GREMLIN Database
YWOH - Uncharacterized HTH-type transcriptional regulator YwoH
UniProt: P94578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (127)
Sequences: 21118 (15426)
Seq/√Len: 1368.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_P92_V3.2321.00
123_D133_M3.1051.00
81_R92_V3.0531.00
79_Q92_V2.5691.00
50_T88_E2.4851.00
120_R123_D2.4251.00
126_A129_H2.3521.00
126_A130_L2.2031.00
44_R101_Y2.1311.00
82_Q89_K2.1311.00
50_T53_E1.9791.00
36_Q75_N1.9571.00
119_F130_L1.9421.00
123_D126_A1.7831.00
44_R93_L1.7821.00
76_G96_E1.6521.00
36_Q71_R1.6031.00
73_E80_R1.5851.00
51_Q69_I1.5841.00
48_P90_L1.5551.00
96_E100_K1.5541.00
123_D129_H1.5451.00
96_E99_K1.5301.00
11_Q132_R1.5291.00
100_K103_E1.5231.00
69_I91_V1.5191.00
70_K74_E1.4741.00
46_I57_Y1.4661.00
33_Y36_Q1.4601.00
127_F130_L1.4461.00
30_F107_K1.4351.00
39_V68_T1.4111.00
48_P81_R1.3781.00
26_Q107_K1.3351.00
130_L133_M1.3201.00
44_R98_E1.3201.00
42_C57_Y1.3171.00
30_F103_E1.3011.00
11_Q128_S1.2991.00
51_Q89_K1.2801.00
70_K86_K1.2751.00
53_E56_S1.2651.00
52_K62_A1.2501.00
99_K103_E1.2371.00
60_V64_T1.1871.00
129_H133_M1.1601.00
61_E64_T1.1371.00
26_Q110_K1.1311.00
128_S132_R1.1111.00
52_K56_S1.1061.00
39_V65_V1.1031.00
24_N28_E1.0941.00
26_Q114_E1.0891.00
107_K110_K1.0881.00
77_W100_K1.0791.00
66_T70_K1.0761.00
122_E126_A1.0551.00
112_E115_L1.0491.00
51_Q91_V1.0481.00
123_D130_L1.0381.00
124_K128_S1.0191.00
95_K98_E1.0161.00
93_L97_A1.0131.00
75_N100_K1.0091.00
47_G98_E1.0071.00
31_G75_N1.0021.00
75_N96_E0.9651.00
13_N16_A0.9621.00
49_M57_Y0.9561.00
51_Q65_V0.9551.00
30_F104_I0.9551.00
46_I49_M0.9551.00
70_K73_E0.9551.00
80_R89_K0.9511.00
63_P66_T0.9481.00
61_E67_R0.9411.00
49_M53_E0.9261.00
98_E102_E0.9251.00
35_S68_T0.9231.00
16_A20_A0.9171.00
24_N34_S0.9161.00
64_T67_R0.9161.00
95_K99_K0.9121.00
15_S131_F0.9091.00
108_M112_E0.8871.00
69_I78_V0.8831.00
119_F134_F0.8741.00
110_K114_E0.8721.00
44_R102_E0.8691.00
60_V65_V0.8671.00
53_E57_Y0.8661.00
43_L78_V0.8621.00
82_Q86_K0.8611.00
37_W104_I0.8581.00
83_G90_L0.8571.00
51_Q62_A0.8551.00
67_R71_R0.8511.00
121_D125_E0.8481.00
22_K111_F0.8481.00
40_L101_Y0.8341.00
79_Q94_T0.8281.00
81_R90_L0.8231.00
85_D88_E0.8181.00
110_K113_E0.8171.00
29_P107_K0.8081.00
15_S134_F0.8051.00
77_W96_E0.8031.00
93_L98_E0.7931.00
69_I73_E0.7911.00
12_I16_A0.7841.00
42_C58_L0.7811.00
103_E107_K0.7791.00
22_K114_E0.7661.00
42_C49_M0.7631.00
37_W108_M0.7611.00
46_I53_E0.7571.00
72_L77_W0.7511.00
73_E79_Q0.7501.00
44_R105_N0.7461.00
106_V109_L0.7441.00
106_V110_K0.7431.00
38_S58_L0.7381.00
35_S64_T0.7301.00
116_L124_K0.7291.00
122_E125_E0.7281.00
67_R70_K0.7231.00
114_E117_A0.7231.00
12_I15_S0.7231.00
125_E128_S0.7211.00
17_R21_K0.7181.00
26_Q111_F0.7181.00
55_W62_A0.7141.00
109_L113_E0.7131.00
43_L93_L0.7101.00
13_N17_R0.7071.00
126_A133_M0.7061.00
51_Q66_T0.7001.00
99_K102_E0.6881.00
20_A24_N0.6841.00
8_L128_S0.6841.00
70_K80_R0.6831.00
120_R124_K0.6811.00
125_E129_H0.6711.00
71_R74_E0.6711.00
65_V69_I0.6661.00
39_V58_L0.6611.00
37_W101_Y0.6601.00
41_Y45_T0.6591.00
42_C54_I0.6561.00
43_L49_M0.6551.00
47_G92_V0.6541.00
42_C46_I0.6511.00
39_V54_I0.6311.00
36_Q68_T0.6281.00
26_Q29_P0.6271.00
55_W65_V0.6261.00
41_Y105_N0.6141.00
23_A108_M0.5981.00
119_F133_M0.5971.00
120_R133_M0.5971.00
11_Q14_Q0.5941.00
103_E106_V0.5861.00
111_F114_E0.5801.00
71_R75_N0.5771.00
38_S42_C0.5661.00
25_E29_P0.5661.00
14_Q18_L0.5601.00
54_I91_V0.5591.00
105_N109_L0.5581.00
25_E28_E0.5581.00
22_K25_E0.5551.00
119_F124_K0.5551.00
73_E78_V0.5531.00
40_L44_R0.5501.00
23_A26_Q0.5431.00
102_E106_V0.5411.00
18_L22_K0.5381.00
52_K55_W0.5371.00
35_S60_V0.5301.00
116_L120_R0.5301.00
12_I131_F0.5271.00
51_Q88_E0.5251.00
32_L100_K0.5211.00
12_I19_I0.5181.00
41_Y101_Y0.5171.00
102_E105_N0.5141.00
8_L127_F0.5051.00
101_Y105_N0.5041.00
13_N34_S0.5031.00
76_G79_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yifA 2 0.9854 99.9 0.244 Contact Map
3oopA 2 0.9781 99.9 0.245 Contact Map
3deuA 2 0.927 99.9 0.246 Contact Map
3cjnA 2 0.9854 99.9 0.247 Contact Map
3zplA 2 1 99.9 0.248 Contact Map
3u2rA 4 0.9562 99.9 0.25 Contact Map
4rguA 4 0.9927 99.9 0.253 Contact Map
2fbkA 2 0.9416 99.9 0.255 Contact Map
3cdhA 4 0.9562 99.9 0.258 Contact Map
3e6mA 2 1 99.9 0.258 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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