GREMLIN Database
FADB - Probable enoyl-CoA hydratase
UniProt: P94549 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (245)
Sequences: 30278 (20054)
Seq/√Len: 1281.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_E181_K3.1741.00
126_K164_P3.1691.00
178_I189_K3.0591.00
121_A176_V2.9081.00
99_A116_C2.7641.00
189_K192_A2.7561.00
14_V191_K2.6331.00
41_E94_P2.4811.00
38_D89_R2.4411.00
163_E196_K2.3171.00
22_A56_R2.2771.00
5_S18_H2.2481.00
169_E172_D2.2041.00
8_V13_A2.1831.00
124_D182_D2.1801.00
219_S222_G2.1571.00
166_S169_E2.1391.00
157_E163_E2.1141.00
154_K173_L2.0411.00
123_E168_K2.0251.00
14_V52_H2.0201.00
8_V43_D2.0031.00
133_N200_K1.9941.00
159_I208_L1.9901.00
22_A57_F1.9751.00
11_F47_R1.9031.00
6_L13_A1.8851.00
242_E251_R1.8751.00
34_S89_R1.8731.00
106_L128_G1.8721.00
100_A190_A1.8691.00
16_T54_E1.8471.00
120_I180_A1.8371.00
28_R32_E1.8361.00
18_H54_E1.8331.00
100_A187_I1.8091.00
245_Q249_E1.7811.00
16_T52_H1.7571.00
156_L213_Y1.7451.00
185_E188_E1.7311.00
13_A40_C1.7231.00
157_E177_S1.7021.00
117_H209_L1.6681.00
49_I93_F1.6451.00
169_E173_L1.6321.00
123_E182_D1.6231.00
152_T156_L1.6091.00
191_K195_A1.5951.00
13_A46_V1.5811.00
180_A189_K1.5691.00
39_Q43_D1.5621.00
168_K172_D1.5541.00
120_I193_L1.5491.00
31_E82_R1.5451.00
121_A127_L1.5041.00
157_E178_I1.4981.00
41_E89_R1.4941.00
40_C49_I1.4931.00
185_E189_K1.4711.00
119_R153_A1.4421.00
113_A119_R1.4401.00
6_L40_C1.4311.00
156_L160_G1.4241.00
122_A182_D1.4221.00
119_R149_Y1.4211.00
15_L36_C1.4141.00
171_L179_G1.4111.00
9_D191_K1.4051.00
88_E221_E1.3951.00
156_L212_L1.3911.00
88_E92_S1.3861.00
101_I113_A1.3791.00
52_H102_H1.3641.00
10_Q195_A1.3541.00
102_H124_D1.3541.00
5_S54_E1.3451.00
102_H122_A1.3391.00
91_E145_R1.3361.00
101_I105_A1.3341.00
37_L93_F1.3301.00
163_E169_E1.3151.00
90_I97_I1.3111.00
34_S38_D1.3081.00
110_L129_L1.3081.00
186_V190_A1.3031.00
158_L165_I1.2981.00
154_K157_E1.2971.00
9_D14_V1.2851.00
9_D195_A1.2791.00
56_R102_H1.2701.00
48_S194_A1.2631.00
26_S29_I1.2491.00
27_S66_E1.2391.00
128_G164_P1.2361.00
34_S85_Q1.2231.00
132_L162_G1.2101.00
187_I190_A1.2071.00
41_E93_F1.2061.00
187_I191_K1.2041.00
210_E214_S1.1991.00
153_A177_S1.1961.00
104_A126_K1.1911.00
14_V187_I1.1891.00
218_Y222_G1.1861.00
200_K205_L1.1791.00
207_S233_E1.1761.00
17_I29_I1.1741.00
52_H187_I1.1691.00
240_A244_I1.1661.00
154_K169_E1.1631.00
32_E36_C1.1591.00
57_F104_A1.1591.00
8_V45_G1.1561.00
167_G179_G1.1161.00
7_A16_T1.1121.00
165_I173_L1.0991.00
17_I59_S1.0941.00
122_A186_V1.0941.00
214_S226_L1.0781.00
92_S221_E1.0731.00
151_G154_K1.0701.00
59_S109_G1.0661.00
8_V39_Q1.0561.00
181_K185_E1.0461.00
188_E192_A1.0391.00
27_S31_E1.0361.00
7_A14_V1.0311.00
83_G140_F1.0241.00
35_S39_Q1.0141.00
32_E35_S1.0101.00
218_Y226_L1.0071.00
49_I95_K1.0061.00
5_S16_T1.0011.00
97_I116_C1.0011.00
118_I193_L1.0001.00
19_N63_D0.9981.00
111_E142_G0.9901.00
194_A198_A0.9741.00
150_V154_K0.9701.00
123_E179_G0.9541.00
203_Q239_D0.9511.00
52_H100_A0.9451.00
36_C39_Q0.9431.00
171_L176_V0.9311.00
55_G102_H0.9291.00
50_I190_A0.9281.00
46_V95_K0.9271.00
149_Y153_A0.9251.00
49_I97_I0.9231.00
168_K171_L0.9191.00
143_T227_E0.9191.00
110_L127_L0.9091.00
210_E230_R0.9021.00
132_L208_L0.8951.00
14_V50_I0.8951.00
222_G225_K0.8921.00
241_K245_Q0.8911.00
126_K166_S0.8901.00
94_P206_A0.8821.00
22_A60_A0.8751.00
101_I127_L0.8751.00
100_A186_V0.8731.00
30_L86_L0.8701.00
12_V48_S0.8691.00
144_Q223_S0.8681.00
44_A95_K0.8491.00
202_P206_A0.8471.00
101_I119_R0.8451.00
226_L229_K0.8411.00
137_I234_A0.8361.00
118_I177_S0.8361.00
190_A194_A0.8301.00
152_T216_K0.8291.00
102_H186_V0.8271.00
8_V46_V0.8231.00
65_K248_L0.8201.00
122_A184_A0.8171.00
191_K194_A0.8141.00
188_E191_K0.8131.00
34_S82_R0.8111.00
106_L164_P0.8041.00
159_I212_L0.7981.00
15_L49_I0.7951.00
37_L90_I0.7911.00
158_L173_L0.7901.00
178_I193_L0.7901.00
38_D85_Q0.7881.00
189_K193_L0.7871.00
211_L230_R0.7851.00
207_S230_R0.7811.00
111_E131_E0.7811.00
150_V158_L0.7721.00
19_N26_S0.7711.00
146_L150_V0.7711.00
171_L178_I0.7681.00
197_F205_L0.7661.00
192_A196_K0.7661.00
157_E161_S0.7621.00
38_D42_T0.7621.00
120_I178_I0.7591.00
31_E35_S0.7591.00
27_S82_R0.7591.00
41_E95_K0.7581.00
71_K74_E0.7551.00
196_K200_K0.7501.00
19_N24_A0.7471.00
51_I116_C0.7461.00
94_P210_E0.7391.00
107_G130_P0.7361.00
170_A175_L0.7351.00
40_C46_V0.7341.00
25_L29_I0.7341.00
26_S66_E0.7341.00
133_N164_P0.7321.00
167_G176_V0.7311.00
230_R233_E0.7291.00
87_M115_A0.7281.00
192_A195_A0.7271.00
93_F97_I0.7261.00
34_S86_L0.7251.00
151_G155_A0.7231.00
207_S210_E0.7191.00
6_L36_C0.7191.00
238_E241_K0.7181.00
57_F102_H0.7181.00
201_S239_D0.7171.00
207_S234_A0.7161.00
226_L230_R0.7161.00
114_M175_L0.7131.00
81_E85_Q0.7121.00
124_D167_G0.7101.00
220_Y224_L0.7071.00
144_Q147_P0.7041.00
244_I248_L0.6931.00
180_A186_V0.6901.00
181_K184_A0.6871.00
176_V179_G0.6871.00
131_E139_G0.6851.00
101_I125_A0.6831.00
202_P205_L0.6811.00
225_K229_K0.6801.00
22_A104_A0.6781.00
47_R202_P0.6731.00
228_A232_G0.6731.00
81_E228_A0.6711.00
195_A199_E0.6681.00
6_L39_Q0.6661.00
152_T213_Y0.6651.00
127_L176_V0.6631.00
137_I211_L0.6561.00
12_V50_I0.6541.00
50_I191_K0.6541.00
43_D46_V0.6521.00
51_I97_I0.6521.00
11_F45_G0.6511.00
106_L130_P0.6501.00
161_S193_L0.6471.00
29_I32_E0.6441.00
120_I190_A0.6441.00
102_H182_D0.6391.00
131_E138_P0.6381.00
128_G162_G0.6381.00
50_I100_A0.6381.00
36_C40_C0.6371.00
203_Q237_S0.6351.00
40_C95_K0.6341.00
28_R31_E0.6321.00
221_E225_K0.6321.00
68_T245_Q0.6321.00
77_S81_E0.6311.00
138_P208_L0.6311.00
229_K233_E0.6301.00
120_I186_V0.6291.00
93_F96_P0.6271.00
193_L196_K0.6221.00
8_V11_F0.6211.00
154_K171_L0.6211.00
121_A125_A0.6191.00
48_S98_I0.6141.00
214_S218_Y0.6121.00
43_D95_K0.6081.00
111_E139_G0.6071.00
168_K179_G0.6061.00
131_E231_F0.6041.00
35_S38_D0.6021.00
12_V191_K0.5991.00
152_T212_L0.5981.00
48_S198_A0.5961.00
38_D41_E0.5951.00
211_L226_L0.5921.00
243_G246_A0.5911.00
99_A119_R0.5901.00
120_I189_K0.5871.00
143_T223_S0.5861.00
242_E249_E0.5861.00
85_Q88_E0.5861.00
33_L86_L0.5831.00
242_E246_A0.5821.00
104_A164_P0.5801.00
98_I194_A0.5781.00
62_A67_F0.5771.00
144_Q148_R0.5741.00
160_G205_L0.5731.00
239_D243_G0.5731.00
208_L211_L0.5681.00
242_E245_Q0.5681.00
47_R198_A0.5661.00
129_L142_G0.5651.00
245_Q248_L0.5641.00
157_E169_E0.5641.00
113_A116_C0.5641.00
167_G171_L0.5641.00
6_L15_L0.5631.00
165_I170_A0.5631.00
136_I240_A0.5601.00
129_L159_I0.5591.00
149_Y177_S0.5581.00
37_L89_R0.5581.00
166_S172_D0.5541.00
238_E242_E0.5531.00
203_Q234_A0.5501.00
150_V155_A0.5491.00
77_S229_K0.5491.00
102_H125_A0.5491.00
111_E129_L0.5481.00
15_L51_I0.5471.00
15_L37_L0.5471.00
161_S196_K0.5471.00
161_S197_F0.5411.00
111_E141_A0.5401.00
110_L175_L0.5391.00
115_A145_R0.5381.00
30_L34_S0.5371.00
150_V173_L0.5371.00
135_G201_S0.5351.00
28_R66_E0.5351.00
12_V194_A0.5351.00
196_K199_E0.5311.00
154_K172_D0.5311.00
122_A125_A0.5301.00
64_I134_L0.5291.00
37_L97_I0.5281.00
77_S232_G0.5271.00
107_G129_L0.5271.00
118_I197_F0.5261.00
170_A176_V0.5261.00
137_I208_L0.5251.00
132_L200_K0.5241.00
182_D185_E0.5241.00
129_L146_L0.5221.00
163_E178_I0.5221.00
78_L82_R0.5201.00
91_E220_Y0.5191.00
85_Q89_R0.5181.00
24_A60_A0.5181.00
185_E192_A0.5181.00
99_A113_A0.5161.00
82_R85_Q0.5161.00
156_L209_L0.5131.00
108_G140_F0.5121.00
100_A194_A0.5121.00
110_L114_M0.5111.00
25_L108_G0.5091.00
46_V49_I0.5071.00
157_E193_L0.5051.00
147_P150_V0.5041.00
147_P215_N0.5011.00
218_Y223_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3peaA 3 0.9922 100 0.092 Contact Map
4lk5A 3 0.9574 100 0.095 Contact Map
3kqfA 3 0.9922 100 0.096 Contact Map
3tlfA 5 0.9922 100 0.099 Contact Map
4mi2A 3 0.9922 100 0.099 Contact Map
2ej5A 3 0.9651 100 0.099 Contact Map
3g64A 6 0.9961 100 0.1 Contact Map
4jfcA 3 0.9845 100 0.1 Contact Map
3sllA 6 0.9806 100 0.1 Contact Map
2fbmA 3 0.9496 100 0.101 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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