GREMLIN Database
YSNE - Uncharacterized N-acetyltransferase YsnE
UniProt: P94562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (130)
Sequences: 6331 (4915)
Seq/√Len: 431.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_I129_F3.6631.00
58_A82_H3.0631.00
89_K126_S2.8941.00
19_E79_S2.7491.00
51_A87_V2.7061.00
89_K127_F2.6461.00
93_Q127_F2.5671.00
125_E131_Y2.4251.00
61_G95_I2.4151.00
98_E101_K2.3911.00
92_L127_F2.3801.00
98_E102_R2.1981.00
96_I107_L2.1481.00
69_R105_E2.1391.00
53_E85_K2.0531.00
49_W94_H2.0101.00
53_E58_A1.9831.00
56_E81_S1.9171.00
94_H97_E1.8651.00
50_S57_L1.8551.00
65_E104_Y1.8491.00
52_W57_L1.8381.00
70_H108_S1.6411.00
47_T98_E1.6291.00
109_L124_Y1.5801.00
71_G104_Y1.5731.00
121_R125_E1.5511.00
94_H98_E1.5271.00
59_G87_V1.4911.00
71_G107_L1.4601.00
14_V18_N1.4481.00
61_G91_V1.4231.00
52_W55_D1.4161.00
12_Q52_W1.3811.00
111_T115_A1.3791.00
122_K125_E1.3641.00
51_A59_G1.3461.00
73_I92_L1.3431.00
59_G78_T1.3421.00
53_E82_H1.3401.00
70_H106_R1.3231.00
48_F62_A1.3051.00
76_M92_L1.2941.00
12_Q15_S1.2591.00
121_R131_Y1.2581.00
89_K93_Q1.2581.00
11_R15_S1.2541.00
49_W98_E1.2341.00
97_E101_K1.1881.00
36_L39_E1.1881.00
93_Q97_E1.1771.00
53_E56_E1.1371.00
72_E75_S1.1301.00
18_N22_H1.1241.00
27_M119_P1.1161.00
23_S27_M1.1041.00
63_L95_I1.1031.00
61_G76_M1.0981.00
56_E79_S1.0901.00
71_G99_A1.0741.00
107_L129_F1.0711.00
63_L98_E1.0581.00
19_E81_S1.0111.00
34_H37_G1.0101.00
58_A87_V1.0091.00
131_Y134_P1.0011.00
109_L120_A0.9851.00
86_G89_K0.9851.00
99_A107_L0.9691.00
90_Q93_Q0.9461.00
79_S82_H0.9451.00
120_A124_Y0.9351.00
33_I37_G0.9341.00
97_E100_E0.8971.00
118_E122_K0.8911.00
82_H85_K0.8841.00
20_H24_M0.8791.00
92_L123_L0.8731.00
83_L119_P0.8721.00
123_L127_F0.8681.00
115_A118_E0.8661.00
108_S132_C0.8631.00
87_V90_Q0.8611.00
15_S19_E0.8611.00
110_E136_A0.8561.00
92_L124_Y0.8551.00
119_P122_K0.8461.00
12_Q56_E0.8451.00
67_D70_H0.8231.00
12_Q57_L0.8211.00
63_L102_R0.8201.00
23_S80_A0.8191.00
73_I76_M0.8191.00
9_T52_W0.8191.00
96_I100_E0.8091.00
36_L40_K0.7981.00
32_S36_L0.7971.00
37_G41_L0.7961.00
111_T124_Y0.7921.00
65_E102_R0.7921.00
23_S83_L0.7911.00
78_T87_V0.7891.00
63_L71_G0.7681.00
43_G46_I0.7621.00
51_A78_T0.7471.00
118_E121_R0.7351.00
59_G91_V0.7301.00
122_K126_S0.7301.00
114_M118_E0.7251.00
111_T120_A0.7181.00
90_Q94_H0.7161.00
28_S31_E0.7161.00
73_I95_I0.7121.00
61_G73_I0.7061.00
16_L57_L0.7001.00
9_T12_Q0.7001.00
115_A119_P0.6991.00
64_K110_E0.6971.00
15_S18_N0.6841.00
15_S56_E0.6791.00
32_S35_A0.6771.00
13_V48_F0.6691.00
89_K122_K0.6691.00
74_K110_E0.6540.99
63_L99_A0.6540.99
17_V20_H0.6540.99
47_T102_R0.6500.99
33_I41_L0.6470.99
15_S79_S0.6460.99
10_G13_V0.6410.99
135_F138_Y0.6370.99
111_T121_R0.6370.99
72_E108_S0.6350.99
11_R14_V0.6330.99
22_H26_L0.6280.99
66_L72_E0.6190.99
62_A74_K0.6190.99
56_E82_H0.6150.99
63_L104_Y0.6150.99
34_H41_L0.6130.99
49_W91_V0.6110.99
48_F60_C0.6080.99
17_V21_L0.6060.99
94_H101_K0.6060.99
7_D42_R0.6020.99
85_K123_L0.5980.99
73_I124_Y0.5980.99
20_H28_S0.5960.99
47_T51_A0.5940.99
62_A72_E0.5930.99
38_L42_R0.5930.99
62_A75_S0.5910.99
76_M124_Y0.5880.99
49_W95_I0.5860.99
64_K74_K0.5790.99
100_E103_G0.5780.99
45_E65_E0.5760.99
23_S26_L0.5750.99
41_L46_I0.5700.99
113_S123_L0.5680.99
113_S131_Y0.5620.98
16_L77_R0.5610.98
24_M28_S0.5600.98
25_T33_I0.5560.98
84_R122_K0.5540.98
106_R132_C0.5530.98
60_C77_R0.5530.98
39_E42_R0.5510.98
120_A123_L0.5450.98
37_G40_K0.5450.98
132_C135_F0.5400.98
7_D10_G0.5390.98
63_L73_I0.5380.98
73_I107_L0.5380.98
19_E77_R0.5340.98
25_T28_S0.5340.98
61_G92_L0.5340.98
16_L28_S0.5310.98
112_G115_A0.5300.98
23_S77_R0.5290.98
65_E68_T0.5280.98
90_Q97_E0.5270.98
18_N21_L0.5270.98
78_T91_V0.5240.98
20_H77_R0.5230.97
76_M127_F0.5210.97
69_R106_R0.5160.97
20_H23_S0.5120.97
24_M119_P0.5090.97
86_G90_Q0.5040.97
115_A121_R0.5030.97
13_V60_C0.5010.97
26_L112_G0.5010.97
46_I62_A0.5000.97
66_L70_H0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lodA 1 0.9272 99.9 0.328 Contact Map
1yx0A 1 0.9868 99.9 0.33 Contact Map
3d8pA 1 0.9868 99.9 0.338 Contact Map
3dr6A 2 0.9868 99.9 0.348 Contact Map
2j8mA 2 0.9868 99.9 0.353 Contact Map
1n71A 4 0.9536 99.8 0.368 Contact Map
2fiaA 1 0.9735 99.8 0.376 Contact Map
2r7hA 2 0.9801 99.8 0.379 Contact Map
3fixA 2 0.9404 99.8 0.382 Contact Map
3fynA 2 0.8675 99.8 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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