GREMLIN Database
YSNF - Stress response protein YsnF
UniProt: P94560 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (211)
Sequences: 476 (411)
Seq/√Len: 28.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_H241_E4.2461.00
171_E255_R3.5221.00
149_L254_P3.4831.00
168_I234_V3.4231.00
184_R238_T3.2381.00
224_K247_E3.0831.00
66_F116_D3.0641.00
187_E239_V2.8851.00
193_R233_V2.6571.00
170_K252_E2.5780.99
173_K253_E2.4280.99
165_E212_R2.3460.99
151_E251_K2.2910.99
196_D199_K2.2760.98
128_S131_F2.1940.98
158_K236_K2.1700.98
153_Q225_K2.1540.98
153_Q229_T2.1520.98
174_T250_K2.1130.97
199_K203_A2.0500.97
64_S69_L2.0230.97
166_V256_L1.9760.96
162_Q165_E1.9350.96
58_H109_V1.9190.95
232_V256_L1.8860.95
154_L247_E1.8220.94
103_D106_K1.7810.93
159_E221_E1.7740.93
88_L92_T1.7670.93
155_K225_K1.7580.93
114_D118_I1.7420.92
178_D246_S1.7280.92
178_D244_H1.7220.92
178_D247_E1.7130.92
196_D201_D1.7080.92
55_I68_K1.6800.91
65_F69_L1.6640.91
77_D82_S1.6490.90
167_E257_N1.6440.90
160_D219_K1.6390.90
157_D221_E1.6360.90
170_K182_P1.5840.88
67_D72_Y1.5810.88
180_D242_N1.5130.86
183_V241_E1.4790.85
119_A261_K1.4640.84
124_G222_V1.4380.83
184_R240_E1.4220.82
67_D74_T1.4060.81
158_K212_R1.3970.81
190_V263_D1.3930.81
57_A68_K1.3880.80
153_Q191_E1.3800.80
189_Y237_R1.3760.80
124_G128_S1.3520.79
159_E219_K1.3390.78
199_K202_A1.3390.78
131_F139_Y1.3360.78
60_D72_Y1.3170.77
124_G127_L1.3170.77
95_I113_T1.3120.77
186_D236_K1.2830.75
161_V217_E1.2820.75
147_M165_E1.2550.73
162_Q218_E1.2360.72
192_R230_D1.2190.71
60_D161_V1.2160.71
85_L94_E1.2020.70
112_D115_A1.1860.69
218_E256_L1.1830.69
83_K109_V1.1830.69
231_E236_K1.1820.69
228_V231_E1.1760.68
215_I252_E1.1720.68
199_K211_I1.1640.67
56_D68_K1.1640.67
139_Y143_E1.1580.67
74_T147_M1.1520.67
177_R250_K1.1510.66
78_T255_R1.1420.66
75_M100_E1.1380.66
122_D127_L1.1360.65
122_D126_A1.1270.65
209_E236_K1.1220.64
98_Y236_K1.1180.64
157_D220_L1.1160.64
185_H247_E1.1000.63
220_L233_V1.0970.63
89_D111_V1.0920.62
167_E208_S1.0740.61
85_L92_T1.0560.60
212_R221_E1.0440.59
182_P186_D1.0360.58
227_V252_E1.0270.57
189_Y235_G1.0210.57
149_L253_E1.0130.56
148_P203_A1.0100.56
121_I127_L1.0080.56
229_T251_K0.9970.55
54_A59_Q0.9970.55
70_K73_F0.9940.55
67_D73_F0.9900.55
189_Y232_V0.9870.54
250_K255_R0.9840.54
153_Q219_K0.9820.54
125_N128_S0.9790.54
127_L131_F0.9790.54
89_D95_I0.9780.54
130_G133_S0.9700.53
170_K175_E0.9550.52
137_L140_T0.9520.52
96_D100_E0.9490.52
220_L248_T0.9460.51
123_N129_G0.9450.51
57_A64_S0.9390.51
135_N139_Y0.9350.50
182_P252_E0.9320.50
164_G224_K0.9210.49
194_P198_N0.9210.49
125_N130_G0.9200.49
160_D217_E0.9170.49
80_T242_N0.9170.49
177_R212_R0.9150.49
166_V228_V0.9120.49
151_E172_V0.9070.48
136_E190_V0.9040.48
161_V213_V0.9030.48
165_E209_E0.9010.48
111_V115_A0.9000.48
153_Q205_V0.8990.48
158_K253_E0.8980.48
224_K231_E0.8970.48
101_D237_R0.8970.48
126_A197_E0.8950.47
232_V237_R0.8860.47
150_R170_K0.8780.46
169_G181_I0.8770.46
209_E241_E0.8740.46
191_E235_G0.8710.46
119_A132_S0.8700.45
167_E249_V0.8600.45
135_N190_V0.8600.45
127_L132_S0.8510.44
118_I129_G0.8500.44
122_D125_N0.8500.44
140_T145_K0.8490.44
154_L236_K0.8490.44
193_R231_E0.8460.44
128_S132_S0.8440.43
169_G234_V0.8420.43
122_D133_S0.8380.43
148_P231_E0.8310.43
119_A223_T0.8300.42
185_H217_E0.8250.42
190_V232_V0.8170.41
125_N129_G0.8150.41
81_H149_L0.8110.41
123_N127_L0.8100.41
96_D113_T0.8070.41
77_D186_D0.8060.41
89_D96_D0.8050.41
170_K215_I0.8030.40
81_H95_I0.8010.40
213_V232_V0.7980.40
150_R252_E0.7970.40
137_L190_V0.7950.40
55_I59_Q0.7940.40
157_D169_G0.7920.40
209_E232_V0.7880.39
183_V227_V0.7870.39
119_A131_F0.7860.39
114_D264_G0.7850.39
172_V233_V0.7780.39
158_K255_R0.7760.38
66_F191_E0.7710.38
216_V225_K0.7620.37
196_D249_V0.7540.37
162_Q195_V0.7530.37
70_K190_V0.7480.36
225_K233_V0.7480.36
158_K218_E0.7460.36
62_S69_L0.7440.36
195_V228_V0.7420.36
173_K216_V0.7420.36
149_L252_E0.7390.36
161_V166_V0.7370.36
170_K209_E0.7360.36
145_K258_K0.7330.35
176_K179_M0.7320.35
211_I231_E0.7320.35
215_I227_V0.7260.35
191_E196_D0.7250.35
188_I239_V0.7250.35
235_G255_R0.7250.35
194_P255_R0.7230.35
129_G134_T0.7190.34
190_V251_K0.7180.34
68_K257_N0.7100.34
59_Q249_V0.7060.33
146_T187_E0.7000.33
154_L179_M0.6990.33
124_G130_G0.6980.33
183_V248_T0.6950.33
178_D182_P0.6930.33
215_I230_D0.6920.33
205_V242_N0.6910.32
105_G194_P0.6850.32
170_K217_E0.6840.32
85_L158_K0.6840.32
73_F97_K0.6840.32
156_V240_E0.6840.32
185_H239_V0.6790.32
64_S67_D0.6760.31
173_K189_Y0.6740.31
55_I247_E0.6730.31
208_S261_K0.6700.31
63_E95_I0.6690.31
171_E233_V0.6600.30
92_T256_L0.6590.30
190_V246_S0.6530.30
171_E235_G0.6520.30
89_D109_V0.6510.30
147_M176_K0.6500.30
71_D75_M0.6490.30
167_E212_R0.6470.30
66_F72_Y0.6460.29
88_L93_D0.6440.29
69_L72_Y0.6440.29
159_E206_N0.6430.29
209_E252_E0.6410.29
133_S136_E0.6360.29
175_E217_E0.6360.29
132_S256_L0.6350.29
167_E206_N0.6260.28
105_G177_R0.6230.28
79_A117_V0.6200.28
159_E167_E0.6200.28
105_G108_L0.6200.28
88_L94_E0.6170.28
162_Q214_P0.6160.28
182_P185_H0.6150.28
163_T172_V0.6130.27
136_E139_Y0.6100.27
185_H215_I0.6090.27
143_E148_P0.6080.27
179_M252_E0.6080.27
132_S138_D0.6070.27
137_L194_P0.6070.27
168_I233_V0.6030.27
101_D236_K0.6020.27
113_T117_V0.5950.26
107_L238_T0.5940.26
114_D117_V0.5940.26
149_L153_Q0.5920.26
119_A190_V0.5910.26
223_T226_P0.5910.26
205_V212_R0.5880.26
193_R234_V0.5860.26
126_A132_S0.5840.26
167_E250_K0.5840.26
219_K245_I0.5820.26
88_L96_D0.5820.26
196_D203_A0.5780.25
201_D226_P0.5750.25
150_R216_V0.5740.25
127_L138_D0.5730.25
65_F73_F0.5710.25
65_F72_Y0.5630.24
71_D92_T0.5620.24
247_E260_G0.5610.24
66_F78_T0.5610.24
178_D224_K0.5590.24
149_L251_K0.5550.24
136_E141_T0.5550.24
177_R188_I0.5550.24
78_T96_D0.5550.24
178_D186_D0.5540.24
157_D177_R0.5540.24
179_M213_V0.5530.24
66_F193_R0.5520.24
170_K187_E0.5510.24
149_L170_K0.5490.24
71_D166_V0.5440.23
185_H252_E0.5430.23
64_S194_P0.5430.23
160_D184_R0.5420.23
146_T168_I0.5410.23
124_G129_G0.5400.23
149_L228_V0.5340.23
77_D103_D0.5330.23
132_S201_D0.5300.23
62_S263_D0.5280.23
112_D240_E0.5280.23
208_S257_N0.5280.23
192_R224_K0.5280.23
72_Y153_Q0.5260.22
69_L75_M0.5250.22
54_A57_A0.5230.22
93_D111_V0.5230.22
171_E234_V0.5230.22
182_P187_E0.5190.22
158_K231_E0.5170.22
125_N131_F0.5140.22
179_M226_P0.5130.22
62_S66_F0.5110.22
189_Y251_K0.5080.21
59_Q64_S0.5080.21
158_K224_K0.5050.21
126_A133_S0.5040.21
131_F255_R0.5030.21
83_K94_E0.5030.21
63_E147_M0.5020.21
135_N143_E0.5020.21
184_R209_E0.5020.21
173_K234_V0.5000.21
98_Y102_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wjnH 1 0.5128 87.7 0.931 Contact Map
1rzhH 1 0.5018 83.1 0.935 Contact Map
3htrA 2 0.3297 81.6 0.936 Contact Map
1eysH 1 0.5385 71.8 0.941 Contact Map
1x60A 1 0.1245 46 0.95 Contact Map
1utaA 1 0.1319 40.1 0.952 Contact Map
1t1vA 2 0.3114 18.5 0.959 Contact Map
2lfvA 1 0.1575 12.8 0.962 Contact Map
4oi3A 2 0.1355 10.2 0.964 Contact Map
1gudA 1 0.3333 9.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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