GREMLIN Database
GLCR - HTH-type transcriptional repressor GlcR
UniProt: P94591 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (246)
Sequences: 7683 (5607)
Seq/√Len: 357.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_D167_K3.2961.00
85_L88_S3.0541.00
107_C204_L2.9741.00
136_E143_K2.7091.00
168_A198_A2.5651.00
13_F28_L2.3441.00
99_D191_K2.3261.00
207_H230_D2.2281.00
109_K128_V2.2211.00
195_I219_A2.2171.00
226_L249_L2.1991.00
91_H94_D2.1141.00
161_S193_K2.0801.00
167_K202_I2.0571.00
202_I226_L2.0531.00
13_F17_H2.0451.00
9_A12_D2.0191.00
97_I165_V1.9821.00
84_R110_H1.9811.00
80_N106_A1.9781.00
195_I201_V1.9741.00
217_Q220_E1.9311.00
98_L104_V1.9031.00
167_K200_Q1.8971.00
158_E161_S1.8931.00
233_P238_C1.8471.00
97_I194_M1.8341.00
106_A109_K1.7771.00
92_D114_V1.7691.00
238_C242_D1.7591.00
119_I165_V1.7571.00
200_Q226_L1.7461.00
86_A169_L1.6941.00
220_E223_E1.6661.00
165_V194_M1.6571.00
85_L249_L1.6531.00
158_E162_S1.6451.00
193_K196_Q1.5921.00
86_A204_L1.5911.00
157_I189_M1.5811.00
139_L151_L1.5641.00
140_L159_K1.5601.00
126_A139_L1.5531.00
166_D199_K1.5181.00
75_V208_S1.5181.00
107_C169_L1.5131.00
180_I203_A1.4981.00
180_I224_I1.4971.00
31_V36_A1.4911.00
25_I36_A1.4891.00
161_S196_Q1.4861.00
87_A110_H1.4711.00
19_R57_I1.4701.00
156_V190_V1.4481.00
118_V129_L1.4361.00
239_D243_R1.4331.00
7_L46_Q1.4291.00
80_N110_H1.4201.00
10_I25_I1.4181.00
83_G110_H1.4101.00
140_L151_L1.4061.00
50_I59_P1.4031.00
40_L56_A1.3961.00
9_A13_F1.3941.00
75_V78_E1.3941.00
92_D115_D1.3891.00
13_F20_I1.3881.00
15_K58_L1.3821.00
234_N237_F1.3781.00
8_V12_D1.3771.00
193_K197_Q1.3721.00
89_L228_I1.3641.00
144_L151_L1.3601.00
94_D166_D1.3581.00
100_A150_F1.3561.00
203_A224_I1.3551.00
17_H24_Q1.3441.00
78_E230_D1.3371.00
143_K186_E1.3371.00
89_L202_I1.3341.00
207_H232_L1.3201.00
52_T55_G1.3191.00
23_E33_R1.3171.00
7_L42_K1.2981.00
118_V135_I1.2981.00
76_S106_A1.2961.00
112_N132_K1.2901.00
219_A223_E1.2861.00
21_T24_Q1.2761.00
11_L48_A1.2691.00
90_I111_L1.2531.00
175_I210_L1.2521.00
9_A28_L1.2431.00
93_G115_D1.2411.00
3_Q7_L1.2391.00
34_D38_R1.2371.00
79_K102_T1.2371.00
140_L156_V1.2341.00
200_Q225_D1.2311.00
85_L89_L1.2251.00
80_N109_K1.2091.00
235_Q239_D1.2081.00
117_T138_Y1.1961.00
9_A29_L1.1671.00
89_L249_L1.1671.00
97_I197_Q1.1541.00
172_V205_A1.1491.00
108_A129_L1.1461.00
239_D242_D1.1441.00
196_Q223_E1.1401.00
14_L49_I1.1301.00
76_S80_N1.1241.00
78_E207_H1.1241.00
77_E80_N1.1241.00
157_I190_V1.1231.00
169_L202_I1.1191.00
41_V45_E1.1141.00
91_H167_K1.1101.00
14_L58_L1.1041.00
210_L233_P1.1031.00
117_T136_E1.1021.00
11_L14_L1.1011.00
17_H28_L1.0981.00
226_L247_E1.0971.00
12_D16_Q1.0961.00
172_V218_Y1.0801.00
155_S159_K1.0801.00
50_I57_I1.0751.00
201_V224_I1.0721.00
174_G181_T1.0631.00
49_I56_A1.0351.00
202_I228_I1.0241.00
22_T40_L1.0241.00
237_F240_L1.0201.00
87_A90_I1.0181.00
86_A107_C1.0131.00
138_Y143_K1.0111.00
68_Y102_T1.0051.00
42_K46_Q1.0041.00
83_G87_A1.0041.00
119_I163_Y1.0001.00
26_C33_R0.9931.00
210_L227_L0.9881.00
78_E82_I0.9861.00
175_I205_A0.9861.00
140_L160_L0.9821.00
98_L107_C0.9821.00
90_I169_L0.9801.00
5_E9_A0.9761.00
155_S163_Y0.9741.00
89_L226_L0.9511.00
104_V125_L0.9431.00
3_Q42_K0.9421.00
108_A128_V0.9391.00
13_F16_Q0.9391.00
157_I193_K0.9381.00
87_A107_C0.9381.00
189_M192_R0.9361.00
173_V182_I0.9331.00
80_N84_R0.9321.00
176_S213_T0.9291.00
222_N244_N0.9281.00
172_V203_A0.9271.00
164_H178_H0.9221.00
168_A194_M0.9171.00
101_S104_V0.9161.00
162_S192_R0.9151.00
42_K45_E0.9041.00
107_C110_H0.9011.00
41_V44_E0.9001.00
82_I103_T0.8961.00
103_T206_D0.8961.00
75_V206_D0.8901.00
188_G216_Y0.8861.00
124_N149_R0.8841.00
164_H199_K0.8831.00
24_Q28_L0.8821.00
83_G107_C0.8791.00
238_C248_L0.8791.00
20_I56_A0.8781.00
79_K103_T0.8761.00
83_G106_A0.8731.00
79_K209_K0.8711.00
104_V107_C0.8711.00
26_C36_A0.8691.00
20_I25_I0.8651.00
122_S125_L0.8591.00
137_I144_L0.8531.00
43_L48_A0.8471.00
108_A125_L0.8461.00
169_L204_L0.8441.00
199_K213_T0.8441.00
130_S149_R0.8431.00
11_L15_K0.8421.00
240_L243_R0.8401.00
103_T209_K0.8341.00
155_S162_S0.8231.00
115_D134_G0.8201.00
148_H173_V0.8181.00
160_L194_M0.8171.00
5_E8_V0.8121.00
160_L193_K0.8041.00
163_Y185_E0.8021.00
164_H217_Q0.7981.00
12_D15_K0.7981.00
81_K84_R0.7971.00
182_I188_G0.7941.00
201_V225_D0.7841.00
185_E216_Y0.7831.00
104_V204_L0.7781.00
164_H213_T0.7761.00
233_P248_L0.7741.00
175_I180_I0.7731.00
71_R173_V0.7641.00
178_H213_T0.7621.00
41_V51_R0.7621.00
86_A228_I0.7601.00
127_D149_R0.7561.00
97_I160_L0.7521.00
164_H197_Q0.7521.00
105_Q128_V0.7471.00
132_K135_I0.7471.00
145_E187_D0.7431.00
75_V207_H0.7421.00
181_T213_T0.7421.00
98_L108_A0.7381.00
162_S217_Q0.7371.00
195_I218_Y0.7331.00
18_N58_L0.7321.00
24_Q27_T0.7311.00
128_V131_D0.7301.00
233_P237_F0.7271.00
40_L51_R0.7251.00
5_E19_R0.7240.99
98_L118_V0.7170.99
77_E81_K0.7110.99
172_V180_I0.7110.99
102_T209_K0.7080.99
7_L11_L0.7060.99
67_S70_G0.7040.99
165_V198_A0.7040.99
112_N128_V0.7030.99
180_I218_Y0.6980.99
65_I71_R0.6940.99
100_A148_H0.6930.99
145_E152_Y0.6910.99
182_I218_Y0.6900.99
192_R196_Q0.6900.99
126_A144_L0.6870.99
23_E27_T0.6830.99
205_A227_L0.6810.99
106_A110_H0.6800.99
168_A201_V0.6780.99
141_G156_V0.6760.99
84_R88_S0.6750.99
72_L105_Q0.6730.99
126_A151_L0.6730.99
175_I221_L0.6720.99
11_L43_L0.6690.99
52_T57_I0.6690.99
141_G159_K0.6670.99
235_Q238_C0.6670.99
182_I187_D0.6660.99
240_L244_N0.6660.99
96_V118_V0.6620.99
31_V34_D0.6620.99
95_R119_I0.6620.99
158_E189_M0.6590.99
153_G156_V0.6590.99
25_I40_L0.6540.99
44_E51_R0.6530.99
131_D149_R0.6510.99
82_I204_L0.6500.99
81_K85_L0.6490.99
44_E49_I0.6490.99
236_A240_L0.6480.99
154_S189_M0.6480.99
206_D209_K0.6470.99
161_S197_Q0.6380.99
113_A132_K0.6380.99
154_S158_E0.6330.99
96_V167_K0.6320.99
22_T36_A0.6290.99
123_I151_L0.6280.99
121_N194_M0.6260.99
114_V134_G0.6220.98
14_L20_I0.6220.98
202_I225_D0.6180.98
170_I198_A0.6170.98
105_Q124_N0.6170.98
34_D122_S0.6140.98
6_R39_D0.6110.98
90_I107_C0.6110.98
115_D136_E0.6100.98
237_F241_L0.6080.98
173_V214_S0.6050.98
163_Y216_Y0.6050.98
29_L36_A0.5990.98
123_I139_L0.5980.98
101_S171_G0.5970.98
95_R215_F0.5950.98
198_A201_V0.5950.98
123_I127_D0.5920.98
186_E189_M0.5900.98
154_S157_I0.5890.98
4_E7_L0.5880.98
120_T126_A0.5860.98
119_I215_F0.5860.98
156_V159_K0.5840.98
176_S181_T0.5840.98
200_Q247_E0.5840.98
78_E232_L0.5820.98
145_E184_H0.5800.98
188_G218_Y0.5790.98
219_A224_I0.5790.98
124_N127_D0.5780.98
150_F187_D0.5760.97
38_R175_I0.5750.97
232_L238_C0.5740.97
157_I161_S0.5700.97
190_V193_K0.5680.97
170_I218_Y0.5650.97
210_L237_F0.5640.97
119_I138_Y0.5620.97
170_I195_I0.5620.97
207_H233_P0.5620.97
99_D104_V0.5570.97
173_V187_D0.5550.97
180_I219_A0.5500.97
96_V169_L0.5500.97
81_K231_R0.5490.97
173_V183_A0.5480.97
170_I201_V0.5480.97
171_G182_I0.5470.97
72_L106_A0.5460.97
183_A214_S0.5440.96
191_K218_Y0.5410.96
154_S186_E0.5400.96
155_S158_E0.5400.96
201_V223_E0.5380.96
34_D173_V0.5370.96
122_S187_D0.5360.96
69_S72_L0.5330.96
71_R102_T0.5300.96
97_I168_A0.5290.96
22_T26_C0.5290.96
101_S173_V0.5280.96
79_K206_D0.5260.96
71_R187_D0.5240.96
174_G212_S0.5220.96
211_G237_F0.5220.96
65_I145_E0.5210.96
100_A187_D0.5210.96
96_V107_C0.5190.95
78_E81_K0.5170.95
113_A134_G0.5160.95
71_R99_D0.5140.95
182_I191_K0.5130.95
158_E192_R0.5110.95
68_Y149_R0.5090.95
27_T30_Q0.5090.95
210_L229_T0.5080.95
97_I119_I0.5040.95
65_I183_A0.5040.95
174_G214_S0.5040.95
238_C241_L0.5030.95
138_Y155_S0.5020.95
155_S185_E0.5010.94
10_I29_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9457 100 0.524 Contact Map
3rrlB 1 0.6783 100 0.544 Contact Map
2w48A 3 0.907 100 0.577 Contact Map
2o0mA 1 0.6822 100 0.616 Contact Map
3l7oA 2 0.6008 100 0.627 Contact Map
1uj6A 2 0.6008 100 0.636 Contact Map
1o8bA 2 0.593 99.9 0.639 Contact Map
4l5jA 4 0.9031 99.9 0.639 Contact Map
1lk5A 4 0.6124 99.9 0.639 Contact Map
3ixqA 4 0.6085 99.9 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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