MURI1 - BACSU - GREMLIN Contacts

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MURI1 - Glutamate racemase 1

UniProt:	P94556	Sequences: MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGPRPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGARAAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDKTADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVSTILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (248)
Sequences:	3700 (2491)
Seq/√Len:	158.2

ECOLI - MURI
BACSU - MURI1 MURI2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_V	22_I	3.665	1.00
34_V	240_T	3.442	1.00
163_D	197_R	3.345	1.00
69_M	216_V	3.261	1.00
55_W	88_S	2.824	1.00
21_E	24_R	2.759	1.00
19_A	31_I	2.678	1.00
67_I	70_L	2.668	1.00
39_R	53_Y	2.634	1.00
60_Y	238_L	2.534	1.00
29_E	68_K	2.390	1.00
30_N	233_P	2.373	1.00
112_H	139_K	2.348	1.00
215_E	218_T	2.329	1.00
192_K	196_Q	2.275	1.00
58_T	70_L	2.259	1.00
128_E	142_N	2.247	1.00
152_V	191_L	2.239	1.00
65_H	236_Q	2.151	1.00
148_L	166_V	2.092	1.00
112_H	141_E	2.054	1.00
22_I	31_I	2.029	1.00
25_Q	217_S	1.959	1.00
5_P	68_K	1.948	1.00
4_Q	66_H	1.927	1.00
60_Y	65_H	1.893	1.00
117_G	122_I	1.888	1.00
59_N	88_S	1.850	1.00
71_V	216_V	1.832	1.00
122_I	142_N	1.824	1.00
116_I	181_L	1.823	1.00
22_I	216_V	1.769	1.00
111_Q	135_N	1.719	1.00
72_I	82_L	1.674	1.00
119_E	123_K	1.644	1.00
156_K	159_D	1.632	1.00
82_L	95_G	1.618	1.00
39_R	56_E	1.610	1.00
181_L	199_M	1.596	1.00
163_D	194_A	1.575	1.00
114_G	178_I	1.567	1.00
143_L	169_S	1.565	1.00
50_V	120_N	1.547	1.00
59_N	89_V	1.536	1.00
89_V	93_V	1.532	1.00
51_L	84_D	1.518	1.00
112_H	177_S	1.489	1.00
21_E	210_D	1.483	1.00
23_M	235_H	1.473	1.00
108_T	138_L	1.470	1.00
62_L	91_I	1.466	1.00
8_V	19_A	1.444	1.00
22_I	71_V	1.435	1.00
34_V	57_L	1.433	1.00
195_I	205_I	1.430	1.00
143_L	172_P	1.423	1.00
149_V	188_Y	1.419	1.00
192_K	207_S	1.417	1.00
53_Y	56_E	1.416	1.00
125_N	142_N	1.414	1.00
108_T	179_D	1.412	1.00
114_G	173_L	1.408	1.00
52_Q	56_E	1.392	1.00
189_P	209_G	1.391	1.00
94_V	219_I	1.382	1.00
55_W	84_D	1.379	1.00
125_N	128_E	1.374	1.00
199_M	203_V	1.356	1.00
5_P	29_E	1.347	1.00
49_E	53_Y	1.345	1.00
19_A	235_H	1.337	1.00
167_K	171_Y	1.325	1.00
58_T	85_I	1.305	1.00
174_K	199_M	1.305	1.00
102_R	215_E	1.300	1.00
65_H	238_L	1.297	1.00
108_T	111_Q	1.297	1.00
126_A	130_A	1.296	1.00
115_V	140_V	1.296	1.00
196_Q	205_I	1.295	1.00
131_L	140_V	1.287	1.00
147_L	150_P	1.284	1.00
47_E	80_I	1.282	1.00
156_K	161_T	1.278	1.00
147_L	168_T	1.255	1.00
166_V	198_Y	1.255	1.00
45_R	53_Y	1.252	1.00
17_T	190_I	1.235	1.00
159_D	162_A	1.213	1.00
128_E	132_L	1.209	1.00
37_T	239_T	1.201	1.00
163_D	198_Y	1.194	1.00
22_I	213_A	1.186	1.00
125_N	129_E	1.184	1.00
7_G	67_I	1.181	1.00
219_I	223_K	1.165	1.00
163_D	167_K	1.163	1.00
69_M	94_V	1.158	1.00
151_F	162_A	1.154	1.00
44_P	119_E	1.151	1.00
150_P	188_Y	1.146	1.00
108_T	180_S	1.142	1.00
192_K	205_I	1.137	1.00
70_L	91_I	1.137	1.00
72_I	85_I	1.128	1.00
101_A	131_L	1.125	1.00
5_P	30_N	1.123	1.00
247_A	251_D	1.118	1.00
19_A	22_I	1.111	1.00
210_D	214_R	1.105	1.00
127_Y	142_N	1.102	1.00
23_M	31_I	1.087	0.99
45_R	49_E	1.083	0.99
122_I	144_A	1.079	0.99
129_E	133_A	1.076	0.99
49_E	52_Q	1.072	0.99
6_I	29_E	1.070	0.99
46_P	49_E	1.062	0.99
68_K	225_L	1.056	0.99
85_I	93_V	1.052	0.99
80_I	120_N	1.049	0.99
147_L	188_Y	1.044	0.99
111_Q	137_D	1.032	0.99
215_E	219_I	1.032	0.99
101_A	130_A	1.028	0.99
167_K	198_Y	1.026	0.99
166_V	169_S	1.024	0.99
103_A	211_E	1.023	0.99
217_S	221_S	1.020	0.99
18_V	212_T	1.014	0.99
147_L	165_I	1.013	0.99
21_E	209_G	1.013	0.99
194_A	197_R	1.011	0.99
221_S	226_L	1.006	0.99
114_G	181_L	1.003	0.99
159_D	163_D	1.000	0.99
160_K	164_E	0.991	0.99
84_D	88_S	0.982	0.99
180_S	204_N	0.981	0.99
26_L	217_S	0.981	0.99
82_L	86_Q	0.981	0.99
103_A	106_K	0.980	0.99
53_Y	57_L	0.978	0.99
145_C	188_Y	0.975	0.99
110_N	179_D	0.975	0.99
58_T	93_V	0.971	0.99
208_S	211_E	0.971	0.99
171_Y	175_D	0.971	0.99
164_E	167_K	0.971	0.99
30_N	234_D	0.969	0.99
71_V	94_V	0.963	0.99
25_Q	214_R	0.959	0.99
218_T	222_Y	0.957	0.99
29_E	225_L	0.948	0.99
112_H	178_I	0.944	0.98
195_I	198_Y	0.933	0.98
5_P	32_I	0.932	0.98
110_N	180_S	0.929	0.98
196_Q	201_E	0.929	0.98
17_T	189_P	0.925	0.98
48_E	52_Q	0.924	0.98
54_T	57_L	0.918	0.98
50_V	54_T	0.917	0.98
54_T	77_A	0.913	0.98
107_V	204_N	0.910	0.98
129_E	132_L	0.908	0.98
180_S	206_I	0.905	0.98
147_L	169_S	0.904	0.98
78_T	95_G	0.903	0.98
119_E	144_A	0.901	0.98
166_V	195_I	0.900	0.98
152_V	188_Y	0.897	0.98
44_P	188_Y	0.891	0.98
166_V	194_A	0.889	0.98
68_K	220_L	0.888	0.98
86_Q	130_A	0.886	0.98
200_G	203_V	0.883	0.98
21_E	213_A	0.882	0.98
30_N	227_N	0.881	0.98
152_V	162_A	0.866	0.97
44_P	120_N	0.860	0.97
95_G	98_Q	0.856	0.97
113_I	138_L	0.853	0.97
237_F	246_F	0.853	0.97
246_F	250_A	0.853	0.97
33_Y	37_T	0.848	0.97
7_G	61_L	0.847	0.97
47_E	51_L	0.846	0.97
131_L	182_I	0.844	0.97
127_Y	131_L	0.843	0.97
9_I	57_L	0.835	0.97
130_A	133_A	0.834	0.97
62_L	89_V	0.831	0.97
94_V	216_V	0.828	0.97
78_T	82_L	0.825	0.96
25_Q	213_A	0.824	0.96
193_E	196_Q	0.820	0.96
59_N	63_E	0.812	0.96
58_T	81_A	0.808	0.96
40_C	239_T	0.808	0.96
26_L	29_E	0.803	0.96
149_V	153_E	0.797	0.96
199_M	205_I	0.797	0.96
181_L	205_I	0.795	0.96
165_I	169_S	0.792	0.96
100_G	208_S	0.788	0.95
30_N	231_I	0.787	0.95
62_L	93_V	0.787	0.95
83_D	87_R	0.784	0.95
20_K	24_R	0.782	0.95
9_I	58_T	0.776	0.95
100_G	103_A	0.774	0.95
97_I	126_A	0.774	0.95
151_F	165_I	0.770	0.95
37_T	40_C	0.766	0.95
19_A	23_M	0.765	0.95
39_R	45_R	0.765	0.95
100_G	104_A	0.756	0.94
162_A	191_L	0.755	0.94
122_I	127_Y	0.741	0.94
116_I	195_I	0.740	0.94
249_I	253_W	0.740	0.94
63_E	66_H	0.737	0.93
81_A	85_I	0.736	0.93
250_A	253_W	0.734	0.93
85_I	89_V	0.732	0.93
29_E	220_L	0.731	0.93
108_T	113_I	0.730	0.93
166_V	170_L	0.728	0.93
96_V	212_T	0.727	0.93
141_E	176_T	0.724	0.93
244_D	248_K	0.724	0.93
220_L	226_L	0.721	0.93
8_V	213_A	0.717	0.92
103_A	107_V	0.715	0.92
115_V	182_I	0.715	0.92
162_A	194_A	0.713	0.92
98_Q	130_A	0.711	0.92
227_N	231_I	0.704	0.92
115_V	122_I	0.703	0.92
39_R	49_E	0.699	0.92
161_T	165_I	0.695	0.91
76_T	118_T	0.691	0.91
178_I	181_L	0.689	0.91
13_V	249_I	0.688	0.91
178_I	199_M	0.687	0.91
107_V	206_I	0.683	0.91
32_I	238_L	0.678	0.90
84_D	87_R	0.675	0.90
151_F	191_L	0.672	0.90
55_W	58_T	0.671	0.90
149_V	208_S	0.669	0.90
54_T	85_I	0.667	0.90
148_L	191_L	0.666	0.89
248_K	251_D	0.663	0.89
101_A	127_Y	0.660	0.89
120_N	124_S	0.659	0.89
70_L	93_V	0.657	0.89
10_D	14_G	0.656	0.89
62_L	90_G	0.656	0.89
164_E	168_T	0.652	0.88
40_C	149_V	0.650	0.88
51_L	55_W	0.648	0.88
157_F	162_A	0.648	0.88
83_D	129_E	0.648	0.88
30_N	236_Q	0.647	0.88
77_A	99_P	0.644	0.88
196_Q	204_N	0.643	0.88
244_D	247_A	0.641	0.88
170_L	195_I	0.640	0.88
32_I	61_L	0.638	0.87
243_R	247_A	0.635	0.87
96_V	100_G	0.634	0.87
242_A	245_Q	0.633	0.87
131_L	138_L	0.631	0.87
58_T	62_L	0.630	0.87
102_R	134_L	0.624	0.86
211_E	214_R	0.621	0.86
26_L	68_K	0.619	0.86
194_A	198_Y	0.618	0.86
105_I	135_N	0.612	0.85
146_P	188_Y	0.609	0.85
145_C	148_L	0.607	0.85
55_W	59_N	0.606	0.85
49_E	241_G	0.603	0.84
160_K	163_D	0.603	0.84
139_K	176_T	0.598	0.84
21_E	25_Q	0.597	0.84
45_R	54_T	0.590	0.83
147_L	156_K	0.590	0.83
120_N	209_G	0.589	0.83
190_I	253_W	0.586	0.83
40_C	45_R	0.585	0.82
69_M	219_I	0.585	0.82
30_N	235_H	0.585	0.82
118_T	185_C	0.583	0.82
38_K	242_A	0.582	0.82
74_C	185_C	0.581	0.82
236_Q	239_T	0.581	0.82
94_V	212_T	0.580	0.82
86_Q	102_R	0.579	0.82
224_G	227_N	0.578	0.82
111_Q	138_L	0.577	0.82
17_T	209_G	0.577	0.82
158_L	197_R	0.576	0.81
30_N	68_K	0.576	0.81
141_E	178_I	0.574	0.81
9_I	54_T	0.573	0.81
105_I	134_L	0.569	0.81
158_L	194_A	0.569	0.81
31_I	235_H	0.568	0.81
107_V	180_S	0.568	0.81
79_A	124_S	0.568	0.81
11_S	15_G	0.565	0.80
112_H	179_D	0.565	0.80
82_L	130_A	0.563	0.80
174_K	177_S	0.562	0.80
81_A	84_D	0.561	0.80
28_K	229_S	0.561	0.80
193_E	197_R	0.561	0.80
96_V	208_S	0.560	0.80
35_G	241_G	0.560	0.80
104_A	108_T	0.558	0.79
196_Q	200_G	0.557	0.79
54_T	72_I	0.551	0.79
32_I	65_H	0.551	0.79
237_F	250_A	0.550	0.78
209_G	253_W	0.550	0.78
219_I	222_Y	0.549	0.78
15_G	74_C	0.546	0.78
49_E	154_S	0.546	0.78
217_S	226_L	0.545	0.78
58_T	61_L	0.545	0.78
104_A	113_I	0.543	0.78
8_V	96_V	0.543	0.78
98_Q	102_R	0.543	0.78
178_I	203_V	0.541	0.77
54_T	58_T	0.540	0.77
79_A	97_I	0.538	0.77
61_L	70_L	0.536	0.77
68_K	226_L	0.536	0.77
9_I	33_Y	0.535	0.77
145_C	169_S	0.530	0.76
100_G	211_E	0.528	0.76
241_G	245_Q	0.527	0.75
149_V	191_L	0.524	0.75
54_T	81_A	0.523	0.75
95_G	100_G	0.521	0.75
28_K	226_L	0.520	0.75
102_R	211_E	0.516	0.74
13_V	250_A	0.515	0.74
18_V	189_P	0.514	0.74
231_I	234_D	0.514	0.74
170_L	181_L	0.514	0.74
11_S	118_T	0.513	0.74
40_C	150_P	0.511	0.73
7_G	66_H	0.511	0.73
247_A	250_A	0.510	0.73
79_A	126_A	0.510	0.73
104_A	179_D	0.510	0.73
104_A	180_S	0.508	0.73
116_I	145_C	0.506	0.73
75_N	209_G	0.505	0.72
156_K	162_A	0.505	0.72
189_P	207_S	0.504	0.72
15_G	185_C	0.503	0.72
69_M	92_P	0.503	0.72
17_T	37_T	0.502	0.72
70_L	180_S	0.501	0.72
100_G	209_G	0.500	0.72
8_V	31_I	0.500	0.72
81_A	141_E	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zuwA	2	0.9669	100	0.217	Contact Map
2dwuA	2	0.9779	100	0.218	Contact Map
2vvtA	2	0.9779	100	0.26	Contact Map
2gzmA	3	0.9779	100	0.263	Contact Map
2jfqA	2	0.9669	100	0.265	Contact Map
2ohoA	2	0.9669	100	0.275	Contact Map
3istA	2	0.9816	100	0.277	Contact Map
3outA	5	0.9669	100	0.28	Contact Map
2jfnA	1	0.9669	100	0.285	Contact Map
3uhfA	1	0.9154	100	0.318	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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