GREMLIN Database
YSNB - Putative metallophosphoesterase YsnB
UniProt: P94559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (150)
Sequences: 4584 (3557)
Seq/√Len: 290.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_C104_C3.9121.00
122_I139_A3.9051.00
31_I76_V3.7191.00
113_S120_L2.9311.00
29_L49_A2.8701.00
4_L27_V2.5401.00
74_I102_V2.5081.00
22_R138_Y2.2921.00
4_L23_H2.2581.00
9_S32_H2.2461.00
5_I104_C2.2241.00
33_C76_V2.1901.00
105_F112_G2.1101.00
49_A65_L2.1091.00
17_Q44_A2.1021.00
9_S127_I2.0751.00
72_R101_D2.0521.00
75_L100_A2.0441.00
5_I141_L1.8721.00
7_S33_C1.7801.00
58_A62_K1.7471.00
2_N142_T1.6581.00
111_A137_S1.6251.00
105_F121_M1.6231.00
20_A44_A1.6011.00
68_T73_K1.5611.00
6_I16_L1.5021.00
27_V140_I1.4651.00
73_K101_D1.4521.00
108_S123_N1.4081.00
13_E40_T1.4051.00
36_S50_V1.3901.00
39_E43_P1.3711.00
30_M48_Y1.3651.00
115_V120_L1.3591.00
2_N140_I1.3531.00
32_H36_S1.3391.00
132_V137_S1.3271.00
5_I122_I1.3011.00
62_K65_L1.2891.00
32_H50_V1.2771.00
9_S16_L1.2661.00
13_E17_Q1.2641.00
17_Q21_K1.2601.00
68_T71_S1.2541.00
25_A151_R1.2481.00
93_Y97_E1.2471.00
124_P139_A1.2251.00
4_L138_Y1.2231.00
58_A61_F1.2151.00
23_H30_M1.1911.00
76_V104_C1.1881.00
15_E136_E1.1851.00
4_L30_M1.1721.00
4_L19_I1.1651.00
7_S106_G1.1511.00
12_L15_E1.1471.00
87_T90_N1.1191.00
113_S122_I1.1131.00
95_A119_K1.0861.00
13_E44_A1.0801.00
77_T82_H1.0801.00
14_E17_Q1.0791.00
67_L74_I1.0691.00
3_V29_L1.0681.00
18_T22_R1.0581.00
38_L41_R1.0481.00
23_H27_V1.0471.00
12_L128_R1.0311.00
104_C141_L1.0281.00
6_I19_I1.0271.00
126_S130_P1.0251.00
70_G143_L1.0251.00
37_E55_C1.0191.00
77_T81_L1.0181.00
103_I119_K1.0111.00
62_K66_L1.0101.00
57_F84_I1.0081.00
65_L76_V0.9901.00
66_L100_A0.9831.00
66_L73_K0.9751.00
102_V120_L0.9741.00
6_I32_H0.9741.00
113_S150_V0.9731.00
142_T149_T0.9731.00
142_T151_R0.9711.00
5_I31_I0.9531.00
130_P136_E0.9491.00
38_L42_H0.9481.00
19_I23_H0.9451.00
104_C122_I0.9441.00
72_R146_D0.9401.00
54_N107_H0.9371.00
23_H138_Y0.9351.00
19_I127_I0.9331.00
100_A103_I0.9331.00
92_Y116_L0.9281.00
95_A103_I0.9081.00
29_L69_A0.8971.00
115_V118_G0.8881.00
126_S131_R0.8831.00
64_E75_L0.8831.00
127_I138_Y0.8781.00
18_T21_K0.8681.00
31_I67_L0.8681.00
6_I30_M0.8491.00
105_F108_S0.8411.00
90_N93_Y0.8341.00
72_R102_V0.8311.00
87_T91_V0.8311.00
45_L61_F0.8291.00
116_L119_K0.8281.00
64_E94_R0.8261.00
79_G108_S0.8231.00
10_H109_H0.8101.00
4_L140_I0.8091.00
96_E117_R0.8071.00
111_A134_R0.8010.99
36_S41_R0.8000.99
144_E147_A0.7950.99
84_I105_F0.7830.99
6_I9_S0.7800.99
52_K57_F0.7770.99
70_G146_D0.7670.99
137_S152_F0.7630.99
55_C129_L0.7550.99
42_H46_E0.7530.99
8_D109_H0.7480.99
6_I127_I0.7470.99
89_L93_Y0.7430.99
15_E18_T0.7410.99
102_V141_L0.7390.99
22_R25_A0.7390.99
20_A24_E0.7370.99
19_I138_Y0.7340.99
39_E58_A0.7330.99
86_Q90_N0.7230.99
104_C124_P0.7190.99
4_L26_E0.7060.99
111_A132_V0.7050.99
69_A72_R0.7040.99
27_V30_M0.7040.99
43_P46_E0.7030.99
63_D80_H0.7020.99
3_V141_L0.6980.99
6_I23_H0.6940.99
132_V152_F0.6910.98
77_T103_I0.6910.98
72_R143_L0.6890.98
94_R98_L0.6870.98
62_K67_L0.6870.98
120_L150_V0.6830.98
103_I121_M0.6810.98
49_A67_L0.6800.98
17_Q40_T0.6790.98
74_I104_C0.6680.98
61_F65_L0.6600.98
29_L47_P0.6550.98
21_K24_E0.6540.98
67_L76_V0.6530.98
92_Y96_E0.6520.98
2_N25_A0.6510.98
148_A151_R0.6500.98
40_T43_P0.6490.98
2_N28_D0.6460.98
33_C51_V0.6450.98
74_I143_L0.6450.98
80_H138_Y0.6410.98
88_L114_E0.6340.97
61_F66_L0.6330.97
106_G124_P0.6260.97
19_I22_R0.6180.97
36_S61_F0.6180.97
88_L92_Y0.6170.97
64_E77_T0.6170.97
91_V95_A0.6170.97
59_G62_K0.6100.97
66_L98_L0.6100.97
22_R151_R0.6090.97
52_K63_D0.6090.97
39_E42_H0.6080.97
40_T44_A0.6040.96
59_G66_L0.5980.96
111_A139_A0.5970.96
4_L22_R0.5910.96
35_D54_N0.5880.96
111_A152_F0.5790.95
14_E18_T0.5780.95
55_C131_R0.5780.95
50_V61_F0.5770.95
80_H83_G0.5770.95
25_A140_I0.5750.95
91_V94_R0.5750.95
11_G38_L0.5700.95
23_H26_E0.5680.95
96_E116_L0.5590.95
100_A119_K0.5590.95
39_E46_E0.5560.94
37_E42_H0.5560.94
36_S52_K0.5550.94
46_E60_D0.5520.94
5_I124_P0.5470.94
64_E82_H0.5410.94
9_S36_S0.5390.93
15_E128_R0.5380.93
7_S10_H0.5370.93
63_D66_L0.5360.93
108_S112_G0.5360.93
31_I74_I0.5350.93
41_R44_A0.5340.93
56_D137_S0.5330.93
97_E100_A0.5320.93
110_I134_R0.5290.93
73_K99_G0.5290.93
139_A150_V0.5250.93
42_H61_F0.5230.92
16_L45_L0.5230.92
102_V143_L0.5220.92
52_K58_A0.5190.92
7_S79_G0.5120.92
112_G121_M0.5050.91
83_G90_N0.5010.91
10_H107_H0.5010.91
13_E16_L0.5010.91
84_I103_I0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nnwA 2 1 100 0.327 Contact Map
3ck2A 1 1 100 0.333 Contact Map
3qfmA 2 1 100 0.36 Contact Map
3rqzA 1 0.9941 100 0.368 Contact Map
1z2wA 2 1 100 0.38 Contact Map
2a22A 1 1 100 0.391 Contact Map
1s3lA 1 0.858 100 0.41 Contact Map
2kknA 1 0.8639 100 0.411 Contact Map
1su1A 3 0.9172 100 0.435 Contact Map
1uf3A 6 0.8698 99.9 0.48 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.