GREMLIN Database
ETFA - Electron transfer flavoprotein subunit alpha
UniProt: P94551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (309)
Sequences: 4011 (2421)
Seq/√Len: 137.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
305_G310_V4.9061.00
296_F302_G3.4181.00
266_C287_I3.3411.00
204_K261_D3.1741.00
208_A268_I3.0861.00
94_F104_S3.0451.00
59_K174_E2.7101.00
37_I61_L2.6021.00
206_I258_V2.5511.00
220_Q223_Q2.5091.00
26_A29_T2.5081.00
266_C311_V2.4461.00
27_G36_V2.4141.00
209_G219_F2.4071.00
53_I171_G2.3771.00
25_A163_S2.3541.00
228_V315_T2.3381.00
84_I92_V2.2011.00
9_G20_T2.1531.00
220_Q224_E2.1411.00
43_E64_E2.0441.00
245_C249_L2.0341.00
46_Q175_S2.0211.00
221_P224_E1.9921.00
59_K172_S1.9881.00
218_G221_P1.9811.00
224_E315_T1.9681.00
235_A245_C1.9341.00
35_E59_K1.9241.00
9_G38_G1.8941.00
23_A93_I1.8871.00
275_L298_I1.8821.00
209_G222_L1.8761.00
286_A299_A1.8751.00
283_V301_Y1.8641.00
205_I231_A1.8521.00
225_L315_T1.8401.00
223_Q233_V1.8331.00
4_K35_E1.8161.00
9_G16_L1.8131.00
119_A153_A1.7921.00
236_S268_I1.7851.00
124_V129_V1.7611.00
43_E69_K1.7491.00
35_E58_D1.7471.00
132_T141_F1.7301.00
266_C307_L1.7181.00
213_V222_L1.7061.00
218_G308_F1.7021.00
77_S110_R1.6991.00
262_L285_V1.6911.00
43_E66_P1.6681.00
222_L266_C1.6591.00
208_A265_A1.6571.00
121_D132_T1.6561.00
81_R110_R1.6481.00
81_R107_L1.6441.00
225_L311_V1.6321.00
68_L79_V1.6291.00
263_Y274_H1.6181.00
261_D282_K1.6121.00
37_I89_P1.6071.00
286_A295_I1.5721.00
258_V278_M1.5701.00
200_L206_I1.5531.00
313_L316_E1.5451.00
225_L229_L1.5421.00
37_I58_D1.5331.00
208_A251_I1.5221.00
104_S154_T1.5181.00
199_D202_E1.5181.00
206_I234_G1.5171.00
46_Q50_Q1.5131.00
278_M281_S1.5121.00
44_N64_E1.4881.00
207_V225_L1.4781.00
93_I153_A1.4761.00
246_D249_L1.4421.00
86_Q176_I1.4381.00
72_T75_G1.4351.00
82_G86_Q1.4341.00
81_R85_E1.4041.00
219_F233_V1.3921.00
85_E88_N1.3851.00
116_I146_S1.3831.00
28_R58_D1.3801.00
5_V27_G1.3701.00
123_S132_T1.3531.00
73_A102_D1.3531.00
23_A95_G1.3441.00
223_Q227_E1.3341.00
47_S50_Q1.3331.00
235_A239_A1.3251.00
53_I169_R1.3031.00
61_L174_E1.2981.00
197_G227_E1.2881.00
215_S244_Y1.2761.00
120_I132_T1.2551.00
62_T175_S1.2471.00
80_M107_L1.2421.00
224_E228_V1.2421.00
228_V318_F1.2411.00
76_Y103_L1.2371.00
82_G85_E1.2341.00
4_K37_I1.2251.00
19_V95_G1.2201.00
309_E313_L1.2181.00
124_V128_N1.2121.00
54_H165_K1.2031.00
265_A274_H1.2031.00
63_A79_V1.2011.00
10_E97_T1.1991.00
66_P69_K1.1971.00
65_D68_L1.1941.00
8_L103_L1.1871.00
61_L176_I1.1851.00
213_V307_L1.1851.00
83_V176_I1.1831.00
265_A268_I1.1811.00
70_T190_V1.1750.99
39_V80_M1.1730.99
22_E158_N1.1710.99
129_V151_I1.1620.99
217_E220_Q1.1620.99
51_E54_H1.1590.99
107_L152_F1.1580.99
313_L317_E1.1570.99
90_D150_M1.1510.99
118_D156_R1.1440.99
235_A240_C1.1420.99
28_R36_V1.1420.99
234_G251_I1.1400.99
64_E175_S1.1340.99
303_I310_V1.1330.99
130_V143_R1.1280.99
53_I60_V1.1270.99
135_I140_A1.1220.99
221_P311_V1.1190.99
216_K220_Q1.1190.99
24_I57_A1.1110.99
201_S256_K1.1020.99
236_S251_I1.0940.99
120_I141_F1.0920.99
54_H167_T1.0890.99
41_I79_V1.0790.99
208_A258_V1.0790.99
6_I83_V1.0750.99
209_G239_A1.0660.99
29_T121_D1.0650.99
219_F239_A1.0620.99
7_V24_I1.0610.99
213_V218_G1.0590.99
129_V145_I1.0590.99
11_I48_I1.0560.99
16_L21_F1.0530.99
119_A155_I1.0450.99
54_H168_S1.0440.99
208_A234_G1.0440.99
208_A236_S1.0400.99
8_L80_M1.0290.99
216_K245_C1.0280.99
45_V62_T1.0280.99
41_I76_Y1.0240.99
40_L48_I1.0230.99
296_F304_V1.0180.99
311_V315_T1.0170.99
123_S143_R1.0160.98
9_G52_L1.0150.98
46_Q64_E1.0150.98
49_A53_I1.0110.98
238_G242_A1.0110.98
84_I111_L1.0040.98
226_A233_V1.0020.98
80_M103_L1.0020.98
50_Q54_H1.0010.98
37_I59_K0.9950.98
30_I93_I0.9860.98
227_E230_G0.9840.98
51_E165_K0.9840.98
77_S107_L0.9790.98
209_G213_V0.9780.98
71_Y76_Y0.9750.98
61_L87_E0.9690.98
115_L152_F0.9680.98
77_S106_K0.9670.98
60_V171_G0.9670.98
307_L312_P0.9660.98
305_G309_E0.9610.98
55_Y164_E0.9590.98
240_C250_Q0.9440.98
87_E174_E0.9400.98
111_L152_F0.9370.97
234_G249_L0.9260.97
20_T38_G0.9180.97
251_I265_A0.9150.97
259_T280_N0.9120.97
101_K118_D0.9120.97
212_G244_Y0.9080.97
38_G52_L0.9060.97
58_D169_R0.8980.97
21_F51_E0.8940.97
214_K308_F0.8940.97
81_R111_L0.8930.97
209_G245_C0.8930.97
113_T152_F0.8910.97
78_Q82_G0.8900.97
28_R55_Y0.8850.96
200_L234_G0.8820.96
187_I190_V0.8810.96
157_P257_V0.8800.96
264_I287_I0.8780.96
104_S115_L0.8730.96
116_I119_A0.8720.96
232_A249_L0.8690.96
45_V64_E0.8650.96
119_A122_V0.8650.96
239_A245_C0.8650.96
114_G148_D0.8580.96
34_G90_D0.8540.96
131_F153_A0.8510.96
212_G221_P0.8440.95
115_L154_T0.8390.95
239_A244_Y0.8380.95
48_I51_E0.8350.95
74_D184_R0.8340.95
128_N145_I0.8320.95
41_I68_L0.8280.95
16_L48_I0.8270.95
132_T143_R0.8240.95
219_F222_L0.8220.95
82_G179_S0.8220.95
215_S218_G0.8210.95
221_P315_T0.8210.95
24_I163_S0.8210.95
53_I173_I0.8190.94
78_Q182_D0.8190.94
96_H118_D0.8160.94
287_I310_V0.8150.94
22_E162_A0.8120.94
200_L256_K0.8100.94
219_F245_C0.8070.94
108_A115_L0.8040.94
114_G146_S0.8030.94
224_E233_V0.7990.94
168_S171_G0.7920.93
122_V131_F0.7910.93
10_E17_R0.7870.93
213_V221_P0.7840.93
50_Q53_I0.7820.93
106_K110_R0.7780.93
61_L83_V0.7730.93
86_Q174_E0.7730.93
4_K34_G0.7720.93
42_G45_V0.7680.92
94_F154_T0.7670.92
13_D45_V0.7640.92
222_L233_V0.7610.92
71_Y102_D0.7560.92
221_P266_C0.7560.92
84_I150_M0.7560.92
11_I20_T0.7550.92
6_I39_V0.7530.92
12_R17_R0.7500.91
260_P281_S0.7480.91
181_T184_R0.7450.91
131_F151_I0.7430.91
130_V145_I0.7420.91
213_V216_K0.7410.91
213_V219_F0.7380.91
85_E150_M0.7360.91
129_V153_A0.7350.91
206_I232_A0.7310.90
8_L94_F0.7300.90
51_E55_Y0.7300.90
27_G93_I0.7280.90
46_Q62_T0.7270.90
38_G57_A0.7260.90
96_H100_G0.7250.90
6_I87_E0.7210.90
12_R15_E0.7210.90
70_T187_I0.7190.90
169_R172_S0.7170.90
216_K244_Y0.7170.90
212_G216_K0.7160.89
7_V93_I0.7150.89
49_A173_I0.7120.89
212_G218_G0.7110.89
9_G40_L0.7070.89
49_A60_V0.7070.89
134_P156_R0.7070.89
71_Y103_L0.7070.89
85_E111_L0.7040.89
7_V23_A0.7010.88
39_V83_V0.6930.88
146_S151_I0.6920.88
18_N202_E0.6920.88
76_Y99_M0.6920.88
90_D149_P0.6910.88
241_D250_Q0.6890.88
207_V233_V0.6870.87
73_A106_K0.6860.87
21_F162_A0.6860.87
278_M298_I0.6860.87
213_V308_F0.6840.87
75_G183_L0.6810.87
15_E51_E0.6790.87
24_I38_G0.6780.87
45_V48_I0.6780.87
42_G64_E0.6770.87
119_A131_F0.6740.86
111_L150_M0.6690.86
52_L60_V0.6640.86
100_G103_L0.6620.85
119_A124_V0.6620.85
215_S308_F0.6610.85
87_E176_I0.6580.85
275_L297_K0.6580.85
27_G31_S0.6570.85
209_G235_A0.6570.85
26_A160_I0.6560.85
14_G45_V0.6520.85
104_S107_L0.6510.85
6_I92_V0.6490.84
295_I302_G0.6460.84
28_R31_S0.6460.84
80_M84_I0.6440.84
94_F100_G0.6430.84
229_L264_I0.6430.84
211_R238_G0.6410.84
67_K180_L0.6400.84
216_K223_Q0.6390.83
47_S51_E0.6380.83
213_V244_Y0.6360.83
53_I57_A0.6360.83
264_I285_V0.6330.83
94_F107_L0.6300.83
161_Q164_E0.6260.82
19_V97_T0.6250.82
258_V281_S0.6230.82
21_F55_Y0.6190.81
165_K169_R0.6190.81
236_S265_A0.6170.81
84_I89_P0.6160.81
131_F155_I0.6120.81
207_V311_V0.6110.81
71_Y99_M0.6100.81
55_Y165_K0.6100.81
78_Q180_L0.6080.80
31_S36_V0.6040.80
25_A28_R0.6040.80
8_L92_V0.6030.80
137_S156_R0.6010.80
77_S81_R0.6000.79
99_M103_L0.5990.79
65_D180_L0.5970.79
228_V231_A0.5970.79
205_I230_G0.5960.79
8_L20_T0.5940.79
265_A295_I0.5940.79
219_F235_A0.5890.78
223_Q231_A0.5880.78
236_S275_L0.5880.78
283_V300_D0.5870.78
124_V145_I0.5860.78
225_L228_V0.5840.78
251_I278_M0.5840.78
207_V228_V0.5810.77
233_V249_L0.5810.77
74_D183_L0.5810.77
209_G233_V0.5810.77
54_H169_R0.5770.77
5_V30_I0.5760.77
156_R253_Q0.5740.76
306_D309_E0.5740.76
79_V82_G0.5740.76
40_L60_V0.5730.76
15_E48_I0.5730.76
207_V229_L0.5710.76
49_A171_G0.5690.76
193_K291_P0.5680.76
54_H164_E0.5640.75
198_V232_A0.5610.75
208_A274_H0.5600.75
263_Y268_I0.5580.74
165_K168_S0.5570.74
83_V87_E0.5560.74
8_L76_Y0.5560.74
221_P312_P0.5560.74
8_L38_G0.5530.74
5_V93_I0.5530.74
68_L179_S0.5520.74
92_V150_M0.5500.73
41_I63_A0.5500.73
133_R273_Q0.5500.73
19_V22_E0.5490.73
18_N22_E0.5470.73
275_L278_M0.5460.73
87_E162_A0.5460.73
199_D256_K0.5440.73
82_G180_L0.5440.73
25_A164_E0.5430.72
41_I80_M0.5430.72
310_V313_L0.5420.72
236_S289_K0.5410.72
63_A176_I0.5410.72
205_I229_L0.5410.72
75_G181_T0.5400.72
258_V298_I0.5400.72
106_K109_A0.5400.72
78_Q181_T0.5380.72
101_K117_S0.5370.72
67_K182_D0.5360.71
78_Q110_R0.5350.71
184_R189_E0.5350.71
219_F253_Q0.5340.71
19_V157_P0.5340.71
213_V239_A0.5330.71
112_Q148_D0.5330.71
135_I142_E0.5330.71
237_R250_Q0.5330.71
208_A263_Y0.5320.71
88_N150_M0.5320.71
301_Y308_F0.5310.71
63_A82_G0.5310.71
311_V318_F0.5300.71
222_L251_I0.5290.70
18_N261_D0.5290.70
286_A296_F0.5280.70
108_A152_F0.5270.70
21_F165_K0.5270.70
284_I298_I0.5260.70
78_Q183_L0.5260.70
65_D177_D0.5240.70
218_G224_E0.5230.70
131_F160_I0.5210.69
133_R144_V0.5210.69
213_V311_V0.5200.69
294_D297_K0.5190.69
63_A83_V0.5180.69
114_G142_E0.5170.69
286_A302_G0.5170.69
254_T272_I0.5170.69
116_I131_F0.5170.69
215_S239_A0.5160.69
205_I261_D0.5160.69
208_A278_M0.5140.68
278_M295_I0.5130.68
84_I152_F0.5110.68
119_A144_V0.5110.68
116_I231_A0.5110.68
26_A155_I0.5100.68
37_I41_I0.5100.68
92_V152_F0.5100.68
7_V20_T0.5090.68
82_G177_D0.5090.68
197_G200_L0.5090.68
146_S149_P0.5070.67
75_G78_Q0.5070.67
247_Y251_I0.5070.67
115_L119_A0.5070.67
232_A241_D0.5040.67
37_I87_E0.5040.67
5_V31_S0.5000.66
212_G307_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2iA 1 0.9938 100 0.055 Contact Map
1o97D 1 0.9508 100 0.073 Contact Map
1efvA 1 0.9569 100 0.078 Contact Map
1efpA 1 0.9385 100 0.089 Contact Map
3ih5A 6 0.6031 100 0.639 Contact Map
1efvB 1 0.6615 100 0.731 Contact Map
3fetA 2 0.4985 99.9 0.734 Contact Map
1efpB 1 0.6431 99.9 0.735 Contact Map
1o97C 1 0.6523 99.9 0.739 Contact Map
4l2iB 1 0.6831 99.9 0.744 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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