GREMLIN Database
MUTS2 - Endonuclease MutS2
UniProt: P94545 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 785 (772)
Sequences: 1909 (1459)
Seq/√Len: 52.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
304_L307_A6.5821.00
373_E407_N5.3461.00
715_E723_R5.0871.00
348_L445_L4.7391.00
639_F656_L4.6681.00
285_Y289_V4.3201.00
724_V754_V4.0211.00
19_I32_L3.9721.00
496_K502_D3.8191.00
712_L754_V3.5741.00
712_L724_V3.5071.00
21_H288_A3.4941.00
11_F357_S3.4541.00
373_E409_N3.4491.00
755_Q769_F3.4261.00
306_K321_D3.4011.00
496_K509_K3.1921.00
717_Y753_G3.1901.00
355_A369_A3.1591.00
352_T375_V3.1581.00
502_D506_G3.1201.00
100_K133_E3.0801.00
306_K364_D3.0121.00
153_T156_G2.9631.00
135_D258_K2.9551.00
436_D440_T2.9521.00
51_D293_K2.9381.00
293_K360_H2.8601.00
709_E740_S2.8181.00
300_G370_A2.7811.00
286_A360_H2.7681.00
37_S46_Q2.7361.00
22_A31_L2.7301.00
18_V285_Y2.6951.00
307_A351_L2.6951.00
40_I44_K2.6871.00
37_S42_E2.6811.00
665_W678_E2.6671.00
312_L317_V2.6451.00
728_L739_V2.6381.00
52_E118_L2.6311.00
161_L237_L2.6091.00
435_D456_Y2.5801.00
649_T680_D2.5781.00
665_W681_L2.5501.00
295_I368_E2.5141.00
303_R368_E2.4881.00
157_I240_A2.4631.00
572_A576_A2.4611.00
185_L199_I2.4541.00
146_V248_I2.4311.00
29_E72_R2.4211.00
47_L360_H2.4111.00
717_Y749_A2.3561.00
435_D507_Q2.3461.00
89_F259_T2.3321.00
75_L267_F2.2641.00
567_K571_E2.2591.00
296_M369_A2.2531.00
658_E666_N2.2001.00
325_G328_F2.1881.00
303_R323_E2.1871.00
301_F368_E2.1731.00
158_R244_E2.1691.00
17_Q285_Y2.1561.00
135_D138_S2.1311.00
97_Y137_N2.1151.00
706_V727_Y2.1041.00
352_T370_A2.1001.00
141_D147_L2.0931.00
741_I782_V2.0781.00
766_S783_E2.0771.00
770_G774_E2.0661.00
548_E552_K2.0641.00
726_K730_D2.0621.00
262_Y265_E2.0341.00
709_E742_I2.0301.00
52_E117_P2.0171.00
86_P146_V2.0171.00
78_A256_T2.0121.00
322_I348_L2.0071.00
11_F15_K2.0041.00
361_I367_S2.0011.00
330_T444_V1.9981.00
356_Q371_V1.9941.00
646_K682_E1.9881.00
77_R88_E1.9821.00
48_D293_K1.9791.00
164_L237_L1.9781.00
656_L665_W1.9751.00
46_Q49_E1.9741.00
37_S43_I1.9611.00
30_M275_T1.9601.00
770_G779_V1.9591.00
157_I251_I1.9511.00
168_V237_L1.9471.00
738_R783_E1.9391.00
643_D683_F1.9351.00
40_I298_D1.9270.99
31_L278_F1.9160.99
212_I231_V1.9130.99
641_P659_K1.9070.99
540_T547_A1.9040.99
436_D503_H1.9020.99
153_T157_I1.8960.99
157_I244_E1.8770.99
535_E539_E1.8730.99
238_Q241_K1.8640.99
647_V669_I1.8620.99
302_I348_L1.8610.99
768_R783_E1.8550.99
361_I369_A1.8490.99
555_Q559_I1.8460.99
727_Y739_V1.8460.99
53_A280_F1.8000.99
769_F777_S1.7890.99
71_I266_L1.7770.99
666_N675_K1.7700.99
660_T663_N1.7620.99
149_H155_R1.7520.99
297_N368_E1.7510.99
132_L259_T1.7490.99
768_R774_E1.7470.99
15_K31_L1.7470.99
135_D254_V1.7440.99
677_K680_D1.7410.99
39_S42_E1.7360.99
93_S137_N1.7320.99
286_A291_A1.7260.99
664_E677_K1.7130.99
731_A739_V1.7110.99
544_R548_E1.7100.99
533_A540_T1.6810.99
30_M274_Q1.6770.99
724_V741_I1.6610.98
148_D158_R1.6420.98
56_I105_F1.6340.98
44_K293_K1.6300.98
24_S27_G1.6280.98
51_D360_H1.6280.98
659_K665_W1.6270.98
610_I613_K1.6250.98
10_E13_K1.6240.98
549_K553_E1.6210.98
21_H285_Y1.6130.98
569_L573_E1.6120.98
27_G274_Q1.6080.98
257_E260_A1.6000.98
436_D439_R1.6000.98
465_N486_P1.5980.98
29_E33_E1.5920.98
184_M209_Y1.5910.98
239_Q243_K1.5850.98
297_N300_G1.5800.98
99_V269_D1.5780.98
374_H407_N1.5750.98
764_V782_V1.5740.98
614_K617_E1.5640.98
648_L682_E1.5630.98
329_S443_R1.5620.98
160_Q236_S1.5590.98
740_S781_V1.5550.98
532_R536_E1.5480.98
765_K783_E1.5360.97
161_L241_K1.5360.97
579_K583_A1.5170.97
102_M273_L1.5160.97
706_V734_A1.5090.97
725_E757_L1.5050.97
751_R769_F1.4980.97
647_V676_V1.4930.97
715_E719_N1.4900.97
538_S542_S1.4850.97
571_E575_Q1.4830.97
307_A347_T1.4820.97
53_A279_I1.4800.97
329_S462_G1.4790.97
770_G773_G1.4750.97
434_L446_A1.4700.97
24_S273_L1.4670.97
551_H555_Q1.4600.97
535_E538_S1.4550.96
140_I146_V1.4510.96
141_D145_E1.4340.96
773_G776_G1.4310.96
414_F437_V1.4250.96
721_L757_L1.4240.96
546_E551_H1.4210.96
439_R507_Q1.4160.96
304_L351_L1.4140.96
51_D55_D1.4110.96
196_R226_E1.4030.96
559_I563_S1.4030.96
469_E480_K1.4020.96
42_E46_Q1.3820.95
173_E177_R1.3820.95
268_L271_Q1.3770.95
469_E478_T1.3760.95
172_L190_V1.3750.95
49_E275_T1.3690.95
69_V91_E1.3670.95
18_V359_L1.3650.95
140_I255_L1.3650.95
247_E250_R1.3600.95
552_K556_Q1.3560.95
324_L331_I1.3540.95
576_A579_K1.3510.95
64_P105_F1.3470.95
301_F326_R1.3420.94
210_G228_Q1.3400.94
83_V253_R1.3340.94
54_S360_H1.3320.94
255_L259_T1.3300.94
387_Q419_A1.3240.94
536_E544_R1.3210.94
554_L557_Q1.3210.94
22_A28_K1.3200.94
659_K678_E1.3150.94
76_R79_E1.3150.94
45_K49_E1.3040.94
554_L558_I1.3000.93
206_R223_L1.2990.93
250_R254_V1.2930.93
46_Q282_K1.2900.93
706_V736_Y1.2880.93
175_M209_Y1.2870.93
34_L278_F1.2850.93
40_I296_M1.2840.93
407_N410_S1.2800.93
43_I371_V1.2760.93
401_G404_E1.2750.93
79_E264_E1.2750.93
198_V214_H1.2740.93
304_L369_A1.2740.93
320_N344_T1.2710.93
768_R771_E1.2660.92
11_F14_V1.2650.92
54_S286_A1.2630.92
353_L375_V1.2610.92
172_L230_I1.2580.92
641_P658_E1.2560.92
716_R749_A1.2510.92
168_V230_I1.2500.92
195_D241_K1.2490.92
609_L612_A1.2460.92
127_I265_E1.2460.92
660_T665_W1.2430.92
664_E675_K1.2400.92
38_A373_E1.2340.91
609_L613_K1.2290.91
278_F282_K1.2260.91
507_Q510_S1.2250.91
749_A753_G1.2200.91
523_I526_L1.2170.91
313_P317_V1.2130.91
324_L328_F1.2110.91
545_K549_K1.2090.91
582_A586_E1.2090.91
49_E279_I1.2080.91
657_L673_K1.2030.90
560_E563_S1.2020.90
34_L282_K1.2010.90
430_A450_Y1.1930.90
184_M205_Y1.1900.90
15_K19_I1.1890.90
614_K618_G1.1880.90
540_T543_I1.1870.90
528_Q532_R1.1850.90
15_K32_L1.1850.90
724_V782_V1.1850.90
578_E581_K1.1810.90
659_K663_N1.1770.89
374_H405_Q1.1720.89
141_D144_G1.1710.89
41_D44_K1.1700.89
558_I562_N1.1700.89
45_K121_Q1.1630.89
745_K751_R1.1610.89
153_T250_R1.1570.89
541_E545_K1.1560.89
48_D118_L1.1560.89
153_T243_K1.1560.89
406_V442_A1.1530.88
724_V757_L1.1530.88
79_E267_F1.1520.88
106_I123_A1.1500.88
6_L11_F1.1480.88
313_P316_Q1.1480.88
654_G669_I1.1480.88
533_A537_L1.1480.88
589_D593_E1.1440.88
300_G443_R1.1440.88
757_L761_H1.1370.88
542_S546_E1.1370.88
47_L355_A1.1340.88
7_S12_H1.1330.88
737_P784_L1.1330.88
406_V437_V1.1280.87
745_K777_S1.1270.87
556_Q560_E1.1260.87
49_E122_H1.1260.87
299_T326_R1.1260.87
372_F443_R1.1240.87
431_M511_E1.1230.87
438_H456_Y1.1210.87
401_G405_Q1.1150.87
745_K769_F1.1130.87
378_D395_H1.1130.87
752_K756_D1.1120.87
382_E387_Q1.1080.86
570_E574_Q1.1060.86
302_I370_A1.1050.86
506_G510_S1.1010.86
561_L568_M1.0980.86
44_K48_D1.0960.86
26_L270_L1.0960.86
541_E544_R1.0960.86
710_L741_I1.0940.86
304_L367_S1.0930.86
65_F276_L1.0920.86
771_E779_V1.0890.85
330_T463_V1.0850.85
585_K589_D1.0830.85
51_D286_A1.0820.85
412_V437_V1.0820.85
581_K585_K1.0770.85
639_F678_E1.0740.85
543_I551_H1.0730.85
16_E19_I1.0720.84
739_V782_V1.0710.84
68_L98_A1.0710.84
330_T438_H1.0710.84
345_L413_L1.0700.84
286_A293_K1.0690.84
338_T387_Q1.0690.84
43_I46_Q1.0680.84
759_K767_S1.0660.84
546_E549_K1.0650.84
399_I414_F1.0650.84
232_D236_S1.0620.84
78_A259_T1.0610.84
275_T279_I1.0580.84
26_L274_Q1.0580.84
543_I546_E1.0570.84
530_K534_E1.0570.84
506_G509_K1.0550.84
539_E543_I1.0540.83
331_I457_G1.0480.83
323_E328_F1.0430.83
89_F255_L1.0420.83
338_T388_S1.0390.83
9_L349_G1.0360.82
76_R80_I1.0340.82
305_K367_S1.0330.82
351_L362_P1.0330.82
702_K730_D1.0310.82
200_P222_T1.0270.82
46_Q50_V1.0260.82
575_Q578_E1.0260.82
17_Q21_H1.0250.82
163_T167_R1.0250.82
758_L782_V1.0230.82
646_K653_K1.0230.82
30_M271_Q1.0210.81
536_E539_E1.0180.81
646_K651_G1.0180.81
285_Y359_L1.0150.81
471_D474_T1.0150.81
552_K555_Q1.0140.81
43_I358_G1.0130.81
640_K643_D1.0110.81
755_Q767_S1.0110.81
333_I344_T1.0110.81
510_S514_A1.0090.81
406_V412_V1.0080.81
28_K32_L1.0070.81
349_G413_L1.0060.80
713_R740_S1.0060.80
538_S541_E1.0040.80
768_R773_G0.9990.80
203_Q223_L0.9980.80
297_N370_A0.9960.80
745_K750_L0.9950.80
167_R170_D0.9920.80
578_E582_A0.9900.79
244_E248_I0.9880.79
196_R235_N0.9870.79
93_S136_I0.9870.79
562_N565_K0.9850.79
145_E248_I0.9840.79
78_A263_T0.9840.79
713_R742_I0.9830.79
16_E20_G0.9820.79
403_L504_I0.9820.79
304_L363_A0.9810.79
121_Q124_E0.9790.79
553_E558_I0.9780.79
721_L753_G0.9770.78
656_L678_E0.9760.78
391_T420_G0.9760.78
130_S134_R0.9760.78
148_D244_E0.9700.78
637_R683_F0.9700.78
297_N301_F0.9670.78
564_K567_K0.9670.78
756_D759_K0.9640.78
469_E482_L0.9640.78
254_V258_K0.9640.78
96_L266_L0.9630.77
728_L763_S0.9630.77
773_G779_V0.9620.77
617_E620_M0.9610.77
601_H604_F0.9600.77
610_I614_K0.9600.77
328_F483_I0.9600.77
139_C255_L0.9560.77
171_R174_S0.9550.77
18_V278_F0.9540.77
458_Y519_V0.9510.77
518_E521_T0.9500.77
711_D740_S0.9490.76
68_L95_L0.9490.76
27_G453_L0.9480.76
135_D139_C0.9470.76
559_I562_N0.9440.76
551_H554_L0.9430.76
537_L541_E0.9420.76
312_L316_Q0.9420.76
770_G776_G0.9400.76
468_V776_G0.9400.76
165_E241_K0.9390.76
547_A550_L0.9380.76
36_P357_S0.9360.75
18_V289_V0.9350.75
50_V360_H0.9320.75
240_A244_E0.9270.75
294_P355_A0.9250.75
560_E564_K0.9210.74
50_V289_V0.9200.74
201_V225_I0.9200.74
209_Y225_I0.9180.74
400_V498_L0.9180.74
717_Y721_L0.9160.74
531_K535_E0.9130.74
44_K296_M0.9130.74
354_M359_L0.9120.74
455_A519_V0.9120.74
164_L236_S0.9110.73
690_P693_E0.9100.73
305_K366_G0.9080.73
767_S780_T0.9070.73
400_V500_L0.9070.73
553_E557_Q0.9070.73
85_S88_E0.9060.73
667_V676_V0.9060.73
305_K321_D0.9040.73
231_V235_N0.9030.73
557_Q562_N0.9010.73
563_S567_K0.9010.73
71_I95_L0.8990.72
292_T367_S0.8980.72
151_S244_E0.8980.72
460_R463_V0.8960.72
332_V463_V0.8950.72
39_S43_I0.8950.72
534_E538_S0.8930.72
392_F425_E0.8920.72
338_T498_L0.8920.72
25_S28_K0.8880.72
540_T544_R0.8870.71
757_L760_N0.8850.71
719_N722_S0.8840.71
164_L240_A0.8840.71
434_L444_V0.8820.71
397_V401_G0.8780.71
26_L70_D0.8770.71
728_L761_H0.8750.70
567_K570_E0.8750.70
307_A363_A0.8730.70
99_V126_L0.8710.70
41_D45_K0.8710.70
427_A452_E0.8710.70
185_L201_V0.8710.70
302_I361_I0.8700.70
87_S91_E0.8700.70
473_E656_L0.8690.70
43_I356_Q0.8690.70
547_A554_L0.8680.70
307_A367_S0.8660.70
338_T490_N0.8620.69
258_K261_E0.8620.69
639_F683_F0.8610.69
351_L363_A0.8600.69
126_L272_V0.8540.69
712_L741_I0.8540.69
656_L659_K0.8540.69
83_V249_E0.8530.68
31_L285_Y0.8470.68
86_P140_I0.8470.68
710_L716_R0.8450.68
63_A102_M0.8450.68
654_G681_L0.8440.68
279_I282_K0.8440.68
728_L757_L0.8440.68
122_H275_T0.8440.68
737_P783_E0.8420.67
168_V344_T0.8410.67
196_R234_N0.8410.67
302_I372_F0.8410.67
659_K662_G0.8390.67
370_A375_V0.8340.67
624_E629_P0.8340.67
387_Q490_N0.8340.67
414_F446_A0.8330.67
711_D747_T0.8330.67
332_V434_L0.8330.67
624_E627_K0.8280.66
438_H463_V0.8260.66
526_L529_S0.8240.66
647_V650_F0.8240.66
668_Q671_I0.8230.66
373_E410_S0.8230.66
75_L78_A0.8200.65
161_L240_A0.8180.65
383_Q487_G0.8180.65
228_Q232_D0.8170.65
58_R287_K0.8170.65
164_L168_V0.8160.65
738_R784_L0.8150.65
338_T494_I0.8120.65
561_L565_K0.8120.65
81_G260_A0.8100.64
545_K548_E0.8100.64
769_F773_G0.8100.64
331_I464_M0.8080.64
5_V8_A0.8080.64
12_H16_E0.8080.64
54_S287_K0.8070.64
184_M204_E0.8050.64
644_E653_K0.8040.64
609_L616_L0.8030.64
403_L501_P0.8030.64
175_M199_I0.8020.64
755_Q777_S0.8020.64
18_V31_L0.8020.64
725_E761_H0.8020.64
741_I754_V0.8010.64
173_E190_V0.7990.63
495_S500_L0.7980.63
78_A260_A0.7970.63
456_Y463_V0.7970.63
168_V375_V0.7970.63
142_D147_L0.7970.63
127_I269_D0.7950.63
475_L494_I0.7940.63
732_V784_L0.7930.63
25_S29_E0.7910.63
74_A91_E0.7900.62
685_K689_E0.7900.62
529_S537_L0.7890.62
438_H460_R0.7880.62
574_Q578_E0.7870.62
771_E774_E0.7860.62
694_K697_T0.7850.62
724_V764_V0.7830.62
328_F464_M0.7810.62
74_A88_E0.7800.61
97_Y101_Q0.7790.61
644_E655_T0.7770.61
758_L764_V0.7770.61
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131_D134_R0.5010.33
553_E573_E0.5010.33
24_S56_I0.5010.33
86_P144_G0.5010.33
244_E354_M0.5010.33
342_T490_N0.5010.33
646_K684_I0.5010.33
50_V53_A0.5000.33
217_S381_D0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wb9A 2 0.6293 100 0.606 Contact Map
3thxB 1 0.6777 100 0.628 Contact Map
3thxA 1 0.7134 100 0.635 Contact Map
2o8bB 1 0.6408 100 0.659 Contact Map
1ewqA 2 0.6178 100 0.667 Contact Map
4od6A 1 0.1032 100 0.889 Contact Map
2zqeA 1 0.1006 100 0.89 Contact Map
4hseA 1 0.4293 99.9 0.891 Contact Map
3qd7X 1 0.158 99.9 0.897 Contact Map
2d9iA 1 0.1006 99.8 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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