GREMLIN Database
LEUD - 3-isopropylmalate dehydratase small subunit
UniProt: P94568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (170)
Sequences: 5468 (2730)
Seq/√Len: 209.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_T141_T3.9411.00
49_D53_E2.6621.00
73_A100_A2.6531.00
122_P125_N2.6131.00
97_I142_V2.5481.00
8_T139_Q2.5341.00
148_L156_Q2.4661.00
167_E171_N2.2901.00
7_H69_S2.2151.00
75_E101_P2.1921.00
147_Q166_K2.1701.00
164_H168_M2.1521.00
143_D146_N2.1191.00
37_G40_R2.0631.00
49_D55_N2.0481.00
41_F44_F2.0241.00
23_Q46_W1.9891.00
76_N79_C1.9711.00
111_C118_P1.9131.00
87_P104_A1.8841.00
111_C116_M1.8751.00
150_H156_Q1.8711.00
42_A89_A1.8021.00
9_G69_S1.7921.00
141_T150_H1.7511.00
90_L116_M1.7431.00
151_D155_N1.6891.00
20_D23_Q1.6811.00
70_I97_I1.6641.00
121_M126_W1.6551.00
13_V65_Y1.6161.00
10_K139_Q1.6041.00
17_I75_E1.6021.00
128_Q155_N1.5721.00
29_F44_F1.5561.00
112_F118_P1.5181.00
145_E170_I1.5121.00
162_D165_W1.5051.00
113_K175_E1.4951.00
13_V55_N1.4921.00
145_E166_K1.4771.00
61_N65_Y1.4351.00
112_F165_W1.4231.00
28_Q45_D1.3991.00
147_Q163_P1.3751.00
17_I74_G1.3611.00
126_W129_L1.3601.00
17_I101_P1.3391.00
54_P66_Q1.3291.00
18_N76_N1.3141.00
129_L155_N1.2991.00
70_I140_M1.2911.00
148_L158_S1.2891.00
9_G70_I1.2731.00
101_P126_W1.2651.00
42_A93_Y1.2631.00
166_K170_I1.2561.00
11_A140_M1.2541.00
12_A68_A1.2531.00
171_N178_L1.2491.00
35_R39_G1.2451.00
32_R38_Y1.2251.00
108_H165_W1.2191.00
27_K45_D1.2181.00
101_P128_Q1.2081.00
74_G130_V1.1951.00
144_L147_Q1.1941.00
15_N130_V1.1901.00
173_Y177_S1.1891.00
99_I126_W1.1811.00
123_Y127_K1.1721.00
87_P116_M1.1431.00
11_A14_L1.1201.00
15_N19_V1.1171.00
138_L151_D1.1111.00
77_F107_F1.1081.00
143_D148_L1.1031.00
107_F111_C1.1031.00
10_K137_S1.1031.00
72_I130_V1.1001.00
163_P167_E1.0781.00
31_K37_G1.0761.00
91_D116_M1.0621.00
25_I89_A1.0581.00
25_I42_A1.0511.00
10_K67_G1.0431.00
24_I43_F1.0401.00
75_E123_Y1.0401.00
149_I157_I1.0261.00
91_D96_K1.0181.00
120_R160_E1.0081.00
69_S95_F1.0071.00
28_Q44_F1.0071.00
112_F161_V1.0041.00
108_H112_F0.9971.00
154_G157_I0.9961.00
165_W168_M0.9781.00
9_G68_A0.9731.00
36_T92_D0.9711.00
171_N175_E0.9681.00
108_H120_R0.9561.00
85_H88_W0.9541.00
43_F47_R0.9541.00
64_V67_G0.9531.00
70_I99_I0.9520.99
7_H97_I0.9490.99
69_S96_K0.9310.99
151_D157_I0.9280.99
91_D114_N0.9240.99
126_W130_V0.9200.99
147_Q161_V0.9180.99
140_M151_D0.9170.99
149_I154_G0.9150.99
125_N157_I0.9100.99
152_S155_N0.9020.99
174_D177_S0.8990.99
125_N128_Q0.8980.99
101_P123_Y0.8860.99
15_N134_E0.8800.99
74_G127_K0.8770.99
85_H104_A0.8730.99
29_F41_F0.8710.99
43_F46_W0.8680.99
148_L151_D0.8600.99
15_N74_G0.8550.99
77_F90_L0.8540.99
168_M175_E0.8460.99
71_L95_F0.8360.99
119_I159_F0.8360.99
49_D56_P0.8340.99
56_P60_L0.8290.99
135_N151_D0.8180.98
38_Y85_H0.8140.98
51_N127_K0.8080.98
63_P66_Q0.8080.98
75_E124_D0.8030.98
135_N138_L0.8010.98
73_A98_I0.7900.98
38_Y89_A0.7810.98
11_A72_I0.7790.98
112_F168_M0.7740.98
35_R88_W0.7740.98
149_I159_F0.7730.98
30_L85_H0.7690.98
23_Q45_D0.7650.98
72_I99_I0.7650.98
101_P127_K0.7580.98
117_L144_L0.7580.98
34_E41_F0.7550.97
87_P111_C0.7530.97
135_N153_E0.7520.97
42_A90_L0.7520.97
27_K44_F0.7490.97
20_D30_L0.7370.97
55_N58_F0.7340.97
146_N156_Q0.7300.97
149_I152_S0.7270.97
32_R41_F0.7200.97
151_D156_Q0.7190.97
115_G172_G0.7190.97
14_L51_N0.7170.97
16_R52_G0.7100.96
167_E173_Y0.7090.96
39_G92_D0.7090.96
138_L152_S0.7080.96
148_L152_S0.7060.96
38_Y88_W0.7040.96
60_L63_P0.7000.96
16_R46_W0.6940.96
10_K66_Q0.6870.96
148_L154_G0.6790.95
152_S156_Q0.6740.95
58_F61_N0.6730.95
99_I121_M0.6650.95
48_Y52_G0.6640.95
49_D52_G0.6610.95
122_P158_S0.6540.94
151_D154_G0.6520.94
40_R44_F0.6520.94
25_I32_R0.6480.94
31_K41_F0.6470.94
13_V59_E0.6340.93
18_N79_C0.6310.93
14_L127_K0.6300.93
88_W114_N0.6190.92
72_I121_M0.6180.92
40_R48_Y0.6170.92
139_Q152_S0.6140.92
62_Q66_Q0.6120.92
27_K85_H0.6040.91
161_V166_K0.5990.91
17_I123_Y0.5950.91
123_Y126_W0.5930.91
108_H118_P0.5920.91
75_E102_S0.5880.90
25_I38_Y0.5860.90
137_S152_S0.5790.90
25_I98_I0.5790.90
15_N71_L0.5790.90
15_N73_A0.5790.90
161_V169_L0.5760.89
87_P114_N0.5740.89
167_E178_L0.5740.89
11_A130_V0.5740.89
58_F62_Q0.5720.89
39_G91_D0.5720.89
25_I30_L0.5700.89
128_Q157_I0.5690.89
38_Y41_F0.5690.89
168_M178_L0.5670.89
34_E92_D0.5670.89
167_E170_I0.5660.89
48_Y54_P0.5660.89
32_R48_Y0.5600.88
59_E62_Q0.5560.88
91_D98_I0.5560.88
175_E179_T0.5540.88
72_I140_M0.5540.88
36_T60_L0.5530.87
7_H70_I0.5510.87
87_P173_Y0.5510.87
44_F48_Y0.5480.87
57_E62_Q0.5470.87
175_E178_L0.5460.87
33_I85_H0.5460.87
164_H178_L0.5390.86
146_N150_H0.5390.86
173_Y176_I0.5370.86
117_L161_V0.5360.86
57_E61_N0.5340.86
88_W92_D0.5340.86
51_N54_P0.5330.86
122_P126_W0.5330.86
142_V145_E0.5320.85
99_I149_I0.5300.85
16_R19_V0.5270.85
146_N158_S0.5240.85
176_I179_T0.5240.85
12_A62_Q0.5220.84
119_I149_I0.5200.84
72_I127_K0.5190.84
155_N160_E0.5190.84
26_P103_F0.5180.84
76_N102_S0.5180.84
8_T125_N0.5170.84
14_L128_Q0.5170.84
61_N64_V0.5150.84
150_H154_G0.5140.83
173_Y179_T0.5130.83
122_P141_T0.5090.83
43_F71_L0.5080.83
86_A110_N0.5070.83
38_Y95_F0.5040.82
9_G97_I0.5030.82
159_F166_K0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q3wA 1 0.8894 100 0.119 Contact Map
2hcuA 1 0.8593 100 0.123 Contact Map
3h5jA 1 0.8392 100 0.226 Contact Map
3vbaA 2 0.8291 100 0.31 Contact Map
2pkpA 2 0.8191 100 0.319 Contact Map
1v7lA 6 0.804 100 0.324 Contact Map
1l5jA 1 0.9548 100 0.35 Contact Map
1c96A 1 0.8945 100 0.399 Contact Map
2b3yA 1 0.8744 100 0.409 Contact Map
3idwA 1 0.3317 20.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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