GREMLIN Database
FABZ - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
UniProt: P94584 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (133)
Sequences: 3761 (2085)
Seq/√Len: 180.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_K128_E2.8941.00
27_E30_K2.8611.00
34_G67_V2.6551.00
63_A105_L2.4191.00
33_K104_H2.3821.00
64_L105_L2.3361.00
88_I91_C2.3341.00
90_N134_E2.3281.00
35_Y102_Q2.2851.00
60_I103_L2.1361.00
44_F55_M2.1101.00
108_E120_K2.1061.00
122_V129_V2.0611.00
124_T129_V2.0551.00
106_E124_T1.9951.00
33_K106_E1.8951.00
91_C133_V1.8771.00
110_I120_K1.8061.00
120_K134_E1.7791.00
35_Y104_H1.6881.00
52_Y96_Q1.6591.00
124_T127_G1.6551.00
31_R108_E1.6481.00
6_Q9_E1.6471.00
68_G119_G1.6401.00
60_I131_C1.6391.00
24_T35_Y1.6091.00
22_R35_Y1.5991.00
37_N102_Q1.5981.00
43_E46_N1.5911.00
31_R106_E1.5871.00
25_E31_R1.5691.00
25_E33_K1.5601.00
106_E122_V1.5461.00
36_K42_E1.4471.00
27_E31_R1.4411.00
107_V121_G1.4371.00
32_A71_A1.4241.00
23_I70_V1.3261.00
104_H124_T1.3211.00
30_K108_E1.2951.00
117_G137_F1.2891.00
15_Y46_N1.2471.00
84_F96_Q1.2171.00
52_Y98_K1.2081.00
105_L123_A1.2081.00
38_V55_M1.2001.00
20_V67_V1.1791.00
121_G135_L1.1751.00
55_M59_L1.1711.00
23_I34_G1.1611.00
29_G75_K1.1601.00
95_K130_V1.1341.00
94_K132_E1.1211.00
52_Y82_L1.1031.00
123_A131_C1.1031.00
32_A67_V1.0851.00
54_V84_F1.0781.00
8_K51_Q1.0771.00
101_D125_V1.0771.00
86_A136_T1.0671.00
8_K40_A1.0661.00
68_G107_V1.0611.00
112_A117_G1.0491.00
61_V88_I1.0401.00
85_F88_I1.0361.00
104_H127_G1.0311.00
6_Q74_I1.0240.99
103_L123_A1.0140.99
87_G136_T1.0090.99
52_Y84_F1.0080.99
129_V132_E1.0000.99
60_I123_A1.0000.99
49_F57_G0.9970.99
102_Q126_D0.9960.99
97_V130_V0.9930.99
55_M63_A0.9920.99
24_T104_H0.9850.99
15_Y41_N0.9760.99
24_T33_K0.9640.99
64_L133_V0.9630.99
48_H57_G0.9600.99
22_R37_N0.9520.99
71_A75_K0.9510.99
86_A138_A0.9410.99
8_K18_L0.9360.99
109_I117_G0.9290.99
10_I73_L0.9230.99
83_A137_F0.9160.99
61_V91_C0.9090.99
112_A115_T0.9060.99
15_Y40_A0.9030.99
110_I118_R0.8860.99
78_N81_R0.8810.98
122_V132_E0.8730.98
10_I70_V0.8730.98
119_G137_F0.8650.98
108_E122_V0.8450.98
118_R136_T0.8360.98
39_T42_E0.8260.98
11_I69_A0.8230.98
48_H54_V0.8230.98
15_Y37_N0.8200.98
26_V32_A0.8190.98
32_A70_V0.8140.97
26_V74_I0.8130.97
64_L131_C0.7960.97
110_I134_E0.7930.97
86_A116_I0.7880.97
6_Q10_I0.7820.97
73_L117_G0.7740.97
36_K39_T0.7670.96
20_V70_V0.7600.96
86_A137_F0.7590.96
89_D118_R0.7550.96
94_K129_V0.7530.96
89_D134_E0.7510.96
120_K132_E0.7510.96
97_V103_L0.7500.96
13_H19_L0.7460.96
111_R114_G0.7430.96
72_M117_G0.7390.95
8_K53_P0.7340.95
91_C131_C0.7320.95
44_F59_L0.7220.95
48_H53_P0.7220.95
92_R136_T0.7210.95
9_E76_E0.7030.94
22_R102_Q0.6950.94
40_A44_F0.6800.93
19_L59_L0.6790.93
67_V71_A0.6720.93
49_F83_A0.6680.92
28_E75_K0.6670.92
32_A68_G0.6620.92
38_V97_V0.6620.92
13_H69_A0.6600.92
15_Y22_R0.6600.92
13_H17_F0.6560.92
71_A119_G0.6540.92
23_I67_V0.6510.91
88_I93_F0.6510.91
61_V133_V0.6470.91
98_K101_D0.6460.91
48_H58_V0.6410.91
38_V44_F0.6400.91
77_E81_R0.6310.90
83_A119_G0.6300.90
8_K15_Y0.6180.89
36_K41_N0.6140.89
40_A43_E0.6140.89
95_K98_K0.6110.89
64_L121_G0.6070.88
68_G121_G0.6050.88
47_G58_V0.6020.88
37_N40_A0.6010.88
41_N44_F0.5860.87
40_A53_P0.5830.86
40_A46_N0.5830.86
104_H126_D0.5800.86
37_N41_N0.5790.86
72_M119_G0.5770.86
113_R116_I0.5740.85
15_Y39_T0.5680.85
26_V31_R0.5680.85
111_R118_R0.5680.85
28_E74_I0.5650.85
67_V105_L0.5650.85
9_E51_Q0.5630.84
22_R126_D0.5620.84
39_T100_G0.5600.84
10_I81_R0.5590.84
87_G92_R0.5550.83
72_M83_A0.5530.83
20_V105_L0.5510.83
10_I74_I0.5510.83
116_I136_T0.5500.83
92_R132_E0.5470.83
47_G57_G0.5430.82
64_L123_A0.5420.82
109_I119_G0.5410.82
75_K112_A0.5390.82
77_E80_G0.5380.82
41_N46_N0.5370.81
29_G109_I0.5320.81
49_F54_V0.5320.81
48_H92_R0.5260.80
107_V137_F0.5200.79
76_E81_R0.5170.79
45_F48_H0.5160.79
55_M60_I0.5150.79
10_I77_E0.5130.78
47_G50_P0.5110.78
45_F99_P0.5110.78
97_V123_A0.5080.78
48_H97_V0.5070.78
121_G133_V0.5050.77
23_I32_A0.5020.77
76_E112_A0.5020.77
20_V34_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gllA 3 1 100 0.164 Contact Map
1u1zA 3 0.9929 100 0.169 Contact Map
3d6xA 3 1 100 0.226 Contact Map
1z6bA 3 0.9716 100 0.231 Contact Map
2cf2C 2 0.9787 100 0.234 Contact Map
3q62A 2 0.9787 100 0.255 Contact Map
4i83A 3 0.9858 100 0.277 Contact Map
4h4gA 3 0.9716 100 0.279 Contact Map
4b0bA 2 0.9787 100 0.302 Contact Map
3esiA 4 0.844 99.9 0.482 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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