GREMLIN Database
YSOA - TPR repeat-containing protein YsoA
UniProt: P94569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (289)
Sequences: 737 (678)
Seq/√Len: 39.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_A74_C4.5841.00
37_L57_M4.5241.00
57_M73_V4.4801.00
101_K104_E4.4371.00
93_M109_I3.9581.00
66_E69_E3.9511.00
43_A77_M3.8291.00
78_L89_L3.6731.00
61_F69_E3.6111.00
134_R139_P2.8101.00
24_G40_F2.7811.00
47_D50_E2.7121.00
35_E38_E2.6131.00
71_E92_Y2.5781.00
37_L60_C2.5711.00
92_Y108_T2.5351.00
21_V56_G2.3971.00
306_E310_M2.3241.00
44_M54_H2.3021.00
32_K35_E2.2841.00
71_E95_I2.2491.00
273_L278_P2.1000.99
41_S57_M2.0920.99
55_L91_V2.0830.99
81_G84_H2.0100.99
92_Y96_L1.9460.99
33_Y67_L1.8860.98
24_G39_L1.8830.98
307_L310_M1.8240.98
304_S310_M1.7910.98
20_L54_H1.7880.98
305_E309_M1.7400.97
61_F66_E1.7150.97
280_L284_D1.7110.97
112_V122_S1.6890.97
55_L95_I1.6790.96
300_I310_M1.6650.96
45_K82_Y1.6590.96
89_L108_T1.6390.96
269_H273_L1.6350.96
308_H311_Y1.6340.96
27_S35_E1.6230.96
148_E151_E1.6180.96
75_E92_Y1.6180.96
48_D51_S1.5660.95
130_L133_S1.5500.94
20_L42_E1.5410.94
19_R53_L1.5400.94
305_E308_H1.5320.94
153_T157_E1.5240.94
89_L111_A1.5160.94
307_L311_Y1.5030.94
135_K138_D1.4980.93
258_L262_V1.4930.93
57_M92_Y1.4890.93
54_H73_V1.4870.93
300_I308_H1.4680.93
304_S309_M1.4570.92
300_I306_E1.4520.92
115_E118_L1.4490.92
284_D291_H1.4260.92
93_M112_V1.4220.91
284_D298_H1.4190.91
262_V269_H1.4090.91
74_C81_G1.3880.90
84_H92_Y1.3760.90
255_N262_V1.3640.90
136_M139_P1.3530.89
74_C91_V1.3420.89
291_H295_Y1.3380.89
284_D287_A1.3360.89
77_M88_V1.3080.88
63_E88_V1.3080.88
206_L210_E1.3070.88
271_Y275_P1.3040.87
74_C95_I1.2980.87
91_V95_I1.2920.87
55_L62_L1.2840.87
255_N258_L1.2750.86
40_F77_M1.2750.86
19_R23_K1.2600.86
288_A292_K1.2540.85
20_L39_L1.2390.85
123_A127_Y1.2380.85
275_P278_P1.2360.84
25_M40_F1.2360.84
39_L73_V1.2230.84
150_Y155_D1.2130.83
59_I91_V1.2090.83
81_G85_Y1.2080.83
68_E99_L1.2070.83
207_A210_E1.2040.83
69_E72_S1.2020.83
196_P208_E1.1980.83
23_K39_L1.1900.82
163_P168_N1.1830.82
55_L77_M1.1720.81
263_E269_H1.1670.81
303_E306_E1.1540.80
306_E311_Y1.1470.80
292_K311_Y1.1320.79
59_I74_C1.1300.79
87_T91_V1.1140.78
32_K65_G1.1100.77
300_I311_Y1.1080.77
71_E74_C1.1060.77
164_E168_N1.1050.77
285_L294_G1.1030.77
144_E147_A1.1030.77
93_M105_V1.1000.77
301_E308_H1.0990.77
302_I308_H1.0980.77
56_G91_V1.0930.76
57_M61_F1.0920.76
60_C95_I1.0810.75
62_L91_V1.0790.75
56_G59_I1.0760.75
89_L97_I1.0740.75
60_C64_L1.0710.75
167_M174_K1.0630.74
202_I206_L1.0570.74
93_M96_L1.0490.73
299_G308_H1.0450.73
84_H87_T1.0430.73
88_V122_S1.0410.73
288_A300_I1.0380.72
199_K210_E1.0370.72
56_G77_M1.0370.72
287_A291_H1.0370.72
95_I99_L1.0320.72
291_H300_I1.0310.72
147_A151_E1.0250.71
33_Y84_H1.0230.71
35_E75_E1.0190.71
58_A73_V1.0180.71
130_L139_P1.0180.71
54_H77_M1.0080.70
58_A105_V1.0060.70
92_Y109_I1.0060.70
171_H184_L1.0050.70
267_R271_Y0.9970.69
288_A311_Y0.9890.69
303_E311_Y0.9850.68
297_M300_I0.9820.68
130_L134_R0.9750.68
294_G300_I0.9750.68
91_V97_I0.9740.68
170_I177_N0.9730.67
300_I307_L0.9620.67
207_A212_S0.9620.67
294_G307_L0.9590.66
300_I305_E0.9590.66
67_L95_I0.9550.66
147_A156_T0.9500.66
167_M170_I0.9400.65
262_V268_R0.9390.65
59_I63_E0.9370.65
305_E310_M0.9360.64
302_I310_M0.9320.64
21_V28_L0.9260.64
281_L301_E0.9230.63
292_K304_S0.9230.63
291_H311_Y0.9150.63
240_L307_L0.9150.63
273_L285_L0.9150.63
268_R271_Y0.9140.63
298_H308_H0.9050.62
23_K26_S0.9010.61
23_K27_S0.8960.61
20_L89_L0.8940.61
25_M28_L0.8920.61
266_W274_Y0.8910.61
55_L74_C0.8900.60
43_A53_L0.8890.60
291_H299_G0.8860.60
294_G298_H0.8830.60
202_I210_E0.8830.60
266_W290_L0.8820.60
97_I109_I0.8810.60
161_A166_Q0.8790.60
133_S137_T0.8790.60
303_E310_M0.8700.59
123_A139_P0.8670.58
23_K57_M0.8670.58
27_S71_E0.8660.58
28_L40_F0.8660.58
27_S32_K0.8640.58
132_F135_K0.8600.58
216_H220_F0.8590.58
129_L136_M0.8550.57
42_E67_L0.8530.57
69_E74_C0.8470.57
117_Q121_E0.8450.56
58_A92_Y0.8420.56
222_E225_T0.8410.56
295_Y300_I0.8360.56
91_V94_T0.8350.56
299_G306_E0.8350.56
302_I309_M0.8330.55
259_Y264_E0.8330.55
285_L293_V0.8320.55
132_F139_P0.8290.55
295_Y301_E0.8260.55
140_D152_D0.8220.54
263_E285_L0.8220.54
298_H304_S0.8200.54
53_L71_E0.8170.54
24_G47_D0.8120.53
281_L284_D0.8120.53
32_K38_E0.8120.53
303_E308_H0.8110.53
261_A268_R0.8030.53
85_Y93_M0.8020.53
299_G311_Y0.8020.53
63_E77_M0.8010.52
78_L82_Y0.7980.52
301_E307_L0.7960.52
75_E78_L0.7850.51
296_E301_E0.7850.51
151_E159_V0.7840.51
25_M99_L0.7820.51
285_L288_A0.7810.51
200_T208_E0.7800.51
40_F56_G0.7800.51
221_G225_T0.7790.50
149_E155_D0.7790.50
291_H294_G0.7780.50
291_H298_H0.7780.50
22_E29_K0.7770.50
30_E33_Y0.7760.50
104_E107_S0.7750.50
263_E266_W0.7720.50
152_D155_D0.7700.50
290_L297_M0.7680.49
55_L59_I0.7680.49
25_M59_I0.7670.49
68_E79_K0.7670.49
49_T66_E0.7650.49
62_L98_Q0.7640.49
122_S138_D0.7630.49
304_S307_L0.7610.49
55_L63_E0.7610.49
268_R272_V0.7590.49
301_E306_E0.7560.48
200_T209_H0.7550.48
292_K296_E0.7510.48
294_G299_G0.7490.48
71_E80_E0.7480.48
266_W286_W0.7480.48
299_G307_L0.7470.48
63_E95_I0.7460.47
285_L306_E0.7450.47
109_I116_N0.7440.47
80_E112_V0.7420.47
122_S125_Q0.7400.47
301_E304_S0.7390.47
57_M91_V0.7380.47
106_K110_E0.7380.47
154_I157_E0.7370.47
288_A291_H0.7360.47
284_D292_K0.7340.46
168_N172_S0.7330.46
26_S75_E0.7320.46
64_L100_K0.7300.46
153_T156_T0.7290.46
289_A293_V0.7280.46
24_G56_G0.7280.46
24_G124_E0.7260.46
301_E310_M0.7220.45
127_Y136_M0.7210.45
202_I209_H0.7180.45
82_Y85_Y0.7170.45
116_N119_P0.7170.45
30_E67_L0.7130.44
269_H278_P0.7130.44
127_Y131_D0.7110.44
131_D135_K0.7100.44
40_F57_M0.7100.44
31_K35_E0.7090.44
297_M306_E0.7060.44
296_E311_Y0.7040.44
59_I62_L0.7030.44
179_A182_T0.7020.43
23_K30_E0.7010.43
127_Y134_R0.7010.43
102_Y106_K0.6990.43
131_D136_M0.6980.43
269_H280_L0.6960.43
302_I305_E0.6920.43
291_H297_M0.6910.42
205_L209_H0.6870.42
201_M204_M0.6860.42
284_D288_A0.6830.42
55_L84_H0.6810.42
294_G297_M0.6800.41
196_P199_K0.6800.41
259_Y270_L0.6790.41
67_L102_Y0.6790.41
58_A96_L0.6790.41
298_H311_Y0.6790.41
162_S169_L0.6780.41
35_E50_E0.6770.41
233_P236_A0.6760.41
167_M172_S0.6750.41
288_A299_G0.6750.41
34_Q60_C0.6710.41
301_E305_E0.6700.41
162_S168_N0.6690.41
296_E310_M0.6670.40
295_Y298_H0.6660.40
293_V296_E0.6650.40
131_D134_R0.6620.40
59_I90_Q0.6600.40
288_A295_Y0.6600.40
25_M95_I0.6590.40
197_I200_T0.6580.40
105_V132_F0.6540.39
285_L292_K0.6510.39
116_N120_A0.6510.39
196_P200_T0.6480.39
96_L104_E0.6470.39
292_K300_I0.6460.38
67_L99_L0.6450.38
24_G59_I0.6430.38
287_A296_E0.6420.38
94_T97_I0.6410.38
295_Y302_I0.6410.38
118_L122_S0.6410.38
25_M87_T0.6400.38
24_G43_A0.6380.38
269_H284_D0.6380.38
288_A308_H0.6370.38
198_I203_V0.6350.38
105_V109_I0.6350.38
60_C90_Q0.6330.37
289_A299_G0.6330.37
62_L71_E0.6320.37
273_L280_L0.6320.37
126_F139_P0.6320.37
62_L95_I0.6300.37
262_V266_W0.6270.37
63_E91_V0.6270.37
292_K308_H0.6260.37
26_S50_E0.6250.37
23_K58_A0.6230.37
50_E67_L0.6220.36
113_L123_A0.6190.36
23_K71_E0.6180.36
60_C63_E0.6130.36
162_S181_Y0.6130.36
163_P166_Q0.6120.36
286_W291_H0.6110.36
269_H288_A0.6060.35
286_W294_G0.6060.35
66_E113_L0.6040.35
54_H89_L0.6030.35
304_S308_H0.6020.35
298_H306_E0.6010.35
90_Q95_I0.6000.35
19_R22_E0.5990.35
189_L196_P0.5940.34
216_H226_I0.5930.34
72_S107_S0.5920.34
28_L63_E0.5910.34
203_V210_E0.5910.34
283_A294_G0.5880.34
110_E113_L0.5850.33
145_A148_E0.5840.33
23_K35_E0.5840.33
22_E47_D0.5840.33
296_E304_S0.5800.33
227_E231_I0.5800.33
180_K185_L0.5800.33
42_E45_K0.5790.33
23_K32_K0.5780.33
285_L291_H0.5780.33
299_G305_E0.5760.33
62_L78_L0.5760.33
170_I173_L0.5750.33
147_A150_Y0.5750.33
239_I245_R0.5720.32
302_I306_E0.5710.32
55_L88_V0.5710.32
296_E307_L0.5680.32
169_L175_D0.5660.32
40_F51_S0.5650.32
199_K203_V0.5640.32
261_A266_W0.5640.32
40_F124_E0.5640.32
33_Y45_K0.5630.32
288_A293_V0.5630.32
61_F89_L0.5620.32
230_E236_A0.5620.32
229_S232_V0.5600.31
271_Y274_Y0.5590.31
155_D159_V0.5560.31
99_L108_T0.5560.31
203_V206_L0.5560.31
281_L295_Y0.5510.31
241_H247_L0.5500.31
45_K49_T0.5500.31
61_F68_E0.5500.31
299_G302_I0.5500.31
52_D91_V0.5490.30
94_T98_Q0.5490.30
77_M87_T0.5490.30
126_F133_S0.5490.30
189_L217_I0.5490.30
117_Q123_A0.5470.30
265_L286_W0.5450.30
47_D51_S0.5450.30
42_E76_K0.5440.30
283_A286_W0.5410.30
238_P251_L0.5400.30
269_H286_W0.5370.30
289_A292_K0.5360.29
79_K82_Y0.5350.29
260_A269_H0.5320.29
159_V241_H0.5290.29
25_M91_V0.5290.29
73_V92_Y0.5260.29
41_S87_T0.5220.28
21_V53_L0.5210.28
56_G60_C0.5180.28
20_L44_M0.5180.28
106_K123_A0.5140.28
54_H59_I0.5080.27
267_R274_Y0.5070.27
298_H302_I0.5060.27
169_L180_K0.5060.27
105_V112_V0.5060.27
237_A244_L0.5040.27
23_K37_L0.5020.27
295_Y310_M0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q7aA 1 0.6437 99.9 0.536 Contact Map
3dssA 1 0.5988 99.9 0.539 Contact Map
2pziA 1 0.6168 99.9 0.541 Contact Map
1p5qA 5 0.476 99.9 0.542 Contact Map
1kt0A 2 0.4251 99.9 0.542 Contact Map
1w3bA 2 0.5778 99.9 0.548 Contact Map
4l9pA 1 0.6108 99.9 0.551 Contact Map
2h6fA 1 0.6946 99.9 0.552 Contact Map
1fchA 3 0.4701 99.8 0.554 Contact Map
4eqfA 1 0.4671 99.8 0.555 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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