ETFA - BACSU - GREMLIN Contacts

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ETFA - Electron transfer flavoprotein subunit alpha

UniProt:	P94551	Sequences: MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGENVQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKDLSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNIQASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEGFQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (309)
Sequences:	4011 (2421)
Seq/√Len:	137.7

ECOLI - YDIR FIXB YGCQ
BACSU - ETFA
HALSA - Q9HND2
SULSO - Q97V19 Q97V72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
305_G	310_V	4.906	1.00
296_F	302_G	3.418	1.00
266_C	287_I	3.341	1.00
204_K	261_D	3.174	1.00
208_A	268_I	3.086	1.00
94_F	104_S	3.045	1.00
59_K	174_E	2.710	1.00
37_I	61_L	2.602	1.00
206_I	258_V	2.551	1.00
220_Q	223_Q	2.509	1.00
26_A	29_T	2.508	1.00
266_C	311_V	2.446	1.00
27_G	36_V	2.414	1.00
209_G	219_F	2.407	1.00
53_I	171_G	2.377	1.00
25_A	163_S	2.354	1.00
228_V	315_T	2.338	1.00
84_I	92_V	2.201	1.00
9_G	20_T	2.153	1.00
220_Q	224_E	2.141	1.00
43_E	64_E	2.044	1.00
245_C	249_L	2.034	1.00
46_Q	175_S	2.021	1.00
221_P	224_E	1.992	1.00
59_K	172_S	1.988	1.00
218_G	221_P	1.981	1.00
224_E	315_T	1.968	1.00
235_A	245_C	1.934	1.00
35_E	59_K	1.924	1.00
9_G	38_G	1.894	1.00
23_A	93_I	1.887	1.00
275_L	298_I	1.882	1.00
209_G	222_L	1.876	1.00
286_A	299_A	1.875	1.00
283_V	301_Y	1.864	1.00
205_I	231_A	1.852	1.00
225_L	315_T	1.840	1.00
223_Q	233_V	1.833	1.00
4_K	35_E	1.816	1.00
9_G	16_L	1.813	1.00
119_A	153_A	1.792	1.00
236_S	268_I	1.785	1.00
124_V	129_V	1.761	1.00
43_E	69_K	1.749	1.00
35_E	58_D	1.747	1.00
132_T	141_F	1.730	1.00
266_C	307_L	1.718	1.00
213_V	222_L	1.706	1.00
218_G	308_F	1.702	1.00
77_S	110_R	1.699	1.00
262_L	285_V	1.691	1.00
43_E	66_P	1.668	1.00
222_L	266_C	1.659	1.00
208_A	265_A	1.657	1.00
121_D	132_T	1.656	1.00
81_R	110_R	1.648	1.00
81_R	107_L	1.644	1.00
225_L	311_V	1.632	1.00
68_L	79_V	1.629	1.00
263_Y	274_H	1.618	1.00
261_D	282_K	1.612	1.00
37_I	89_P	1.607	1.00
286_A	295_I	1.572	1.00
258_V	278_M	1.570	1.00
200_L	206_I	1.553	1.00
313_L	316_E	1.545	1.00
225_L	229_L	1.542	1.00
37_I	58_D	1.533	1.00
208_A	251_I	1.522	1.00
104_S	154_T	1.518	1.00
199_D	202_E	1.518	1.00
206_I	234_G	1.517	1.00
46_Q	50_Q	1.513	1.00
278_M	281_S	1.512	1.00
44_N	64_E	1.488	1.00
207_V	225_L	1.478	1.00
93_I	153_A	1.476	1.00
246_D	249_L	1.442	1.00
86_Q	176_I	1.438	1.00
72_T	75_G	1.435	1.00
82_G	86_Q	1.434	1.00
81_R	85_E	1.404	1.00
219_F	233_V	1.392	1.00
85_E	88_N	1.385	1.00
116_I	146_S	1.383	1.00
28_R	58_D	1.380	1.00
5_V	27_G	1.370	1.00
123_S	132_T	1.353	1.00
73_A	102_D	1.353	1.00
23_A	95_G	1.344	1.00
223_Q	227_E	1.334	1.00
47_S	50_Q	1.333	1.00
235_A	239_A	1.325	1.00
53_I	169_R	1.303	1.00
61_L	174_E	1.298	1.00
197_G	227_E	1.288	1.00
215_S	244_Y	1.276	1.00
120_I	132_T	1.255	1.00
62_T	175_S	1.247	1.00
80_M	107_L	1.242	1.00
224_E	228_V	1.242	1.00
228_V	318_F	1.241	1.00
76_Y	103_L	1.237	1.00
82_G	85_E	1.234	1.00
4_K	37_I	1.225	1.00
19_V	95_G	1.220	1.00
309_E	313_L	1.218	1.00
124_V	128_N	1.212	1.00
54_H	165_K	1.203	1.00
265_A	274_H	1.203	1.00
63_A	79_V	1.201	1.00
10_E	97_T	1.199	1.00
66_P	69_K	1.197	1.00
65_D	68_L	1.194	1.00
8_L	103_L	1.187	1.00
61_L	176_I	1.185	1.00
213_V	307_L	1.185	1.00
83_V	176_I	1.183	1.00
265_A	268_I	1.181	1.00
70_T	190_V	1.175	0.99
39_V	80_M	1.173	0.99
22_E	158_N	1.171	0.99
129_V	151_I	1.162	0.99
217_E	220_Q	1.162	0.99
51_E	54_H	1.159	0.99
107_L	152_F	1.158	0.99
313_L	317_E	1.157	0.99
90_D	150_M	1.151	0.99
118_D	156_R	1.144	0.99
235_A	240_C	1.142	0.99
28_R	36_V	1.142	0.99
234_G	251_I	1.140	0.99
64_E	175_S	1.134	0.99
303_I	310_V	1.133	0.99
130_V	143_R	1.128	0.99
53_I	60_V	1.127	0.99
135_I	140_A	1.122	0.99
221_P	311_V	1.119	0.99
216_K	220_Q	1.119	0.99
24_I	57_A	1.111	0.99
201_S	256_K	1.102	0.99
236_S	251_I	1.094	0.99
120_I	141_F	1.092	0.99
54_H	167_T	1.089	0.99
41_I	79_V	1.079	0.99
208_A	258_V	1.079	0.99
6_I	83_V	1.075	0.99
209_G	239_A	1.066	0.99
29_T	121_D	1.065	0.99
219_F	239_A	1.062	0.99
7_V	24_I	1.061	0.99
213_V	218_G	1.059	0.99
129_V	145_I	1.059	0.99
11_I	48_I	1.056	0.99
16_L	21_F	1.053	0.99
119_A	155_I	1.045	0.99
54_H	168_S	1.044	0.99
208_A	234_G	1.044	0.99
208_A	236_S	1.040	0.99
8_L	80_M	1.029	0.99
216_K	245_C	1.028	0.99
45_V	62_T	1.028	0.99
41_I	76_Y	1.024	0.99
40_L	48_I	1.023	0.99
296_F	304_V	1.018	0.99
311_V	315_T	1.017	0.99
123_S	143_R	1.016	0.98
9_G	52_L	1.015	0.98
46_Q	64_E	1.015	0.98
49_A	53_I	1.011	0.98
238_G	242_A	1.011	0.98
84_I	111_L	1.004	0.98
226_A	233_V	1.002	0.98
80_M	103_L	1.002	0.98
50_Q	54_H	1.001	0.98
37_I	59_K	0.995	0.98
30_I	93_I	0.986	0.98
227_E	230_G	0.984	0.98
51_E	165_K	0.984	0.98
77_S	107_L	0.979	0.98
209_G	213_V	0.978	0.98
71_Y	76_Y	0.975	0.98
61_L	87_E	0.969	0.98
115_L	152_F	0.968	0.98
77_S	106_K	0.967	0.98
60_V	171_G	0.967	0.98
307_L	312_P	0.966	0.98
305_G	309_E	0.961	0.98
55_Y	164_E	0.959	0.98
240_C	250_Q	0.944	0.98
87_E	174_E	0.940	0.98
111_L	152_F	0.937	0.97
234_G	249_L	0.926	0.97
20_T	38_G	0.918	0.97
251_I	265_A	0.915	0.97
259_T	280_N	0.912	0.97
101_K	118_D	0.912	0.97
212_G	244_Y	0.908	0.97
38_G	52_L	0.906	0.97
58_D	169_R	0.898	0.97
21_F	51_E	0.894	0.97
214_K	308_F	0.894	0.97
81_R	111_L	0.893	0.97
209_G	245_C	0.893	0.97
113_T	152_F	0.891	0.97
78_Q	82_G	0.890	0.97
28_R	55_Y	0.885	0.96
200_L	234_G	0.882	0.96
187_I	190_V	0.881	0.96
157_P	257_V	0.880	0.96
264_I	287_I	0.878	0.96
104_S	115_L	0.873	0.96
116_I	119_A	0.872	0.96
232_A	249_L	0.869	0.96
45_V	64_E	0.865	0.96
119_A	122_V	0.865	0.96
239_A	245_C	0.865	0.96
114_G	148_D	0.858	0.96
34_G	90_D	0.854	0.96
131_F	153_A	0.851	0.96
212_G	221_P	0.844	0.95
115_L	154_T	0.839	0.95
239_A	244_Y	0.838	0.95
48_I	51_E	0.835	0.95
74_D	184_R	0.834	0.95
128_N	145_I	0.832	0.95
41_I	68_L	0.828	0.95
16_L	48_I	0.827	0.95
132_T	143_R	0.824	0.95
219_F	222_L	0.822	0.95
82_G	179_S	0.822	0.95
215_S	218_G	0.821	0.95
221_P	315_T	0.821	0.95
24_I	163_S	0.821	0.95
53_I	173_I	0.819	0.94
78_Q	182_D	0.819	0.94
96_H	118_D	0.816	0.94
287_I	310_V	0.815	0.94
22_E	162_A	0.812	0.94
200_L	256_K	0.810	0.94
219_F	245_C	0.807	0.94
108_A	115_L	0.804	0.94
114_G	146_S	0.803	0.94
224_E	233_V	0.799	0.94
168_S	171_G	0.792	0.93
122_V	131_F	0.791	0.93
10_E	17_R	0.787	0.93
213_V	221_P	0.784	0.93
50_Q	53_I	0.782	0.93
106_K	110_R	0.778	0.93
61_L	83_V	0.773	0.93
86_Q	174_E	0.773	0.93
4_K	34_G	0.772	0.93
42_G	45_V	0.768	0.92
94_F	154_T	0.767	0.92
13_D	45_V	0.764	0.92
222_L	233_V	0.761	0.92
71_Y	102_D	0.756	0.92
221_P	266_C	0.756	0.92
84_I	150_M	0.756	0.92
11_I	20_T	0.755	0.92
6_I	39_V	0.753	0.92
12_R	17_R	0.750	0.91
260_P	281_S	0.748	0.91
181_T	184_R	0.745	0.91
131_F	151_I	0.743	0.91
130_V	145_I	0.742	0.91
213_V	216_K	0.741	0.91
213_V	219_F	0.738	0.91
85_E	150_M	0.736	0.91
129_V	153_A	0.735	0.91
206_I	232_A	0.731	0.90
8_L	94_F	0.730	0.90
51_E	55_Y	0.730	0.90
27_G	93_I	0.728	0.90
46_Q	62_T	0.727	0.90
38_G	57_A	0.726	0.90
96_H	100_G	0.725	0.90
6_I	87_E	0.721	0.90
12_R	15_E	0.721	0.90
70_T	187_I	0.719	0.90
169_R	172_S	0.717	0.90
216_K	244_Y	0.717	0.90
212_G	216_K	0.716	0.89
7_V	93_I	0.715	0.89
49_A	173_I	0.712	0.89
212_G	218_G	0.711	0.89
9_G	40_L	0.707	0.89
49_A	60_V	0.707	0.89
134_P	156_R	0.707	0.89
71_Y	103_L	0.707	0.89
85_E	111_L	0.704	0.89
7_V	23_A	0.701	0.88
39_V	83_V	0.693	0.88
146_S	151_I	0.692	0.88
18_N	202_E	0.692	0.88
76_Y	99_M	0.692	0.88
90_D	149_P	0.691	0.88
241_D	250_Q	0.689	0.88
207_V	233_V	0.687	0.87
73_A	106_K	0.686	0.87
21_F	162_A	0.686	0.87
278_M	298_I	0.686	0.87
213_V	308_F	0.684	0.87
75_G	183_L	0.681	0.87
15_E	51_E	0.679	0.87
24_I	38_G	0.678	0.87
45_V	48_I	0.678	0.87
42_G	64_E	0.677	0.87
119_A	131_F	0.674	0.86
111_L	150_M	0.669	0.86
52_L	60_V	0.664	0.86
100_G	103_L	0.662	0.85
119_A	124_V	0.662	0.85
215_S	308_F	0.661	0.85
87_E	176_I	0.658	0.85
275_L	297_K	0.658	0.85
27_G	31_S	0.657	0.85
209_G	235_A	0.657	0.85
26_A	160_I	0.656	0.85
14_G	45_V	0.652	0.85
104_S	107_L	0.651	0.85
6_I	92_V	0.649	0.84
295_I	302_G	0.646	0.84
28_R	31_S	0.646	0.84
80_M	84_I	0.644	0.84
94_F	100_G	0.643	0.84
229_L	264_I	0.643	0.84
211_R	238_G	0.641	0.84
67_K	180_L	0.640	0.84
216_K	223_Q	0.639	0.83
47_S	51_E	0.638	0.83
213_V	244_Y	0.636	0.83
53_I	57_A	0.636	0.83
264_I	285_V	0.633	0.83
94_F	107_L	0.630	0.83
161_Q	164_E	0.626	0.82
19_V	97_T	0.625	0.82
258_V	281_S	0.623	0.82
21_F	55_Y	0.619	0.81
165_K	169_R	0.619	0.81
236_S	265_A	0.617	0.81
84_I	89_P	0.616	0.81
131_F	155_I	0.612	0.81
207_V	311_V	0.611	0.81
71_Y	99_M	0.610	0.81
55_Y	165_K	0.610	0.81
78_Q	180_L	0.608	0.80
31_S	36_V	0.604	0.80
25_A	28_R	0.604	0.80
8_L	92_V	0.603	0.80
137_S	156_R	0.601	0.80
77_S	81_R	0.600	0.79
99_M	103_L	0.599	0.79
65_D	180_L	0.597	0.79
228_V	231_A	0.597	0.79
205_I	230_G	0.596	0.79
8_L	20_T	0.594	0.79
265_A	295_I	0.594	0.79
219_F	235_A	0.589	0.78
223_Q	231_A	0.588	0.78
236_S	275_L	0.588	0.78
283_V	300_D	0.587	0.78
124_V	145_I	0.586	0.78
225_L	228_V	0.584	0.78
251_I	278_M	0.584	0.78
207_V	228_V	0.581	0.77
233_V	249_L	0.581	0.77
74_D	183_L	0.581	0.77
209_G	233_V	0.581	0.77
54_H	169_R	0.577	0.77
5_V	30_I	0.576	0.77
156_R	253_Q	0.574	0.76
306_D	309_E	0.574	0.76
79_V	82_G	0.574	0.76
40_L	60_V	0.573	0.76
15_E	48_I	0.573	0.76
207_V	229_L	0.571	0.76
49_A	171_G	0.569	0.76
193_K	291_P	0.568	0.76
54_H	164_E	0.564	0.75
198_V	232_A	0.561	0.75
208_A	274_H	0.560	0.75
263_Y	268_I	0.558	0.74
165_K	168_S	0.557	0.74
83_V	87_E	0.556	0.74
8_L	76_Y	0.556	0.74
221_P	312_P	0.556	0.74
8_L	38_G	0.553	0.74
5_V	93_I	0.553	0.74
68_L	179_S	0.552	0.74
92_V	150_M	0.550	0.73
41_I	63_A	0.550	0.73
133_R	273_Q	0.550	0.73
19_V	22_E	0.549	0.73
18_N	22_E	0.547	0.73
275_L	278_M	0.546	0.73
87_E	162_A	0.546	0.73
199_D	256_K	0.544	0.73
82_G	180_L	0.544	0.73
25_A	164_E	0.543	0.72
41_I	80_M	0.543	0.72
310_V	313_L	0.542	0.72
236_S	289_K	0.541	0.72
63_A	176_I	0.541	0.72
205_I	229_L	0.541	0.72
75_G	181_T	0.540	0.72
258_V	298_I	0.540	0.72
106_K	109_A	0.540	0.72
78_Q	181_T	0.538	0.72
101_K	117_S	0.537	0.72
67_K	182_D	0.536	0.71
78_Q	110_R	0.535	0.71
184_R	189_E	0.535	0.71
219_F	253_Q	0.534	0.71
19_V	157_P	0.534	0.71
213_V	239_A	0.533	0.71
112_Q	148_D	0.533	0.71
135_I	142_E	0.533	0.71
237_R	250_Q	0.533	0.71
208_A	263_Y	0.532	0.71
88_N	150_M	0.532	0.71
301_Y	308_F	0.531	0.71
63_A	82_G	0.531	0.71
311_V	318_F	0.530	0.71
222_L	251_I	0.529	0.70
18_N	261_D	0.529	0.70
286_A	296_F	0.528	0.70
108_A	152_F	0.527	0.70
21_F	165_K	0.527	0.70
284_I	298_I	0.526	0.70
78_Q	183_L	0.526	0.70
65_D	177_D	0.524	0.70
218_G	224_E	0.523	0.70
131_F	160_I	0.521	0.69
133_R	144_V	0.521	0.69
213_V	311_V	0.520	0.69
294_D	297_K	0.519	0.69
63_A	83_V	0.518	0.69
114_G	142_E	0.517	0.69
286_A	302_G	0.517	0.69
254_T	272_I	0.517	0.69
116_I	131_F	0.517	0.69
215_S	239_A	0.516	0.69
205_I	261_D	0.516	0.69
208_A	278_M	0.514	0.68
278_M	295_I	0.513	0.68
84_I	152_F	0.511	0.68
119_A	144_V	0.511	0.68
116_I	231_A	0.511	0.68
26_A	155_I	0.510	0.68
37_I	41_I	0.510	0.68
92_V	152_F	0.510	0.68
7_V	20_T	0.509	0.68
82_G	177_D	0.509	0.68
197_G	200_L	0.509	0.68
146_S	149_P	0.507	0.67
75_G	78_Q	0.507	0.67
247_Y	251_I	0.507	0.67
115_L	119_A	0.507	0.67
232_A	241_D	0.504	0.67
37_I	87_E	0.504	0.67
5_V	31_S	0.500	0.66
212_G	307_L	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l2iA	1	0.9938	100	0.055	Contact Map
1o97D	1	0.9508	100	0.073	Contact Map
1efvA	1	0.9569	100	0.078	Contact Map
1efpA	1	0.9385	100	0.089	Contact Map
3ih5A	6	0.6031	100	0.639	Contact Map
1efvB	1	0.6615	100	0.731	Contact Map
3fetA	2	0.4985	99.9	0.734	Contact Map
1efpB	1	0.6431	99.9	0.735	Contact Map
1o97C	1	0.6523	99.9	0.739	Contact Map
4l2iB	1	0.6831	99.9	0.744	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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