GREMLIN Database
YWOB - Uncharacterized protein YwoB
UniProt: P94572 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (139)
Sequences: 233 (199)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_A85_L4.8571.00
105_V109_Y3.8461.00
44_V64_G3.4921.00
82_V86_I3.3310.99
20_F125_M2.9770.98
105_V120_T2.5690.96
91_A133_D2.4980.95
101_I104_I2.4050.94
72_F106_L2.3830.94
21_R90_A2.2450.92
75_F79_L2.2250.92
56_F114_G1.9570.85
63_F73_I1.9400.85
26_F85_L1.8370.81
31_Y56_F1.8310.81
44_V119_S1.8210.81
20_F128_I1.8090.80
48_I52_A1.8000.80
24_L97_F1.7550.78
36_V78_I1.7240.77
109_Y120_T1.6000.71
36_V76_G1.5770.70
80_A97_F1.5760.70
108_N119_S1.5670.69
28_F97_F1.5400.68
76_G100_I1.5260.67
59_A107_I1.5010.66
36_V58_I1.4860.65
11_A83_L1.4810.65
97_F126_C1.4080.61
26_F78_I1.3960.60
62_F65_Y1.3860.60
55_G114_G1.3600.58
41_F60_W1.3540.58
68_V110_C1.3360.57
20_F129_L1.3230.56
113_I116_Q1.3210.56
34_A39_G1.3140.55
28_F58_I1.3140.55
105_V119_S1.2850.54
119_S129_L1.2730.53
28_F80_A1.2600.52
79_L134_R1.2560.52
12_V111_F1.2500.52
22_L87_P1.2310.51
8_L11_A1.2070.49
41_F70_E1.2040.49
84_L94_A1.1930.48
58_I72_F1.1900.48
112_D116_Q1.1810.48
66_S102_V1.1530.46
16_I19_T1.1450.45
139_G143_Q1.1270.44
16_I28_F1.1110.43
70_E73_I1.1010.43
16_I128_I1.1000.43
50_A58_I1.1000.43
97_F120_T1.0960.43
92_L96_I1.0960.43
17_P133_D1.0920.42
31_Y122_L1.0790.42
31_Y104_I1.0550.40
69_Y77_E1.0540.40
76_G102_V1.0530.40
87_P111_F1.0480.40
60_W115_V1.0360.39
44_V108_N1.0330.39
60_W112_D1.0260.39
41_F63_F1.0250.38
138_M142_R1.0230.38
64_G122_L1.0010.37
32_G78_I1.0000.37
96_I143_Q0.9950.37
68_V123_M0.9930.37
98_M127_L0.9910.37
54_K66_S0.9840.36
18_A79_L0.9750.36
22_L96_I0.9600.35
50_A108_N0.9580.35
86_I130_L0.9550.35
56_F113_I0.9500.34
36_V71_L0.9330.33
71_L111_F0.9270.33
62_F69_Y0.9230.33
51_A108_N0.9130.32
96_I119_S0.8930.31
27_N121_I0.8710.30
22_L100_I0.8690.30
59_A62_F0.8580.30
112_D115_V0.8390.29
38_I57_T0.8340.28
133_D136_K0.8290.28
69_Y103_N0.8290.28
53_G111_F0.8290.28
52_A82_V0.8260.28
22_L118_L0.8250.28
104_I126_C0.8180.28
75_F136_K0.8170.28
24_L43_E0.8150.28
116_Q122_L0.8090.27
12_V46_P0.8080.27
74_G77_E0.8070.27
78_I82_V0.8050.27
29_F78_I0.8020.27
117_D140_I0.8020.27
118_L121_I0.7950.27
100_I103_N0.7940.27
20_F51_A0.7890.26
7_R11_A0.7880.26
38_I70_E0.7800.26
114_G117_D0.7780.26
18_A72_F0.7770.26
25_A129_L0.7650.25
28_F81_A0.7590.25
73_I115_V0.7580.25
104_I136_K0.7580.25
104_I107_I0.7560.25
131_W135_R0.7540.25
51_A112_D0.7520.25
16_I111_F0.7510.25
107_I113_I0.7490.24
54_K113_I0.7460.24
58_I103_N0.7450.24
101_I116_Q0.7420.24
22_L102_V0.7260.23
56_F65_Y0.7250.23
18_A52_A0.7230.23
72_F80_A0.7200.23
23_F111_F0.7140.23
72_F76_G0.7110.23
56_F60_W0.6980.22
76_G80_A0.6940.22
23_F27_N0.6860.22
23_F64_G0.6790.22
54_K114_G0.6740.21
32_G36_V0.6730.21
7_R99_P0.6680.21
71_L102_V0.6680.21
60_W95_V0.6650.21
97_F100_I0.6650.21
56_F140_I0.6600.21
36_V102_V0.6590.21
55_G66_S0.6580.21
20_F50_A0.6580.21
80_A90_A0.6580.21
21_R84_L0.6550.21
14_K59_A0.6530.21
37_V133_D0.6530.21
90_A96_I0.6470.20
24_L81_A0.6430.20
25_A88_R0.6400.20
31_Y116_Q0.6350.20
127_L131_W0.6330.20
124_V142_R0.6330.20
139_G144_E0.6300.20
38_I41_F0.6260.19
85_L88_R0.6220.19
59_A70_E0.6210.19
29_F81_A0.6140.19
61_T125_M0.6140.19
10_K13_R0.6120.19
51_A116_Q0.6120.19
116_Q132_M0.6060.19
42_G70_E0.6060.19
44_V122_L0.6040.19
12_V16_I0.6010.19
24_L126_C0.5960.18
47_E79_L0.5960.18
17_P129_L0.5950.18
84_L93_G0.5950.18
67_H125_M0.5910.18
6_G10_K0.5890.18
64_G91_A0.5880.18
67_H77_E0.5790.18
30_V45_T0.5780.18
12_V131_W0.5760.18
98_M130_L0.5740.18
55_G115_V0.5720.18
92_L110_C0.5700.17
22_L143_Q0.5690.17
9_R71_L0.5630.17
22_L86_I0.5620.17
74_G94_A0.5600.17
21_R25_A0.5560.17
32_G81_A0.5560.17
60_W116_Q0.5550.17
19_T81_A0.5520.17
56_F112_D0.5470.17
8_L99_P0.5470.17
22_L103_N0.5430.17
39_G104_I0.5410.17
50_A92_L0.5400.16
80_A101_I0.5400.16
127_L137_F0.5400.16
58_I65_Y0.5390.16
92_L139_G0.5300.16
10_K99_P0.5280.16
75_F80_A0.5260.16
79_L98_M0.5240.16
67_H70_E0.5230.16
8_L37_V0.5230.16
29_F110_C0.5230.16
82_V104_I0.5120.16
13_R22_L0.5080.15
63_F101_I0.5070.15
40_Q74_G0.5040.15
85_L118_L0.5040.15
7_R73_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4tA 1 0.8831 8.3 0.955 Contact Map
4ev6A 3 0.461 6.4 0.957 Contact Map
4humA 1 0.9416 5.3 0.959 Contact Map
3j61U 1 0.2078 4.9 0.959 Contact Map
3mktA 1 0.9221 4.5 0.96 Contact Map
3b5dA 2 0.539 3.5 0.962 Contact Map
4lz6A 1 0.9026 3.2 0.963 Contact Map
4i0uA 4 0.4481 3.1 0.963 Contact Map
4wjvI 1 0.039 2.7 0.964 Contact Map
3j9pD 4 0.9091 1.9 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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