GREMLIN Database
MURI1 - Glutamate racemase 1
UniProt: P94556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (248)
Sequences: 3700 (2491)
Seq/√Len: 158.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_V22_I3.6651.00
34_V240_T3.4421.00
163_D197_R3.3451.00
69_M216_V3.2611.00
55_W88_S2.8241.00
21_E24_R2.7591.00
19_A31_I2.6781.00
67_I70_L2.6681.00
39_R53_Y2.6341.00
60_Y238_L2.5341.00
29_E68_K2.3901.00
30_N233_P2.3731.00
112_H139_K2.3481.00
215_E218_T2.3291.00
192_K196_Q2.2751.00
58_T70_L2.2591.00
128_E142_N2.2471.00
152_V191_L2.2391.00
65_H236_Q2.1511.00
148_L166_V2.0921.00
112_H141_E2.0541.00
22_I31_I2.0291.00
25_Q217_S1.9591.00
5_P68_K1.9481.00
4_Q66_H1.9271.00
60_Y65_H1.8931.00
117_G122_I1.8881.00
59_N88_S1.8501.00
71_V216_V1.8321.00
122_I142_N1.8241.00
116_I181_L1.8231.00
22_I216_V1.7691.00
111_Q135_N1.7191.00
72_I82_L1.6741.00
119_E123_K1.6441.00
156_K159_D1.6321.00
82_L95_G1.6181.00
39_R56_E1.6101.00
181_L199_M1.5961.00
163_D194_A1.5751.00
114_G178_I1.5671.00
143_L169_S1.5651.00
50_V120_N1.5471.00
59_N89_V1.5361.00
89_V93_V1.5321.00
51_L84_D1.5181.00
112_H177_S1.4891.00
21_E210_D1.4831.00
23_M235_H1.4731.00
108_T138_L1.4701.00
62_L91_I1.4661.00
8_V19_A1.4441.00
22_I71_V1.4351.00
34_V57_L1.4331.00
195_I205_I1.4301.00
143_L172_P1.4231.00
149_V188_Y1.4191.00
192_K207_S1.4171.00
53_Y56_E1.4161.00
125_N142_N1.4141.00
108_T179_D1.4121.00
114_G173_L1.4081.00
52_Q56_E1.3921.00
189_P209_G1.3911.00
94_V219_I1.3821.00
55_W84_D1.3791.00
125_N128_E1.3741.00
199_M203_V1.3561.00
5_P29_E1.3471.00
49_E53_Y1.3451.00
19_A235_H1.3371.00
167_K171_Y1.3251.00
58_T85_I1.3051.00
174_K199_M1.3051.00
102_R215_E1.3001.00
65_H238_L1.2971.00
108_T111_Q1.2971.00
126_A130_A1.2961.00
115_V140_V1.2961.00
196_Q205_I1.2951.00
131_L140_V1.2871.00
147_L150_P1.2841.00
47_E80_I1.2821.00
156_K161_T1.2781.00
147_L168_T1.2551.00
166_V198_Y1.2551.00
45_R53_Y1.2521.00
17_T190_I1.2351.00
159_D162_A1.2131.00
128_E132_L1.2091.00
37_T239_T1.2011.00
163_D198_Y1.1941.00
22_I213_A1.1861.00
125_N129_E1.1841.00
7_G67_I1.1811.00
219_I223_K1.1651.00
163_D167_K1.1631.00
69_M94_V1.1581.00
151_F162_A1.1541.00
44_P119_E1.1511.00
150_P188_Y1.1461.00
108_T180_S1.1421.00
192_K205_I1.1371.00
70_L91_I1.1371.00
72_I85_I1.1281.00
101_A131_L1.1251.00
5_P30_N1.1231.00
247_A251_D1.1181.00
19_A22_I1.1111.00
210_D214_R1.1051.00
127_Y142_N1.1021.00
23_M31_I1.0870.99
45_R49_E1.0830.99
122_I144_A1.0790.99
129_E133_A1.0760.99
49_E52_Q1.0720.99
6_I29_E1.0700.99
46_P49_E1.0620.99
68_K225_L1.0560.99
85_I93_V1.0520.99
80_I120_N1.0490.99
147_L188_Y1.0440.99
111_Q137_D1.0320.99
215_E219_I1.0320.99
101_A130_A1.0280.99
167_K198_Y1.0260.99
166_V169_S1.0240.99
103_A211_E1.0230.99
217_S221_S1.0200.99
18_V212_T1.0140.99
147_L165_I1.0130.99
21_E209_G1.0130.99
194_A197_R1.0110.99
221_S226_L1.0060.99
114_G181_L1.0030.99
159_D163_D1.0000.99
160_K164_E0.9910.99
84_D88_S0.9820.99
180_S204_N0.9810.99
26_L217_S0.9810.99
82_L86_Q0.9810.99
103_A106_K0.9800.99
53_Y57_L0.9780.99
145_C188_Y0.9750.99
110_N179_D0.9750.99
58_T93_V0.9710.99
208_S211_E0.9710.99
171_Y175_D0.9710.99
164_E167_K0.9710.99
30_N234_D0.9690.99
71_V94_V0.9630.99
25_Q214_R0.9590.99
218_T222_Y0.9570.99
29_E225_L0.9480.99
112_H178_I0.9440.98
195_I198_Y0.9330.98
5_P32_I0.9320.98
110_N180_S0.9290.98
196_Q201_E0.9290.98
17_T189_P0.9250.98
48_E52_Q0.9240.98
54_T57_L0.9180.98
50_V54_T0.9170.98
54_T77_A0.9130.98
107_V204_N0.9100.98
129_E132_L0.9080.98
180_S206_I0.9050.98
147_L169_S0.9040.98
78_T95_G0.9030.98
119_E144_A0.9010.98
166_V195_I0.9000.98
152_V188_Y0.8970.98
44_P188_Y0.8910.98
166_V194_A0.8890.98
68_K220_L0.8880.98
86_Q130_A0.8860.98
200_G203_V0.8830.98
21_E213_A0.8820.98
30_N227_N0.8810.98
152_V162_A0.8660.97
44_P120_N0.8600.97
95_G98_Q0.8560.97
113_I138_L0.8530.97
237_F246_F0.8530.97
246_F250_A0.8530.97
33_Y37_T0.8480.97
7_G61_L0.8470.97
47_E51_L0.8460.97
131_L182_I0.8440.97
127_Y131_L0.8430.97
9_I57_L0.8350.97
130_A133_A0.8340.97
62_L89_V0.8310.97
94_V216_V0.8280.97
78_T82_L0.8250.96
25_Q213_A0.8240.96
193_E196_Q0.8200.96
59_N63_E0.8120.96
58_T81_A0.8080.96
40_C239_T0.8080.96
26_L29_E0.8030.96
149_V153_E0.7970.96
199_M205_I0.7970.96
181_L205_I0.7950.96
165_I169_S0.7920.96
100_G208_S0.7880.95
30_N231_I0.7870.95
62_L93_V0.7870.95
83_D87_R0.7840.95
20_K24_R0.7820.95
9_I58_T0.7760.95
100_G103_A0.7740.95
97_I126_A0.7740.95
151_F165_I0.7700.95
37_T40_C0.7660.95
19_A23_M0.7650.95
39_R45_R0.7650.95
100_G104_A0.7560.94
162_A191_L0.7550.94
122_I127_Y0.7410.94
116_I195_I0.7400.94
249_I253_W0.7400.94
63_E66_H0.7370.93
81_A85_I0.7360.93
250_A253_W0.7340.93
85_I89_V0.7320.93
29_E220_L0.7310.93
108_T113_I0.7300.93
166_V170_L0.7280.93
96_V212_T0.7270.93
141_E176_T0.7240.93
244_D248_K0.7240.93
220_L226_L0.7210.93
8_V213_A0.7170.92
103_A107_V0.7150.92
115_V182_I0.7150.92
162_A194_A0.7130.92
98_Q130_A0.7110.92
227_N231_I0.7040.92
115_V122_I0.7030.92
39_R49_E0.6990.92
161_T165_I0.6950.91
76_T118_T0.6910.91
178_I181_L0.6890.91
13_V249_I0.6880.91
178_I199_M0.6870.91
107_V206_I0.6830.91
32_I238_L0.6780.90
84_D87_R0.6750.90
151_F191_L0.6720.90
55_W58_T0.6710.90
149_V208_S0.6690.90
54_T85_I0.6670.90
148_L191_L0.6660.89
248_K251_D0.6630.89
101_A127_Y0.6600.89
120_N124_S0.6590.89
70_L93_V0.6570.89
10_D14_G0.6560.89
62_L90_G0.6560.89
164_E168_T0.6520.88
40_C149_V0.6500.88
51_L55_W0.6480.88
157_F162_A0.6480.88
83_D129_E0.6480.88
30_N236_Q0.6470.88
77_A99_P0.6440.88
196_Q204_N0.6430.88
244_D247_A0.6410.88
170_L195_I0.6400.88
32_I61_L0.6380.87
243_R247_A0.6350.87
96_V100_G0.6340.87
242_A245_Q0.6330.87
131_L138_L0.6310.87
58_T62_L0.6300.87
102_R134_L0.6240.86
211_E214_R0.6210.86
26_L68_K0.6190.86
194_A198_Y0.6180.86
105_I135_N0.6120.85
146_P188_Y0.6090.85
145_C148_L0.6070.85
55_W59_N0.6060.85
49_E241_G0.6030.84
160_K163_D0.6030.84
139_K176_T0.5980.84
21_E25_Q0.5970.84
45_R54_T0.5900.83
147_L156_K0.5900.83
120_N209_G0.5890.83
190_I253_W0.5860.83
40_C45_R0.5850.82
69_M219_I0.5850.82
30_N235_H0.5850.82
118_T185_C0.5830.82
38_K242_A0.5820.82
74_C185_C0.5810.82
236_Q239_T0.5810.82
94_V212_T0.5800.82
86_Q102_R0.5790.82
224_G227_N0.5780.82
111_Q138_L0.5770.82
17_T209_G0.5770.82
158_L197_R0.5760.81
30_N68_K0.5760.81
141_E178_I0.5740.81
9_I54_T0.5730.81
105_I134_L0.5690.81
158_L194_A0.5690.81
31_I235_H0.5680.81
107_V180_S0.5680.81
79_A124_S0.5680.81
11_S15_G0.5650.80
112_H179_D0.5650.80
82_L130_A0.5630.80
174_K177_S0.5620.80
81_A84_D0.5610.80
28_K229_S0.5610.80
193_E197_R0.5610.80
96_V208_S0.5600.80
35_G241_G0.5600.80
104_A108_T0.5580.79
196_Q200_G0.5570.79
54_T72_I0.5510.79
32_I65_H0.5510.79
237_F250_A0.5500.78
209_G253_W0.5500.78
219_I222_Y0.5490.78
15_G74_C0.5460.78
49_E154_S0.5460.78
217_S226_L0.5450.78
58_T61_L0.5450.78
104_A113_I0.5430.78
8_V96_V0.5430.78
98_Q102_R0.5430.78
178_I203_V0.5410.77
54_T58_T0.5400.77
79_A97_I0.5380.77
61_L70_L0.5360.77
68_K226_L0.5360.77
9_I33_Y0.5350.77
145_C169_S0.5300.76
100_G211_E0.5280.76
241_G245_Q0.5270.75
149_V191_L0.5240.75
54_T81_A0.5230.75
95_G100_G0.5210.75
28_K226_L0.5200.75
102_R211_E0.5160.74
13_V250_A0.5150.74
18_V189_P0.5140.74
231_I234_D0.5140.74
170_L181_L0.5140.74
11_S118_T0.5130.74
40_C150_P0.5110.73
7_G66_H0.5110.73
247_A250_A0.5100.73
79_A126_A0.5100.73
104_A179_D0.5100.73
104_A180_S0.5080.73
116_I145_C0.5060.73
75_N209_G0.5050.72
156_K162_A0.5050.72
189_P207_S0.5040.72
15_G185_C0.5030.72
69_M92_P0.5030.72
17_T37_T0.5020.72
70_L180_S0.5010.72
100_G209_G0.5000.72
8_V31_I0.5000.72
81_A141_E0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zuwA 2 0.9669 100 0.217 Contact Map
2dwuA 2 0.9779 100 0.218 Contact Map
2vvtA 2 0.9779 100 0.26 Contact Map
2gzmA 3 0.9779 100 0.263 Contact Map
2jfqA 2 0.9669 100 0.265 Contact Map
2ohoA 2 0.9669 100 0.275 Contact Map
3istA 2 0.9816 100 0.277 Contact Map
3outA 5 0.9669 100 0.28 Contact Map
2jfnA 1 0.9669 100 0.285 Contact Map
3uhfA 1 0.9154 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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