GREMLIN Database
FADR - Fatty acid metabolism regulator protein
UniProt: P94548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (181)
Sequences: 42155 (33096)
Seq/√Len: 2460.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_S40_D3.9741.00
22_N31_K3.9361.00
17_E35_Q3.5871.00
48_K52_D2.7251.00
19_I27_S2.4121.00
49_N52_D2.2611.00
33_A43_I2.1461.00
131_D150_R2.1241.00
18_V31_K2.0451.00
18_V27_S2.0161.00
18_V35_Q2.0131.00
82_K136_E1.9811.00
21_E35_Q1.9771.00
9_M60_E1.9761.00
7_K10_Q1.9571.00
14_A35_Q1.9301.00
131_D135_T1.9201.00
78_T81_E1.8811.00
8_Y56_S1.8761.00
30_S34_K1.8591.00
10_Q14_A1.8541.00
18_V22_N1.8501.00
135_T149_V1.7241.00
135_T139_Q1.7011.00
14_A17_E1.7001.00
39_A42_T1.6521.00
16_V60_E1.6191.00
9_M13_D1.6181.00
135_T138_I1.5901.00
12_I56_S1.5901.00
29_V44_Y1.5521.00
56_S59_K1.5131.00
16_V61_K1.4831.00
17_E21_E1.4761.00
138_I145_E1.4761.00
15_A19_I1.4751.00
29_V40_D1.4701.00
28_Q31_K1.4641.00
31_K35_Q1.4461.00
31_K34_K1.4431.00
151_L182_S1.4311.00
60_E64_Q1.4121.00
70_E129_I1.3991.00
155_M159_T1.3811.00
27_S32_I1.3751.00
16_V57_L1.3711.00
55_I59_K1.3651.00
84_A181_N1.3581.00
23_G27_S1.3531.00
47_F56_S1.3481.00
6_P10_Q1.3311.00
59_K118_K1.3311.00
137_G143_I1.3301.00
15_A53_I1.3301.00
136_E140_S1.3141.00
42_T45_L1.3131.00
29_V43_I1.2981.00
8_Y46_Y1.2961.00
138_I147_L1.2881.00
22_N26_Q1.2751.00
13_D60_E1.2701.00
80_K84_A1.2501.00
14_A18_V1.2471.00
88_S180_S1.2241.00
84_A88_S1.2041.00
23_G26_Q1.2041.00
137_G142_E1.1971.00
68_R89_K1.1881.00
38_V42_T1.1791.00
148_D151_L1.1721.00
81_E85_L1.1721.00
127_L154_Q1.1681.00
55_I118_K1.1481.00
88_S177_V1.1421.00
39_A45_L1.1331.00
175_D178_A1.1291.00
82_K133_I1.1211.00
52_D56_S1.1131.00
51_E55_I1.0961.00
127_L131_D1.0951.00
40_D44_Y1.0921.00
85_L88_S1.0901.00
19_I24_Y1.0881.00
88_S181_N1.0881.00
41_G45_L1.0791.00
44_Y49_N1.0731.00
14_A36_A1.0701.00
138_I149_V1.0681.00
12_I57_L1.0571.00
24_Y54_L1.0471.00
32_I53_I1.0461.00
144_K147_L1.0421.00
12_I47_F1.0291.00
129_I132_G1.0251.00
16_V20_A1.0251.00
66_I125_G1.0181.00
78_T142_E1.0171.00
6_P9_M1.0151.00
133_I137_G1.0121.00
43_I53_I1.0091.00
13_D17_E1.0071.00
118_K121_E1.0041.00
77_A85_L1.0031.00
42_T46_Y1.0011.00
59_K63_G0.9971.00
7_K46_Y0.9891.00
52_D55_I0.9821.00
84_A184_L0.9781.00
15_A57_L0.9761.00
22_N35_Q0.9751.00
124_K128_N0.9741.00
51_E112_N0.9671.00
68_R71_E0.9641.00
76_K82_K0.9631.00
5_R9_M0.9501.00
131_D149_V0.9501.00
158_G162_E0.9471.00
151_L178_A0.9451.00
72_D89_K0.9351.00
132_G136_E0.9321.00
79_A140_S0.9281.00
93_L97_D0.9261.00
51_E114_E0.9251.00
81_E84_A0.9221.00
56_S60_E0.9221.00
101_A104_T0.9191.00
178_A182_S0.9121.00
72_D85_L0.9091.00
181_N185_E0.8991.00
85_L89_K0.8941.00
7_K38_V0.8901.00
33_A40_D0.8891.00
132_G135_T0.8861.00
84_A185_E0.8851.00
88_S92_S0.8811.00
133_I136_E0.8801.00
128_N132_G0.8681.00
138_I141_G0.8661.00
121_E125_G0.8641.00
150_R154_Q0.8631.00
138_I143_I0.8571.00
89_K92_S0.8561.00
18_V21_E0.8541.00
60_E63_G0.8531.00
61_K64_Q0.8511.00
79_A137_G0.8481.00
17_E99_N0.8471.00
147_L152_A0.8471.00
34_K40_D0.8421.00
127_L150_R0.8261.00
11_I43_I0.8251.00
40_D45_L0.8181.00
182_S185_E0.8141.00
66_I70_E0.8081.00
136_E139_Q0.8031.00
117_Q121_E0.7921.00
77_A81_E0.7911.00
67_E71_E0.7891.00
131_D153_R0.7851.00
63_G67_E0.7801.00
116_R120_N0.7781.00
10_Q36_A0.7741.00
177_V181_N0.7741.00
10_Q13_D0.7641.00
104_T107_E0.7531.00
100_L103_V0.7521.00
87_I156_I0.7511.00
70_E74_K0.7501.00
118_K122_I0.7501.00
113_L117_Q0.7431.00
102_I105_Q0.7411.00
120_N124_K0.7361.00
167_W170_N0.7291.00
66_I129_I0.7281.00
111_S114_E0.7281.00
76_K81_E0.7161.00
22_N27_S0.7141.00
64_Q67_E0.7071.00
12_I60_E0.7021.00
125_G129_I0.7021.00
134_L149_V0.6981.00
11_I36_A0.6891.00
180_S184_L0.6871.00
151_L155_M0.6791.00
182_S186_L0.6781.00
75_E85_L0.6751.00
128_N131_D0.6741.00
95_A176_L0.6581.00
134_L138_I0.6561.00
12_I16_V0.6561.00
30_S44_Y0.6551.00
158_G161_D0.6541.00
180_S183_V0.6471.00
19_I54_L0.6471.00
138_I144_K0.6441.00
29_V33_A0.6431.00
125_G128_N0.6431.00
102_I106_L0.6411.00
88_S184_L0.6411.00
84_A87_I0.6401.00
71_E89_K0.6381.00
151_L154_Q0.6371.00
76_K85_L0.6361.00
92_S177_V0.6351.00
176_L180_S0.6341.00
24_Y50_K0.6301.00
59_K121_E0.6291.00
13_D16_V0.6281.00
21_E31_K0.6271.00
24_Y51_E0.6241.00
36_A39_A0.6241.00
92_S180_S0.6181.00
179_L183_V0.6161.00
134_L156_I0.6141.00
155_M158_G0.6101.00
25_H107_E0.6041.00
7_K42_T0.6031.00
106_L110_Q0.6031.00
177_V180_S0.6031.00
149_V153_R0.6011.00
113_L116_R0.5981.00
79_A142_E0.5911.00
40_D43_I0.5881.00
78_T82_K0.5781.00
107_E110_Q0.5781.00
67_E70_E0.5771.00
92_S96_G0.5741.00
90_H94_L0.5741.00
11_I46_Y0.5711.00
117_Q120_N0.5701.00
25_H110_Q0.5701.00
80_K142_E0.5691.00
29_V50_K0.5661.00
87_I90_H0.5621.00
174_Y177_V0.5611.00
101_A105_Q0.5551.00
174_Y178_A0.5541.00
38_V46_Y0.5511.00
134_L152_A0.5451.00
59_K122_I0.5451.00
158_G166_T0.5431.00
148_D182_S0.5401.00
120_N123_L0.5391.00
71_E75_E0.5391.00
24_Y27_S0.5381.00
137_G141_G0.5361.00
7_K39_A0.5351.00
15_A32_I0.5331.00
143_I148_D0.5321.00
112_N115_L0.5321.00
55_I117_Q0.5291.00
33_A38_V0.5251.00
107_E111_S0.5241.00
82_K137_G0.5241.00
179_L182_S0.5241.00
72_D75_E0.5231.00
63_G122_I0.5221.00
178_A181_N0.5211.00
62_M122_I0.5211.00
68_R93_L0.5211.00
145_E148_D0.5211.00
176_L179_L0.5191.00
166_T170_N0.5191.00
181_N184_L0.5161.00
5_R8_Y0.5151.00
73_I129_I0.5121.00
159_T183_V0.5121.00
92_S176_L0.5081.00
103_V106_L0.5031.00
64_Q68_R0.5031.00
135_T150_R0.5031.00
62_M125_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vi0A 2 0.9742 100 0.183 Contact Map
2ibdA 2 0.9845 100 0.187 Contact Map
4udsA 2 0.9536 100 0.194 Contact Map
3dcfA 2 0.9433 100 0.208 Contact Map
3nrgA 2 1 100 0.212 Contact Map
3npiA 2 0.9845 100 0.212 Contact Map
2xdnA 2 0.9897 100 0.213 Contact Map
4gckA 2 0.9691 100 0.215 Contact Map
4jykA 2 0.9897 100 0.217 Contact Map
3anpC 2 0.9948 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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