FABZ - BACSU - GREMLIN Contacts

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FABZ - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

UniProt:	P94584	Sequences: MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEFFNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQLHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	141 (133)
Sequences:	3761 (2085)
Seq/√Len:	180.8

ECOLI - FABZ FABA
BACSU - FABZ YCSD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_K	128_E	2.894	1.00
27_E	30_K	2.861	1.00
34_G	67_V	2.655	1.00
63_A	105_L	2.419	1.00
33_K	104_H	2.382	1.00
64_L	105_L	2.336	1.00
88_I	91_C	2.334	1.00
90_N	134_E	2.328	1.00
35_Y	102_Q	2.285	1.00
60_I	103_L	2.136	1.00
44_F	55_M	2.110	1.00
108_E	120_K	2.106	1.00
122_V	129_V	2.061	1.00
124_T	129_V	2.055	1.00
106_E	124_T	1.995	1.00
33_K	106_E	1.895	1.00
91_C	133_V	1.877	1.00
110_I	120_K	1.806	1.00
120_K	134_E	1.779	1.00
35_Y	104_H	1.688	1.00
52_Y	96_Q	1.659	1.00
124_T	127_G	1.655	1.00
31_R	108_E	1.648	1.00
6_Q	9_E	1.647	1.00
68_G	119_G	1.640	1.00
60_I	131_C	1.639	1.00
24_T	35_Y	1.609	1.00
22_R	35_Y	1.599	1.00
37_N	102_Q	1.598	1.00
43_E	46_N	1.591	1.00
31_R	106_E	1.587	1.00
25_E	31_R	1.569	1.00
25_E	33_K	1.560	1.00
106_E	122_V	1.546	1.00
36_K	42_E	1.447	1.00
27_E	31_R	1.441	1.00
107_V	121_G	1.437	1.00
32_A	71_A	1.424	1.00
23_I	70_V	1.326	1.00
104_H	124_T	1.321	1.00
30_K	108_E	1.295	1.00
117_G	137_F	1.289	1.00
15_Y	46_N	1.247	1.00
84_F	96_Q	1.217	1.00
52_Y	98_K	1.208	1.00
105_L	123_A	1.208	1.00
38_V	55_M	1.200	1.00
20_V	67_V	1.179	1.00
121_G	135_L	1.175	1.00
55_M	59_L	1.171	1.00
23_I	34_G	1.161	1.00
29_G	75_K	1.160	1.00
95_K	130_V	1.134	1.00
94_K	132_E	1.121	1.00
52_Y	82_L	1.103	1.00
123_A	131_C	1.103	1.00
32_A	67_V	1.085	1.00
54_V	84_F	1.078	1.00
8_K	51_Q	1.077	1.00
101_D	125_V	1.077	1.00
86_A	136_T	1.067	1.00
8_K	40_A	1.066	1.00
68_G	107_V	1.061	1.00
112_A	117_G	1.049	1.00
61_V	88_I	1.040	1.00
85_F	88_I	1.036	1.00
104_H	127_G	1.031	1.00
6_Q	74_I	1.024	0.99
103_L	123_A	1.014	0.99
87_G	136_T	1.009	0.99
52_Y	84_F	1.008	0.99
129_V	132_E	1.000	0.99
60_I	123_A	1.000	0.99
49_F	57_G	0.997	0.99
102_Q	126_D	0.996	0.99
97_V	130_V	0.993	0.99
55_M	63_A	0.992	0.99
24_T	104_H	0.985	0.99
15_Y	41_N	0.976	0.99
24_T	33_K	0.964	0.99
64_L	133_V	0.963	0.99
48_H	57_G	0.960	0.99
22_R	37_N	0.952	0.99
71_A	75_K	0.951	0.99
86_A	138_A	0.941	0.99
8_K	18_L	0.936	0.99
109_I	117_G	0.929	0.99
10_I	73_L	0.923	0.99
83_A	137_F	0.916	0.99
61_V	91_C	0.909	0.99
112_A	115_T	0.906	0.99
15_Y	40_A	0.903	0.99
110_I	118_R	0.886	0.99
78_N	81_R	0.881	0.98
122_V	132_E	0.873	0.98
10_I	70_V	0.873	0.98
119_G	137_F	0.865	0.98
108_E	122_V	0.845	0.98
118_R	136_T	0.836	0.98
39_T	42_E	0.826	0.98
11_I	69_A	0.823	0.98
48_H	54_V	0.823	0.98
15_Y	37_N	0.820	0.98
26_V	32_A	0.819	0.98
32_A	70_V	0.814	0.97
26_V	74_I	0.813	0.97
64_L	131_C	0.796	0.97
110_I	134_E	0.793	0.97
86_A	116_I	0.788	0.97
6_Q	10_I	0.782	0.97
73_L	117_G	0.774	0.97
36_K	39_T	0.767	0.96
20_V	70_V	0.760	0.96
86_A	137_F	0.759	0.96
89_D	118_R	0.755	0.96
94_K	129_V	0.753	0.96
89_D	134_E	0.751	0.96
120_K	132_E	0.751	0.96
97_V	103_L	0.750	0.96
13_H	19_L	0.746	0.96
111_R	114_G	0.743	0.96
72_M	117_G	0.739	0.95
8_K	53_P	0.734	0.95
91_C	131_C	0.732	0.95
44_F	59_L	0.722	0.95
48_H	53_P	0.722	0.95
92_R	136_T	0.721	0.95
9_E	76_E	0.703	0.94
22_R	102_Q	0.695	0.94
40_A	44_F	0.680	0.93
19_L	59_L	0.679	0.93
67_V	71_A	0.672	0.93
49_F	83_A	0.668	0.92
28_E	75_K	0.667	0.92
32_A	68_G	0.662	0.92
38_V	97_V	0.662	0.92
13_H	69_A	0.660	0.92
15_Y	22_R	0.660	0.92
13_H	17_F	0.656	0.92
71_A	119_G	0.654	0.92
23_I	67_V	0.651	0.91
88_I	93_F	0.651	0.91
61_V	133_V	0.647	0.91
98_K	101_D	0.646	0.91
48_H	58_V	0.641	0.91
38_V	44_F	0.640	0.91
77_E	81_R	0.631	0.90
83_A	119_G	0.630	0.90
8_K	15_Y	0.618	0.89
36_K	41_N	0.614	0.89
40_A	43_E	0.614	0.89
95_K	98_K	0.611	0.89
64_L	121_G	0.607	0.88
68_G	121_G	0.605	0.88
47_G	58_V	0.602	0.88
37_N	40_A	0.601	0.88
41_N	44_F	0.586	0.87
40_A	53_P	0.583	0.86
40_A	46_N	0.583	0.86
104_H	126_D	0.580	0.86
37_N	41_N	0.579	0.86
72_M	119_G	0.577	0.86
113_R	116_I	0.574	0.85
15_Y	39_T	0.568	0.85
26_V	31_R	0.568	0.85
111_R	118_R	0.568	0.85
28_E	74_I	0.565	0.85
67_V	105_L	0.565	0.85
9_E	51_Q	0.563	0.84
22_R	126_D	0.562	0.84
39_T	100_G	0.560	0.84
10_I	81_R	0.559	0.84
87_G	92_R	0.555	0.83
72_M	83_A	0.553	0.83
20_V	105_L	0.551	0.83
10_I	74_I	0.551	0.83
116_I	136_T	0.550	0.83
92_R	132_E	0.547	0.83
47_G	57_G	0.543	0.82
64_L	123_A	0.542	0.82
109_I	119_G	0.541	0.82
75_K	112_A	0.539	0.82
77_E	80_G	0.538	0.82
41_N	46_N	0.537	0.81
29_G	109_I	0.532	0.81
49_F	54_V	0.532	0.81
48_H	92_R	0.526	0.80
107_V	137_F	0.520	0.79
76_E	81_R	0.517	0.79
45_F	48_H	0.516	0.79
55_M	60_I	0.515	0.79
10_I	77_E	0.513	0.78
47_G	50_P	0.511	0.78
45_F	99_P	0.511	0.78
97_V	123_A	0.508	0.78
48_H	97_V	0.507	0.78
121_G	133_V	0.505	0.77
23_I	32_A	0.502	0.77
76_E	112_A	0.502	0.77
20_V	34_G	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gllA	3	1	100	0.164	Contact Map
1u1zA	3	0.9929	100	0.169	Contact Map
3d6xA	3	1	100	0.226	Contact Map
1z6bA	3	0.9716	100	0.231	Contact Map
2cf2C	2	0.9787	100	0.234	Contact Map
3q62A	2	0.9787	100	0.255	Contact Map
4i83A	3	0.9858	100	0.277	Contact Map
4h4gA	3	0.9716	100	0.279	Contact Map
4b0bA	2	0.9787	100	0.302	Contact Map
3esiA	4	0.844	99.9	0.482	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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