GREMLIN Database
YSHE - UPF0719 transmembrane protein YshE
UniProt: P94546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (124)
Sequences: 777 (547)
Seq/√Len: 49.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_E112_N4.6731.00
54_G121_V4.1191.00
120_F124_V3.0641.00
51_M120_F2.9831.00
49_V108_I2.9041.00
37_K40_E2.8901.00
103_K106_Q2.7891.00
40_E44_K2.6681.00
106_Q110_N2.6151.00
59_G127_S2.5851.00
62_N127_S2.5811.00
55_G116_G2.4011.00
63_V84_G2.3261.00
51_M116_G2.1181.00
68_I133_G2.0271.00
66_H70_Q2.0201.00
48_A111_D1.8310.99
18_V74_L1.7860.99
30_F56_K1.6980.98
58_L124_V1.6630.98
78_I82_V1.6220.98
71_H76_Q1.6130.98
51_M113_R1.6090.98
111_D114_A1.5640.97
22_C81_G1.5490.97
68_I77_M1.5010.96
63_V127_S1.4550.96
15_Y68_I1.4530.96
41_E44_K1.2970.92
13_A90_I1.2930.92
26_F85_F1.2850.92
112_N115_V1.2800.92
117_F120_F1.2710.91
100_P103_K1.2550.91
75_L125_G1.2230.90
62_N124_V1.2150.89
23_L61_A1.2090.89
65_Q128_F1.2050.89
76_Q79_G1.1830.88
22_C78_I1.1760.88
12_I67_S1.1650.87
38_N92_Y1.1550.87
14_A74_L1.1500.87
26_F60_I1.1290.85
104_I115_V1.1120.85
90_I93_F1.1100.84
56_K130_V1.0820.83
117_F121_V1.0750.83
18_V21_L1.0710.82
62_N65_Q1.0640.82
77_M133_G1.0260.79
84_G130_V1.0150.79
89_L93_F1.0020.78
33_V93_F0.9960.77
41_E46_N0.9930.77
129_V133_G0.9920.77
94_I113_R0.9830.76
82_V129_V0.9630.75
87_M90_I0.9570.75
34_T38_N0.9550.74
67_S72_N0.9520.74
108_I111_D0.9480.74
48_A128_F0.9470.74
109_E119_S0.9460.74
86_V93_F0.9380.73
47_L117_F0.9370.73
31_E120_F0.9220.72
96_E99_T0.9220.72
107_E110_N0.9070.70
43_Q132_A0.9070.70
36_Y105_D0.8990.70
75_L86_V0.8950.69
87_M118_I0.8910.69
91_S126_L0.8850.69
47_L113_R0.8830.68
51_M121_V0.8790.68
18_V77_M0.8610.66
15_Y71_H0.8610.66
18_V78_I0.8520.66
34_T80_W0.8520.66
27_L57_I0.8380.64
17_S98_L0.8370.64
21_L86_V0.8270.63
126_L130_V0.8220.63
36_Y49_V0.8130.62
63_V130_V0.8080.61
32_L98_L0.8070.61
66_H131_A0.7880.60
14_A58_L0.7850.59
81_G123_S0.7780.59
28_T32_L0.7730.58
36_Y107_E0.7690.58
63_V88_L0.7670.57
105_D128_F0.7670.57
70_Q90_I0.7600.57
11_E90_I0.7600.57
75_L82_V0.7600.57
71_H80_W0.7600.57
66_H127_S0.7560.56
68_I87_M0.7520.56
20_V90_I0.7460.55
60_I130_V0.7440.55
15_Y91_S0.7340.54
30_F84_G0.7330.54
78_I81_G0.7270.53
16_Y24_V0.7230.53
80_W88_L0.7220.53
71_H88_L0.7210.53
99_T118_I0.7060.51
21_L28_T0.7040.51
11_E14_A0.7030.51
116_G120_F0.6950.50
59_G92_Y0.6950.50
67_S83_Y0.6950.50
63_V125_G0.6950.50
55_G120_F0.6930.50
31_E39_W0.6890.50
16_Y26_F0.6890.50
26_F56_K0.6800.49
38_N125_G0.6780.48
105_D108_I0.6640.47
48_A118_I0.6630.47
10_V82_V0.6600.47
13_A75_L0.6580.46
40_E94_I0.6550.46
44_K58_L0.6520.46
59_G88_L0.6470.45
50_A70_Q0.6470.45
82_V85_F0.6470.45
12_I87_M0.6430.45
50_A59_G0.6370.44
8_E11_E0.6320.44
12_I127_S0.6320.44
79_G82_V0.6240.43
78_I91_S0.6230.43
17_S53_T0.6220.43
107_E115_V0.6210.43
82_V86_V0.6200.43
95_F99_T0.6170.42
41_E127_S0.6070.41
50_A96_E0.6050.41
32_L53_T0.6040.41
79_G98_L0.5990.41
52_A105_D0.5970.40
16_Y121_V0.5880.39
49_V115_V0.5850.39
76_Q83_Y0.5840.39
106_Q109_E0.5820.39
89_L98_L0.5810.39
64_F81_G0.5780.39
51_M108_I0.5770.38
54_G78_I0.5770.38
36_Y126_L0.5750.38
72_N76_Q0.5740.38
12_I15_Y0.5710.38
60_I85_F0.5670.37
12_I133_G0.5640.37
74_L78_I0.5590.37
41_E130_V0.5560.36
9_L37_K0.5550.36
11_E58_L0.5550.36
58_L128_F0.5490.36
86_V113_R0.5480.36
57_I104_I0.5480.36
39_W98_L0.5460.35
124_V129_V0.5460.35
41_E88_L0.5450.35
57_I116_G0.5410.35
57_I94_I0.5390.35
60_I77_M0.5390.35
18_V25_L0.5350.34
59_G123_S0.5320.34
20_V23_L0.5290.34
117_F128_F0.5290.34
95_F119_S0.5220.33
37_K42_I0.5160.33
67_S89_L0.5090.32
15_Y76_Q0.5090.32
21_L47_L0.5080.32
29_V36_Y0.5070.32
68_I132_A0.5070.32
47_L128_F0.5070.32
81_G129_V0.5040.32
96_E116_G0.5030.32
42_I111_D0.5000.31
21_L29_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8H 1 0.8657 8.2 0.931 Contact Map
4n7wA 2 0.7388 6 0.935 Contact Map
3qnqA 2 0.3433 5.7 0.936 Contact Map
1rh1A 1 0.7537 3.5 0.942 Contact Map
2xq2A 2 0.3209 3.4 0.943 Contact Map
4z7fA 2 0.7239 3.1 0.944 Contact Map
4o93A 2 0.6716 2.5 0.946 Contact Map
3giaA 1 0.7015 2.2 0.948 Contact Map
3l1lA 2 0.6716 2.2 0.948 Contact Map
3zuxA 1 0.6866 2.1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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