GREMLIN Database
NTPA - Non-canonical purine NTP pyrophosphatase
UniProt: P94558 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (188)
Sequences: 4641 (3224)
Seq/√Len: 235.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G52_E3.3291.00
151_R173_E3.0381.00
142_V171_M3.0291.00
84_R109_E2.6881.00
103_I161_I2.6791.00
77_S121_R2.3991.00
175_T178_E2.3901.00
46_T56_M2.3631.00
121_R141_H2.3561.00
6_E32_K2.3271.00
6_E30_D2.3161.00
147_A170_T2.2671.00
54_A127_A2.2611.00
105_K109_E2.2481.00
121_R143_E2.2191.00
169_K178_E2.1471.00
79_D119_T2.1391.00
78_I106_V2.0481.00
138_V195_L2.0251.00
51_E139_E2.0131.00
79_D121_R1.9721.00
92_Y109_E1.9521.00
77_S123_R1.9421.00
147_A163_I1.9231.00
15_G18_K1.9071.00
98_D101_A1.9031.00
100_Q104_E1.8811.00
108_S111_K1.8601.00
79_D117_Q1.8321.00
123_R139_E1.8271.00
100_Q150_P1.7721.00
104_E150_P1.7691.00
55_I59_E1.7441.00
17_V33_S1.6441.00
167_K178_E1.6371.00
22_E180_N1.6351.00
6_E67_K1.6281.00
59_E135_T1.6261.00
114_E117_Q1.5971.00
186_A190_K1.5581.00
127_A137_T1.5441.00
103_I150_P1.4841.00
68_M128_V1.4691.00
43_I60_A1.4591.00
55_I137_T1.4461.00
55_I135_T1.4421.00
32_K37_I1.4261.00
187_D190_K1.4221.00
9_I20_F1.4071.00
48_H52_E1.4041.00
59_E63_K1.4021.00
147_A151_R1.3911.00
58_A127_A1.3761.00
12_H35_A1.3611.00
84_R92_Y1.3591.00
145_Y165_K1.3521.00
104_E108_S1.3481.00
43_I56_M1.3401.00
50_F77_S1.3381.00
51_E137_T1.3121.00
136_K195_L1.3101.00
8_I61_V1.2981.00
145_Y163_I1.2661.00
178_E181_K1.2511.00
62_A131_P1.2291.00
128_V192_L1.2221.00
60_A64_A1.2191.00
11_T17_V1.2121.00
163_I168_D1.1961.00
112_G148_E1.1851.00
97_K101_A1.1771.00
62_A129_S1.1721.00
120_A146_I1.1621.00
96_Q101_A1.1491.00
50_F74_S1.1471.00
65_V69_V1.1461.00
93_A102_N1.1411.00
164_V174_L1.1411.00
174_L178_E1.1301.00
163_I166_D1.1271.00
107_L161_I1.1201.00
51_E127_A1.1171.00
39_F65_V1.1141.00
167_K182_I1.1021.00
123_R141_H1.0991.00
169_K174_L1.0921.00
191_K194_K1.0891.00
55_I127_A1.0851.00
47_G56_M1.0701.00
143_E165_K1.0701.00
106_V161_I1.0691.00
14_P18_K1.0571.00
166_D187_D1.0551.00
44_E56_M1.0541.00
61_V69_V1.0531.00
20_F126_L1.0521.00
93_A101_A1.0451.00
70_I192_L1.0201.00
76_L146_I1.0191.00
56_M60_A1.0051.00
70_I126_L1.0011.00
129_S135_T0.9971.00
164_V167_K0.9951.00
8_I67_K0.9891.00
49_T87_V0.9691.00
103_I160_P0.9681.00
55_I129_S0.9661.00
32_K36_E0.9621.00
59_E129_S0.9611.00
138_V192_L0.9611.00
113_I117_Q0.9561.00
126_L192_L0.9531.00
107_L118_R0.9491.00
26_P193_S0.9371.00
167_K174_L0.9361.00
79_D83_G0.9221.00
130_I133_E0.9101.00
58_A129_S0.9061.00
12_H34_L0.9051.00
125_A139_E0.8970.99
119_T143_E0.8930.99
80_N113_I0.8930.99
8_I69_V0.8890.99
154_Y175_T0.8890.99
74_S124_C0.8880.99
89_S158_Y0.8870.99
99_D102_N0.8720.99
68_M130_I0.8720.99
17_V21_K0.8670.99
191_K195_L0.8630.99
164_V182_I0.8590.99
171_M174_L0.8530.99
43_I61_V0.8510.99
138_V191_K0.8480.99
126_L189_L0.8400.99
125_A137_T0.8380.99
152_G172_A0.8260.99
15_G20_F0.8220.99
22_E176_S0.8200.99
190_K193_S0.8140.99
101_A104_E0.8120.99
93_A105_K0.8110.99
142_V187_D0.8060.99
22_E25_E0.7960.99
17_V31_V0.7940.99
53_N87_V0.7870.99
142_V182_I0.7830.99
93_A97_K0.7800.99
49_T52_E0.7740.99
9_I70_I0.7700.98
130_I134_E0.7700.98
40_T64_A0.7630.98
147_A161_I0.7620.98
33_S36_E0.7620.98
92_Y105_K0.7530.98
110_L146_I0.7500.98
60_A63_K0.7480.98
9_I31_V0.7380.98
20_F189_L0.7360.98
113_I118_R0.7350.98
8_I65_V0.7320.98
76_L122_F0.7250.98
21_K30_D0.7240.98
164_V171_M0.7200.98
187_D191_K0.7170.98
102_N105_K0.7160.98
190_K194_K0.7140.97
112_G118_R0.7140.97
159_D179_K0.7090.97
153_E173_E0.6950.97
15_G99_D0.6930.97
34_L61_V0.6920.97
12_H39_F0.6860.97
20_F24_L0.6850.97
18_K22_E0.6840.97
110_L118_R0.6830.97
14_P35_A0.6820.97
42_E45_E0.6820.97
107_L147_A0.6790.97
170_T173_E0.6770.97
119_T145_Y0.6710.96
164_V168_D0.6690.96
111_K148_E0.6690.96
18_K21_K0.6680.96
15_G23_I0.6660.96
179_K183_S0.6630.96
48_H87_V0.6580.96
87_V91_R0.6570.96
145_Y148_E0.6550.96
79_D143_E0.6540.96
151_R163_I0.6530.96
125_A138_V0.6510.96
18_K176_S0.6480.96
48_H88_Y0.6470.96
102_N106_V0.6460.96
140_G187_D0.6440.95
23_I189_L0.6440.95
50_F123_R0.6420.95
14_P21_K0.6380.95
169_K173_E0.6350.95
171_M182_I0.6310.95
23_I176_S0.6310.95
95_E98_D0.6290.95
124_C188_A0.6290.95
21_K36_E0.6220.94
113_I119_T0.6190.94
122_F161_I0.6190.94
70_I128_V0.6160.94
74_S103_I0.6160.94
23_I126_L0.6100.94
109_E112_G0.6080.94
105_K108_S0.6070.94
21_K25_E0.6060.94
163_I167_K0.6030.94
39_F64_A0.6020.93
156_F159_D0.6010.93
163_I169_K0.6010.93
19_E180_N0.6000.93
19_E179_K0.5990.93
122_F171_M0.5980.93
34_L38_G0.5970.93
156_F179_K0.5930.93
103_I107_L0.5880.93
122_F158_Y0.5860.93
128_V136_K0.5830.92
34_L39_F0.5790.92
181_K186_A0.5780.92
50_F75_G0.5770.92
66_N69_V0.5770.92
93_A98_D0.5770.92
94_G97_K0.5770.92
114_E118_R0.5740.92
114_E119_T0.5730.92
14_P36_E0.5730.92
51_E125_A0.5720.92
107_L110_L0.5680.91
40_T60_A0.5680.91
97_K102_N0.5650.91
62_A68_M0.5650.91
146_I161_I0.5650.91
78_I120_A0.5640.91
151_R170_T0.5640.91
103_I106_V0.5620.91
54_A137_T0.5610.91
45_E57_K0.5580.91
22_E177_D0.5560.91
99_D106_V0.5530.90
62_A130_I0.5520.90
110_L113_I0.5500.90
139_E191_K0.5480.90
20_F70_I0.5480.90
180_N183_S0.5450.90
152_G156_F0.5430.89
34_L43_I0.5430.89
82_G85_P0.5400.89
40_T61_V0.5390.89
7_A128_V0.5360.89
172_A180_N0.5330.89
150_P160_P0.5320.89
130_I136_K0.5310.88
77_S83_G0.5310.88
19_E185_R0.5280.88
23_I180_N0.5240.88
165_K168_D0.5220.88
118_R146_I0.5210.87
46_T87_V0.5200.87
150_P161_I0.5190.87
175_T186_A0.5160.87
117_Q145_Y0.5150.87
94_G98_D0.5140.87
125_A140_G0.5130.87
78_I161_I0.5120.87
169_K175_T0.5110.86
63_K66_N0.5110.86
101_A105_K0.5070.86
166_D169_K0.5060.86
97_K106_V0.5050.86
118_R147_A0.5030.86
74_S89_S0.5030.86
62_A69_V0.5020.86
78_I81_L0.5000.85
142_V164_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k7kA 1 0.9848 100 0.023 Contact Map
1vp2A 3 0.9394 100 0.053 Contact Map
3tquA 2 0.9798 100 0.065 Contact Map
2carA 2 0.9343 100 0.083 Contact Map
1b78A 2 0.9091 100 0.084 Contact Map
1v7rA 1 0.9192 100 0.084 Contact Map
4bnqA 2 0.9596 100 0.106 Contact Map
4jhcA 2 0.7525 96.6 0.892 Contact Map
2amhA 1 0.7778 96.1 0.898 Contact Map
1ex2A 2 0.7576 95.5 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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