GREMLIN Database
RAPD - Response regulator aspartate phosphatase D
UniProt: P94583 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (298)
Sequences: 2009 (1786)
Seq/√Len: 103.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_N270_E5.2561.00
226_K229_E5.0471.00
186_R189_K4.3121.00
178_A194_F4.0341.00
145_S148_L3.9571.00
137_A153_V3.9421.00
218_G234_F3.8151.00
105_A108_H3.7681.00
97_G113_F3.4981.00
191_E217_L3.3541.00
133_Y152_Y3.1521.00
150_V177_L3.0181.00
259_V275_L2.8841.00
231_L258_S2.7261.00
270_E273_A2.6131.00
57_Q61_Q2.5951.00
178_A193_L2.5741.00
214_Y236_K2.5371.00
113_F135_Q2.5161.00
234_F257_E2.4681.00
93_Y112_H2.3941.00
258_S262_L2.1711.00
110_V140_Y2.1601.00
262_L270_E2.1541.00
214_Y233_Y2.1191.00
258_S274_V2.1111.00
182_I194_F2.1061.00
255_V274_V2.0671.00
195_K217_L2.0631.00
231_L261_A2.0301.00
153_V176_L2.0201.00
136_T140_Y2.0101.00
100_E108_H2.0061.00
221_K229_E1.9981.00
217_L221_K1.9921.00
100_E105_A1.9881.00
229_E232_L1.9361.00
97_G116_A1.9111.00
66_N69_G1.9101.00
177_L181_Y1.8981.00
140_Y148_L1.8951.00
218_G233_Y1.8611.00
191_E224_E1.8501.00
134_Y176_L1.8361.00
101_M113_F1.8271.00
174_K193_L1.8271.00
262_L267_N1.8081.00
97_G112_H1.7731.00
180_N184_Q1.7561.00
148_L151_Q1.7441.00
211_C237_V1.7251.00
174_K196_E1.7081.00
93_Y115_K1.6961.00
181_Y189_K1.6901.00
58_A70_L1.6551.00
96_S100_E1.6541.00
307_P310_Q1.6111.00
228_Q265_T1.5571.00
191_E220_L1.5451.00
307_P311_L1.5261.00
221_K226_K1.5261.00
257_E260_R1.5251.00
191_E195_K1.5071.00
189_K192_Q1.4941.00
133_Y155_K1.4931.00
231_L265_T1.4741.00
90_Y116_A1.4611.00
221_K262_L1.4481.00
231_L262_L1.4421.00
259_V274_V1.4421.00
130_A156_A1.4331.00
138_G176_L1.4241.00
150_V180_N1.4081.00
58_A74_F1.4031.00
235_R270_E1.4001.00
33_K37_D1.3981.00
198_I210_L1.3891.00
235_R258_S1.3891.00
116_A119_Y1.3881.00
191_E221_K1.3661.00
252_L259_V1.3260.99
136_T152_Y1.3150.99
34_E38_Q1.3150.99
231_L235_R1.3130.99
171_I197_I1.3000.99
262_L274_V1.2980.99
58_A77_L1.2880.99
336_E339_K1.2880.99
255_V277_K1.2740.99
114_K148_L1.2670.99
137_A152_Y1.2630.99
218_G230_A1.2630.99
113_F117_E1.2550.99
154_K177_L1.2510.99
334_I338_Y1.2420.99
261_A265_T1.2410.99
110_V136_T1.2330.99
132_L135_Q1.2330.99
137_A156_A1.2320.99
202_Q210_L1.2250.99
114_K136_T1.2250.99
197_I237_V1.2150.99
217_L233_Y1.2100.99
110_V114_K1.2040.99
329_V333_D1.2010.99
175_L197_I1.1970.99
97_G109_A1.1890.99
278_G281_L1.1860.99
136_T177_L1.1850.99
218_G237_V1.1830.99
93_Y116_A1.1810.99
94_F135_Q1.1720.98
219_F234_F1.1690.98
259_V278_G1.1640.98
178_A197_I1.1520.98
156_A159_I1.1520.98
134_Y173_C1.1270.98
227_D261_A1.1220.98
215_Y254_C1.1140.98
187_Y227_D1.1040.98
179_V194_F1.1020.98
135_Q138_G1.0930.98
193_L197_I1.0910.98
238_L251_Y1.0850.97
36_I39_H1.0560.97
191_E231_L1.0500.97
140_Y152_Y1.0480.97
315_V318_L1.0450.97
151_Q155_K1.0420.97
61_Q70_L1.0390.97
327_L331_L1.0380.97
177_L193_L1.0360.97
215_Y257_E1.0240.96
98_L113_F1.0190.96
108_H111_H1.0180.96
110_V139_A0.9970.96
107_K143_M0.9950.96
232_L236_K0.9930.96
311_L314_Y0.9920.96
202_Q205_H0.9870.96
272_K276_Q0.9800.95
292_L299_A0.9770.95
181_Y186_R0.9750.95
309_E313_E0.9700.95
33_K40_L0.9620.95
238_L255_V0.9580.95
126_T129_A0.9540.95
238_L258_S0.9520.95
309_E312_L0.9480.94
323_A326_D0.9430.94
100_E112_H0.9430.94
252_L278_G0.9340.94
237_V240_N0.9270.94
218_G258_S0.9220.94
38_Q41_P0.9110.93
260_R275_L0.9100.93
37_D40_L0.9040.93
216_N219_F0.8980.93
55_L59_R0.8940.93
256_Y260_R0.8930.93
201_T204_L0.8890.92
278_G282_S0.8880.92
52_R56_F0.8860.92
110_V143_M0.8860.92
219_F257_E0.8810.92
179_V216_N0.8800.92
94_F113_F0.8780.92
155_K158_H0.8770.92
175_L216_N0.8770.92
140_Y145_S0.8750.92
256_Y278_G0.8750.92
196_E200_K0.8690.91
263_F275_L0.8640.91
96_S112_H0.8600.91
146_P150_V0.8590.91
117_E133_Y0.8520.91
173_C194_F0.8500.91
152_Y156_A0.8470.90
295_K302_T0.8440.90
295_K298_E0.8440.90
222_A227_D0.8370.90
150_V154_K0.8360.90
241_Q254_C0.8350.90
198_I214_Y0.8150.89
291_Y295_K0.8150.89
256_Y275_L0.8120.88
60_H64_F0.8090.88
194_F217_L0.8080.88
153_V173_C0.8060.88
32_L37_D0.8060.88
193_L196_E0.8040.88
188_E224_E0.8010.88
32_L43_I0.7940.87
157_L174_K0.7940.87
310_Q313_E0.7930.87
293_K298_E0.7930.87
241_Q250_S0.7890.87
194_F216_N0.7810.86
268_I272_K0.7770.86
38_Q43_I0.7750.86
307_P314_Y0.7740.86
198_I217_L0.7730.86
207_E210_L0.7710.86
201_T213_A0.7630.85
39_H43_I0.7610.85
118_Q121_A0.7610.85
308_Y311_L0.7550.85
116_A132_L0.7540.84
90_Y139_A0.7540.84
328_E331_L0.7530.84
227_D264_K0.7530.84
325_V328_E0.7520.84
184_Q265_T0.7500.84
55_L58_A0.7450.84
171_I201_T0.7430.84
134_Y172_T0.7410.83
222_A234_F0.7410.83
285_V288_Q0.7410.83
133_Y255_V0.7380.83
106_P139_A0.7380.83
290_I293_K0.7380.83
32_L35_K0.7370.83
45_K49_L0.7360.83
272_K298_E0.7350.83
32_L39_H0.7340.83
238_L254_C0.7340.83
138_G153_V0.7310.83
315_V319_E0.7260.82
297_L301_Y0.7240.82
55_L70_L0.7210.82
35_K45_K0.7200.82
333_D336_E0.7190.82
196_E199_K0.7160.81
38_Q42_K0.7140.81
35_K39_H0.7140.81
237_V254_C0.7140.81
68_N284_K0.7120.81
74_F78_Y0.7120.81
178_A190_A0.7120.81
157_L177_L0.7110.81
231_L267_N0.7110.81
46_N50_W0.7110.81
202_Q236_K0.7100.81
112_H116_A0.7090.81
278_G288_Q0.7080.81
129_A133_Y0.7060.80
61_Q65_E0.7050.80
180_N261_A0.7050.80
74_F96_S0.7040.80
325_V333_D0.7030.80
93_Y119_Y0.7030.80
197_I200_K0.7010.80
332_E335_T0.7010.80
202_Q214_Y0.7000.80
235_R262_L0.6990.80
55_L65_E0.6980.80
324_W331_L0.6980.80
153_V177_L0.6980.80
228_Q272_K0.6960.79
33_K36_I0.6950.79
298_E304_A0.6920.79
73_L76_G0.6920.79
117_E132_L0.6920.79
248_P251_Y0.6860.78
170_V173_C0.6850.78
306_D310_Q0.6840.78
33_K53_Y0.6820.78
198_I213_A0.6820.78
327_L334_I0.6810.78
61_Q64_F0.6800.78
72_S75_D0.6790.78
139_A143_M0.6780.78
304_A310_Q0.6770.78
299_A304_A0.6760.77
291_Y298_E0.6760.77
133_Y156_A0.6750.77
60_H63_L0.6740.77
70_L77_L0.6740.77
175_L213_A0.6730.77
126_T159_I0.6730.77
134_Y138_G0.6730.77
234_F238_L0.6730.77
34_E40_L0.6710.77
278_G294_L0.6690.77
58_A65_E0.6660.76
107_K147_P0.6660.76
40_L44_K0.6660.76
45_K48_K0.6640.76
55_L60_H0.6610.76
217_L258_S0.6610.76
320_K326_D0.6610.76
328_E332_E0.6600.76
53_Y57_Q0.6550.75
77_L80_L0.6520.75
255_V278_G0.6520.75
147_P184_Q0.6510.75
323_A329_V0.6500.75
36_I40_L0.6440.74
133_Y174_K0.6440.74
150_V184_Q0.6410.74
54_Q61_Q0.6410.74
94_F97_G0.6380.73
197_I213_A0.6330.73
225_K268_I0.6310.72
113_F139_A0.6280.72
85_D88_L0.6270.72
227_D268_I0.6270.72
335_T339_K0.6270.72
127_F166_Y0.6270.72
148_L229_E0.6260.72
201_T209_L0.6240.72
49_L52_R0.6170.71
46_N52_R0.6150.71
217_L220_L0.6130.70
59_R95_F0.6130.70
114_K140_Y0.6130.70
90_Y97_G0.6130.70
97_G139_A0.6110.70
319_E328_E0.6100.70
327_L333_D0.6100.70
167_I248_P0.6090.70
68_N103_K0.6080.70
40_L46_N0.6080.70
230_A234_F0.6070.70
96_S109_A0.6070.70
226_K260_R0.6060.69
176_L179_V0.6060.69
167_I170_V0.6020.69
269_T276_Q0.6000.69
51_M60_H0.6000.69
35_K41_P0.6000.69
94_F98_L0.5970.68
104_T142_L0.5960.68
312_L316_L0.5930.68
167_I203_Q0.5930.68
311_L318_L0.5920.68
294_L297_L0.5920.68
328_E339_K0.5900.67
259_V271_A0.5890.67
33_K52_R0.5880.67
98_L135_Q0.5870.67
284_K313_E0.5870.67
94_F116_A0.5840.67
233_Y236_K0.5840.67
59_R62_L0.5840.67
269_T272_K0.5830.66
308_Y312_L0.5820.66
229_E233_Y0.5800.66
140_Y294_L0.5790.66
35_K42_K0.5790.66
275_L292_L0.5790.66
153_V180_N0.5780.66
154_K158_H0.5780.66
294_L298_E0.5770.66
189_K229_E0.5770.66
191_E226_K0.5750.65
32_L41_P0.5750.65
41_P46_N0.5720.65
181_Y193_L0.5710.65
293_K326_D0.5690.65
214_Y255_V0.5690.65
221_K225_K0.5690.65
32_L44_K0.5690.65
183_D278_G0.5670.64
70_L99_Y0.5670.64
324_W335_T0.5670.64
140_Y143_M0.5650.64
330_L333_D0.5650.64
177_L217_L0.5640.64
171_I190_A0.5630.64
40_L50_W0.5620.64
42_K49_L0.5610.64
33_K43_I0.5610.64
236_K239_K0.5590.63
150_V181_Y0.5570.63
214_Y237_V0.5560.63
47_T51_M0.5540.63
263_F272_K0.5530.62
215_Y219_F0.5530.62
37_D43_I0.5520.62
156_A173_C0.5500.62
172_T175_L0.5470.62
58_A61_Q0.5460.61
229_E270_E0.5460.61
33_K49_L0.5460.61
188_E192_Q0.5430.61
35_K40_L0.5400.61
298_E303_S0.5390.60
40_L43_I0.5380.60
133_Y214_Y0.5380.60
191_E194_F0.5380.60
326_D330_L0.5370.60
47_T50_W0.5370.60
137_A176_L0.5360.60
32_L36_I0.5360.60
46_N49_L0.5350.60
62_L70_L0.5350.60
319_E331_L0.5350.60
35_K43_I0.5350.60
133_Y137_A0.5330.60
328_E334_I0.5330.60
251_Y255_V0.5330.60
32_L40_L0.5320.59
214_Y232_L0.5320.59
283_E300_L0.5300.59
79_G82_D0.5290.59
90_Y94_F0.5280.59
73_L81_E0.5270.59
65_E70_L0.5270.59
239_K269_T0.5270.59
134_Y153_V0.5260.59
277_K280_E0.5250.58
275_L279_K0.5250.58
43_I52_R0.5250.58
54_Q73_L0.5240.58
326_D333_D0.5230.58
39_H44_K0.5230.58
37_D42_K0.5220.58
283_E288_Q0.5200.58
49_L228_Q0.5200.58
220_L261_A0.5190.58
333_D338_Y0.5180.57
138_G279_K0.5180.57
170_V174_K0.5170.57
332_E336_E0.5160.57
323_A328_E0.5150.57
77_L81_E0.5150.57
154_K195_K0.5150.57
36_I42_K0.5140.57
328_E336_E0.5130.57
175_L215_Y0.5130.57
111_H144_K0.5110.56
34_E44_K0.5110.56
140_Y147_P0.5100.56
109_A113_F0.5090.56
141_Y180_N0.5080.56
331_L334_I0.5070.56
276_Q288_Q0.5070.56
32_L38_Q0.5050.56
134_Y156_A0.5050.56
122_A210_L0.5040.55
60_H65_E0.5030.55
334_I339_K0.5030.55
316_L326_D0.5020.55
297_L320_K0.5020.55
79_G225_K0.5000.55
89_K119_Y0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i1aA 2 0.9576 100 0.248 Contact Map
3ulqA 1 0.9802 100 0.248 Contact Map
4gyoA 2 0.9774 100 0.251 Contact Map
3q15A 2 0.9774 100 0.256 Contact Map
4gpkA 3 0.9576 100 0.288 Contact Map
1w3bA 2 0.8588 100 0.367 Contact Map
3sf4A 1 0.8616 100 0.381 Contact Map
4ui9C 2 0.8757 100 0.39 Contact Map
4ui9J 2 0.8701 100 0.391 Contact Map
3ro2A 1 0.8616 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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