YWPJ - BACSU - GREMLIN Contacts

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YWPJ - Putative phosphatase YwpJ

UniProt:	P94592	Sequences: MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRAHFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYEVFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQELFEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQALKRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHGVAHMMKHLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	285 (253)
Sequences:	10701 (8714)
Seq/√Len:	547.8

ECOLI - SUPH YBHA YIDA YBJI COF YIGL MPGP
BACSU - YWPJ YWTE YHAX YXEH YITU YKRA YCSE NTDB
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
270_L	279_H	4.168	1.00
15_S	273_D	3.536	1.00
234_A	248_A	3.137	1.00
271_T	274_E	2.971	1.00
245_L	251_G	2.864	1.00
20_S	275_H	2.714	1.00
22_E	275_H	2.595	1.00
222_A	232_T	2.556	1.00
259_E	263_S	2.465	1.00
22_E	282_K	2.455	1.00
6_I	37_V	2.436	1.00
14_N	18_Q	2.414	1.00
41_T	48_V	2.341	1.00
246_E	264_I	2.340	1.00
219_K	247_A	2.301	1.00
229_L	247_A	2.070	1.00
2_K	231_E	2.046	1.00
213_S	243_S	2.039	1.00
29_Q	32_R	1.925	1.00
21_L	25_N	1.924	1.00
242_K	261_I	1.881	1.00
239_L	260_D	1.881	1.00
78_H	220_R	1.850	1.00
253_A	265_A	1.831	1.00
251_G	266_D	1.830	1.00
242_K	264_I	1.821	1.00
27_L	37_V	1.815	1.00
29_Q	282_K	1.804	1.00
259_E	262_K	1.803	1.00
30_A	35_I	1.773	1.00
270_L	274_E	1.766	1.00
24_E	54_P	1.764	1.00
239_L	258_R	1.763	1.00
3_L	38_V	1.746	1.00
83_D	86_R	1.722	1.00
228_P	231_E	1.714	1.00
219_K	223_K	1.700	1.00
250_K	267_A	1.661	1.00
29_Q	33_D	1.660	1.00
5_A	218_L	1.651	1.00
250_K	266_D	1.617	1.00
71_D	75_R	1.615	1.00
220_R	224_Q	1.604	1.00
220_R	223_K	1.594	1.00
86_R	194_D	1.586	1.00
252_V	280_M	1.576	1.00
261_I	264_I	1.570	1.00
218_L	244_M	1.558	1.00
215_G	247_A	1.546	1.00
20_S	23_N	1.544	1.00
8_L	13_L	1.543	1.00
216_Q	219_K	1.542	1.00
80_E	220_R	1.534	1.00
6_I	235_V	1.517	1.00
94_L	174_G	1.514	1.00
267_A	284_L	1.494	1.00
36_E	225_L	1.471	1.00
267_A	280_M	1.468	1.00
235_V	277_V	1.452	1.00
23_N	275_H	1.449	1.00
156_S	159_E	1.446	1.00
95_E	112_P	1.442	1.00
25_N	29_Q	1.441	1.00
234_A	244_M	1.426	1.00
230_E	249_G	1.415	1.00
186_W	190_E	1.402	1.00
89_D	194_D	1.401	1.00
22_E	279_H	1.398	1.00
24_E	28_R	1.373	1.00
253_A	257_A	1.332	1.00
31_Q	58_K	1.305	1.00
76_L	79_H	1.302	1.00
255_G	271_T	1.300	1.00
86_R	89_D	1.298	1.00
245_L	261_I	1.292	1.00
235_V	280_M	1.289	1.00
26_A	278_A	1.287	1.00
79_H	168_D	1.274	1.00
242_K	246_E	1.263	1.00
229_L	232_T	1.262	1.00
222_A	229_L	1.260	1.00
5_A	40_S	1.257	1.00
196_T	243_S	1.244	1.00
80_E	209_S	1.241	1.00
93_W	97_E	1.233	1.00
181_K	184_A	1.228	1.00
97_E	188_R	1.216	1.00
28_R	32_R	1.199	1.00
262_K	268_V	1.194	1.00
260_D	263_S	1.190	1.00
68_V	76_L	1.189	1.00
84_K	88_Y	1.184	1.00
4_I	281_M	1.183	1.00
267_A	283_H	1.176	1.00
26_A	282_K	1.173	1.00
86_R	195_L	1.172	1.00
14_N	273_D	1.163	1.00
60_W	225_L	1.163	1.00
3_L	227_I	1.152	1.00
4_I	35_I	1.145	1.00
79_H	170_Y	1.140	1.00
3_L	222_A	1.137	1.00
232_T	248_A	1.134	1.00
183_E	199_S	1.128	1.00
277_V	281_M	1.124	1.00
38_V	221_L	1.115	1.00
38_V	60_W	1.111	1.00
22_E	26_A	1.103	1.00
256_N	272_N	1.101	1.00
269_T	280_M	1.100	1.00
4_I	30_A	1.094	1.00
258_R	261_I	1.094	1.00
183_E	187_K	1.094	1.00
196_T	211_K	1.094	1.00
234_A	245_L	1.088	1.00
233_A	284_L	1.087	1.00
229_L	249_G	1.086	1.00
194_D	210_R	1.084	1.00
69_I	220_R	1.078	1.00
31_Q	59_T	1.078	1.00
5_A	232_T	1.069	1.00
62_I	217_A	1.061	1.00
21_L	24_E	1.057	1.00
28_R	31_Q	1.056	1.00
269_T	276_G	1.053	1.00
254_M	276_G	1.050	1.00
252_V	269_T	1.042	1.00
171_N	206_E	1.042	1.00
233_A	250_K	1.042	1.00
15_S	272_N	1.040	1.00
209_S	212_A	1.035	1.00
248_A	251_G	1.030	1.00
8_L	51_I	1.013	1.00
252_V	267_A	1.005	1.00
238_S	258_R	1.004	1.00
198_V	208_S	1.002	1.00
233_A	280_M	0.998	1.00
213_S	216_Q	0.991	1.00
222_A	247_A	0.978	1.00
278_A	282_K	0.978	1.00
233_A	252_V	0.976	1.00
218_L	248_A	0.974	1.00
222_A	227_I	0.972	1.00
93_W	96_S	0.965	1.00
255_G	262_K	0.964	1.00
12_L	23_N	0.959	1.00
3_L	232_T	0.959	1.00
270_L	276_G	0.959	1.00
92_S	96_S	0.959	1.00
69_I	78_H	0.958	1.00
28_R	56_G	0.957	1.00
12_L	27_L	0.952	1.00
257_A	262_K	0.949	1.00
176_S	181_K	0.944	1.00
219_K	229_L	0.943	1.00
81_T	168_D	0.942	1.00
187_K	190_E	0.940	1.00
79_H	106_G	0.937	1.00
253_A	261_I	0.935	1.00
67_A	212_A	0.935	1.00
35_I	233_A	0.929	1.00
45_H	63_S	0.926	1.00
221_L	225_L	0.926	1.00
215_G	243_S	0.925	1.00
6_I	277_V	0.921	1.00
80_E	211_K	0.916	1.00
280_M	284_L	0.915	1.00
88_Y	92_S	0.912	1.00
184_A	188_R	0.903	1.00
280_M	283_H	0.902	1.00
184_A	187_K	0.902	1.00
239_L	242_K	0.900	1.00
176_S	182_L	0.898	1.00
279_H	283_H	0.898	1.00
70_H	76_L	0.896	1.00
255_G	270_L	0.895	1.00
25_N	28_R	0.894	1.00
254_M	269_T	0.885	1.00
89_D	92_S	0.883	1.00
30_A	37_V	0.879	1.00
49_M	74_G	0.875	1.00
208_S	213_S	0.872	1.00
222_A	249_G	0.872	1.00
232_T	249_G	0.869	1.00
69_I	217_A	0.862	1.00
63_S	68_V	0.860	1.00
116_R	120_D	0.857	1.00
82_I	209_S	0.850	1.00
255_G	274_E	0.847	1.00
41_T	63_S	0.846	1.00
49_M	53_E	0.844	1.00
81_T	170_Y	0.843	1.00
279_H	282_K	0.843	1.00
183_E	186_W	0.841	1.00
70_H	74_G	0.839	1.00
5_A	38_V	0.839	1.00
92_S	158_Q	0.832	1.00
77_Y	224_Q	0.832	1.00
260_D	264_I	0.829	1.00
117_E	121_V	0.828	1.00
4_I	233_A	0.827	1.00
45_H	70_H	0.826	1.00
23_N	278_A	0.826	1.00
154_I	157_F	0.825	1.00
155_N	158_Q	0.823	1.00
62_I	221_L	0.819	1.00
60_W	221_L	0.818	1.00
6_I	12_L	0.816	1.00
8_L	39_V	0.810	1.00
30_A	281_M	0.807	1.00
117_E	120_D	0.807	1.00
155_N	159_E	0.806	1.00
232_T	247_A	0.804	1.00
249_G	266_D	0.801	1.00
245_L	264_I	0.797	1.00
234_A	251_G	0.792	1.00
36_E	60_W	0.789	1.00
85_K	89_D	0.787	1.00
40_S	62_I	0.786	1.00
93_W	188_R	0.786	1.00
14_N	20_S	0.783	1.00
23_N	26_A	0.780	1.00
63_S	70_H	0.780	1.00
197_L	207_L	0.780	1.00
96_S	188_R	0.776	1.00
89_D	93_W	0.771	1.00
116_R	119_L	0.771	1.00
12_L	19_V	0.767	1.00
44_A	64_A	0.762	1.00
16_K	273_D	0.760	1.00
245_L	265_A	0.752	1.00
26_A	29_Q	0.752	1.00
152_A	155_N	0.749	1.00
179_K	183_E	0.745	1.00
178_F	181_K	0.742	1.00
60_W	71_D	0.741	1.00
196_T	213_S	0.741	1.00
270_L	283_H	0.738	1.00
35_I	231_E	0.737	1.00
254_M	257_A	0.736	1.00
91_L	95_E	0.736	1.00
186_W	199_S	0.732	1.00
237_D	257_A	0.727	1.00
257_A	261_I	0.726	1.00
84_K	168_D	0.724	1.00
39_V	48_V	0.717	1.00
218_L	234_A	0.716	1.00
14_N	272_N	0.714	1.00
88_Y	158_Q	0.709	1.00
22_E	278_A	0.707	1.00
97_E	184_A	0.707	1.00
216_Q	220_R	0.705	1.00
75_R	224_Q	0.703	1.00
95_E	101_Y	0.700	1.00
48_V	63_S	0.691	1.00
10_G	254_M	0.688	1.00
67_A	209_S	0.683	1.00
105_T	169_F	0.681	1.00
193_E	210_R	0.679	1.00
65_N	206_E	0.676	1.00
108_A	152_A	0.676	1.00
173_L	206_E	0.674	1.00
231_E	249_G	0.673	1.00
212_A	216_Q	0.671	1.00
251_G	261_I	0.670	1.00
219_K	222_A	0.669	1.00
12_L	272_N	0.669	1.00
267_A	279_H	0.668	1.00
187_K	191_H	0.667	1.00
237_D	254_M	0.667	1.00
48_V	61_V	0.663	1.00
251_G	265_A	0.660	1.00
40_S	244_M	0.660	1.00
235_V	252_V	0.660	1.00
171_N	200_S	0.659	1.00
250_K	280_M	0.658	1.00
243_S	246_E	0.656	1.00
88_Y	162_E	0.656	1.00
22_E	25_N	0.651	1.00
87_A	169_F	0.641	1.00
179_K	202_E	0.638	1.00
267_A	270_L	0.637	1.00
235_V	269_T	0.637	1.00
85_K	88_Y	0.633	1.00
8_L	48_V	0.630	1.00
239_L	261_I	0.623	1.00
68_V	170_Y	0.619	1.00
179_K	199_S	0.618	1.00
256_N	262_K	0.618	1.00
196_T	210_R	0.612	1.00
68_V	106_G	0.611	1.00
201_A	238_S	0.611	1.00
261_I	265_A	0.609	1.00
45_H	49_M	0.605	1.00
91_L	103_V	0.605	1.00
118_L	121_V	0.603	1.00
52_F	61_V	0.602	1.00
159_E	162_E	0.601	1.00
173_L	204_N	0.600	1.00
13_L	272_N	0.597	1.00
95_E	158_Q	0.594	1.00
275_H	278_A	0.593	1.00
188_R	191_H	0.593	1.00
4_I	235_V	0.591	1.00
105_T	108_A	0.586	1.00
197_L	205_F	0.584	1.00
242_K	245_L	0.583	1.00
76_L	106_G	0.581	0.99
84_K	162_E	0.578	0.99
8_L	12_L	0.578	0.99
253_A	264_I	0.578	0.99
58_K	72_P	0.577	0.99
19_V	24_E	0.575	0.99
269_T	279_H	0.574	0.99
20_S	278_A	0.573	0.99
113_Q	155_N	0.572	0.99
31_Q	56_G	0.570	0.99
103_V	169_F	0.570	0.99
26_A	30_A	0.570	0.99
98_N	181_K	0.568	0.99
254_M	272_N	0.566	0.99
30_A	278_A	0.565	0.99
93_W	189_Y	0.564	0.99
190_E	197_L	0.564	0.99
256_N	271_T	0.563	0.99
106_G	168_D	0.562	0.99
50_S	53_E	0.561	0.99
235_V	281_M	0.560	0.99
64_A	170_Y	0.560	0.99
149_S	152_A	0.559	0.99
227_I	249_G	0.558	0.99
3_L	221_L	0.557	0.99
227_I	231_E	0.556	0.99
102_E	173_L	0.553	0.99
252_V	266_D	0.552	0.99
215_G	219_K	0.552	0.99
227_I	232_T	0.550	0.99
64_A	204_N	0.547	0.99
91_L	101_Y	0.545	0.99
275_H	279_H	0.544	0.99
23_N	27_L	0.544	0.99
19_V	43_R	0.544	0.99
27_L	281_M	0.542	0.99
69_I	224_Q	0.542	0.99
211_K	216_Q	0.542	0.99
69_I	221_L	0.541	0.99
6_I	30_A	0.541	0.99
39_V	52_F	0.539	0.99
196_T	208_S	0.539	0.99
101_Y	172_I	0.539	0.99
151_F	155_N	0.539	0.99
215_G	232_T	0.538	0.99
36_E	59_T	0.538	0.99
106_G	170_Y	0.536	0.99
105_T	110_Y	0.535	0.99
278_A	281_M	0.533	0.99
180_E	184_A	0.533	0.99
64_A	67_A	0.532	0.99
174_G	207_L	0.527	0.99
71_D	224_Q	0.527	0.99
71_D	77_Y	0.526	0.99
182_L	205_F	0.526	0.99
99_Y	185_G	0.526	0.99
87_A	91_L	0.524	0.99
87_A	172_I	0.523	0.99
270_L	280_M	0.522	0.99
176_S	185_G	0.521	0.99
150_G	153_Y	0.520	0.99
218_L	222_A	0.514	0.99
182_L	186_W	0.514	0.99
229_L	248_A	0.513	0.99
258_R	262_K	0.512	0.99
12_L	277_V	0.512	0.99
27_L	31_Q	0.510	0.99
12_L	39_V	0.509	0.99
48_V	51_I	0.509	0.99
44_A	47_D	0.507	0.99
105_T	170_Y	0.504	0.99
42_G	240_N	0.502	0.99
25_N	282_K	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nrwA	1	1	100	0.205	Contact Map
3pgvA	3	0.8912	100	0.234	Contact Map
3l7yA	1	0.9018	100	0.255	Contact Map
2b30A	2	0.9088	100	0.258	Contact Map
1nf2A	4	0.9053	100	0.262	Contact Map
1rkqA	1	0.9123	100	0.263	Contact Map
4qjbA	1	0.9018	100	0.266	Contact Map
3daoA	1	0.9053	100	0.266	Contact Map
2rbkA	1	0.8877	100	0.272	Contact Map
3dnpA	2	0.9368	100	0.277	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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