GREMLIN Database
IABF2 - Intracellular exo-alpha-L-arabinofuranosidase 2
UniProt: P94552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 495 (447)
Sequences: 2141 (1531)
Seq/√Len: 72.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_K159_E4.6021.00
107_H162_W4.2821.00
107_H156_N3.6241.00
57_E61_Q3.4341.00
381_L412_I3.3541.00
132_Q136_E3.2661.00
48_I53_K3.2321.00
78_Y83_G3.1031.00
15_G334_C2.9421.00
416_I481_L2.8241.00
113_C120_P2.7821.00
411_D490_T2.7711.00
58_A360_M2.7411.00
56_L116_L2.7371.00
49_N111_M2.7241.00
119_E165_K2.6831.00
114_E158_R2.6461.00
458_D461_H2.6451.00
36_G40_G2.5781.00
152_W155_Q2.5481.00
79_H133_E2.5121.00
36_G39_V2.4861.00
81_A136_E2.4831.00
426_E480_K2.4671.00
383_T404_A2.4661.00
144_E147_T2.3631.00
452_A461_H2.3601.00
196_V204_I2.2891.00
416_I427_A2.2061.00
49_N115_L2.1771.00
140_Y156_N2.1661.00
400_I425_A2.1631.00
184_Y187_D2.1561.00
61_Q370_N2.1351.00
110_M120_P2.1251.00
181_H187_D2.1221.00
61_Q366_Y2.0831.00
447_A452_A2.0681.00
31_R40_G2.0661.00
146_G151_D2.0201.00
158_R162_W2.0151.00
29_L311_L2.0101.00
460_H463_K2.0021.00
31_R36_G1.9831.00
37_I40_G1.9761.00
370_N443_V1.9681.00
441_S466_S1.9571.00
112_L116_L1.9521.00
455_T459_P1.9431.00
197_R231_D1.9391.00
61_Q362_L1.9131.00
420_D423_N1.8911.00
142_T163_K1.8771.00
110_M114_E1.8751.00
145_E150_S1.8731.00
481_L487_V1.8711.00
424_K483_P1.8611.00
424_K480_K1.8441.00
220_D224_K1.8431.00
84_V156_N1.8361.00
324_A417_C1.8261.00
107_H158_R1.8241.00
84_V152_W1.8111.00
31_R39_V1.7911.00
317_I446_T1.7861.00
122_I137_W1.7851.00
9_Q432_R1.7801.00
400_I481_L1.7761.00
6_A427_A1.7501.00
235_L291_L1.7471.00
250_S253_E1.7271.00
151_D155_Q1.6981.00
31_R37_I1.6941.00
444_I487_V1.6761.00
141_M164_L1.6621.00
448_E452_A1.6561.00
152_W156_N1.6451.00
449_K452_A1.6360.99
138_I196_V1.6180.99
200_S203_D1.6160.99
43_S46_P1.6110.99
332_Q401_S1.6010.99
63_H374_V1.5950.99
6_A385_T1.5880.99
413_N490_T1.5810.99
124_G134_M1.5620.99
290_G338_Q1.5470.99
442_G487_V1.5380.99
293_I337_V1.5350.99
444_I482_P1.5350.99
380_L403_S1.5350.99
407_Q411_D1.5290.99
482_P487_V1.5190.99
150_S154_K1.5180.99
321_L486_V1.5140.99
66_V341_N1.5130.99
143_F150_S1.5090.99
35_E39_V1.5090.99
31_R38_W1.5010.99
81_A149_M1.4930.99
58_A362_L1.4900.99
43_S47_N1.4790.99
287_Q335_R1.4730.99
428_E476_K1.4660.99
426_E478_K1.4620.99
136_E149_M1.4590.99
367_H370_N1.4550.99
107_H140_Y1.4500.99
145_E154_K1.4490.99
415_T488_L1.4400.99
148_P152_W1.4280.99
47_N115_L1.4260.99
442_G467_F1.4210.99
86_D155_Q1.4180.99
205_Y232_G1.4140.99
6_A402_I1.4130.99
98_T310_F1.4120.98
132_Q135_S1.4110.98
56_L115_L1.4070.98
389_D396_T1.3950.98
20_N166_Y1.3810.98
149_M152_W1.3730.98
167_F196_V1.3660.98
383_T402_I1.3650.98
317_I447_A1.3630.98
111_M115_L1.3550.98
334_C380_L1.3530.98
428_E478_K1.3500.98
479_V489_L1.3480.98
5_Q428_E1.3430.98
48_I115_L1.3350.98
325_S417_C1.3340.98
208_A222_L1.3330.98
190_R229_L1.3300.98
429_I477_L1.3300.98
154_K158_R1.3270.98
182_P221_V1.3270.98
328_H372_F1.3220.98
106_T137_W1.3200.98
298_T322_V1.3160.98
217_N220_D1.3130.98
441_S490_T1.3100.98
51_I104_F1.3100.98
114_E160_E1.3090.98
44_D47_N1.3060.97
359_R457_D1.3000.97
110_M164_L1.2900.97
356_E359_R1.2830.97
331_H415_T1.2720.97
35_E356_E1.2690.97
67_L118_C1.2690.97
110_M141_M1.2610.97
111_M158_R1.2580.97
10_T433_G1.2550.97
327_F330_F1.2520.97
106_T141_M1.2520.97
196_V200_S1.2490.97
440_H489_L1.2400.97
234_S294_D1.2300.96
181_H184_Y1.2260.96
427_A481_L1.2100.96
83_G106_T1.2090.96
5_Q386_M1.1990.96
328_H403_S1.1950.96
375_H405_S1.1940.96
328_H417_C1.1810.95
391_E396_T1.1770.95
135_S138_I1.1690.95
183_E225_K1.1620.95
191_R194_T1.1600.95
19_K119_E1.1580.95
35_E40_G1.1570.95
124_G196_V1.1550.95
371_M488_L1.1530.95
45_I53_K1.1520.95
62_L370_N1.1500.95
183_E221_V1.1500.95
371_M445_L1.1490.95
399_Q420_D1.1460.95
20_N66_V1.1450.95
14_K382_A1.1340.94
16_T19_K1.1310.94
14_K380_L1.1250.94
317_I484_M1.1250.94
124_G167_F1.1200.94
84_V149_M1.1160.94
188_L191_R1.1130.94
17_I380_L1.1120.94
416_I489_L1.1100.94
19_K377_D1.1050.94
454_N459_P1.1030.93
454_N462_V1.1020.93
416_I487_V1.0980.93
375_H490_T1.0910.93
217_N221_V1.0850.93
421_H484_M1.0800.93
391_E395_E1.0740.93
53_K57_E1.0680.92
362_L366_Y1.0600.92
10_T434_L1.0570.92
300_F316_T1.0560.92
193_Q206_K1.0550.92
81_A152_W1.0550.92
31_R35_E1.0540.92
42_D46_P1.0540.92
370_N374_V1.0530.92
391_E394_G1.0480.92
400_I416_I1.0450.91
122_I164_L1.0430.91
146_G150_S1.0410.91
414_I429_I1.0410.91
18_N338_Q1.0380.91
253_E451_N1.0370.91
430_E433_G1.0360.91
122_I141_M1.0330.91
447_A461_H1.0330.91
194_T198_N1.0310.91
34_Y37_I1.0310.91
142_T167_F1.0300.91
186_A225_K1.0290.91
189_Y193_Q1.0290.91
277_G336_R1.0280.91
135_S199_Y1.0240.91
5_Q430_E1.0220.91
372_F486_V1.0210.91
450_M484_M1.0190.90
381_L406_K1.0190.90
73_C76_D1.0150.90
105_G108_E1.0130.90
144_E150_S1.0130.90
120_P165_K1.0110.90
35_E38_W1.0100.90
24_H67_L1.0100.90
249_G301_D1.0090.90
44_D49_N1.0080.90
31_R312_Y0.9990.90
13_A379_S0.9980.89
56_L112_L0.9980.89
66_V339_M0.9950.89
361_L455_T0.9940.89
18_N21_I0.9940.89
195_Y198_N0.9910.89
420_D425_A0.9880.89
37_I112_L0.9880.89
23_G27_E0.9860.89
11_D432_R0.9830.89
89_T99_I0.9820.89
151_D154_K0.9790.89
65_P373_K0.9690.88
12_I382_A0.9690.88
180_M188_L0.9660.88
79_H132_Q0.9590.88
141_M162_W0.9590.88
367_H463_K0.9560.87
84_V107_H0.9550.87
134_M167_F0.9500.87
446_T482_P0.9490.87
138_I192_F0.9470.87
366_Y370_N0.9410.87
385_T402_I0.9410.87
324_A328_H0.9360.86
7_V432_R0.9330.86
368_V486_V0.9270.86
407_Q410_G0.9260.86
317_I321_L0.9250.86
138_I199_Y0.9240.86
379_S406_K0.9180.85
8_I404_A0.9140.85
4_H425_A0.9140.85
332_Q403_S0.9090.85
17_I405_S0.9080.85
473_S476_K0.9060.84
455_T458_D0.9050.84
361_L456_F0.9020.84
443_V488_L0.9010.84
328_H401_S0.9000.84
359_R456_F0.8970.84
442_G489_L0.8970.84
4_H387_S0.8940.84
45_I48_I0.8910.83
35_E357_G0.8890.83
67_L116_L0.8880.83
121_Y207_I0.8850.83
81_A129_G0.8810.83
4_H385_T0.8790.83
24_H59_L0.8780.82
299_W319_D0.8710.82
22_Y185_Y0.8670.82
147_T150_S0.8670.82
85_G105_G0.8660.82
23_G66_V0.8660.82
477_L489_L0.8620.81
43_S49_N0.8620.81
375_H488_L0.8600.81
232_G290_G0.8580.81
138_I149_M0.8580.81
17_I22_Y0.8560.81
65_P376_Q0.8560.81
207_I232_G0.8560.81
452_A462_V0.8540.81
276_H291_L0.8530.81
392_W395_E0.8440.80
316_T451_N0.8430.80
125_N128_S0.8410.80
51_I56_L0.8380.79
164_L167_F0.8340.79
371_M443_V0.8330.79
443_V464_P0.8330.79
110_M162_W0.8320.79
81_A132_Q0.8320.79
477_L491_L0.8310.79
57_E60_K0.8290.79
16_T379_S0.8270.79
472_L489_L0.8250.78
138_I164_L0.8240.78
166_Y339_M0.8240.78
7_V11_D0.8240.78
66_V166_Y0.8240.78
18_N334_C0.8220.78
63_H373_K0.8210.78
131_V195_Y0.8190.78
189_Y230_M0.8160.78
39_V43_S0.8110.77
143_F146_G0.8100.77
375_H413_N0.8100.77
74_F100_E0.8080.77
321_L419_I0.8080.77
51_I112_L0.8060.77
472_L477_L0.8050.77
32_G40_G0.8040.77
114_E162_W0.8020.76
442_G479_V0.8000.76
139_E143_F0.8000.76
141_M167_F0.7990.76
299_W344_Q0.7950.76
107_H111_M0.7930.76
131_V192_F0.7880.75
309_G356_E0.7850.75
146_G154_K0.7840.75
74_F102_N0.7830.75
127_G175_G0.7790.74
108_E139_E0.7760.74
210_G215_D0.7740.74
314_Q353_I0.7730.74
6_A383_T0.7730.74
316_T320_A0.7710.74
367_H464_P0.7690.73
311_L342_I0.7660.73
327_F331_H0.7660.73
353_I362_L0.7650.73
190_R194_T0.7640.73
82_N102_N0.7630.73
199_Y204_I0.7600.72
32_G39_V0.7590.72
291_L445_L0.7580.72
293_I330_F0.7580.72
324_A486_V0.7560.72
90_M102_N0.7560.72
81_A133_E0.7560.72
55_V346_V0.7550.72
370_N373_K0.7550.72
39_V45_I0.7550.72
39_V42_D0.7550.72
47_N50_G0.7540.72
251_A318_R0.7530.72
32_G36_G0.7530.72
211_A215_D0.7520.72
42_D45_I0.7510.72
133_E136_E0.7510.72
240_I243_D0.7500.71
31_R34_Y0.7450.71
299_W313_Q0.7420.71
208_A230_M0.7420.71
64_I116_L0.7390.70
34_Y39_V0.7370.70
180_M191_R0.7370.70
79_H82_N0.7370.70
344_Q348_V0.7370.70
7_V430_E0.7360.70
169_V189_Y0.7360.70
474_K477_L0.7350.70
205_Y292_I0.7350.70
340_A369_F0.7310.69
343_A348_V0.7300.69
406_K409_E0.7300.69
412_I431_L0.7300.69
446_T484_M0.7290.69
9_Q382_A0.7290.69
467_F487_V0.7280.69
88_K193_Q0.7280.69
126_V169_V0.7280.69
211_A219_T0.7270.69
34_Y38_W0.7270.69
4_H7_V0.7250.69
173_N209_G0.7240.69
438_A480_K0.7180.68
430_E475_N0.7180.68
232_G292_I0.7180.68
138_I142_T0.7170.68
292_I339_M0.7160.68
26_A32_G0.7160.68
135_S195_Y0.7150.68
439_D489_L0.7150.68
439_D469_Q0.7130.68
13_A406_K0.7130.68
446_T465_E0.7120.67
448_E461_H0.7120.67
400_I479_V0.7110.67
40_G43_S0.7110.67
399_Q425_A0.7090.67
373_K376_Q0.7080.67
393_N396_T0.7070.67
479_V487_V0.7070.67
6_A429_I0.7070.67
125_N129_G0.7060.67
463_K480_K0.7050.67
5_Q10_T0.7050.67
24_H64_I0.7050.67
331_H403_S0.7000.66
77_E127_G0.7000.66
392_W396_T0.7000.66
123_C141_M0.6990.66
153_R161_P0.6990.66
124_G192_F0.6970.66
40_G46_P0.6960.66
372_F488_L0.6940.65
9_Q12_I0.6920.65
45_I49_N0.6920.65
39_V46_P0.6910.65
67_L112_L0.6890.65
43_S50_G0.6880.65
11_D433_G0.6870.65
207_I234_S0.6870.65
55_V355_T0.6870.65
414_I491_L0.6870.65
131_V135_S0.6860.65
84_V106_T0.6860.65
299_W347_N0.6850.64
427_A479_V0.6850.64
196_V199_Y0.6850.64
330_F340_A0.6840.64
24_H345_T0.6840.64
87_R105_G0.6840.64
73_C94_H0.6830.64
359_R459_P0.6800.64
387_S398_P0.6780.64
29_L342_I0.6760.63
12_I15_G0.6750.63
28_H31_R0.6720.63
30_G34_Y0.6710.63
442_G470_Y0.6690.63
143_F154_K0.6680.63
168_G294_D0.6680.63
431_L475_N0.6670.62
79_H136_E0.6660.62
193_Q197_R0.6640.62
24_H352_M0.6640.62
85_G108_E0.6630.62
111_M114_E0.6610.62
327_F368_V0.6610.62
253_E394_G0.6610.62
407_Q413_N0.6600.62
403_S429_I0.6580.61
277_G287_Q0.6580.61
317_I445_L0.6540.61
160_E408_A0.6540.61
28_H34_Y0.6520.61
437_A491_L0.6510.61
440_H469_Q0.6500.60
9_Q384_E0.6480.60
327_F372_F0.6480.60
19_K22_Y0.6480.60
59_L116_L0.6470.60
276_H289_V0.6450.60
79_H129_G0.6450.60
348_V351_A0.6450.60
139_E150_S0.6440.60
344_Q349_L0.6420.59
320_A364_P0.6420.59
20_N205_Y0.6370.59
333_H336_R0.6360.59
219_T233_L0.6360.59
328_H402_I0.6360.59
17_I426_E0.6350.59
67_L113_C0.6340.59
76_D177_G0.6330.58
7_V384_E0.6310.58
205_Y231_D0.6310.58
435_H438_A0.6310.58
29_L34_Y0.6280.58
331_H380_L0.6280.58
373_K377_D0.6270.58
43_S48_I0.6230.57
20_N119_E0.6210.57
25_F73_C0.6210.57
445_L464_P0.6210.57
232_G338_Q0.6200.57
311_L344_Q0.6200.57
355_T358_E0.6200.57
78_Y106_T0.6180.57
430_E483_P0.6180.57
325_S419_I0.6180.57
110_M158_R0.6160.56
32_G37_I0.6140.56
277_G333_H0.6140.56
466_S489_L0.6120.56
113_C324_A0.6120.56
110_M113_C0.6120.56
125_N175_G0.6120.56
324_A327_F0.6100.56
402_I416_I0.6080.55
67_L120_P0.6070.55
104_F120_P0.6060.55
74_F78_Y0.6050.55
12_I432_R0.6040.55
321_L450_M0.6040.55
94_H195_Y0.6040.55
88_K317_I0.6000.54
299_W349_L0.6000.54
153_R157_G0.5960.54
436_K475_N0.5950.54
297_G351_A0.5910.53
77_E93_T0.5890.53
59_L345_T0.5890.53
77_E132_Q0.5880.53
160_E458_D0.5860.53
211_A216_F0.5860.53
389_D395_E0.5860.53
104_F109_F0.5860.53
353_I366_Y0.5840.52
460_H465_E0.5840.52
167_F206_K0.5840.52
414_I489_L0.5830.52
188_L192_F0.5830.52
38_W47_N0.5820.52
144_E160_E0.5810.52
218_W222_L0.5810.52
18_N453_H0.5800.52
239_T330_F0.5780.52
134_M196_V0.5740.51
15_G380_L0.5730.51
142_T196_V0.5690.51
444_I467_F0.5680.50
241_P301_D0.5680.50
40_G47_N0.5670.50
68_R72_G0.5660.50
21_I334_C0.5640.50
457_D460_H0.5630.50
299_W343_A0.5630.50
444_I469_Q0.5630.50
211_A291_L0.5620.50
421_H450_M0.5620.50
17_I242_G0.5610.50
65_P118_C0.5600.49
226_A231_D0.5600.49
95_W105_G0.5590.49
51_I115_L0.5580.49
110_M118_C0.5580.49
73_C130_T0.5580.49
32_G120_P0.5560.49
76_D173_N0.5550.49
104_F110_M0.5540.49
73_C177_G0.5530.49
114_E159_E0.5520.48
145_E159_E0.5500.48
385_T457_D0.5500.48
166_Y207_I0.5500.48
241_P244_F0.5500.48
22_Y331_H0.5500.48
122_I130_T0.5490.48
398_P452_A0.5480.48
106_T110_M0.5480.48
358_E486_V0.5480.48
363_T368_V0.5480.48
100_E347_N0.5470.48
299_W315_N0.5470.48
296_W340_A0.5450.48
330_F337_V0.5450.48
455_T461_H0.5450.48
254_F318_R0.5440.48
218_W221_V0.5440.48
75_A123_C0.5420.47
109_F113_C0.5420.47
109_F120_P0.5410.47
469_Q472_L0.5410.47
430_E476_K0.5400.47
113_C118_C0.5390.47
208_A226_A0.5390.47
319_D347_N0.5390.47
380_L383_T0.5380.47
311_L348_V0.5370.47
147_T156_N0.5360.47
129_G133_E0.5350.46
51_I111_M0.5350.46
77_E198_N0.5340.46
73_C363_T0.5340.46
167_F204_I0.5340.46
457_D461_H0.5340.46
42_D412_I0.5340.46
14_K383_T0.5330.46
90_M149_M0.5320.46
37_I345_T0.5320.46
40_G45_I0.5310.46
311_L343_A0.5310.46
75_A125_N0.5300.46
126_V188_L0.5300.46
240_I301_D0.5290.46
472_L475_N0.5290.46
348_V355_T0.5290.46
343_A346_V0.5290.46
160_E396_T0.5280.46
4_H427_A0.5280.46
314_Q453_H0.5270.45
7_V382_A0.5270.45
156_N162_W0.5270.45
409_E446_T0.5270.45
371_M464_P0.5270.45
412_I491_L0.5260.45
22_Y376_Q0.5250.45
160_E386_M0.5240.45
140_Y152_W0.5240.45
38_W43_S0.5230.45
9_Q433_G0.5230.45
321_L417_C0.5230.45
111_M116_L0.5230.45
414_I476_K0.5220.45
111_M162_W0.5220.45
239_T326_H0.5220.45
200_S204_I0.5210.45
8_I383_T0.5200.45
138_I204_I0.5200.45
226_A288_R0.5200.45
296_W323_A0.5200.45
155_Q391_E0.5190.44
325_S401_S0.5160.44
38_W46_P0.5150.44
434_L438_A0.5140.44
48_I111_M0.5130.44
389_D398_P0.5130.44
4_H388_A0.5130.44
297_G313_Q0.5120.44
113_C204_I0.5120.44
68_R172_E0.5110.43
57_E466_S0.5110.43
436_K440_H0.5110.43
13_A382_A0.5090.43
83_G102_N0.5080.43
376_Q405_S0.5080.43
91_L147_T0.5080.43
64_I345_T0.5060.43
7_V10_T0.5050.43
135_S200_S0.5050.43
8_I466_S0.5040.43
372_F413_N0.5040.43
232_G339_M0.5040.43
213_V240_I0.5040.43
77_E195_Y0.5040.43
389_D393_N0.5040.43
372_F403_S0.5040.43
157_G161_P0.5030.43
142_T165_K0.5030.43
38_W103_E0.5020.42
140_Y153_R0.5020.42
169_V230_M0.5020.42
443_V490_T0.5010.42
473_S478_K0.5010.42
139_E321_L0.5000.42
13_A16_T0.5000.42
386_M392_W0.5000.42
416_I479_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vrqA 1 0.9798 100 0.219 Contact Map
2c7fA 2 0.9657 100 0.246 Contact Map
2y2wA 3 0.9758 100 0.246 Contact Map
1qw9A 4 0.9657 100 0.258 Contact Map
3ug3A 4 0.9333 100 0.268 Contact Map
3ik2A 1 0.8283 100 0.404 Contact Map
2e4tA 1 0.8141 100 0.413 Contact Map
2yihA 1 0.8283 100 0.418 Contact Map
3ii1A 1 0.8182 100 0.462 Contact Map
3vnyA 3 0.8747 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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