GREMLIN Database
YWPE - Putative cysteine protease YwpE
UniProt: P94587 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (95)
Sequences: 337 (251)
Seq/√Len: 25.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_I92_G5.8311.00
40_I73_I3.1161.00
2_R67_E2.7480.99
94_L97_S2.6760.99
57_I89_V2.5020.99
76_I89_V2.3450.98
6_K9_E2.2370.98
68_T72_E2.1860.97
2_R65_V2.1640.97
32_I36_A2.1030.96
2_R13_P1.9870.95
32_I51_V1.9640.95
72_E91_K1.8970.94
79_D86_G1.8780.93
50_S95_V1.7850.92
38_I90_V1.6890.89
80_K84_T1.6210.87
57_I76_I1.6050.86
59_E84_T1.5620.85
18_H27_G1.5510.84
16_G19_L1.5440.84
29_L32_I1.5090.83
64_V76_I1.4960.82
52_T72_E1.4790.81
45_K97_S1.4090.78
70_K93_E1.3630.76
9_E71_K1.3300.74
53_S91_K1.3170.73
74_T89_V1.3170.73
50_S93_E1.3100.73
62_A66_E1.3060.72
37_Q48_I1.2640.70
37_Q50_S1.2550.69
79_D84_T1.2540.69
38_I73_I1.2400.68
2_R68_T1.2120.67
18_H79_D1.1830.65
13_P65_V1.1690.64
53_S64_V1.1310.61
39_V46_D1.0980.59
51_V90_V1.0790.57
36_A51_V1.0790.57
7_M42_D1.0760.57
14_L75_L1.0640.56
7_M12_Y1.0580.56
38_I51_V1.0550.56
39_V42_D1.0070.52
6_K34_T1.0020.52
71_K94_L0.9770.50
2_R43_F0.9710.50
54_K88_L0.9460.48
8_G12_Y0.9410.47
5_Q12_Y0.9400.47
12_Y42_D0.9350.47
10_G15_A0.9280.46
55_D61_D0.9030.45
56_I70_K0.8510.41
20_K84_T0.8460.41
22_K93_E0.8280.39
81_A86_G0.8220.39
64_V89_V0.8210.39
30_E59_E0.8200.39
7_M92_G0.8040.38
7_M73_I0.8010.37
37_Q62_A0.7740.36
15_A84_T0.7610.35
34_T56_I0.7560.34
19_L84_T0.7550.34
16_G54_K0.7520.34
8_G42_D0.7450.34
5_Q8_G0.7400.33
12_Y28_P0.7400.33
41_T46_D0.7390.33
30_E80_K0.7380.33
59_E62_A0.7370.33
67_E71_K0.7360.33
9_E35_G0.7320.33
16_G27_G0.7310.33
48_I98_F0.7240.32
33_K45_K0.7240.32
4_D13_P0.7020.31
29_L65_V0.7010.31
37_Q58_S0.6900.30
79_D85_E0.6900.30
34_T95_V0.6770.29
48_I95_V0.6760.29
50_S96_D0.6730.29
56_I86_G0.6620.28
25_L39_V0.6570.28
13_P71_K0.6420.27
2_R69_N0.6380.27
28_P42_D0.6330.27
27_G80_K0.6320.27
42_D47_Y0.6280.26
30_E54_K0.6270.26
64_V84_T0.6250.26
26_F77_T0.6180.26
44_K69_N0.6170.26
81_A84_T0.6170.26
18_H48_I0.6110.25
7_M15_A0.6110.25
29_L88_L0.6070.25
8_G41_T0.5950.25
80_K85_E0.5940.24
51_V98_F0.5890.24
34_T54_K0.5850.24
18_H30_E0.5790.24
84_T90_V0.5750.23
18_H84_T0.5710.23
2_R72_E0.5700.23
54_K90_V0.5700.23
3_R50_S0.5680.23
10_G35_G0.5640.23
31_N37_Q0.5580.23
38_I58_S0.5580.23
29_L77_T0.5570.23
45_K51_V0.5560.22
52_T93_E0.5470.22
44_K52_T0.5430.22
52_T60_M0.5410.22
52_T76_I0.5400.22
9_E21_Q0.5400.22
8_G15_A0.5380.22
30_E33_K0.5380.22
58_S61_D0.5370.22
19_L24_L0.5360.21
54_K79_D0.5270.21
24_L36_A0.5270.21
31_N96_D0.5250.21
20_K23_N0.5250.21
33_K71_K0.5220.21
18_H25_L0.5210.21
23_N57_I0.5200.21
33_K69_N0.5180.21
7_M16_G0.5130.20
7_M41_T0.5130.20
44_K58_S0.5130.20
18_H59_E0.5110.20
18_H24_L0.5050.20
5_Q40_I0.5030.20
37_Q97_S0.5000.20
14_L42_D0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tqxA 1 0.9902 99.9 0.42 Contact Map
2kw8A 1 0.9902 99.9 0.439 Contact Map
4o8tA 2 0.9902 99.9 0.442 Contact Map
3fn5A 1 0.9902 99.9 0.443 Contact Map
3rccA 5 0.9314 99.9 0.452 Contact Map
1t2wA 2 0.9412 99.9 0.465 Contact Map
4d70A 1 0.9216 99.9 0.47 Contact Map
2xwgA 1 0.9706 99.9 0.473 Contact Map
3o0pA 1 0.9706 99.8 0.487 Contact Map
2w1jA 1 0.9706 99.8 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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