GREMLIN Database
ALLP - Probable allantoin permease
UniProt: P94575 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 490 (428)
Sequences: 4815 (3062)
Seq/√Len: 148.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
393_A461_F6.9791.00
404_S407_D6.9721.00
393_A465_I5.9401.00
431_L463_F4.5001.00
85_G248_P4.2871.00
23_Q256_T4.2691.00
428_A463_F3.5431.00
64_L277_F3.3441.00
428_A432_G3.3041.00
432_G460_S3.2671.00
200_W204_D3.1291.00
69_T233_V3.0801.00
397_I461_F2.9871.00
428_A467_L2.9491.00
432_G463_F2.8641.00
229_F233_V2.7671.00
53_L232_G2.7451.00
394_D399_R2.7311.00
389_G393_A2.7071.00
22_G25_K2.7041.00
296_D299_D2.6721.00
435_I459_I2.6611.00
423_Y427_A2.6431.00
390_V429_T2.5541.00
59_S62_Q2.5321.00
407_D410_S2.4391.00
397_I465_I2.3581.00
40_C328_A2.3261.00
426_F430_M2.3151.00
66_I229_F2.2981.00
73_I237_I2.2751.00
196_G200_W2.2241.00
107_I426_F2.1541.00
16_E25_K2.1311.00
325_N329_N2.1181.00
26_R89_G2.0661.00
389_G457_V2.0561.00
199_V274_L2.0561.00
459_I463_F2.0511.00
120_L358_A2.0401.00
432_G459_I2.0331.00
255_E259_E2.0261.00
436_S456_G2.0251.00
258_K262_K1.9881.00
82_G251_T1.9781.00
362_V365_K1.9751.00
469_R472_P1.9511.00
170_L355_A1.9341.00
103_Y106_N1.9341.00
53_L63_V1.9191.00
463_F467_L1.8951.00
166_W359_L1.8871.00
98_A403_L1.8611.00
124_T169_H1.8511.00
404_S414_R1.8381.00
160_L164_F1.8341.00
454_F458_L1.8341.00
346_N349_R1.8301.00
120_L325_N1.8291.00
84_A95_I1.8171.00
60_P64_L1.8081.00
119_W122_I1.8021.00
465_I469_R1.8001.00
127_G165_F1.7961.00
462_L466_V1.7851.00
63_V280_I1.7751.00
16_E19_V1.7431.00
167_A171_L1.7071.00
389_G460_S1.6971.00
427_A467_L1.6961.00
182_R185_V1.6921.00
175_H179_S1.6881.00
99_S394_D1.6651.00
30_A259_E1.6641.00
163_V167_A1.6621.00
62_Q225_T1.6421.00
65_A229_F1.6291.00
431_L459_I1.6221.00
434_L438_I1.6201.00
390_V428_A1.6151.00
118_M376_F1.6091.00
105_A339_N1.5701.00
347_F351_S1.5581.00
61_W65_A1.5491.00
461_F465_I1.5461.00
458_L461_F1.5261.00
269_P273_A1.5241.00
352_F356_L1.5241.00
458_L462_L1.5151.00
67_I280_I1.5131.00
169_H325_N1.5031.00
79_A265_F1.4941.00
262_K266_Y1.4921.00
100_Y425_A1.4911.00
69_T229_F1.4791.00
390_V425_A1.4591.00
32_N185_V1.4581.00
466_V469_R1.4571.00
107_I421_Y1.4451.00
193_L197_G1.4381.00
95_I248_P1.4351.00
421_Y426_F1.4161.00
29_K32_N1.4161.00
345_I353_I1.4131.00
132_N161_S1.4051.00
351_S355_A1.4021.00
394_D398_I1.3951.00
415_Y420_G1.3701.00
128_S161_S1.3701.00
425_A428_A1.3671.00
67_I276_A1.3661.00
199_V278_A1.3521.00
76_G80_L1.3451.00
410_S413_G1.3371.00
354_T358_A1.3281.00
425_A464_Y1.3181.00
172_V183_F1.3161.00
58_L66_I1.3091.00
120_L355_A1.3091.00
123_Q329_N1.3041.00
85_G251_T1.3041.00
129_T296_D1.2921.00
430_M434_L1.2891.00
87_K257_Q1.2841.00
279_S283_T1.2771.00
407_D414_R1.2751.00
83_H87_K1.2581.00
159_L163_V1.2561.00
358_A361_T1.2551.00
65_A69_T1.2551.00
66_I232_G1.2481.00
333_P354_T1.2441.00
268_L272_F1.2431.00
99_S391_M1.2401.00
398_I465_I1.2301.00
116_A246_N1.2171.00
389_G461_F1.2151.00
456_G460_S1.2051.00
390_V432_G1.2041.00
259_E263_G1.2041.00
250_F332_S1.1981.00
386_P456_G1.1911.00
392_M396_F1.1881.00
66_I233_V1.1851.00
388_A392_M1.1821.00
345_I349_R1.1751.00
118_M377_L1.1651.00
111_L384_L1.1541.00
121_G358_A1.1521.00
38_M271_T1.1481.00
16_E21_L1.1471.00
354_T361_T1.1471.00
14_S19_V1.1401.00
274_L278_A1.1330.99
229_F232_G1.1300.99
464_Y468_M1.1300.99
355_A358_A1.1280.99
253_F335_Y1.1260.99
68_I273_A1.1250.99
16_E22_G1.1210.99
361_T365_K1.1190.99
82_G260_Q1.1150.99
134_L311_V1.1070.99
80_L396_F1.1030.99
466_V470_V1.1030.99
81_N391_M1.1000.99
273_A277_F1.0960.99
70_A236_I1.0790.99
226_F230_A1.0770.99
97_R105_A1.0740.99
424_R467_L1.0700.99
365_K368_E1.0690.99
100_Y104_G1.0670.99
241_A385_G1.0660.99
67_I71_S1.0620.99
212_I215_Q1.0600.99
424_R468_M1.0590.99
71_S276_A1.0580.99
123_Q325_N1.0490.99
248_P251_T1.0470.99
345_I350_G1.0430.99
349_R352_F1.0350.99
77_A244_I1.0350.99
215_Q284_S1.0340.99
75_F79_A1.0340.99
134_L314_V1.0240.99
439_G455_V1.0190.99
435_I455_V1.0170.99
84_A88_Y1.0100.99
338_A350_G1.0090.99
70_A233_V1.0070.99
459_I462_L1.0020.99
44_I321_T1.0010.99
197_G200_W0.9990.99
342_P345_I0.9930.99
64_L68_I0.9920.99
346_N351_S0.9900.99
124_T166_W0.9870.99
278_A282_V0.9840.99
72_L269_P0.9800.99
424_R428_A0.9790.98
407_D413_G0.9780.98
393_A398_I0.9780.98
409_Y415_Y0.9720.98
270_G279_S0.9710.98
182_R186_W0.9670.98
448_L455_V0.9670.98
22_G26_R0.9650.98
424_R427_A0.9650.98
462_L465_I0.9640.98
451_I455_V0.9620.98
408_L415_Y0.9590.98
66_I70_A0.9580.98
299_D303_R0.9580.98
281_T285_G0.9550.98
98_A408_L0.9540.98
33_F251_T0.9540.98
92_F248_P0.9530.98
433_A436_S0.9500.98
272_F276_A0.9490.98
353_I357_L0.9440.98
51_G126_A0.9380.98
189_P192_Y0.9370.98
94_V97_R0.9360.98
244_I388_A0.9350.98
415_Y422_N0.9350.98
74_L240_W0.9280.98
256_T259_E0.9240.98
88_Y403_L0.9200.98
234_T454_F0.9180.98
428_A464_Y0.9170.98
332_S336_D0.9150.98
294_I300_I0.9130.98
128_S132_N0.9120.98
422_N468_M0.9100.98
198_M304_F0.9090.98
134_L315_I0.9080.98
42_H191_V0.9060.98
83_H396_F0.9060.98
262_K265_F0.9030.97
103_Y420_G0.9030.97
229_F236_I0.8960.97
433_A438_I0.8950.97
120_L330_I0.8920.97
100_Y108_P0.8920.97
197_G201_W0.8900.97
121_G361_T0.8890.97
119_W377_L0.8890.97
75_F269_P0.8870.97
62_Q65_A0.8830.97
271_T275_F0.8820.97
82_G85_G0.8810.97
320_A323_S0.8750.97
230_A234_T0.8690.97
184_E323_S0.8680.97
46_T49_T0.8670.97
450_D455_V0.8670.97
125_F128_S0.8670.97
435_I438_I0.8630.97
124_T325_N0.8630.97
272_F275_F0.8620.97
104_G426_F0.8620.97
123_Q321_T0.8600.97
102_I411_E0.8580.97
202_A206_A0.8580.97
203_V281_T0.8580.97
73_I233_V0.8580.97
100_Y429_T0.8570.97
222_F225_T0.8570.97
192_Y196_G0.8570.97
197_G309_V0.8570.97
422_N425_A0.8570.97
360_F400_K0.8540.96
173_L351_S0.8530.96
71_S239_I0.8520.96
84_A391_M0.8500.96
233_V237_I0.8450.96
18_L94_V0.8400.96
300_I304_F0.8380.96
127_G321_T0.8370.96
67_I273_A0.8360.96
431_L438_I0.8350.96
37_W93_P0.8350.96
320_A324_V0.8320.96
300_I303_R0.8310.96
461_F464_Y0.8300.96
42_H324_V0.8300.96
47_Y282_V0.8300.96
346_N350_G0.8270.96
202_A282_V0.8260.96
196_G431_L0.8220.96
113_A337_I0.8220.96
111_L380_I0.8220.96
427_A431_L0.8190.95
97_R339_N0.8170.95
92_F332_S0.8150.95
34_A38_M0.8140.95
430_M433_A0.8130.95
242_T384_L0.8130.95
445_L448_L0.8090.95
254_A257_Q0.8070.95
120_L123_Q0.8060.95
81_N247_I0.8050.95
468_M471_H0.8050.95
178_E182_R0.8020.95
44_I47_Y0.8020.95
132_N157_S0.8010.95
437_L441_Y0.7960.95
394_D468_M0.7940.95
265_F269_P0.7920.95
199_V282_V0.7920.95
45_P321_T0.7900.95
283_T286_S0.7860.94
83_H401_R0.7850.94
191_V324_V0.7850.94
68_I164_F0.7830.94
277_F281_T0.7800.94
397_I400_K0.7790.94
261_I265_F0.7760.94
81_N392_M0.7740.94
135_L138_M0.7740.94
34_A266_Y0.7720.94
184_E326_V0.7710.94
427_A430_M0.7690.94
40_C243_L0.7690.94
403_L409_Y0.7670.94
326_V330_I0.7670.94
159_L363_P0.7670.94
397_I401_R0.7660.94
266_Y270_G0.7640.93
363_P366_L0.7640.93
428_A460_S0.7590.93
71_S272_F0.7560.93
235_G374_Y0.7540.93
333_P336_D0.7480.93
14_S331_V0.7470.93
423_Y471_H0.7430.93
331_V335_Y0.7420.92
110_L340_A0.7420.92
75_F321_T0.7400.92
160_L163_V0.7390.92
45_P128_S0.7380.92
177_M253_F0.7380.92
423_Y426_F0.7350.92
170_L174_H0.7350.92
109_A336_D0.7350.92
398_I468_M0.7350.92
395_Y398_I0.7350.92
86_T260_Q0.7300.92
70_A74_L0.7280.92
253_F293_P0.7260.92
424_R471_H0.7260.92
93_P336_D0.7220.91
458_L466_V0.7200.91
382_G440_M0.7200.91
96_I99_S0.7170.91
202_A278_A0.7160.91
68_I277_F0.7150.91
203_V207_G0.7150.91
78_L81_N0.7140.91
12_R24_E0.7110.91
276_A280_I0.7110.91
48_A51_G0.7090.91
430_M463_F0.7090.91
432_G436_S0.7080.91
106_N340_A0.7080.91
29_K255_E0.7070.91
60_P284_S0.7070.91
307_P311_V0.7060.91
196_G337_I0.7060.91
127_G172_V0.7040.90
31_M35_S0.7030.90
113_A243_L0.7020.90
246_N250_F0.7020.90
463_F466_V0.7020.90
86_T254_A0.7000.90
210_G216_P0.6990.90
133_I299_D0.6980.90
365_K369_S0.6980.90
317_L321_T0.6970.90
362_V366_L0.6970.90
433_A437_L0.6970.90
79_A82_G0.6960.90
428_A461_F0.6950.90
267_G271_T0.6940.90
80_L397_I0.6920.90
120_L170_L0.6900.89
18_L97_R0.6900.89
112_R332_S0.6880.89
282_V286_S0.6850.89
193_L200_W0.6830.89
83_H257_Q0.6820.89
173_L355_A0.6810.89
90_L95_I0.6800.89
90_L94_V0.6800.89
300_I383_M0.6780.89
157_S160_L0.6770.89
411_E414_R0.6760.89
128_S158_G0.6760.89
452_S456_G0.6750.88
135_L352_F0.6730.88
455_V458_L0.6720.88
63_V67_I0.6720.88
51_G283_T0.6710.88
354_T357_L0.6680.88
40_C321_T0.6670.88
408_L414_R0.6670.88
52_G55_A0.6660.88
344_Y349_R0.6660.88
211_P462_L0.6660.88
259_E262_K0.6650.88
72_L273_A0.6650.88
412_T415_Y0.6640.88
172_V326_V0.6630.88
125_F129_T0.6610.87
43_N46_T0.6610.87
240_W268_L0.6590.87
99_S390_V0.6580.87
41_I272_F0.6550.87
174_H352_F0.6550.87
183_F323_S0.6550.87
225_T230_A0.6550.87
282_V301_L0.6530.87
435_I444_V0.6520.87
252_R331_V0.6520.87
413_G420_G0.6520.87
40_C240_W0.6520.87
361_T366_L0.6510.87
78_L242_T0.6510.87
236_I239_I0.6510.87
393_A397_I0.6500.87
97_R394_D0.6480.86
337_I350_G0.6470.86
96_I105_A0.6460.86
50_V279_S0.6440.86
118_M380_I0.6410.86
169_H322_I0.6410.86
172_V322_I0.6410.86
19_V25_K0.6390.86
27_T178_E0.6380.86
62_Q229_F0.6340.85
49_T453_W0.6340.85
442_V445_L0.6330.85
96_I387_V0.6310.85
111_L387_V0.6300.85
243_L373_V0.6300.85
443_P446_K0.6300.85
112_R246_N0.6270.85
32_N181_K0.6260.84
41_I271_T0.6240.84
81_N84_A0.6240.84
135_L161_S0.6240.84
189_P193_L0.6230.84
186_W189_P0.6230.84
134_L318_C0.6220.84
209_L212_I0.6220.84
164_F406_D0.6200.84
128_S162_F0.6190.84
97_R102_I0.6190.84
390_V460_S0.6190.84
167_A390_V0.6150.83
116_A333_P0.6140.83
270_G283_T0.6120.83
237_I241_A0.6120.83
348_K352_F0.6110.83
116_A329_N0.6100.83
28_W177_M0.6100.83
287_Q432_G0.6090.83
459_I468_M0.6090.83
366_L369_S0.6090.83
41_I93_P0.6080.83
190_L316_T0.6070.83
107_I430_M0.6040.82
191_V320_A0.6030.82
28_W254_A0.6020.82
354_T366_L0.6020.82
58_L62_Q0.6010.82
52_G374_Y0.6000.82
212_I281_T0.6000.82
334_A339_N0.6000.82
431_L434_L0.5980.82
466_V471_H0.5980.82
127_G180_I0.5950.81
30_A263_G0.5950.81
50_V53_L0.5950.81
319_I323_S0.5950.81
224_E228_P0.5940.81
237_I457_V0.5930.81
59_S217_G0.5920.81
169_H172_V0.5910.81
103_Y421_Y0.5910.81
287_Q293_P0.5910.81
194_V316_T0.5900.81
432_G435_I0.5890.81
257_Q315_I0.5890.81
121_G125_F0.5880.81
212_I266_Y0.5880.81
210_G214_S0.5880.81
78_L244_I0.5850.80
130_A134_L0.5850.80
238_G385_G0.5850.80
162_F363_P0.5830.80
48_A126_A0.5830.80
176_G331_V0.5820.80
337_I340_A0.5820.80
21_L89_G0.5800.80
90_L409_Y0.5800.80
53_L236_I0.5780.79
71_S115_T0.5760.79
240_W244_I0.5760.79
24_E462_L0.5750.79
74_L78_L0.5750.79
243_L328_A0.5750.79
450_D453_W0.5750.79
120_L169_H0.5740.79
227_W231_A0.5730.79
386_P432_G0.5730.79
240_W272_F0.5710.79
207_G211_P0.5700.79
282_V300_I0.5700.79
432_G456_G0.5700.79
68_I258_K0.5690.78
297_V301_L0.5680.78
266_Y427_A0.5670.78
301_L304_F0.5660.78
225_T229_F0.5660.78
211_P216_P0.5660.78
246_N332_S0.5630.78
25_K322_I0.5630.78
246_N249_D0.5630.78
107_I429_T0.5630.78
23_Q213_Y0.5620.78
76_G214_S0.5620.78
182_R187_A0.5610.77
328_A332_S0.5590.77
430_M462_L0.5570.77
49_T374_Y0.5570.77
213_Y216_P0.5570.77
61_W64_L0.5570.77
132_N158_G0.5560.77
81_N396_F0.5560.77
334_A350_G0.5550.77
33_F82_G0.5540.77
57_G347_F0.5540.77
300_I318_C0.5520.76
37_W264_Q0.5510.76
229_F426_F0.5500.76
86_T257_Q0.5500.76
19_V22_G0.5500.76
83_H395_Y0.5490.76
22_G253_F0.5480.76
93_P339_N0.5470.76
275_F279_S0.5460.76
173_L330_I0.5460.76
51_G85_G0.5460.76
223_S270_G0.5440.75
446_K449_Y0.5440.75
260_Q264_Q0.5420.75
59_S63_V0.5420.75
196_G274_L0.5410.75
266_Y269_P0.5400.75
20_P88_Y0.5400.75
56_I228_P0.5400.75
191_V323_S0.5390.75
375_A378_G0.5390.75
125_F392_M0.5380.74
14_S17_D0.5380.74
118_M267_G0.5370.74
399_R403_L0.5370.74
46_T123_Q0.5370.74
26_R255_E0.5360.74
212_I277_F0.5350.74
73_I103_Y0.5350.74
116_A332_S0.5350.74
390_V464_Y0.5340.74
160_L311_V0.5340.74
27_T181_K0.5340.74
45_P122_I0.5340.74
98_A415_Y0.5340.74
198_M240_W0.5330.74
124_T128_S0.5330.74
117_I380_I0.5320.74
297_V304_F0.5290.73
43_N47_Y0.5290.73
314_V323_S0.5290.73
385_G389_G0.5290.73
165_F322_I0.5290.73
46_T239_I0.5280.73
15_N346_N0.5280.73
134_L214_S0.5280.73
129_T299_D0.5280.73
279_S286_S0.5270.73
403_L408_L0.5270.73
195_F320_A0.5270.73
284_S288_V0.5260.73
232_G236_I0.5260.73
443_P447_S0.5250.73
13_L17_D0.5240.73
160_L200_W0.5220.72
130_A298_V0.5200.72
393_A464_Y0.5180.72
455_V459_I0.5180.72
33_F254_A0.5170.72
60_P213_Y0.5170.72
123_Q323_S0.5170.72
120_L246_N0.5170.72
87_K401_R0.5160.71
443_P450_D0.5160.71
159_L431_L0.5150.71
81_N85_G0.5150.71
79_A261_I0.5140.71
431_L435_I0.5130.71
384_L453_W0.5130.71
46_T279_S0.5130.71
126_A367_M0.5120.71
168_I322_I0.5110.71
119_W243_L0.5110.71
377_L399_R0.5110.71
432_G461_F0.5110.71
368_E373_V0.5110.71
422_N471_H0.5100.71
39_G184_E0.5090.70
351_S354_T0.5090.70
373_V376_F0.5080.70
115_T377_L0.5080.70
436_S440_M0.5080.70
241_A453_W0.5070.70
364_W369_S0.5070.70
43_N239_I0.5070.70
392_M457_V0.5070.70
109_A339_N0.5060.70
305_D308_Y0.5060.70
321_T383_M0.5060.70
295_W304_F0.5040.70
160_L424_R0.5040.70
341_L458_L0.5030.69
383_M433_A0.5030.69
234_T437_L0.5020.69
37_W44_I0.5010.69
189_P389_G0.5010.69
360_F364_W0.5000.69
210_G213_Y0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.9041 100 0.195 Contact Map
4djkA 2 0.8388 99.6 0.842 Contact Map
3l1lA 2 0.8224 99.5 0.854 Contact Map
3dh4A 3 0.849 99.5 0.857 Contact Map
3giaA 1 0.849 99.4 0.863 Contact Map
2xq2A 2 0.849 99.4 0.865 Contact Map
4wgvA 2 0.7388 98.5 0.904 Contact Map
4us3A 1 0.8245 97.8 0.92 Contact Map
4xp4A 1 0.9122 97.1 0.93 Contact Map
2a65A 2 0.9082 96.8 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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