GREMLIN Database
YWOC - Uncharacterized isochorismatase family protein YwoC
UniProt: P94573 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (167)
Sequences: 10200 (7031)
Seq/√Len: 544.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_D117_R3.2071.00
123_T148_Q2.7521.00
113_D147_Y2.6571.00
43_F48_G2.5771.00
105_G141_E2.5701.00
54_N100_T2.5501.00
12_T123_T2.3241.00
113_D145_L2.2361.00
19_L36_A2.1651.00
36_A127_C2.1651.00
123_T150_I2.1421.00
126_L139_A2.1341.00
161_D165_E2.1291.00
39_L152_I2.0471.00
11_K122_D2.0261.00
171_I176_G1.9521.00
22_G83_W1.8821.00
21_K82_D1.8501.00
111_D115_Q1.8391.00
180_T183_E1.8381.00
142_A149_Q1.8171.00
13_A121_I1.8121.00
136_E140_R1.7801.00
35_N155_A1.7701.00
42_E46_H1.7671.00
99_V115_Q1.7621.00
35_N181_T1.7471.00
106_A138_T1.7311.00
21_K88_P1.7141.00
35_N38_K1.6921.00
153_T178_S1.6491.00
153_T180_T1.6391.00
12_T125_V1.6131.00
51_S115_Q1.6111.00
131_T164_H1.5911.00
24_V87_V1.5861.00
97_Y115_Q1.5281.00
53_V106_A1.5251.00
49_F119_R1.4761.00
125_V152_I1.4521.00
16_I40_V1.4181.00
124_I142_A1.4121.00
44_R96_D1.4111.00
38_K182_E1.3991.00
82_D85_E1.3951.00
154_D181_T1.3901.00
16_I127_C1.3901.00
43_F125_V1.3781.00
158_T164_H1.3521.00
131_T156_M1.3491.00
136_E170_F1.3491.00
115_Q119_R1.3331.00
37_K89_E1.3161.00
37_K41_D1.3131.00
28_Q31_Q1.3091.00
126_L138_T1.3011.00
132_N158_T1.2921.00
162_E165_E1.2751.00
135_V151_F1.2561.00
15_V126_L1.2431.00
79_M100_T1.2291.00
56_A84_A1.2191.00
114_L118_R1.2171.00
131_T168_L1.2171.00
153_T168_L1.2131.00
54_N86_F1.2121.00
41_D45_K1.2051.00
117_R147_Y1.1901.00
16_I19_L1.1771.00
136_E167_T1.1721.00
14_L43_F1.1721.00
32_V36_A1.1641.00
16_I36_A1.1501.00
151_F156_M1.1501.00
17_I134_G1.1471.00
165_E169_R1.1441.00
141_E145_L1.1411.00
155_A181_T1.1181.00
56_A100_T1.1111.00
34_P89_E1.0911.00
54_N98_T1.0751.00
125_V150_I1.0581.00
56_A79_M1.0471.00
139_A151_F1.0371.00
40_V44_R1.0241.00
39_L155_A1.0211.00
124_I149_Q1.0181.00
148_Q177_K0.9801.00
111_D114_L0.9771.00
13_A51_S0.9761.00
12_T48_G0.9741.00
21_K85_E0.9711.00
156_M164_H0.9621.00
107_F142_A0.9601.00
86_F98_T0.9601.00
35_N154_D0.9521.00
150_I177_K0.9451.00
58_H79_M0.9311.00
137_S140_R0.9271.00
40_V52_F0.9101.00
139_A171_I0.9101.00
162_E166_A0.9091.00
160_S163_E0.9051.00
21_K25_P0.9011.00
131_T158_T0.8921.00
115_Q118_R0.8901.00
168_L178_S0.8861.00
162_E169_R0.8801.00
150_I179_R0.8801.00
39_L127_C0.8791.00
75_G78_E0.8771.00
164_H168_L0.8761.00
103_Q146_G0.8671.00
42_E45_K0.8621.00
116_L147_Y0.8621.00
93_Q96_D0.8591.00
52_F86_F0.8551.00
179_R183_E0.8551.00
85_E91_G0.8461.00
41_D93_Q0.8451.00
152_I155_A0.8391.00
32_V157_S0.8311.00
108_F145_L0.8261.00
122_D148_Q0.8221.00
19_L129_I0.8221.00
37_K92_V0.8211.00
15_V112_L0.8171.00
52_F95_G0.8141.00
18_D101_K0.8041.00
38_K41_D0.8031.00
52_F92_V0.8001.00
40_V50_I0.7931.00
11_K123_T0.7921.00
17_I126_L0.7911.00
49_F121_I0.7891.00
152_I179_R0.7871.00
127_C155_A0.7861.00
106_A112_L0.7781.00
51_S119_R0.7721.00
38_K42_E0.7691.00
81_A84_A0.7611.00
78_E81_A0.7601.00
126_L135_V0.7601.00
97_Y119_R0.7571.00
129_I157_S0.7571.00
21_K87_V0.7531.00
141_E144_Q0.7501.00
92_V96_D0.7501.00
169_R172_F0.7481.00
33_V37_K0.7471.00
38_K181_T0.7391.00
31_Q34_P0.7371.00
60_G63_A0.7251.00
39_L181_T0.7231.00
13_A116_L0.7211.00
132_N159_F0.7171.00
166_A170_F0.7111.00
167_T171_I0.7111.00
82_D88_P0.7051.00
132_N170_F0.7051.00
132_N163_E0.7041.00
103_Q109_G0.7041.00
44_R93_Q0.7001.00
163_E166_A0.6991.00
34_P37_K0.6941.00
49_F115_Q0.6891.00
25_P30_G0.6861.00
92_V98_T0.6771.00
14_L39_L0.6751.00
44_R95_G0.6721.00
156_M168_L0.6701.00
23_I134_G0.6671.00
88_P91_G0.6601.00
36_A155_A0.6601.00
16_I52_F0.6581.00
14_L127_C0.6531.00
169_R173_P0.6531.00
32_V129_I0.6521.00
51_S97_Y0.6511.00
139_A176_G0.6481.00
19_L87_V0.6461.00
130_A133_I0.6441.00
114_L117_R0.6431.00
41_D91_G0.6391.00
151_F171_I0.6371.00
34_P38_K0.6361.00
39_L43_F0.6361.00
130_A158_T0.6361.00
37_K91_G0.6351.00
143_F176_G0.6331.00
151_F168_L0.6331.00
80_P85_E0.6221.00
166_A169_R0.6221.00
52_F90_I0.6171.00
33_V87_V0.6161.00
52_F96_D0.6141.00
109_G114_L0.6131.00
87_V90_I0.6111.00
126_L149_Q0.6091.00
59_D75_G0.6011.00
139_A149_Q0.6011.00
11_K120_G0.5951.00
51_S99_V0.5931.00
108_F144_Q0.5911.00
54_N84_A0.5891.00
163_E169_R0.5871.00
149_Q152_I0.5840.99
29_S32_V0.5790.99
108_F141_E0.5790.99
14_L50_I0.5740.99
40_V43_F0.5720.99
29_S129_I0.5680.99
44_R50_I0.5670.99
127_C152_I0.5650.99
24_V33_V0.5630.99
40_V96_D0.5590.99
57_F63_A0.5580.99
71_P75_G0.5580.99
52_F98_T0.5570.99
17_I135_V0.5550.99
140_R174_R0.5550.99
49_F96_D0.5480.99
19_L32_V0.5480.99
130_A159_F0.5460.99
73_Q76_S0.5460.99
33_V89_E0.5430.99
14_L40_V0.5420.99
33_V90_I0.5420.99
153_T164_H0.5410.99
92_V95_G0.5390.99
168_L172_F0.5380.99
135_V156_M0.5350.99
19_L90_I0.5340.99
22_G77_G0.5330.99
105_G144_Q0.5300.99
25_P82_D0.5270.99
24_V29_S0.5220.99
30_G89_E0.5210.99
49_F97_Y0.5190.99
54_N85_E0.5180.99
103_Q108_F0.5180.99
39_L125_V0.5180.99
58_H61_A0.5180.99
153_T172_F0.5170.99
137_S175_I0.5120.99
99_V111_D0.5070.99
43_F49_F0.5050.99
104_W144_Q0.5050.99
31_Q35_N0.5050.99
104_W138_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kl2A 4 0.9894 100 0.149 Contact Map
3irvA 2 0.9788 100 0.16 Contact Map
2fq1A 2 0.9894 100 0.164 Contact Map
3hb7A 3 0.9418 100 0.166 Contact Map
3ot4A 4 0.9841 100 0.166 Contact Map
4l07A 4 1 100 0.169 Contact Map
1j2rA 4 0.9683 100 0.17 Contact Map
1nbaA 4 0.9947 100 0.17 Contact Map
3txyA 2 0.9788 100 0.173 Contact Map
3hu5A 3 0.9524 100 0.175 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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