LEU1 - BACSU - GREMLIN Contacts

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LEU1 - 2-isopropylmalate synthase

UniProt:	P94565	Sequences: MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDYRIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMSGLKNHTAVGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	518 (489)
Sequences:	4289 (2156)
Seq/√Len:	97.5

ECOLI - LEU1
BACSU - LEU1
SULSO - Q980Z1 HOSA LEU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_P	71_G	3.877	1.00
180_G	219_N	3.856	1.00
81_D	127_Y	3.603	1.00
187_K	198_L	3.469	1.00
119_E	123_G	3.448	1.00
113_T	116_Q	3.399	1.00
200_A	216_A	3.356	1.00
301_D	305_K	3.207	1.00
154_V	165_I	3.080	1.00
121_A	153_I	2.949	1.00
391_E	414_Q	2.875	1.00
129_K	163_S	2.863	1.00
450_Y	489_S	2.805	1.00
482_A	491_K	2.803	1.00
103_D	146_E	2.788	1.00
103_D	114_R	2.711	1.00
122_V	126_K	2.648	1.00
155_E	191_P	2.629	1.00
177_A	218_E	2.612	1.00
314_S	317_L	2.584	1.00
115_E	152_E	2.582	1.00
77_K	81_D	2.581	1.00
465_V	488_A	2.569	1.00
122_V	160_A	2.564	1.00
184_K	188_E	2.562	1.00
446_E	470_L	2.529	1.00
51_R	55_L	2.517	1.00
147_L	185_Y	2.495	1.00
106_L	114_R	2.452	1.00
37_L	268_T	2.438	1.00
77_K	123_G	2.398	1.00
341_T	346_Q	2.361	1.00
121_A	157_V	2.355	1.00
207_G	242_E	2.343	1.00
202_C	213_S	2.334	1.00
238_A	243_I	2.312	1.00
112_M	120_R	2.281	1.00
264_E	267_R	2.254	1.00
414_Q	417_A	2.229	1.00
482_A	487_E	2.227	1.00
114_R	152_E	2.217	1.00
422_E	439_R	2.215	1.00
118_I	153_I	2.200	1.00
167_L	186_M	2.195	1.00
393_L	414_Q	2.112	1.00
33_Q	36_R	2.080	1.00
101_T	145_T	2.072	1.00
35_E	66_N	2.060	1.00
433_I	490_A	2.060	1.00
193_I	198_L	2.016	1.00
122_V	156_K	2.010	1.00
185_Y	189_N	1.974	1.00
29_A	274_K	1.971	1.00
58_Q	62_R	1.956	1.00
35_E	67_C	1.953	1.00
77_K	127_Y	1.904	1.00
448_L	470_L	1.892	1.00
118_I	152_E	1.874	1.00
184_K	219_N	1.864	1.00
244_A	260_I	1.850	1.00
393_L	419_L	1.814	1.00
137_W	153_I	1.812	1.00
125_V	135_V	1.805	1.00
412_K	419_L	1.788	1.00
59_E	62_R	1.766	1.00
81_D	131_R	1.752	1.00
6_F	39_A	1.734	1.00
180_G	184_K	1.734	1.00
112_M	116_Q	1.732	1.00
361_E	365_K	1.730	1.00
269_S	280_V	1.725	1.00
55_L	59_E	1.722	1.00
180_G	218_E	1.718	1.00
36_R	264_E	1.710	1.00
106_L	149_F	1.708	1.00
169_D	212_N	1.700	1.00
109_K	140_E	1.695	1.00
198_L	221_A	1.691	1.00
114_R	149_F	1.687	1.00
115_E	118_I	1.680	1.00
62_R	89_D	1.679	1.00
362_L	369_I	1.676	1.00
122_V	157_V	1.657	1.00
87_L	93_P	1.648	1.00
106_L	145_T	1.647	1.00
116_Q	119_E	1.617	1.00
144_R	178_E	1.612	1.00
469_V	496_A	1.606	1.00
106_L	146_E	1.605	1.00
261_T	264_E	1.602	1.00
144_R	173_Y	1.598	1.00
108_H	306_E	1.598	1.00
65_K	91_A	1.589	1.00
44_A	57_V	1.584	1.00
127_Y	131_R	1.584	1.00
71_G	83_A	1.579	1.00
197_K	222_D	1.578	1.00
151_A	186_M	1.574	1.00
122_V	159_D	1.569	1.00
336_F	355_F	1.564	1.00
84_W	132_F	1.563	1.00
58_Q	89_D	1.562	1.00
39_A	260_I	1.539	1.00
54_F	82_A	1.538	1.00
427_A	431_E	1.538	1.00
31_A	56_A	1.522	1.00
24_T	59_E	1.521	1.00
30_I	272_V	1.515	1.00
33_Q	271_L	1.512	1.00
149_F	153_I	1.511	1.00
389_G	416_N	1.511	1.00
82_A	85_E	1.510	1.00
115_E	119_E	1.493	1.00
118_I	149_F	1.486	1.00
357_T	361_E	1.484	1.00
471_V	500_Q	1.483	1.00
213_S	224_I	1.470	1.00
155_E	189_N	1.466	1.00
139_A	154_V	1.464	1.00
156_K	159_D	1.464	1.00
292_F	318_V	1.461	1.00
158_I	165_I	1.455	1.00
158_I	196_A	1.452	1.00
338_D	341_T	1.450	1.00
167_L	182_I	1.449	1.00
155_E	158_I	1.444	1.00
266_K	320_V	1.430	1.00
114_R	146_E	1.429	1.00
84_W	124_M	1.424	1.00
41_I	134_I	1.420	1.00
154_V	167_L	1.419	1.00
47_P	57_V	1.410	1.00
33_Q	268_T	1.410	1.00
98_F	298_I	1.408	1.00
5_N	197_K	1.406	0.99
151_A	185_Y	1.405	0.99
148_P	151_A	1.395	0.99
52_G	364_E	1.394	0.99
103_D	107_K	1.389	0.99
427_A	483_Q	1.386	0.99
112_M	117_V	1.383	0.99
358_M	361_E	1.374	0.99
99_I	137_W	1.368	0.99
414_Q	419_L	1.368	0.99
100_A	105_H	1.366	0.99
75_C	97_V	1.366	0.99
204_D	207_G	1.365	0.99
213_S	217_I	1.362	0.99
106_L	117_V	1.359	0.99
217_I	224_I	1.355	0.99
410_S	423_A	1.352	0.99
229_N	269_S	1.350	0.99
183_F	200_A	1.343	0.99
214_L	246_A	1.338	0.99
100_A	141_D	1.338	0.99
210_V	243_I	1.335	0.99
105_H	141_D	1.313	0.99
181_N	185_Y	1.307	0.99
60_I	69_V	1.306	0.99
40_D	66_N	1.286	0.99
51_R	82_A	1.284	0.99
415_E	418_Q	1.282	0.99
424_A	435_N	1.277	0.99
433_I	486_L	1.276	0.99
5_N	41_I	1.269	0.99
5_N	164_V	1.267	0.99
213_S	243_I	1.264	0.99
411_L	422_E	1.263	0.99
470_L	473_G	1.259	0.99
125_V	160_A	1.258	0.99
408_T	423_A	1.256	0.99
179_Y	200_A	1.256	0.99
348_D	351_E	1.244	0.99
412_K	421_Q	1.231	0.99
151_A	155_E	1.225	0.99
485_V	489_S	1.222	0.99
393_L	412_K	1.219	0.99
155_E	190_V	1.219	0.99
454_S	463_A	1.211	0.98
121_A	156_K	1.211	0.98
295_E	330_H	1.197	0.98
213_S	238_A	1.192	0.98
109_K	301_D	1.192	0.98
429_S	484_D	1.188	0.98
187_K	222_D	1.185	0.98
59_E	63_T	1.185	0.98
226_C	244_A	1.184	0.98
388_I	391_E	1.177	0.98
101_T	153_I	1.177	0.98
33_Q	267_R	1.172	0.98
358_M	381_E	1.167	0.98
68_S	134_I	1.166	0.98
337_K	341_T	1.153	0.98
143_C	174_L	1.149	0.98
36_R	267_R	1.147	0.98
103_D	106_L	1.138	0.98
111_K	305_K	1.135	0.98
376_S	380_E	1.130	0.98
85_E	88_K	1.126	0.98
22_L	275_L	1.126	0.98
104_I	108_H	1.125	0.98
6_F	244_A	1.124	0.98
49_S	330_H	1.122	0.98
25_Q	59_E	1.116	0.97
396_Q	400_G	1.114	0.97
52_G	329_K	1.107	0.97
22_L	30_I	1.106	0.97
7_F	70_T	1.104	0.97
70_T	94_R	1.103	0.97
155_E	159_D	1.098	0.97
183_F	219_N	1.098	0.97
33_Q	264_E	1.097	0.97
271_L	275_L	1.096	0.97
342_A	371_D	1.094	0.97
180_G	215_A	1.094	0.97
92_Q	134_I	1.093	0.97
179_Y	183_F	1.092	0.97
87_L	95_I	1.085	0.97
340_L	378_I	1.085	0.97
151_A	189_N	1.079	0.97
362_L	377_L	1.079	0.97
55_L	58_Q	1.077	0.97
17_S	20_V	1.077	0.97
92_Q	133_P	1.071	0.97
454_S	458_G	1.067	0.97
207_G	239_A	1.066	0.97
215_A	218_E	1.063	0.97
134_I	163_S	1.059	0.96
300_Q	335_A	1.054	0.96
22_L	276_T	1.052	0.96
68_S	92_Q	1.044	0.96
57_V	71_G	1.044	0.96
123_G	127_Y	1.039	0.96
295_E	328_G	1.034	0.96
210_V	238_A	1.032	0.96
159_D	191_P	1.028	0.96
152_E	156_K	1.027	0.96
213_S	226_C	1.026	0.96
177_A	181_N	1.024	0.96
18_P	290_N	1.019	0.96
127_Y	130_E	1.019	0.96
165_I	198_L	1.015	0.95
110_L	310_Y	1.013	0.95
430_V	447_L	1.009	0.95
215_A	219_N	1.009	0.95
97_V	161_G	1.009	0.95
249_T	313_I	1.008	0.95
126_K	160_A	1.005	0.95
136_Q	199_S	1.005	0.95
134_I	164_V	1.002	0.95
100_A	140_E	0.999	0.95
204_D	209_A	0.998	0.95
349_S	353_N	0.995	0.95
453_Q	466_Y	0.989	0.95
151_A	191_P	0.988	0.95
148_P	185_Y	0.987	0.95
148_P	152_E	0.981	0.95
28_L	59_E	0.974	0.94
139_A	150_L	0.973	0.94
32_K	63_T	0.971	0.94
390_Y	415_E	0.965	0.94
15_E	22_L	0.964	0.94
81_D	85_E	0.959	0.94
359_F	377_L	0.959	0.94
75_C	124_M	0.957	0.94
28_L	32_K	0.957	0.94
339_R	342_A	0.955	0.94
445_V	497_V	0.952	0.94
147_L	182_I	0.952	0.94
347_F	355_F	0.951	0.94
207_G	285_A	0.951	0.94
356_F	360_K	0.945	0.93
103_D	145_T	0.945	0.93
7_F	96_H	0.945	0.93
367_K	373_D	0.940	0.93
210_V	213_S	0.939	0.93
9_T	105_H	0.938	0.93
245_V	313_I	0.931	0.93
470_L	475_E	0.931	0.93
396_Q	408_T	0.930	0.93
141_D	144_R	0.926	0.93
422_E	440_C	0.924	0.93
423_A	439_R	0.921	0.93
181_N	184_K	0.918	0.92
464_Q	481_I	0.911	0.92
467_V	493_Y	0.907	0.92
186_M	190_V	0.907	0.92
353_N	357_T	0.904	0.92
244_A	262_L	0.903	0.92
32_K	36_R	0.901	0.92
231_I	278_M	0.898	0.92
217_I	247_L	0.898	0.92
228_V	272_V	0.896	0.91
448_L	475_E	0.895	0.91
409_L	415_E	0.895	0.91
107_K	113_T	0.892	0.91
281_P	284_K	0.889	0.91
200_A	217_I	0.885	0.91
345_F	466_Y	0.884	0.91
48_A	78_G	0.879	0.91
354_K	358_M	0.878	0.91
160_A	163_S	0.878	0.91
140_E	310_Y	0.873	0.90
110_L	140_E	0.872	0.90
431_E	435_N	0.869	0.90
469_V	476_S	0.867	0.90
20_V	277_G	0.866	0.90
407_A	411_L	0.862	0.90
114_R	145_T	0.862	0.90
20_V	30_I	0.857	0.90
153_I	157_V	0.852	0.89
338_D	342_A	0.852	0.89
349_S	352_I	0.851	0.89
97_V	124_M	0.850	0.89
476_S	500_Q	0.844	0.89
143_C	173_Y	0.843	0.89
280_V	287_V	0.840	0.89
154_V	190_V	0.838	0.88
6_F	213_S	0.837	0.88
102_S	105_H	0.836	0.88
468_R	475_E	0.836	0.88
139_A	167_L	0.836	0.88
26_E	277_G	0.836	0.88
185_Y	188_E	0.833	0.88
70_T	96_H	0.832	0.88
340_L	374_L	0.831	0.88
158_I	195_K	0.828	0.88
437_L	490_A	0.824	0.88
155_E	196_A	0.823	0.88
12_R	16_Q	0.823	0.88
31_A	60_I	0.822	0.88
175_A	218_E	0.820	0.87
183_F	186_M	0.819	0.87
94_R	134_I	0.819	0.87
471_V	474_K	0.818	0.87
84_W	93_P	0.818	0.87
452_I	463_A	0.818	0.87
164_V	223_Q	0.817	0.87
76_V	120_R	0.816	0.87
355_F	377_L	0.815	0.87
174_L	179_Y	0.814	0.87
97_V	125_V	0.814	0.87
174_L	178_E	0.809	0.87
100_A	110_L	0.809	0.87
428_G	450_Y	0.808	0.87
183_F	198_L	0.807	0.87
31_A	35_E	0.806	0.86
186_M	198_L	0.806	0.86
158_I	191_P	0.803	0.86
210_V	242_E	0.801	0.86
68_S	93_P	0.800	0.86
39_A	244_A	0.799	0.86
119_E	122_V	0.798	0.86
434_Y	438_E	0.798	0.86
462_F	483_Q	0.796	0.86
5_N	134_I	0.795	0.86
409_L	413_N	0.794	0.86
339_R	374_L	0.794	0.86
125_V	157_V	0.793	0.86
22_L	272_V	0.791	0.85
354_K	357_T	0.790	0.85
120_R	124_M	0.789	0.85
248_H	317_L	0.785	0.85
15_E	330_H	0.784	0.85
100_A	109_K	0.782	0.85
334_H	338_D	0.782	0.85
129_K	162_A	0.781	0.85
17_S	278_M	0.778	0.84
154_V	186_M	0.777	0.84
40_D	259_G	0.777	0.84
17_S	283_N	0.777	0.84
105_H	144_R	0.777	0.84
165_I	196_A	0.775	0.84
42_I	67_C	0.773	0.84
471_V	476_S	0.771	0.84
394_S	412_K	0.767	0.84
169_D	179_Y	0.767	0.84
445_V	471_V	0.767	0.84
228_V	241_E	0.766	0.84
428_G	463_A	0.765	0.83
96_H	138_S	0.763	0.83
177_A	215_A	0.763	0.83
239_A	242_E	0.758	0.83
103_D	149_F	0.757	0.83
109_K	309_T	0.754	0.83
300_Q	331_S	0.754	0.83
469_V	500_Q	0.752	0.82
177_A	180_G	0.752	0.82
128_A	135_V	0.752	0.82
354_K	382_K	0.751	0.82
119_E	126_K	0.750	0.82
28_L	63_T	0.750	0.82
121_A	126_K	0.748	0.82
278_M	281_P	0.747	0.82
118_I	122_V	0.746	0.82
114_R	148_P	0.744	0.82
362_L	365_K	0.741	0.82
57_V	69_V	0.740	0.81
143_C	182_I	0.740	0.81
148_P	189_N	0.740	0.81
118_I	156_K	0.739	0.81
143_C	179_Y	0.739	0.81
428_G	485_V	0.739	0.81
20_V	278_M	0.739	0.81
222_D	256_V	0.738	0.81
138_S	168_P	0.738	0.81
337_K	349_S	0.737	0.81
102_S	141_D	0.736	0.81
46_F	298_I	0.734	0.81
242_E	285_A	0.734	0.81
245_V	286_V	0.731	0.81
410_S	421_Q	0.729	0.80
202_C	238_A	0.729	0.80
136_Q	223_Q	0.728	0.80
34_L	42_I	0.728	0.80
49_S	76_V	0.728	0.80
316_E	322_A	0.726	0.80
145_T	154_V	0.726	0.80
434_Y	493_Y	0.725	0.80
226_C	240_L	0.722	0.80
245_V	262_L	0.722	0.80
241_E	245_V	0.721	0.80
151_A	190_V	0.719	0.80
89_D	93_P	0.719	0.80
399_Y	484_D	0.717	0.79
17_S	231_I	0.717	0.79
123_G	126_K	0.716	0.79
28_L	60_I	0.716	0.79
85_E	127_Y	0.716	0.79
396_Q	410_S	0.715	0.79
95_I	132_F	0.713	0.79
373_D	376_S	0.713	0.79
51_R	361_E	0.712	0.79
37_L	244_A	0.709	0.79
99_I	139_A	0.709	0.79
486_L	489_S	0.709	0.79
200_A	221_A	0.708	0.78
107_K	307_K	0.707	0.78
87_L	131_R	0.706	0.78
23_N	366_K	0.705	0.78
70_T	136_Q	0.704	0.78
248_H	257_E	0.702	0.78
421_Q	425_T	0.702	0.78
63_T	69_V	0.702	0.78
433_I	493_Y	0.701	0.78
13_D	16_Q	0.699	0.78
209_A	247_L	0.698	0.78
187_K	190_V	0.697	0.77
29_A	267_R	0.697	0.77
96_H	166_N	0.697	0.77
281_P	285_A	0.696	0.77
35_E	65_K	0.692	0.77
231_I	276_T	0.692	0.77
389_G	415_E	0.690	0.77
130_E	133_P	0.690	0.77
202_C	243_I	0.690	0.77
372_E	376_S	0.687	0.76
428_G	489_S	0.686	0.76
51_R	357_T	0.685	0.76
385_D	388_I	0.685	0.76
245_V	265_I	0.685	0.76
429_S	485_V	0.684	0.76
445_V	496_A	0.684	0.76
392_F	484_D	0.683	0.76
167_L	179_Y	0.683	0.76
87_L	92_Q	0.680	0.76
255_Q	258_T	0.678	0.75
148_P	357_T	0.678	0.75
20_V	231_I	0.677	0.75
39_A	43_E	0.675	0.75
248_H	260_I	0.675	0.75
49_S	329_K	0.673	0.75
97_V	128_A	0.673	0.75
412_K	425_T	0.671	0.75
352_I	355_F	0.670	0.75
87_L	90_G	0.670	0.75
333_R	353_N	0.668	0.74
438_E	459_E	0.668	0.74
164_V	222_D	0.667	0.74
449_D	453_Q	0.666	0.74
375_V	379_L	0.664	0.74
390_Y	413_N	0.663	0.74
351_E	354_K	0.659	0.73
88_K	91_A	0.659	0.73
242_E	284_K	0.658	0.73
381_E	386_R	0.658	0.73
107_K	114_R	0.657	0.73
392_F	494_L	0.657	0.73
204_D	281_P	0.656	0.73
445_V	469_V	0.656	0.73
246_A	286_V	0.654	0.73
343_L	371_D	0.654	0.73
100_A	117_V	0.653	0.73
456_R	461_A	0.653	0.73
413_N	422_E	0.653	0.73
431_E	485_V	0.653	0.73
109_K	310_Y	0.653	0.73
17_S	22_L	0.653	0.73
255_Q	260_I	0.649	0.72
48_A	82_A	0.649	0.72
487_E	491_K	0.648	0.72
84_W	127_Y	0.647	0.72
438_E	444_D	0.646	0.72
407_A	413_N	0.646	0.72
81_D	130_E	0.645	0.72
336_F	374_L	0.645	0.72
101_T	150_L	0.645	0.72
100_A	149_F	0.645	0.72
395_L	490_A	0.644	0.72
217_I	256_V	0.643	0.72
25_Q	29_A	0.641	0.71
362_L	373_D	0.641	0.71
37_L	265_I	0.639	0.71
282_R	289_D	0.638	0.71
45_G	57_V	0.638	0.71
340_L	347_F	0.638	0.71
337_K	352_I	0.638	0.71
74_R	98_F	0.637	0.71
217_I	243_I	0.636	0.71
428_G	461_A	0.636	0.71
208_M	246_A	0.636	0.71
156_K	160_A	0.636	0.71
455_N	462_F	0.635	0.71
136_Q	166_N	0.633	0.70
392_F	395_L	0.632	0.70
23_N	26_E	0.631	0.70
305_K	337_K	0.631	0.70
154_V	182_I	0.627	0.70
429_S	480_G	0.626	0.70
136_Q	164_V	0.626	0.70
42_I	69_V	0.625	0.69
430_V	493_Y	0.625	0.69
46_F	72_L	0.623	0.69
345_F	464_Q	0.623	0.69
430_V	489_S	0.623	0.69
438_E	493_Y	0.623	0.69
113_T	119_E	0.622	0.69
84_W	88_K	0.621	0.69
450_Y	485_V	0.620	0.69
453_Q	464_Q	0.620	0.69
326_V	330_H	0.619	0.69
447_L	454_S	0.618	0.69
117_V	141_D	0.617	0.68
455_N	481_I	0.616	0.68
295_E	329_K	0.616	0.68
191_P	196_A	0.616	0.68
350_E	468_R	0.613	0.68
358_M	362_L	0.613	0.68
147_L	178_E	0.613	0.68
7_F	141_D	0.612	0.68
363_T	369_I	0.612	0.68
84_W	87_L	0.612	0.68
29_A	271_L	0.612	0.68
229_N	272_V	0.612	0.68
464_Q	479_R	0.611	0.68
155_E	194_H	0.610	0.68
20_V	275_L	0.608	0.67
354_K	499_R	0.608	0.67
436_T	440_C	0.605	0.67
268_T	271_L	0.605	0.67
38_G	66_N	0.604	0.67
73_A	83_A	0.603	0.67
269_S	289_D	0.603	0.67
340_L	345_F	0.602	0.67
336_F	356_F	0.602	0.67
9_T	141_D	0.601	0.66
174_L	182_I	0.599	0.66
326_V	338_D	0.599	0.66
389_G	498_N	0.597	0.66
427_A	459_E	0.596	0.66
21_N	329_K	0.595	0.66
35_E	69_V	0.595	0.66
329_K	360_K	0.593	0.65
105_H	117_V	0.592	0.65
428_G	452_I	0.592	0.65
462_F	481_I	0.591	0.65
117_V	120_R	0.591	0.65
120_R	123_G	0.591	0.65
157_V	165_I	0.590	0.65
241_E	284_K	0.590	0.65
420_I	440_C	0.590	0.65
106_L	113_T	0.589	0.65
350_E	353_N	0.588	0.65
266_K	270_D	0.587	0.65
107_K	111_K	0.587	0.65
224_I	243_I	0.586	0.64
106_L	112_M	0.586	0.64
334_H	452_I	0.586	0.64
416_N	420_I	0.585	0.64
400_G	406_T	0.584	0.64
119_E	152_E	0.583	0.64
370_T	373_D	0.583	0.64
480_G	491_K	0.583	0.64
178_E	182_I	0.582	0.64
61_A	90_G	0.580	0.64
270_D	274_K	0.578	0.63
359_F	374_L	0.577	0.63
463_A	485_V	0.577	0.63
385_D	389_G	0.577	0.63
38_G	261_T	0.576	0.63
169_D	173_Y	0.576	0.63
122_V	153_I	0.575	0.63
7_F	105_H	0.575	0.63
269_S	287_V	0.575	0.63
359_F	362_L	0.574	0.63
302_G	310_Y	0.573	0.63
381_E	499_R	0.572	0.63
390_Y	494_L	0.571	0.62
143_C	169_D	0.571	0.62
330_H	360_K	0.570	0.62
26_E	274_K	0.569	0.62
239_A	284_K	0.569	0.62
415_E	420_I	0.569	0.62
66_N	91_A	0.569	0.62
177_A	184_K	0.569	0.62
206_L	246_A	0.568	0.62
118_I	121_A	0.567	0.62
75_C	99_I	0.567	0.62
256_V	259_G	0.567	0.62
452_I	459_E	0.565	0.62
173_Y	209_A	0.565	0.62
181_N	219_N	0.565	0.62
157_V	179_Y	0.564	0.62
178_E	181_N	0.564	0.62
394_S	399_Y	0.564	0.62
129_K	133_P	0.563	0.61
158_I	190_V	0.562	0.61
97_V	135_V	0.561	0.61
54_F	85_E	0.561	0.61
30_I	34_L	0.561	0.61
413_N	420_I	0.561	0.61
142_A	182_I	0.561	0.61
5_N	222_D	0.561	0.61
429_S	486_L	0.559	0.61
240_L	265_I	0.559	0.61
125_V	162_A	0.559	0.61
313_I	317_L	0.559	0.61
228_V	268_T	0.558	0.61
100_A	145_T	0.558	0.61
73_A	98_F	0.557	0.61
387_K	391_E	0.556	0.60
286_V	292_F	0.555	0.60
126_K	130_E	0.553	0.60
204_D	239_A	0.552	0.60
268_T	272_V	0.551	0.60
138_S	171_V	0.551	0.60
164_V	197_K	0.551	0.60
304_L	341_T	0.551	0.60
452_I	465_V	0.551	0.60
116_Q	125_V	0.550	0.60
175_A	250_R	0.550	0.60
398_H	408_T	0.548	0.59
94_R	164_V	0.548	0.59
455_N	461_A	0.548	0.59
169_D	172_G	0.548	0.59
245_V	249_T	0.548	0.59
433_I	436_T	0.546	0.59
331_S	335_A	0.545	0.59
445_V	449_D	0.544	0.59
229_N	280_V	0.544	0.59
84_W	95_I	0.544	0.59
152_E	155_E	0.544	0.59
445_V	500_Q	0.543	0.59
311_E	322_A	0.542	0.59
433_I	437_L	0.541	0.58
45_G	141_D	0.540	0.58
190_V	198_L	0.539	0.58
9_T	13_D	0.537	0.58
110_L	137_W	0.536	0.58
304_L	337_K	0.536	0.58
143_C	147_L	0.536	0.58
408_T	425_T	0.535	0.58
99_I	340_L	0.532	0.57
41_I	70_T	0.532	0.57
29_A	275_L	0.532	0.57
187_K	193_I	0.531	0.57
104_I	307_K	0.530	0.57
39_A	226_C	0.530	0.57
11_L	14_G	0.529	0.57
136_Q	225_E	0.528	0.57
295_E	360_K	0.528	0.57
53_D	377_L	0.527	0.56
327_L	359_F	0.526	0.56
204_D	264_E	0.526	0.56
463_A	486_L	0.525	0.56
463_A	483_Q	0.525	0.56
100_A	103_D	0.525	0.56
266_K	292_F	0.525	0.56
375_V	383_V	0.523	0.56
32_K	59_E	0.523	0.56
494_L	498_N	0.523	0.56
98_F	138_S	0.523	0.56
5_N	223_Q	0.522	0.56
56_A	60_I	0.522	0.56
407_A	484_D	0.522	0.56
103_D	144_R	0.522	0.56
84_W	131_R	0.521	0.56
172_G	212_N	0.520	0.55
204_D	283_N	0.520	0.55
107_K	116_Q	0.520	0.55
24_T	52_G	0.518	0.55
100_A	106_L	0.517	0.55
20_V	272_V	0.517	0.55
7_F	144_R	0.516	0.55
63_T	66_N	0.516	0.55
188_E	194_H	0.515	0.55
64_I	67_C	0.515	0.55
187_K	195_K	0.515	0.55
143_C	167_L	0.515	0.55
111_K	301_D	0.514	0.55
37_L	264_E	0.514	0.55
82_A	127_Y	0.513	0.54
182_I	186_M	0.512	0.54
208_M	281_P	0.512	0.54
263_N	317_L	0.511	0.54
441_I	444_D	0.511	0.54
8_D	11_L	0.511	0.54
366_K	373_D	0.511	0.54
355_F	381_E	0.511	0.54
227_A	240_L	0.510	0.54
155_E	195_K	0.510	0.54
179_Y	216_A	0.509	0.54
306_E	309_T	0.508	0.54
9_T	125_V	0.506	0.53
47_P	139_A	0.505	0.53
41_I	94_R	0.504	0.53
95_I	133_P	0.504	0.53
84_W	135_V	0.503	0.53
78_G	82_A	0.503	0.53
343_L	375_V	0.502	0.53
409_L	459_E	0.501	0.53
303_F	325_L	0.500	0.53
132_F	135_V	0.500	0.53
74_R	298_I	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hq1A	2	0.9286	100	0.222	Contact Map
4ov4A	2	0.7046	100	0.377	Contact Map
2ztjA	2	0.5985	100	0.391	Contact Map
3rmjA	2	0.5946	100	0.397	Contact Map
3ivsA	2	0.6853	100	0.408	Contact Map
3bleA	2	0.5734	100	0.491	Contact Map
3eegA	2	0.527	100	0.512	Contact Map
2qf7A	4	0.8417	100	0.553	Contact Map
4qshA	4	0.8649	100	0.579	Contact Map
3ewbX	2	0.5212	100	0.582	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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