GREMLIN Database
YWOF - Uncharacterized protein YwoF
UniProt: P94576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 468 (370)
Sequences: 1900 (1693)
Seq/√Len: 88.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_N197_N4.7081.00
255_E290_K3.8301.00
58_A62_E3.7551.00
197_N224_N3.6851.00
222_A255_E3.6511.00
97_N103_V3.2151.00
199_V226_V3.1301.00
72_I133_L3.1171.00
195_E222_A3.1041.00
166_I199_V3.0841.00
290_K318_T3.0841.00
134_T167_R3.0701.00
131_S162_K2.9741.00
224_N257_N2.8961.00
73_R101_E2.8371.00
257_N292_N2.7691.00
294_V322_V2.7271.00
158_H191_D2.7191.00
162_K195_E2.7061.00
73_R98_Y2.7011.00
292_N320_N2.6831.00
223_G256_N2.5561.00
259_V294_V2.5151.00
127_D158_H2.4811.00
202_L229_N2.4591.00
50_K53_P2.2401.00
191_D218_G2.2371.00
318_T348_A2.1991.00
192_I219_F2.1871.00
227_R260_Y2.1851.00
200_E227_R2.1831.00
44_D59_H2.1521.00
165_H200_E2.1371.00
257_N320_N2.1271.00
54_F63_K2.1061.00
36_L54_F2.0791.00
71_M96_R2.0781.00
296_D324_N2.0631.00
229_N262_N2.0491.00
260_Y295_Y2.0471.00
61_S95_F2.0441.00
59_H63_K2.0311.00
163_D196_D2.0301.00
198_T227_R2.0181.00
303_A317_I2.0011.00
226_V259_V1.9891.00
135_I166_I1.9791.00
44_D55_R1.9741.00
196_D223_G1.9651.00
98_Y101_E1.9541.00
47_E52_K1.9501.00
256_N291_N1.9191.00
96_R131_S1.9171.00
228_N261_Q1.9161.00
225_V260_Y1.9071.00
320_N350_N1.8731.00
379_N405_N1.8551.00
322_V352_M1.8511.00
44_D56_T1.8251.00
150_I166_I1.8111.00
64_A70_V1.7991.00
74_E101_E1.7831.00
37_Y73_R1.7511.00
159_I192_I1.7391.00
258_T295_Y1.7331.00
291_N319_D1.7281.00
224_N292_N1.6891.00
70_V95_F1.6551.00
297_N325_N1.6491.00
201_K228_N1.6491.00
262_N297_N1.6441.00
183_V192_I1.6331.00
350_N379_N1.6221.00
164_N224_N1.6211.00
42_G59_H1.6141.00
106_S137_D1.6101.00
97_N132_G1.6051.00
226_V233_G1.6011.00
286_D314_A1.5941.00
95_F130_I1.5921.00
161_I164_N1.5811.00
437_D440_S1.5801.00
162_K196_D1.5761.00
39_S73_R1.5741.00
133_L164_N1.5401.00
325_N355_N1.5131.00
96_R132_G1.5121.00
69_T96_R1.4991.00
251_N286_D1.4851.00
60_A64_A1.4770.99
56_T59_H1.4640.99
46_N52_K1.4390.99
35_Y71_M1.4380.99
427_F431_R1.4170.99
169_I202_L1.4130.99
403_N439_Q1.4080.99
54_F59_H1.4010.99
202_L262_N1.3970.99
136_Q167_R1.3910.99
160_A193_R1.3890.99
293_T323_Y1.3880.99
37_Y53_P1.3850.99
106_S136_Q1.3770.99
197_N257_N1.3630.99
278_G300_G1.3430.99
132_G163_D1.3370.99
72_I77_Y1.3340.99
134_T165_H1.3270.99
168_G201_K1.3200.99
57_L79_E1.3170.99
131_S163_D1.3150.99
221_V234_I1.3040.99
199_V209_A1.2970.99
252_G287_I1.2860.99
279_I289_I1.2840.99
301_I322_V1.2700.98
317_I347_I1.2690.98
107_G137_D1.2540.98
149_G180_G1.2400.98
261_Q296_D1.2300.98
236_L254_V1.2230.98
253_V288_E1.2220.98
48_G54_F1.2110.98
212_L219_F1.2110.98
71_M98_Y1.2070.98
320_N379_N1.2030.98
74_E97_N1.1960.98
42_G55_R1.1950.98
120_I135_I1.1850.98
351_I380_I1.1800.97
42_G46_N1.1680.97
122_I125_K1.1680.97
330_I352_M1.1650.97
282_D304_T1.1580.97
219_F252_G1.1560.97
166_I226_V1.1530.97
74_E103_V1.1450.97
322_V329_G1.1440.97
35_Y69_T1.1270.97
194_I197_N1.1260.97
224_N320_N1.1210.97
40_P72_I1.1160.96
277_G280_Y1.1150.96
220_T255_E1.1070.96
220_T253_V1.1020.96
81_L120_I1.1000.96
293_T321_K1.0980.96
288_E318_T1.0960.96
92_P127_D1.0900.96
234_I279_I1.0740.96
249_V252_G1.0710.96
99_E103_V1.0690.95
193_R220_T1.0620.95
259_V278_G1.0610.95
435_K440_S1.0610.95
135_I149_G1.0610.95
37_Y98_Y1.0590.95
33_G68_T1.0520.95
426_S429_S1.0460.95
225_V258_T1.0410.95
253_V290_K1.0380.95
218_G251_N1.0360.95
60_A70_V1.0350.95
157_S190_K1.0300.94
74_E98_Y1.0280.94
167_R200_E1.0240.94
352_M355_N1.0190.94
149_G169_I1.0170.94
120_I130_I1.0150.94
348_A377_E1.0120.94
324_N354_R1.0110.94
72_I79_E1.0050.94
83_V95_F1.0030.94
46_N49_T1.0020.94
66_A92_P1.0010.94
295_Y323_Y0.9990.94
119_L138_L0.9950.93
289_I317_I0.9870.93
44_D54_F0.9860.93
165_H198_T0.9850.93
279_I294_V0.9820.93
292_N379_N0.9760.93
365_L381_L0.9750.93
427_F430_Y0.9710.93
39_S42_G0.9700.92
61_S93_I0.9610.92
210_V234_I0.9570.92
222_A290_K0.9500.92
193_R222_A0.9400.91
166_I180_G0.9400.91
46_N54_F0.9400.91
97_N101_E0.9350.91
94_T129_A0.9330.91
278_G294_V0.9260.91
290_K319_D0.9260.91
150_I181_I0.9190.90
322_V325_N0.9160.90
441_I445_P0.9090.90
209_A233_G0.9090.90
20_F25_T0.9070.90
36_L64_A0.9040.90
65_A68_T0.9040.90
83_V125_K0.9020.89
275_S302_E0.9010.89
61_S72_I0.9000.89
72_I95_F0.8990.89
49_T52_K0.8940.89
135_I150_I0.8920.89
126_H157_S0.8890.89
19_A24_K0.8890.89
38_V48_G0.8880.89
46_N55_R0.8880.89
292_N350_N0.8860.89
58_A61_S0.8820.88
259_V262_N0.8810.88
346_L375_T0.8800.88
57_L105_I0.8800.88
26_K29_E0.8780.88
199_V233_G0.8770.88
258_T293_T0.8760.88
49_T53_P0.8760.88
404_H439_Q0.8750.88
59_H62_E0.8730.88
212_L221_V0.8710.88
57_L72_I0.8690.88
210_V226_V0.8680.88
61_S64_A0.8660.87
21_V25_T0.8630.87
279_I301_I0.8590.87
105_I119_L0.8570.87
69_T94_T0.8530.87
39_S55_R0.8520.87
445_P448_R0.8490.86
54_F64_A0.8440.86
40_P77_Y0.8420.86
20_F23_D0.8410.86
301_I317_I0.8400.86
166_I169_I0.8390.86
39_S53_P0.8390.86
255_E291_N0.8380.86
190_K218_G0.8370.86
60_A77_Y0.8360.86
65_A85_H0.8330.85
280_Y304_T0.8300.85
160_A195_E0.8280.85
92_P129_A0.8250.85
287_I315_I0.8240.85
195_E223_G0.8200.84
231_N280_Y0.8190.84
197_N320_N0.8170.84
109_S137_D0.8150.84
350_N405_N0.8140.84
435_K438_Q0.8140.84
294_V297_N0.8110.84
27_A33_G0.8110.84
288_E316_Q0.8090.84
38_V54_F0.8060.83
428_S431_R0.8050.83
229_N297_N0.8020.83
329_G355_N0.8000.83
89_D127_D0.7960.83
257_N379_N0.7950.83
374_N400_N0.7940.83
254_V289_I0.7910.82
257_N350_N0.7890.82
76_T104_V0.7870.82
74_E99_E0.7860.82
129_A160_A0.7860.82
316_Q346_L0.7850.82
445_P449_D0.7850.82
20_F27_A0.7830.82
30_E33_G0.7810.81
70_V85_H0.7770.81
263_S276_A0.7750.81
72_I103_V0.7720.81
208_E231_N0.7710.81
162_K193_R0.7690.80
194_I199_V0.7680.80
73_R103_V0.7670.80
63_K70_V0.7660.80
347_I352_M0.7640.80
198_T225_V0.7600.80
210_V221_V0.7520.79
76_T106_S0.7510.79
46_N53_P0.7460.78
21_V29_E0.7440.78
302_E305_S0.7420.78
60_A72_I0.7410.78
294_V325_N0.7400.78
317_I330_I0.7370.78
77_Y99_E0.7370.78
102_N134_T0.7360.77
427_F432_K0.7360.77
169_I229_N0.7350.77
208_E235_D0.7340.77
81_L95_F0.7320.77
89_D92_P0.7320.77
348_A351_I0.7310.77
233_G278_G0.7310.77
199_V259_V0.7300.77
129_A162_K0.7270.77
77_Y96_R0.7260.77
444_D447_F0.7240.76
61_S81_L0.7220.76
195_E255_E0.7220.76
260_Y296_D0.7210.76
275_S303_A0.7210.76
44_D53_P0.7200.76
48_G53_P0.7200.76
179_H182_A0.7190.76
427_F440_S0.7180.76
318_T321_K0.7180.76
77_Y103_V0.7160.76
81_L85_H0.7120.75
126_H183_V0.7110.75
70_V77_Y0.7100.75
22_Y27_A0.7090.75
352_M381_L0.7070.75
61_S85_H0.7050.74
281_V289_I0.7040.74
281_V287_I0.7030.74
50_K98_Y0.7010.74
231_N235_D0.7000.74
431_R440_S0.6990.74
180_G278_G0.6970.74
122_I159_I0.6960.73
232_I235_D0.6950.73
123_H153_S0.6940.73
61_S77_Y0.6930.73
23_D26_K0.6900.73
22_Y25_T0.6900.73
259_V279_I0.6890.73
181_I210_V0.6890.73
107_G135_I0.6870.72
165_H201_K0.6850.72
161_I166_I0.6850.72
83_V128_I0.6820.72
57_L70_V0.6820.72
446_M449_D0.6810.72
428_S432_K0.6800.72
192_I252_G0.6780.72
180_G199_V0.6770.71
349_R380_I0.6770.71
19_A25_T0.6750.71
152_V161_I0.6730.71
138_L169_I0.6730.71
295_Y324_N0.6720.71
105_I110_V0.6700.71
443_A450_E0.6690.71
276_A297_N0.6670.70
29_E32_S0.6650.70
53_P56_T0.6640.70
380_I404_H0.6630.70
198_T228_N0.6620.70
443_A446_M0.6620.70
180_G226_V0.6620.70
430_Y440_S0.6610.70
216_I219_F0.6600.69
278_G325_N0.6550.69
23_D27_A0.6550.69
104_V134_T0.6540.69
119_L135_I0.6530.69
36_L68_T0.6510.68
222_A253_V0.6490.68
189_M192_I0.6470.68
183_V233_G0.6450.68
26_K33_G0.6440.68
289_I303_A0.6430.67
226_V262_N0.6410.67
74_E102_N0.6410.67
134_T168_G0.6410.67
209_A262_N0.6400.67
235_D280_Y0.6400.67
222_A256_N0.6390.67
26_K31_G0.6390.67
345_S374_N0.6380.67
83_V129_A0.6370.67
104_V136_Q0.6370.67
416_I419_W0.6360.67
161_I194_I0.6340.66
315_I345_S0.6340.66
234_I259_V0.6340.66
317_I320_N0.6330.66
304_T331_S0.6310.66
332_I347_I0.6300.66
22_Y28_N0.6280.66
443_A447_F0.6280.66
208_E211_V0.6260.65
25_T31_G0.6260.65
446_M450_E0.6240.65
37_Y48_G0.6240.65
229_N325_N0.6240.65
44_D48_G0.6230.65
130_I150_I0.6220.65
373_N399_G0.6210.65
224_N350_N0.6200.65
34_D68_T0.6170.64
70_V203_T0.6170.64
183_V194_I0.6160.64
235_D282_D0.6160.64
125_K128_I0.6150.64
333_G336_D0.6140.64
402_V405_N0.6130.64
277_G304_T0.6130.64
27_A31_G0.6120.64
61_S70_V0.6100.63
166_I229_N0.6080.63
44_D52_K0.6080.63
159_I219_F0.6070.63
180_G208_E0.6050.63
294_V300_G0.6040.63
57_L95_F0.6030.63
447_F450_E0.6030.63
427_F436_N0.6020.62
152_V183_V0.6020.62
280_Y302_E0.6010.62
122_I152_V0.5990.62
136_Q168_G0.5990.62
70_V128_I0.5990.62
424_Y433_A0.5990.62
96_R99_E0.5980.62
135_I199_V0.5970.62
282_D287_I0.5960.62
353_Y382_T0.5920.61
46_N59_H0.5920.61
301_I330_I0.5920.61
230_N304_T0.5910.61
321_K349_R0.5900.61
332_I374_N0.5900.61
443_A448_R0.5900.61
71_M99_E0.5900.61
51_E90_G0.5890.61
346_L351_I0.5880.61
77_Y132_G0.5870.60
429_S432_K0.5870.60
105_I135_I0.5860.60
440_S444_D0.5850.60
430_Y437_D0.5850.60
330_I347_I0.5840.60
46_N50_K0.5840.60
43_S55_R0.5830.60
38_V44_D0.5820.60
418_M421_K0.5820.60
209_A226_V0.5820.60
291_N321_K0.5810.60
435_K439_Q0.5790.59
36_L60_A0.5780.59
45_Q51_E0.5760.59
120_I149_G0.5740.59
51_E62_E0.5740.59
72_I132_G0.5730.59
82_D85_H0.5720.59
351_I378_K0.5710.58
48_G56_T0.5700.58
61_S83_V0.5700.58
93_I127_D0.5700.58
133_L139_S0.5690.58
46_N51_E0.5680.58
228_N260_Y0.5680.58
24_K28_N0.5660.58
299_I302_E0.5650.58
54_F61_S0.5630.57
344_N373_N0.5630.57
226_V229_N0.5630.57
47_E90_G0.5610.57
319_D349_R0.5600.57
226_V234_I0.5600.57
226_V294_V0.5600.57
32_S35_Y0.5580.57
355_N384_G0.5570.57
137_D169_I0.5560.56
38_V60_A0.5560.56
119_L149_G0.5550.56
231_N304_T0.5550.56
254_V279_I0.5540.56
25_T28_N0.5530.56
188_S196_D0.5530.56
320_N325_N0.5530.56
378_K404_H0.5530.56
209_A229_N0.5530.56
71_M97_N0.5530.56
68_T209_A0.5510.56
19_A22_Y0.5490.55
27_A32_S0.5490.55
442_Y447_F0.5480.55
55_R59_H0.5480.55
403_N407_Y0.5470.55
20_F26_K0.5470.55
31_G34_D0.5460.55
259_V322_V0.5460.55
208_E213_N0.5460.55
66_A85_H0.5450.55
442_Y446_M0.5450.55
349_R353_Y0.5450.55
380_I406_V0.5440.55
37_Y71_M0.5440.55
164_N257_N0.5420.54
218_G223_G0.5420.54
432_K436_N0.5410.54
445_P450_E0.5410.54
43_S59_H0.5400.54
284_G287_I0.5390.54
422_K425_D0.5380.54
94_T124_D0.5380.54
226_V257_N0.5340.53
319_D323_Y0.5340.53
135_I169_I0.5330.53
210_V313_N0.5320.53
127_D191_D0.5310.53
365_L372_K0.5310.53
132_G164_N0.5290.53
444_D449_D0.5290.53
41_N45_Q0.5280.53
58_A79_E0.5280.53
54_F60_A0.5270.52
364_Q368_Q0.5260.52
190_K217_D0.5240.52
197_N292_N0.5230.52
21_V26_K0.5220.52
262_N325_N0.5220.52
181_I234_I0.5220.52
325_N328_T0.5220.52
23_D31_G0.5210.52
207_S210_V0.5180.51
84_K125_K0.5170.51
39_S445_P0.5160.51
23_D33_G0.5150.51
181_I199_V0.5150.51
230_N275_S0.5130.51
64_A68_T0.5120.50
419_W422_K0.5120.50
234_I257_N0.5120.50
180_G229_N0.5110.50
249_V284_G0.5110.50
233_G300_G0.5110.50
54_F79_E0.5100.50
78_H107_G0.5090.50
236_L332_I0.5080.50
282_D305_S0.5080.50
436_N440_S0.5060.50
70_V93_I0.5040.49
429_S433_A0.5040.49
329_G332_I0.5040.49
262_N278_G0.5040.49
365_L376_I0.5030.49
37_Y56_T0.5030.49
95_F120_I0.5030.49
107_G119_L0.5010.49
42_G56_T0.5010.49
426_S431_R0.5010.49
256_N275_S0.5010.49
208_E237_I0.5010.49
137_D168_G0.5010.49
430_Y436_N0.5000.49
195_E220_T0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ru4A 1 0.7692 100 0.492 Contact Map
1dbgA 1 0.7863 100 0.543 Contact Map
3vsvA 4 0.8397 100 0.556 Contact Map
2inuA 3 0.7265 100 0.618 Contact Map
2pygA 1 0.7137 99.9 0.669 Contact Map
4nk6A 2 0.7308 99.9 0.689 Contact Map
1rmgA 1 0.8376 99.9 0.719 Contact Map
4mr0A 1 0.8162 99.9 0.725 Contact Map
3jurA 3 0.7735 99.9 0.726 Contact Map
2uvfA 2 0.844 99.8 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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