GREMLIN Database
ETFB - Electron transfer flavoprotein subunit beta
UniProt: P94550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (242)
Sequences: 3516 (2000)
Seq/√Len: 128.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_D167_K4.1221.00
54_T79_Q3.6641.00
128_A175_T3.3491.00
103_H106_K3.2411.00
48_K78_D3.1561.00
69_L80_A3.0741.00
145_K156_E2.9091.00
203_E206_D2.8911.00
107_D202_L2.8881.00
57_A72_A2.6311.00
43_E46_Q2.6161.00
79_Q200_E2.5421.00
73_L80_A2.3531.00
140_I168_T2.3271.00
2_N54_T2.3161.00
115_G131_L2.2861.00
248_S252_S2.2831.00
43_E181_N2.2251.00
143_I155_A2.1141.00
49_E184_R2.0991.00
4_F105_M2.0771.00
42_E184_R2.0641.00
33_I68_E2.0251.00
143_I174_V1.9971.00
154_E167_K1.9771.00
168_T172_L1.9531.00
153_A168_T1.9251.00
41_I77_C1.9171.00
157_R164_E1.8901.00
56_T81_V1.8891.00
102_Y106_K1.8771.00
6_L115_G1.8491.00
147_E154_E1.7751.00
34_N37_D1.7651.00
66_E70_R1.7611.00
113_I137_I1.7321.00
233_K249_L1.7271.00
83_I100_V1.6991.00
118_V123_G1.6841.00
98_S134_L1.6831.00
235_L242_Q1.6791.00
112_L172_L1.6791.00
56_T79_Q1.6761.00
153_A170_L1.6441.00
59_T65_A1.6301.00
242_Q245_E1.6291.00
156_E165_K1.6101.00
4_F110_F1.6061.00
148_I153_A1.6051.00
107_D200_E1.5921.00
57_A77_C1.5831.00
176_A180_L1.5801.00
63_E84_N1.5761.00
55_I77_C1.5741.00
245_E248_S1.5551.00
92_P100_V1.5491.00
105_M113_I1.5381.00
236_Q242_Q1.5251.00
83_I104_Y1.5061.00
58_V104_Y1.4891.00
233_K245_E1.4611.00
187_S190_G1.4521.00
132_A139_C1.4411.00
81_V104_Y1.4171.00
18_V21_T1.4131.00
3_L52_G1.4091.00
84_N201_E1.4071.00
50_K147_E1.3961.00
62_G65_A1.3941.00
47_L51_H1.3471.00
56_T110_F1.2791.00
236_Q245_E1.2781.00
154_E165_K1.2731.00
66_E201_E1.2691.00
2_N56_T1.2671.00
82_L201_E1.2521.00
152_D169_T1.2431.00
44_A55_I1.2331.00
137_I173_L1.2321.00
149_N154_E1.2221.00
244_K247_V1.2180.99
151_T169_T1.2170.99
144_T156_E1.2080.99
101_L131_L1.1950.99
107_D207_L1.1720.99
73_L197_K1.1710.99
43_E180_L1.1650.99
119_A122_G1.1610.99
99_Q103_H1.1510.99
41_I75_M1.1450.99
43_E146_L1.1440.99
59_T82_L1.1400.99
39_Y181_N1.1360.99
2_N109_E1.1230.99
57_A69_L1.1120.99
111_D151_T1.1030.99
148_I170_L1.1020.99
99_Q134_L1.0990.99
156_E163_V1.0970.99
189_P193_K1.0930.99
45_I190_G1.0910.99
81_V202_L1.0850.99
84_N203_E1.0840.99
105_M131_L1.0570.99
4_F58_V1.0560.99
96_S216_P1.0520.98
102_Y135_L1.0490.98
33_I72_A1.0430.98
202_L207_L1.0410.98
140_I155_A1.0330.98
36_Y117_N1.0230.98
42_E183_P1.0110.98
149_N152_D1.0110.98
42_E46_Q1.0090.98
7_M41_I1.0070.98
243_A247_V1.0060.98
45_I75_M1.0010.98
7_M72_A0.9950.98
146_L155_A0.9930.98
9_R68_E0.9870.98
191_I197_K0.9840.98
129_P139_C0.9830.98
60_V89_L0.9820.98
138_P172_L0.9760.98
114_L174_V0.9730.97
204_L209_L0.9690.97
45_I49_E0.9580.97
38_E75_M0.9560.97
249_L252_S0.9480.97
100_V207_L0.9420.97
63_E66_E0.9410.97
113_I131_L0.9390.97
130_R134_L0.9340.97
249_L253_E0.9330.97
39_Y179_G0.9300.97
43_E145_K0.9260.97
95_Y99_Q0.9230.97
189_P192_M0.9220.97
7_M68_E0.9160.96
114_L176_A0.9090.96
103_H207_L0.9070.96
102_Y131_L0.9060.96
205_D208_D0.9050.96
192_M195_K0.9050.96
125_G129_P0.9030.96
75_M183_P0.8910.96
159_V162_D0.8910.96
26_D62_G0.8890.96
79_Q108_Q0.8880.96
60_V97_I0.8850.96
210_D215_E0.8770.95
98_S130_R0.8740.95
6_L131_L0.8720.95
38_E71_T0.8710.95
225_L228_K0.8640.95
100_V204_L0.8640.95
210_D216_P0.8580.95
52_G55_I0.8560.95
48_K53_G0.8550.95
25_Q28_G0.8540.95
140_I166_I0.8520.95
66_E82_L0.8510.95
81_V200_E0.8500.95
106_K109_E0.8480.94
40_A176_A0.8400.94
146_L153_A0.8390.94
119_A123_G0.8380.94
104_Y202_L0.8360.94
5_V55_I0.8290.94
65_A82_L0.8280.94
110_F137_I0.8280.94
115_G173_L0.8260.94
13_T32_I0.8260.94
105_M135_L0.8200.93
229_K232_G0.8170.93
117_N123_G0.8160.93
43_E50_K0.8150.93
117_N178_Q0.8130.93
185_Y191_I0.8120.93
62_G82_L0.8120.93
93_D217_K0.8090.93
202_L206_D0.8060.93
7_M57_A0.8020.93
71_T75_M0.8010.93
80_A199_L0.7970.92
70_R195_K0.7960.92
129_P141_T0.7940.92
94_Q130_R0.7880.92
66_E199_L0.7860.92
233_K253_E0.7840.92
103_H107_D0.7780.92
133_E139_C0.7740.91
158_D179_G0.7730.91
6_L101_L0.7720.91
40_A114_L0.7680.91
6_L105_M0.7680.91
60_V83_I0.7620.91
147_E156_E0.7610.91
75_M186_P0.7560.90
11_F26_D0.7500.90
92_P96_S0.7470.90
105_M110_F0.7460.90
33_I71_T0.7460.90
39_Y177_Q0.7440.90
139_C173_L0.7420.89
32_I120_I0.7420.89
46_Q184_R0.7410.89
18_V25_Q0.7360.89
149_N167_K0.7360.89
245_E249_L0.7350.89
192_M196_K0.7330.89
157_R166_I0.7300.89
49_E53_G0.7280.89
41_I57_A0.7260.88
96_S215_E0.7220.88
220_T223_R0.7190.88
235_L245_E0.7180.88
36_Y39_Y0.7170.88
193_K197_K0.7150.88
153_A174_V0.7140.88
33_I38_E0.7130.88
44_A114_L0.7080.87
103_H208_D0.7040.87
105_M108_Q0.7030.87
97_I122_G0.7030.87
4_F108_Q0.6990.87
131_L173_L0.6990.87
124_S218_L0.6930.86
117_N177_Q0.6930.86
46_Q49_E0.6930.86
83_I207_L0.6890.86
58_V101_L0.6870.86
62_G91_E0.6820.85
204_L214_A0.6800.85
9_R31_W0.6800.85
106_K136_D0.6800.85
112_L153_A0.6790.85
93_D96_S0.6740.84
23_K220_T0.6720.84
219_K222_E0.6710.84
60_V92_P0.6670.84
84_N89_L0.6650.84
216_P220_T0.6650.84
25_Q29_A0.6620.83
114_L146_L0.6610.83
93_D216_P0.6600.83
194_A197_K0.6590.83
34_N120_I0.6580.83
146_L174_V0.6540.83
31_W64_E0.6530.83
119_A124_S0.6520.82
159_V164_E0.6520.82
89_L100_V0.6510.82
140_I153_A0.6510.82
95_Y134_L0.6500.82
12_D32_I0.6490.82
5_V40_A0.6480.82
120_I123_G0.6480.82
89_L92_P0.6460.82
23_K26_D0.6450.82
129_P175_T0.6430.82
42_E49_E0.6430.82
13_T17_I0.6390.81
5_V44_A0.6390.81
145_K165_K0.6380.81
105_M137_I0.6350.81
249_L254_A0.6350.81
155_A172_L0.6330.81
37_D122_G0.6330.81
112_L174_V0.6320.81
22_G26_D0.6300.80
64_E67_K0.6300.80
117_N142_T0.6290.80
37_D124_S0.6280.80
244_K248_S0.6260.80
94_Q126_Q0.6240.80
74_A190_G0.6220.79
69_L199_L0.6220.79
41_I176_A0.6180.79
142_T177_Q0.6170.79
115_G128_A0.6170.79
8_K59_T0.6150.79
41_I45_I0.6150.79
110_F113_I0.6140.79
138_P168_T0.6100.78
104_Y108_Q0.6060.78
36_Y123_G0.6060.78
60_V101_L0.6020.77
3_L55_I0.6000.77
227_P231_A0.5940.76
158_D177_Q0.5930.76
59_T69_L0.5920.76
94_Q122_G0.5900.76
132_A173_L0.5890.76
95_Y128_A0.5890.76
112_L170_L0.5880.76
143_I146_L0.5880.76
37_D68_E0.5870.75
74_A194_A0.5850.75
144_T158_D0.5820.75
62_G89_L0.5800.75
69_L82_L0.5790.74
92_P97_I0.5780.74
107_D206_D0.5770.74
100_V104_Y0.5770.74
11_F29_A0.5760.74
12_D30_E0.5720.74
72_A77_C0.5680.73
60_V93_D0.5650.73
47_L112_L0.5640.73
118_V125_G0.5630.72
118_V226_P0.5610.72
26_D91_E0.5610.72
168_T174_V0.5600.72
210_D217_K0.5590.72
98_S131_L0.5580.72
106_K135_L0.5560.71
92_P216_P0.5550.71
39_Y178_Q0.5530.71
9_R64_E0.5500.71
99_Q209_L0.5500.71
188_L195_K0.5500.71
70_R198_P0.5480.70
39_Y158_D0.5460.70
126_Q130_R0.5440.70
3_L6_L0.5440.70
33_I41_I0.5410.69
105_M173_L0.5310.68
47_L114_L0.5300.68
95_Y217_K0.5290.68
13_T35_P0.5270.67
227_P230_E0.5260.67
155_A165_K0.5260.67
21_T25_Q0.5260.67
102_Y134_L0.5250.67
204_L208_D0.5250.67
94_Q124_S0.5240.67
117_N179_G0.5240.67
198_P248_S0.5230.67
2_N110_F0.5220.67
20_E23_K0.5210.67
70_R199_L0.5200.66
45_I55_I0.5190.66
53_G111_D0.5180.66
124_S216_P0.5180.66
197_K200_E0.5170.66
73_L199_L0.5170.66
61_G72_A0.5110.65
11_F15_E0.5080.65
3_L114_L0.5080.65
248_S254_A0.5070.64
97_I124_S0.5060.64
123_G139_C0.5050.64
79_Q197_K0.5040.64
47_L52_G0.5030.64
142_T157_R0.5030.64
56_T108_Q0.5020.64
231_A234_L0.5010.64
125_G142_T0.5010.64
147_E165_K0.5010.64
226_P246_L0.5000.63
1_M254_A0.5000.63
40_A116_G0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o97C 1 0.9377 100 0.188 Contact Map
4l2iB 1 0.9922 100 0.19 Contact Map
1efpB 1 0.9377 100 0.223 Contact Map
1efvB 1 0.965 100 0.246 Contact Map
3ih5A 6 0.7704 100 0.614 Contact Map
4l2iA 1 0.8911 100 0.627 Contact Map
1o97D 1 0.8327 100 0.633 Contact Map
1efvA 1 0.8288 99.9 0.669 Contact Map
1efpA 1 0.8093 99.9 0.676 Contact Map
3fetA 2 0.6342 99.9 0.69 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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