.99
254_M272_N0.5660.99
30_A278_A0.5650.99
93_W189_Y0.5640.99
190_E197_L0.5640.99
256_N271_T0.5630.99
106_G168_D0.5620.99
50_S53_E0.5610.99
235_V281_M0.5600.99
64_A170_Y0.5600.99
149_S152_A0.5590.99
227_I249_G0.5580.99
3_L221_L0.5570.99
227_I231_E0.5560.99
102_E173_L0.5530.99
252_V266_D0.5520.99
215_G219_K0.5520.99
227_I232_T0.5500.99
64_A204_N0.5470.99
91_L101_Y0.5450.99
275_H279_H0.5440.99
23_N27_L0.5440.99
19_V43_R0.5440.99
27_L281_M0.5420.99
69_I224_Q0.5420.99
211_K216_Q0.5420.99
69_I221_L0.5410.99
6_I30_A0.5410.99
39_V52_F0.5390.99
196_T208_S0.5390.99
101_Y172_I0.5390.99
151_F155_N0.5390.99
215_G232_T0.5380.99
36_E59_T0.5380.99
106_G170_Y0.5360.99
105_T110_Y0.5350.99
278_A281_M0.5330.99
180_E184_A0.5330.99
64_A67_A0.5320.99
174_G207_L0.5270.99
71_D224_Q0.5270.99
71_D77_Y0.5260.99
182_L205_F0.5260.99
99_Y185_G0.5260.99
87_A91_L0.5240.99
87_A172_I0.5230.99
270_L280_M0.5220.99
176_S185_G0.5210.99
150_G153_Y0.5200.99
218_L222_A0.5140.99
182_L186_W0.5140.99
229_L248_A0.5130.99
258_R262_K0.5120.99
12_L277_V0.5120.99
27_L31_Q0.5100.99
12_L39_V0.5090.99
48_V51_I0.5090.99
44_A47_D0.5070.99
105_T170_Y0.5040.99
42_G240_N0.5020.99
25_N282_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 1 100 0.205 Contact Map
3pgvA 3 0.8912 100 0.234 Contact Map
3l7yA 1 0.9018 100 0.255 Contact Map
2b30A 2 0.9088 100 0.258 Contact Map
1nf2A 4 0.9053 100 0.262 Contact Map
1rkqA 1 0.9123 100 0.263 Contact Map
4qjbA 1 0.9018 100 0.266 Contact Map
3daoA 1 0.9053 100 0.266 Contact Map
2rbkA 1 0.8877 100 0.272 Contact Map
3dnpA 2 0.9368 100 0.277 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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