GREMLIN Database
BCRC - Undecaprenyl-diphosphatase BcrC
UniProt: P94571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (160)
Sequences: 7373 (5834)
Seq/√Len: 461.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_G149_L3.4931.00
110_I156_G3.3021.00
75_F95_A3.1121.00
76_E143_V3.0601.00
67_N103_T2.8871.00
97_F147_G2.7651.00
114_F160_F2.4091.00
62_A155_I2.3581.00
63_G103_T2.3021.00
63_G107_A2.2811.00
20_D136_W2.2381.00
102_T131_G2.2351.00
106_L127_G2.2321.00
70_I74_Y2.2171.00
106_L149_L2.0521.00
31_I35_A2.0061.00
102_T106_L1.9221.00
106_L131_G1.8831.00
148_S152_A1.8601.00
23_M132_F1.8451.00
110_I153_I1.8251.00
46_N49_S1.8171.00
113_L120_G1.7851.00
31_I34_Y1.7671.00
6_F142_P1.7471.00
6_F135_I1.7341.00
152_A156_G1.7321.00
29_Y126_F1.7131.00
131_G145_V1.7111.00
27_T133_S1.7061.00
59_T107_A1.6681.00
109_S127_G1.6451.00
157_F161_R1.6441.00
8_A12_L1.5711.00
26_I129_L1.5491.00
135_I145_V1.5161.00
105_A130_T1.5111.00
32_V35_A1.4841.00
55_Y159_F1.4141.00
41_I45_G1.4131.00
21_S24_V1.4121.00
26_I130_T1.4101.00
71_T100_D1.3981.00
76_E141_Y1.3851.00
102_T149_L1.3791.00
23_M133_S1.3541.00
96_S144_D1.2591.00
16_N19_L1.2581.00
113_L123_L1.2171.00
67_N100_D1.2071.00
120_G123_L1.2041.00
19_L23_M1.1911.00
70_I98_P1.1761.00
32_V36_L1.1651.00
98_P151_V1.1631.00
15_H20_D1.1631.00
74_Y97_F1.1611.00
6_F10_H1.1551.00
10_H15_H1.1501.00
102_T148_S1.1331.00
154_I157_F1.1291.00
49_S52_H1.1001.00
155_I159_F1.0891.00
96_S141_Y1.0871.00
103_T151_V1.0831.00
92_A139_H1.0811.00
127_G149_L1.0771.00
135_I142_P1.0701.00
68_Y72_L1.0691.00
55_Y111_A1.0521.00
109_S123_L1.0431.00
27_T137_V1.0401.00
21_S25_F1.0371.00
18_V22_I1.0271.00
102_T145_V1.0221.00
30_A130_T1.0091.00
9_I12_L1.0081.00
153_I157_F1.0061.00
42_W45_G1.0031.00
114_F156_G1.0021.00
105_A127_G0.9981.00
72_L95_A0.9881.00
110_I152_A0.9851.00
69_L73_V0.9811.00
83_H86_H0.9771.00
109_S126_F0.9711.00
121_W125_I0.9581.00
98_P147_G0.9531.00
5_I8_A0.9481.00
77_P81_V0.9441.00
124_V127_G0.9401.00
65_V69_L0.9361.00
133_S137_V0.9351.00
56_A111_A0.9341.00
64_L68_Y0.9261.00
59_T63_G0.9251.00
132_F136_W0.9171.00
73_V77_P0.9151.00
45_G49_S0.9131.00
42_W46_N0.9061.00
109_S113_L0.8981.00
113_L124_V0.8961.00
40_A44_F0.8901.00
97_F144_D0.8751.00
149_L153_I0.8701.00
28_E31_I0.8661.00
76_E96_S0.8621.00
20_D24_V0.8611.00
80_F92_A0.8591.00
33_A36_L0.8361.00
106_L124_V0.8321.00
8_A11_G0.8301.00
112_M123_L0.8291.00
106_L156_G0.8261.00
151_V155_I0.8241.00
24_V28_E0.8231.00
4_E8_A0.8151.00
12_L15_H0.8151.00
22_I129_L0.8091.00
118_K122_P0.8031.00
23_M27_T0.7951.00
67_N151_V0.7801.00
110_I124_V0.7781.00
111_A114_F0.7771.00
89_I139_H0.7771.00
60_G64_L0.7771.00
58_I61_I0.7651.00
63_G104_G0.7611.00
107_A111_A0.7601.00
22_I26_I0.7591.00
128_L149_L0.7581.00
60_G104_G0.7561.00
41_I44_F0.7501.00
110_I114_F0.7491.00
22_I25_F0.7471.00
106_L128_L0.7441.00
62_A159_F0.7441.00
27_T30_A0.7431.00
159_F163_S0.7421.00
59_T156_G0.7411.00
59_T111_A0.7411.00
66_I151_V0.7391.00
85_V90_P0.7381.00
130_T133_S0.7371.00
116_N120_G0.7361.00
23_M136_W0.7331.00
51_K55_Y0.7321.00
44_F49_S0.7191.00
70_I151_V0.7191.00
142_P146_L0.7181.00
7_K11_G0.7161.00
63_G155_I0.7161.00
5_I142_P0.7161.00
71_T78_R0.7111.00
103_T155_I0.7051.00
25_F28_E0.7031.00
139_H142_P0.6941.00
20_D23_M0.6881.00
60_G108_I0.6861.00
102_T105_A0.6861.00
12_L17_S0.6841.00
9_I135_I0.6841.00
27_T139_H0.6841.00
103_T148_S0.6821.00
105_A109_S0.6811.00
80_F141_Y0.6791.00
26_I29_Y0.6781.00
83_H87_T0.6781.00
126_F130_T0.6771.00
100_D104_G0.6701.00
76_E144_D0.6701.00
31_I36_L0.6691.00
111_A160_F0.6691.00
77_P82_A0.6641.00
80_F139_H0.6521.00
31_I100_D0.6441.00
114_F157_F0.6431.00
17_S21_S0.6340.99
66_I155_I0.6340.99
63_G67_N0.6310.99
101_H140_H0.6300.99
86_H90_P0.6280.99
59_T159_F0.6270.99
119_I123_L0.6270.99
39_L42_W0.6240.99
80_F91_H0.6180.99
147_G150_V0.6170.99
111_A156_G0.6150.99
12_L132_F0.6130.99
150_V153_I0.6100.99
83_H90_P0.6090.99
19_L136_W0.6090.99
10_H138_G0.6060.99
105_A126_F0.6000.99
33_A37_I0.5990.99
37_I40_A0.5980.99
106_L153_I0.5970.99
34_Y37_I0.5900.99
54_L58_I0.5870.99
50_R54_L0.5860.99
6_F143_V0.5820.99
131_G135_I0.5800.99
57_G61_I0.5780.99
128_L132_F0.5700.99
12_L16_N0.5690.99
27_T130_T0.5680.99
92_A104_G0.5650.99
27_T134_R0.5650.99
24_V137_V0.5630.99
72_L75_F0.5630.99
51_K54_L0.5620.99
85_V88_L0.5620.99
103_T107_A0.5580.99
55_Y114_F0.5540.99
58_I163_S0.5540.99
122_P125_I0.5510.99
159_F162_F0.5480.99
160_F164_D0.5460.98
4_E7_K0.5450.98
66_I69_L0.5440.98
56_A60_G0.5430.98
129_L133_S0.5420.98
10_H20_D0.5410.98
55_Y59_T0.5390.98
138_G142_P0.5370.98
7_K10_H0.5350.98
5_I135_I0.5340.98
121_W124_V0.5320.98
162_F165_L0.5290.98
16_N21_S0.5240.98
85_V89_I0.5240.98
59_T62_A0.5230.98
107_A156_G0.5220.98
146_L149_L0.5150.98
47_T50_R0.5140.98
59_T152_A0.5120.98
55_Y163_S0.5080.98
27_T105_A0.5070.98
64_L67_N0.5020.97
94_D100_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.9689 100 0.363 Contact Map
1d2tA 5 0.9275 99.9 0.434 Contact Map
4citA 1 0.886 99.9 0.445 Contact Map
2ipbA 2 0.9378 99.9 0.471 Contact Map
1qi9A 2 0.9896 99.9 0.481 Contact Map
1up8A 9 0.9275 99.9 0.495 Contact Map
3w36A 2 0.8705 99.9 0.5 Contact Map
3bb0A 1 0.9896 99.8 0.546 Contact Map
2kluA 1 0.2902 52.5 0.916 Contact Map
4mndA 2 0.8083 16.3 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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