MUTS2 - BACSU - GREMLIN Contacts

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MUTS2 - Endonuclease MutS2

UniProt:	P94545	Sequences: MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIKKQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQMKHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQLRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSSSGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTLDFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVITGPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTFSSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHYPELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQAKSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKDKMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFEKSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLEFIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVSIIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	785 (772)
Sequences:	1909 (1459)
Seq/√Len:	52.5

BACSU - MUTS2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
304_L	307_A	6.582	1.00
373_E	407_N	5.346	1.00
715_E	723_R	5.087	1.00
348_L	445_L	4.739	1.00
639_F	656_L	4.668	1.00
285_Y	289_V	4.320	1.00
724_V	754_V	4.021	1.00
19_I	32_L	3.972	1.00
496_K	502_D	3.819	1.00
712_L	754_V	3.574	1.00
712_L	724_V	3.507	1.00
21_H	288_A	3.494	1.00
11_F	357_S	3.454	1.00
373_E	409_N	3.449	1.00
755_Q	769_F	3.426	1.00
306_K	321_D	3.401	1.00
496_K	509_K	3.192	1.00
717_Y	753_G	3.190	1.00
355_A	369_A	3.159	1.00
352_T	375_V	3.158	1.00
502_D	506_G	3.120	1.00
100_K	133_E	3.080	1.00
306_K	364_D	3.012	1.00
153_T	156_G	2.963	1.00
135_D	258_K	2.955	1.00
436_D	440_T	2.952	1.00
51_D	293_K	2.938	1.00
293_K	360_H	2.860	1.00
709_E	740_S	2.818	1.00
300_G	370_A	2.781	1.00
286_A	360_H	2.768	1.00
37_S	46_Q	2.736	1.00
22_A	31_L	2.730	1.00
18_V	285_Y	2.695	1.00
307_A	351_L	2.695	1.00
40_I	44_K	2.687	1.00
37_S	42_E	2.681	1.00
665_W	678_E	2.667	1.00
312_L	317_V	2.645	1.00
728_L	739_V	2.638	1.00
52_E	118_L	2.631	1.00
161_L	237_L	2.609	1.00
435_D	456_Y	2.580	1.00
649_T	680_D	2.578	1.00
665_W	681_L	2.550	1.00
295_I	368_E	2.514	1.00
303_R	368_E	2.488	1.00
157_I	240_A	2.463	1.00
572_A	576_A	2.461	1.00
185_L	199_I	2.454	1.00
146_V	248_I	2.431	1.00
29_E	72_R	2.421	1.00
47_L	360_H	2.411	1.00
717_Y	749_A	2.356	1.00
435_D	507_Q	2.346	1.00
89_F	259_T	2.332	1.00
75_L	267_F	2.264	1.00
567_K	571_E	2.259	1.00
296_M	369_A	2.253	1.00
658_E	666_N	2.200	1.00
325_G	328_F	2.188	1.00
303_R	323_E	2.187	1.00
301_F	368_E	2.173	1.00
158_R	244_E	2.169	1.00
17_Q	285_Y	2.156	1.00
135_D	138_S	2.131	1.00
97_Y	137_N	2.115	1.00
706_V	727_Y	2.104	1.00
352_T	370_A	2.100	1.00
141_D	147_L	2.093	1.00
741_I	782_V	2.078	1.00
766_S	783_E	2.077	1.00
770_G	774_E	2.066	1.00
548_E	552_K	2.064	1.00
726_K	730_D	2.062	1.00
262_Y	265_E	2.034	1.00
709_E	742_I	2.030	1.00
52_E	117_P	2.017	1.00
86_P	146_V	2.017	1.00
78_A	256_T	2.012	1.00
322_I	348_L	2.007	1.00
11_F	15_K	2.004	1.00
361_I	367_S	2.001	1.00
330_T	444_V	1.998	1.00
356_Q	371_V	1.994	1.00
646_K	682_E	1.988	1.00
77_R	88_E	1.982	1.00
48_D	293_K	1.979	1.00
164_L	237_L	1.978	1.00
656_L	665_W	1.975	1.00
46_Q	49_E	1.974	1.00
37_S	43_I	1.961	1.00
30_M	275_T	1.960	1.00
770_G	779_V	1.959	1.00
157_I	251_I	1.951	1.00
168_V	237_L	1.947	1.00
738_R	783_E	1.939	1.00
643_D	683_F	1.935	1.00
40_I	298_D	1.927	0.99
31_L	278_F	1.916	0.99
212_I	231_V	1.913	0.99
641_P	659_K	1.907	0.99
540_T	547_A	1.904	0.99
436_D	503_H	1.902	0.99
153_T	157_I	1.896	0.99
157_I	244_E	1.877	0.99
535_E	539_E	1.873	0.99
238_Q	241_K	1.864	0.99
647_V	669_I	1.862	0.99
302_I	348_L	1.861	0.99
768_R	783_E	1.855	0.99
361_I	369_A	1.849	0.99
555_Q	559_I	1.846	0.99
727_Y	739_V	1.846	0.99
53_A	280_F	1.800	0.99
769_F	777_S	1.789	0.99
71_I	266_L	1.777	0.99
666_N	675_K	1.770	0.99
660_T	663_N	1.762	0.99
149_H	155_R	1.752	0.99
297_N	368_E	1.751	0.99
132_L	259_T	1.749	0.99
768_R	774_E	1.747	0.99
15_K	31_L	1.747	0.99
135_D	254_V	1.744	0.99
677_K	680_D	1.741	0.99
39_S	42_E	1.736	0.99
93_S	137_N	1.732	0.99
286_A	291_A	1.726	0.99
664_E	677_K	1.713	0.99
731_A	739_V	1.711	0.99
544_R	548_E	1.710	0.99
533_A	540_T	1.681	0.99
30_M	274_Q	1.677	0.99
724_V	741_I	1.661	0.98
148_D	158_R	1.642	0.98
56_I	105_F	1.634	0.98
44_K	293_K	1.630	0.98
24_S	27_G	1.628	0.98
51_D	360_H	1.628	0.98
659_K	665_W	1.627	0.98
610_I	613_K	1.625	0.98
10_E	13_K	1.624	0.98
549_K	553_E	1.621	0.98
21_H	285_Y	1.613	0.98
569_L	573_E	1.612	0.98
27_G	274_Q	1.608	0.98
257_E	260_A	1.600	0.98
436_D	439_R	1.600	0.98
465_N	486_P	1.598	0.98
29_E	33_E	1.592	0.98
184_M	209_Y	1.591	0.98
239_Q	243_K	1.585	0.98
297_N	300_G	1.580	0.98
99_V	269_D	1.578	0.98
374_H	407_N	1.575	0.98
764_V	782_V	1.574	0.98
614_K	617_E	1.564	0.98
648_L	682_E	1.563	0.98
329_S	443_R	1.562	0.98
160_Q	236_S	1.559	0.98
740_S	781_V	1.555	0.98
532_R	536_E	1.548	0.98
765_K	783_E	1.536	0.97
161_L	241_K	1.536	0.97
579_K	583_A	1.517	0.97
102_M	273_L	1.516	0.97
706_V	734_A	1.509	0.97
725_E	757_L	1.505	0.97
751_R	769_F	1.498	0.97
647_V	676_V	1.493	0.97
715_E	719_N	1.490	0.97
538_S	542_S	1.485	0.97
571_E	575_Q	1.483	0.97
307_A	347_T	1.482	0.97
53_A	279_I	1.480	0.97
329_S	462_G	1.479	0.97
770_G	773_G	1.475	0.97
434_L	446_A	1.470	0.97
24_S	273_L	1.467	0.97
551_H	555_Q	1.460	0.97
535_E	538_S	1.455	0.96
140_I	146_V	1.451	0.96
141_D	145_E	1.434	0.96
773_G	776_G	1.431	0.96
414_F	437_V	1.425	0.96
721_L	757_L	1.424	0.96
546_E	551_H	1.421	0.96
439_R	507_Q	1.416	0.96
304_L	351_L	1.414	0.96
51_D	55_D	1.411	0.96
196_R	226_E	1.403	0.96
559_I	563_S	1.403	0.96
469_E	480_K	1.402	0.96
42_E	46_Q	1.382	0.95
173_E	177_R	1.382	0.95
268_L	271_Q	1.377	0.95
469_E	478_T	1.376	0.95
172_L	190_V	1.375	0.95
49_E	275_T	1.369	0.95
69_V	91_E	1.367	0.95
18_V	359_L	1.365	0.95
140_I	255_L	1.365	0.95
247_E	250_R	1.360	0.95
552_K	556_Q	1.356	0.95
324_L	331_I	1.354	0.95
576_A	579_K	1.351	0.95
64_P	105_F	1.347	0.95
301_F	326_R	1.342	0.94
210_G	228_Q	1.340	0.94
83_V	253_R	1.334	0.94
54_S	360_H	1.332	0.94
255_L	259_T	1.330	0.94
387_Q	419_A	1.324	0.94
536_E	544_R	1.321	0.94
554_L	557_Q	1.321	0.94
22_A	28_K	1.320	0.94
659_K	678_E	1.315	0.94
76_R	79_E	1.315	0.94
45_K	49_E	1.304	0.94
554_L	558_I	1.300	0.93
206_R	223_L	1.299	0.93
250_R	254_V	1.293	0.93
46_Q	282_K	1.290	0.93
706_V	736_Y	1.288	0.93
175_M	209_Y	1.287	0.93
34_L	278_F	1.285	0.93
40_I	296_M	1.284	0.93
407_N	410_S	1.280	0.93
43_I	371_V	1.276	0.93
401_G	404_E	1.275	0.93
79_E	264_E	1.275	0.93
198_V	214_H	1.274	0.93
304_L	369_A	1.274	0.93
320_N	344_T	1.271	0.93
768_R	771_E	1.266	0.92
11_F	14_V	1.265	0.92
54_S	286_A	1.263	0.92
353_L	375_V	1.261	0.92
172_L	230_I	1.258	0.92
641_P	658_E	1.256	0.92
716_R	749_A	1.251	0.92
168_V	230_I	1.250	0.92
195_D	241_K	1.249	0.92
609_L	612_A	1.246	0.92
127_I	265_E	1.246	0.92
660_T	665_W	1.243	0.92
664_E	675_K	1.240	0.92
38_A	373_E	1.234	0.91
609_L	613_K	1.229	0.91
278_F	282_K	1.226	0.91
507_Q	510_S	1.225	0.91
749_A	753_G	1.220	0.91
523_I	526_L	1.217	0.91
313_P	317_V	1.213	0.91
324_L	328_F	1.211	0.91
545_K	549_K	1.209	0.91
582_A	586_E	1.209	0.91
49_E	279_I	1.208	0.91
657_L	673_K	1.203	0.90
560_E	563_S	1.202	0.90
34_L	282_K	1.201	0.90
430_A	450_Y	1.193	0.90
184_M	205_Y	1.190	0.90
15_K	19_I	1.189	0.90
614_K	618_G	1.188	0.90
540_T	543_I	1.187	0.90
528_Q	532_R	1.185	0.90
15_K	32_L	1.185	0.90
724_V	782_V	1.185	0.90
578_E	581_K	1.181	0.90
659_K	663_N	1.177	0.89
374_H	405_Q	1.172	0.89
141_D	144_G	1.171	0.89
41_D	44_K	1.170	0.89
558_I	562_N	1.170	0.89
45_K	121_Q	1.163	0.89
745_K	751_R	1.161	0.89
153_T	250_R	1.157	0.89
541_E	545_K	1.156	0.89
48_D	118_L	1.156	0.89
153_T	243_K	1.156	0.89
406_V	442_A	1.153	0.88
724_V	757_L	1.153	0.88
79_E	267_F	1.152	0.88
106_I	123_A	1.150	0.88
6_L	11_F	1.148	0.88
313_P	316_Q	1.148	0.88
654_G	669_I	1.148	0.88
533_A	537_L	1.148	0.88
589_D	593_E	1.144	0.88
300_G	443_R	1.144	0.88
757_L	761_H	1.137	0.88
542_S	546_E	1.137	0.88
47_L	355_A	1.134	0.88
7_S	12_H	1.133	0.88
737_P	784_L	1.133	0.88
406_V	437_V	1.128	0.87
745_K	777_S	1.127	0.87
556_Q	560_E	1.126	0.87
49_E	122_H	1.126	0.87
299_T	326_R	1.126	0.87
372_F	443_R	1.124	0.87
431_M	511_E	1.123	0.87
438_H	456_Y	1.121	0.87
401_G	405_Q	1.115	0.87
745_K	769_F	1.113	0.87
378_D	395_H	1.113	0.87
752_K	756_D	1.112	0.87
382_E	387_Q	1.108	0.86
570_E	574_Q	1.106	0.86
302_I	370_A	1.105	0.86
506_G	510_S	1.101	0.86
561_L	568_M	1.098	0.86
44_K	48_D	1.096	0.86
26_L	270_L	1.096	0.86
541_E	544_R	1.096	0.86
710_L	741_I	1.094	0.86
304_L	367_S	1.093	0.86
65_F	276_L	1.092	0.86
771_E	779_V	1.089	0.85
330_T	463_V	1.085	0.85
585_K	589_D	1.083	0.85
51_D	286_A	1.082	0.85
412_V	437_V	1.082	0.85
581_K	585_K	1.077	0.85
639_F	678_E	1.074	0.85
543_I	551_H	1.073	0.85
16_E	19_I	1.072	0.84
739_V	782_V	1.071	0.84
68_L	98_A	1.071	0.84
330_T	438_H	1.071	0.84
345_L	413_L	1.070	0.84
286_A	293_K	1.069	0.84
338_T	387_Q	1.069	0.84
43_I	46_Q	1.068	0.84
759_K	767_S	1.066	0.84
546_E	549_K	1.065	0.84
399_I	414_F	1.065	0.84
232_D	236_S	1.062	0.84
78_A	259_T	1.061	0.84
275_T	279_I	1.058	0.84
26_L	274_Q	1.058	0.84
543_I	546_E	1.057	0.84
530_K	534_E	1.057	0.84
506_G	509_K	1.055	0.84
539_E	543_I	1.054	0.83
331_I	457_G	1.048	0.83
323_E	328_F	1.043	0.83
89_F	255_L	1.042	0.83
338_T	388_S	1.039	0.83
9_L	349_G	1.036	0.82
76_R	80_I	1.034	0.82
305_K	367_S	1.033	0.82
351_L	362_P	1.033	0.82
702_K	730_D	1.031	0.82
200_P	222_T	1.027	0.82
46_Q	50_V	1.026	0.82
575_Q	578_E	1.026	0.82
17_Q	21_H	1.025	0.82
163_T	167_R	1.025	0.82
758_L	782_V	1.023	0.82
646_K	653_K	1.023	0.82
30_M	271_Q	1.021	0.81
536_E	539_E	1.018	0.81
646_K	651_G	1.018	0.81
285_Y	359_L	1.015	0.81
471_D	474_T	1.015	0.81
552_K	555_Q	1.014	0.81
43_I	358_G	1.013	0.81
640_K	643_D	1.011	0.81
755_Q	767_S	1.011	0.81
333_I	344_T	1.011	0.81
510_S	514_A	1.009	0.81
406_V	412_V	1.008	0.81
28_K	32_L	1.007	0.81
349_G	413_L	1.006	0.80
713_R	740_S	1.006	0.80
538_S	541_E	1.004	0.80
768_R	773_G	0.999	0.80
203_Q	223_L	0.998	0.80
297_N	370_A	0.996	0.80
745_K	750_L	0.995	0.80
167_R	170_D	0.992	0.80
578_E	582_A	0.990	0.79
244_E	248_I	0.988	0.79
196_R	235_N	0.987	0.79
93_S	136_I	0.987	0.79
562_N	565_K	0.985	0.79
145_E	248_I	0.984	0.79
78_A	263_T	0.984	0.79
713_R	742_I	0.983	0.79
16_E	20_G	0.982	0.79
403_L	504_I	0.982	0.79
304_L	363_A	0.981	0.79
121_Q	124_E	0.979	0.79
553_E	558_I	0.978	0.79
721_L	753_G	0.977	0.78
656_L	678_E	0.976	0.78
391_T	420_G	0.976	0.78
130_S	134_R	0.976	0.78
148_D	244_E	0.970	0.78
637_R	683_F	0.970	0.78
297_N	301_F	0.967	0.78
564_K	567_K	0.967	0.78
756_D	759_K	0.964	0.78
469_E	482_L	0.964	0.78
254_V	258_K	0.964	0.78
96_L	266_L	0.963	0.77
728_L	763_S	0.963	0.77
773_G	779_V	0.962	0.77
617_E	620_M	0.961	0.77
601_H	604_F	0.960	0.77
610_I	614_K	0.960	0.77
328_F	483_I	0.960	0.77
139_C	255_L	0.956	0.77
171_R	174_S	0.955	0.77
18_V	278_F	0.954	0.77
458_Y	519_V	0.951	0.77
518_E	521_T	0.950	0.77
711_D	740_S	0.949	0.76
68_L	95_L	0.949	0.76
27_G	453_L	0.948	0.76
135_D	139_C	0.947	0.76
559_I	562_N	0.944	0.76
551_H	554_L	0.943	0.76
537_L	541_E	0.942	0.76
312_L	316_Q	0.942	0.76
770_G	776_G	0.940	0.76
468_V	776_G	0.940	0.76
165_E	241_K	0.939	0.76
547_A	550_L	0.938	0.76
36_P	357_S	0.936	0.75
18_V	289_V	0.935	0.75
50_V	360_H	0.932	0.75
240_A	244_E	0.927	0.75
294_P	355_A	0.925	0.75
560_E	564_K	0.921	0.74
50_V	289_V	0.920	0.74
201_V	225_I	0.920	0.74
209_Y	225_I	0.918	0.74
400_V	498_L	0.918	0.74
717_Y	721_L	0.916	0.74
531_K	535_E	0.913	0.74
44_K	296_M	0.913	0.74
354_M	359_L	0.912	0.74
455_A	519_V	0.912	0.74
164_L	236_S	0.911	0.73
690_P	693_E	0.910	0.73
305_K	366_G	0.908	0.73
767_S	780_T	0.907	0.73
400_V	500_L	0.907	0.73
553_E	557_Q	0.907	0.73
85_S	88_E	0.906	0.73
667_V	676_V	0.906	0.73
305_K	321_D	0.904	0.73
231_V	235_N	0.903	0.73
557_Q	562_N	0.901	0.73
563_S	567_K	0.901	0.73
71_I	95_L	0.899	0.72
292_T	367_S	0.898	0.72
151_S	244_E	0.898	0.72
460_R	463_V	0.896	0.72
332_V	463_V	0.895	0.72
39_S	43_I	0.895	0.72
534_E	538_S	0.893	0.72
392_F	425_E	0.892	0.72
338_T	498_L	0.892	0.72
25_S	28_K	0.888	0.72
540_T	544_R	0.887	0.71
757_L	760_N	0.885	0.71
719_N	722_S	0.884	0.71
164_L	240_A	0.884	0.71
434_L	444_V	0.882	0.71
397_V	401_G	0.878	0.71
26_L	70_D	0.877	0.71
728_L	761_H	0.875	0.70
567_K	570_E	0.875	0.70
307_A	363_A	0.873	0.70
99_V	126_L	0.871	0.70
41_D	45_K	0.871	0.70
427_A	452_E	0.871	0.70
185_L	201_V	0.871	0.70
302_I	361_I	0.870	0.70
87_S	91_E	0.870	0.70
473_E	656_L	0.869	0.70
43_I	356_Q	0.869	0.70
547_A	554_L	0.868	0.70
307_A	367_S	0.866	0.70
338_T	490_N	0.862	0.69
258_K	261_E	0.862	0.69
639_F	683_F	0.861	0.69
351_L	363_A	0.860	0.69
126_L	272_V	0.854	0.69
712_L	741_I	0.854	0.69
656_L	659_K	0.854	0.69
83_V	249_E	0.853	0.68
31_L	285_Y	0.847	0.68
86_P	140_I	0.847	0.68
710_L	716_R	0.845	0.68
63_A	102_M	0.845	0.68
654_G	681_L	0.844	0.68
279_I	282_K	0.844	0.68
728_L	757_L	0.844	0.68
122_H	275_T	0.844	0.68
737_P	783_E	0.842	0.67
168_V	344_T	0.841	0.67
196_R	234_N	0.841	0.67
302_I	372_F	0.841	0.67
659_K	662_G	0.839	0.67
370_A	375_V	0.834	0.67
624_E	629_P	0.834	0.67
387_Q	490_N	0.834	0.67
414_F	446_A	0.833	0.67
711_D	747_T	0.833	0.67
332_V	434_L	0.833	0.67
624_E	627_K	0.828	0.66
438_H	463_V	0.826	0.66
526_L	529_S	0.824	0.66
647_V	650_F	0.824	0.66
668_Q	671_I	0.823	0.66
373_E	410_S	0.823	0.66
75_L	78_A	0.820	0.65
161_L	240_A	0.818	0.65
383_Q	487_G	0.818	0.65
228_Q	232_D	0.817	0.65
58_R	287_K	0.817	0.65
164_L	168_V	0.816	0.65
738_R	784_L	0.815	0.65
338_T	494_I	0.812	0.65
561_L	565_K	0.812	0.65
81_G	260_A	0.810	0.64
545_K	548_E	0.810	0.64
769_F	773_G	0.810	0.64
331_I	464_M	0.808	0.64
5_V	8_A	0.808	0.64
12_H	16_E	0.808	0.64
54_S	287_K	0.807	0.64
184_M	204_E	0.805	0.64
644_E	653_K	0.804	0.64
609_L	616_L	0.803	0.64
403_L	501_P	0.803	0.64
175_M	199_I	0.802	0.64
755_Q	777_S	0.802	0.64
18_V	31_L	0.802	0.64
725_E	761_H	0.802	0.64
741_I	754_V	0.801	0.64
173_E	190_V	0.799	0.63
495_S	500_L	0.798	0.63
78_A	260_A	0.797	0.63
456_Y	463_V	0.797	0.63
168_V	375_V	0.797	0.63
142_D	147_L	0.797	0.63
127_I	269_D	0.795	0.63
475_L	494_I	0.794	0.63
732_V	784_L	0.793	0.63
25_S	29_E	0.791	0.63
74_A	91_E	0.790	0.62
685_K	689_E	0.790	0.62
529_S	537_L	0.789	0.62
438_H	460_R	0.788	0.62
574_Q	578_E	0.787	0.62
771_E	774_E	0.786	0.62
694_K	697_T	0.785	0.62
724_V	764_V	0.783	0.62
328_F	464_M	0.781	0.62
74_A	88_E	0.780	0.61
97_Y	101_Q	0.779	0.61
644_E	655_T	0.777	0.61
758_L	764_V	0.777	0.61
329_S	438_H	0.776	0.61
157_I	250_R	0.775	0.61
347_T	351_L	0.773	0.61
124_E	440_T	0.773	0.61
237_L	240_A	0.769	0.60
723_R	726_K	0.768	0.60
469_E	475_L	0.767	0.60
191_T	198_V	0.764	0.60
380_G	393_S	0.763	0.60
199_I	283_A	0.762	0.60
351_L	361_I	0.762	0.60
712_L	722_S	0.761	0.60
334_T	420_G	0.758	0.59
236_S	239_Q	0.756	0.59
136_I	146_V	0.756	0.59
507_Q	511_E	0.755	0.59
157_I	161_L	0.755	0.59
84_L	256_T	0.755	0.59
214_H	317_V	0.754	0.59
710_L	727_Y	0.754	0.59
668_Q	673_K	0.753	0.59
695_M	698_A	0.752	0.59
410_S	442_A	0.751	0.59
66_G	69_V	0.751	0.59
89_F	139_C	0.750	0.58
11_F	320_N	0.749	0.58
308_R	313_P	0.749	0.58
93_S	255_L	0.748	0.58
677_K	681_L	0.748	0.58
97_Y	133_E	0.747	0.58
400_V	495_S	0.747	0.58
658_E	665_W	0.746	0.58
285_Y	354_M	0.746	0.58
523_I	740_S	0.745	0.58
666_N	673_K	0.742	0.58
639_F	681_L	0.742	0.58
725_E	747_T	0.742	0.58
586_E	590_I	0.741	0.57
169_R	197_F	0.738	0.57
550_L	554_L	0.738	0.57
422_D	467_S	0.738	0.57
519_V	523_I	0.737	0.57
132_L	258_K	0.737	0.57
437_V	442_A	0.737	0.57
217_S	222_T	0.736	0.57
31_L	34_L	0.734	0.57
615_R	618_G	0.734	0.57
768_R	779_V	0.733	0.57
13_K	386_E	0.733	0.57
753_G	757_L	0.732	0.57
79_E	263_T	0.731	0.56
645_V	681_L	0.731	0.56
298_D	691_K	0.730	0.56
150_A	244_E	0.730	0.56
727_Y	731_A	0.728	0.56
336_P	384_S	0.727	0.56
461_E	617_E	0.727	0.56
432_S	436_D	0.726	0.56
69_V	94_G	0.726	0.56
414_F	649_T	0.725	0.56
755_Q	782_V	0.723	0.56
404_E	501_P	0.723	0.56
529_S	533_A	0.721	0.55
539_E	542_S	0.721	0.55
612_A	617_E	0.720	0.55
199_I	219_S	0.720	0.55
338_T	378_D	0.719	0.55
15_K	357_S	0.718	0.55
40_I	47_L	0.718	0.55
381_D	487_G	0.718	0.55
407_N	440_T	0.716	0.55
543_I	547_A	0.714	0.55
254_V	257_E	0.714	0.55
67_G	98_A	0.714	0.55
718_E	721_L	0.713	0.55
431_M	435_D	0.712	0.54
89_F	256_T	0.711	0.54
719_N	723_R	0.710	0.54
647_V	674_M	0.710	0.54
754_V	782_V	0.710	0.54
20_G	288_A	0.708	0.54
108_Q	503_H	0.707	0.54
334_T	452_E	0.707	0.54
315_D	560_E	0.705	0.54
225_I	354_M	0.704	0.54
344_T	348_L	0.703	0.54
351_L	369_A	0.703	0.54
338_T	479_Y	0.703	0.54
129_L	262_Y	0.702	0.53
81_G	256_T	0.701	0.53
709_E	774_E	0.700	0.53
542_S	549_K	0.699	0.53
160_Q	243_K	0.698	0.53
338_T	425_E	0.698	0.53
436_D	504_I	0.696	0.53
6_L	357_S	0.696	0.53
18_V	34_L	0.694	0.53
512_M	516_H	0.693	0.53
533_A	536_E	0.693	0.53
573_E	579_K	0.692	0.52
200_P	498_L	0.692	0.52
9_L	353_L	0.692	0.52
203_Q	206_R	0.692	0.52
11_F	353_L	0.691	0.52
99_V	273_L	0.691	0.52
732_V	763_S	0.690	0.52
27_G	277_D	0.690	0.52
57_I	287_K	0.689	0.52
493_E	509_K	0.689	0.52
446_A	527_E	0.688	0.52
417_L	425_E	0.688	0.52
490_N	670_G	0.688	0.52
307_A	322_I	0.688	0.52
171_R	229_A	0.686	0.52
352_T	411_L	0.686	0.52
396_M	400_V	0.686	0.52
482_L	485_V	0.685	0.52
144_G	147_L	0.685	0.52
564_K	568_M	0.685	0.52
214_H	231_V	0.685	0.52
609_L	620_M	0.685	0.52
16_E	32_L	0.683	0.51
278_F	359_L	0.678	0.51
663_N	678_E	0.678	0.51
580_V	583_A	0.677	0.51
577_A	581_K	0.677	0.51
407_N	442_A	0.674	0.51
488_R	527_E	0.673	0.50
378_D	398_N	0.671	0.50
38_A	43_I	0.671	0.50
338_T	475_L	0.670	0.50
414_F	417_L	0.670	0.50
381_D	477_P	0.669	0.50
104_H	107_T	0.669	0.50
525_S	528_Q	0.669	0.50
636_K	656_L	0.668	0.50
546_E	550_L	0.668	0.50
89_F	93_S	0.667	0.50
385_I	394_S	0.666	0.50
201_V	209_Y	0.666	0.50
334_T	387_Q	0.665	0.50
22_A	32_L	0.664	0.49
21_H	289_V	0.663	0.49
38_A	371_V	0.662	0.49
50_V	278_F	0.662	0.49
263_T	267_F	0.662	0.49
542_S	545_K	0.661	0.49
75_L	92_I	0.661	0.49
289_V	359_L	0.661	0.49
590_I	594_L	0.661	0.49
154_L	244_E	0.660	0.49
716_R	772_A	0.660	0.49
25_S	70_D	0.659	0.49
399_I	417_L	0.659	0.49
328_F	443_R	0.658	0.49
17_Q	20_G	0.656	0.49
646_K	725_E	0.656	0.49
308_R	317_V	0.655	0.49
30_M	33_E	0.654	0.48
396_M	495_S	0.653	0.48
774_E	779_V	0.652	0.48
707_S	728_L	0.652	0.48
576_A	583_A	0.652	0.48
67_G	94_G	0.652	0.48
6_L	708_L	0.652	0.48
608_E	612_A	0.651	0.48
332_V	445_L	0.651	0.48
171_R	230_I	0.651	0.48
228_Q	256_T	0.651	0.48
296_M	355_A	0.651	0.48
542_S	548_E	0.651	0.48
274_Q	278_F	0.651	0.48
772_A	776_G	0.650	0.48
125_Q	268_L	0.649	0.48
308_R	319_A	0.649	0.48
150_A	247_E	0.649	0.48
336_P	486_P	0.648	0.48
636_K	639_F	0.648	0.48
754_V	758_L	0.647	0.48
634_T	694_K	0.647	0.48
735_G	750_L	0.644	0.47
81_G	253_R	0.642	0.47
568_M	572_A	0.641	0.47
5_V	374_H	0.641	0.47
527_E	530_K	0.639	0.47
23_A	67_G	0.638	0.47
342_T	392_F	0.637	0.47
453_L	465_N	0.637	0.47
172_L	175_M	0.637	0.47
619_A	622_A	0.636	0.47
713_R	745_K	0.633	0.46
50_V	279_I	0.632	0.46
425_E	478_T	0.632	0.46
729_D	763_S	0.632	0.46
47_L	51_D	0.631	0.46
11_F	354_M	0.631	0.46
176_L	185_L	0.630	0.46
285_Y	291_A	0.630	0.46
665_W	769_F	0.629	0.46
269_D	272_V	0.628	0.46
168_V	195_D	0.628	0.46
324_L	443_R	0.628	0.46
657_L	666_N	0.628	0.46
769_F	779_V	0.627	0.46
264_E	267_F	0.627	0.46
709_E	713_R	0.625	0.45
553_E	556_Q	0.625	0.45
685_K	690_P	0.625	0.45
153_T	254_V	0.624	0.45
382_E	419_A	0.624	0.45
216_T	223_L	0.623	0.45
129_L	269_D	0.623	0.45
8_A	377_A	0.622	0.45
566_D	573_E	0.621	0.45
745_K	755_Q	0.621	0.45
22_A	30_M	0.621	0.45
669_I	674_M	0.620	0.45
610_I	619_A	0.620	0.45
454_K	457_G	0.618	0.45
251_I	385_I	0.617	0.45
643_D	742_I	0.617	0.45
289_V	312_L	0.617	0.45
596_T	599_E	0.616	0.44
565_K	742_I	0.616	0.44
711_D	742_I	0.615	0.44
142_D	145_E	0.615	0.44
21_H	33_E	0.614	0.44
148_D	151_S	0.614	0.44
393_S	423_P	0.614	0.44
425_E	494_I	0.612	0.44
660_T	678_E	0.612	0.44
156_G	160_Q	0.611	0.44
196_R	214_H	0.611	0.44
50_V	283_A	0.611	0.44
639_F	659_K	0.611	0.44
723_R	730_D	0.610	0.44
205_Y	312_L	0.610	0.44
169_R	173_E	0.610	0.44
512_M	561_L	0.610	0.44
150_A	423_P	0.610	0.44
567_K	574_Q	0.609	0.44
361_I	736_Y	0.609	0.44
583_A	587_A	0.608	0.44
770_G	781_V	0.608	0.44
219_S	718_E	0.607	0.44
716_R	719_N	0.607	0.44
588_E	595_R	0.606	0.43
336_P	468_V	0.606	0.43
348_L	496_K	0.606	0.43
693_E	696_I	0.606	0.43
418_G	423_P	0.605	0.43
125_Q	272_V	0.604	0.43
525_S	530_K	0.604	0.43
558_I	561_L	0.604	0.43
47_L	296_M	0.604	0.43
355_A	363_A	0.603	0.43
237_L	241_K	0.603	0.43
396_M	452_E	0.603	0.43
33_E	542_S	0.602	0.43
392_F	399_I	0.602	0.43
532_R	535_E	0.601	0.43
199_I	253_R	0.601	0.43
195_D	673_K	0.600	0.43
771_E	777_S	0.600	0.43
217_S	454_K	0.600	0.43
90_T	140_I	0.600	0.43
252_L	256_T	0.599	0.43
141_D	458_Y	0.598	0.43
685_K	688_P	0.598	0.43
46_Q	279_I	0.598	0.43
35_K	42_E	0.597	0.42
349_G	470_F	0.597	0.42
712_L	720_A	0.597	0.42
175_M	351_L	0.596	0.42
354_M	362_P	0.596	0.42
543_I	548_E	0.596	0.42
724_V	750_L	0.596	0.42
608_E	611_N	0.595	0.42
490_N	494_I	0.595	0.42
88_E	91_E	0.594	0.42
159_T	163_T	0.594	0.42
292_T	359_L	0.594	0.42
9_L	470_F	0.594	0.42
247_E	423_P	0.594	0.42
706_V	731_A	0.594	0.42
146_V	638_D	0.593	0.42
136_I	506_G	0.593	0.42
283_A	670_G	0.593	0.42
74_A	92_I	0.593	0.42
608_E	621_P	0.592	0.42
205_Y	208_S	0.592	0.42
38_A	356_Q	0.592	0.42
277_D	281_A	0.591	0.42
433_I	437_V	0.591	0.42
349_G	384_S	0.591	0.42
638_D	683_F	0.590	0.42
752_K	781_V	0.590	0.42
164_L	167_R	0.590	0.42
117_P	120_H	0.589	0.42
643_D	665_W	0.589	0.42
8_A	647_V	0.589	0.42
243_K	246_Q	0.589	0.42
111_E	156_G	0.589	0.42
544_R	547_A	0.588	0.42
29_E	621_P	0.588	0.42
465_N	484_G	0.588	0.42
44_K	295_I	0.588	0.42
14_V	17_Q	0.587	0.41
75_L	627_K	0.587	0.41
40_I	43_I	0.587	0.41
28_K	326_R	0.586	0.41
193_R	215_D	0.586	0.41
53_A	283_A	0.586	0.41
314_P	388_S	0.585	0.41
378_D	384_S	0.585	0.41
263_T	674_M	0.584	0.41
424_Q	451_P	0.584	0.41
334_T	490_N	0.584	0.41
133_E	266_L	0.583	0.41
766_S	784_L	0.583	0.41
469_E	490_N	0.582	0.41
430_A	453_L	0.582	0.41
38_A	292_T	0.581	0.41
14_V	20_G	0.581	0.41
435_D	457_G	0.580	0.41
190_V	230_I	0.580	0.41
342_T	425_E	0.580	0.41
548_E	551_H	0.580	0.41
280_F	283_A	0.579	0.41
96_L	123_A	0.579	0.41
257_E	261_E	0.579	0.41
247_E	251_I	0.578	0.41
725_E	763_S	0.578	0.41
15_K	21_H	0.577	0.40
18_V	22_A	0.577	0.40
352_T	356_Q	0.577	0.40
259_T	262_Y	0.576	0.40
20_G	32_L	0.576	0.40
45_K	327_D	0.575	0.40
446_A	488_R	0.574	0.40
532_R	537_L	0.574	0.40
394_S	456_Y	0.574	0.40
19_I	31_L	0.573	0.40
611_N	619_A	0.573	0.40
100_K	134_R	0.573	0.40
298_D	301_F	0.573	0.40
30_M	278_F	0.573	0.40
407_N	439_R	0.573	0.40
707_S	779_V	0.573	0.40
132_L	207_S	0.572	0.40
81_G	92_I	0.572	0.40
574_Q	577_A	0.571	0.40
35_K	541_E	0.571	0.40
52_E	614_K	0.570	0.40
184_M	208_S	0.570	0.40
579_K	587_A	0.569	0.40
601_H	605_K	0.568	0.40
136_I	139_C	0.568	0.40
63_A	280_F	0.567	0.39
613_K	616_L	0.566	0.39
276_L	377_A	0.566	0.39
216_T	376_F	0.566	0.39
312_L	757_L	0.566	0.39
151_S	154_L	0.565	0.39
83_V	756_D	0.565	0.39
740_S	769_F	0.565	0.39
331_I	483_I	0.565	0.39
295_I	366_G	0.565	0.39
397_V	681_L	0.565	0.39
625_K	631_K	0.564	0.39
570_E	573_E	0.564	0.39
132_L	361_I	0.564	0.39
76_R	439_R	0.563	0.39
713_R	747_T	0.563	0.39
710_L	754_V	0.562	0.39
198_V	212_I	0.562	0.39
279_I	641_P	0.562	0.39
162_R	165_E	0.561	0.39
329_S	333_I	0.561	0.39
197_F	669_I	0.559	0.39
750_L	754_V	0.559	0.39
388_S	466_A	0.559	0.39
387_Q	399_I	0.558	0.39
47_L	50_V	0.557	0.38
450_Y	490_N	0.557	0.38
95_L	270_L	0.557	0.38
374_H	410_S	0.556	0.38
515_E	711_D	0.556	0.38
16_E	213_V	0.556	0.38
465_N	670_G	0.556	0.38
214_H	235_N	0.555	0.38
144_G	772_A	0.555	0.38
423_P	470_F	0.555	0.38
198_V	284_R	0.554	0.38
120_H	124_E	0.554	0.38
282_K	436_D	0.554	0.38
742_I	779_V	0.553	0.38
160_Q	240_A	0.552	0.38
135_D	255_L	0.552	0.38
419_A	467_S	0.552	0.38
557_Q	560_E	0.551	0.38
660_T	677_K	0.551	0.38
585_K	711_D	0.550	0.38
436_D	501_P	0.550	0.38
203_Q	219_S	0.550	0.38
170_D	733_L	0.550	0.38
438_H	462_G	0.549	0.38
208_S	672_L	0.549	0.38
633_K	682_E	0.549	0.38
151_S	158_R	0.549	0.38
189_I	334_T	0.548	0.38
96_L	215_D	0.548	0.38
157_I	248_I	0.548	0.38
151_S	423_P	0.547	0.37
5_V	165_E	0.546	0.37
383_Q	477_P	0.546	0.37
547_A	595_R	0.546	0.37
456_Y	460_R	0.545	0.37
167_R	171_R	0.545	0.37
51_D	54_S	0.545	0.37
52_E	161_L	0.545	0.37
227_P	477_P	0.544	0.37
375_V	407_N	0.544	0.37
70_D	270_L	0.543	0.37
391_T	465_N	0.543	0.37
594_L	616_L	0.543	0.37
31_L	359_L	0.542	0.37
245_K	248_I	0.542	0.37
594_L	597_I	0.542	0.37
212_I	779_V	0.542	0.37
353_L	377_A	0.541	0.37
769_F	781_V	0.541	0.37
394_S	433_I	0.540	0.37
226_E	234_N	0.540	0.37
159_T	162_R	0.540	0.37
198_V	235_N	0.540	0.37
690_P	696_I	0.539	0.37
302_I	728_L	0.539	0.37
94_G	98_A	0.539	0.37
348_L	672_L	0.539	0.37
381_D	393_S	0.539	0.37
572_A	579_K	0.539	0.37
227_P	383_Q	0.539	0.37
160_Q	163_T	0.538	0.37
55_D	58_R	0.538	0.37
686_S	694_K	0.538	0.37
613_K	617_E	0.538	0.37
490_N	522_M	0.537	0.36
486_P	523_I	0.537	0.36
452_E	498_L	0.537	0.36
191_T	214_H	0.537	0.36
561_L	564_K	0.537	0.36
36_P	43_I	0.536	0.36
747_T	753_G	0.536	0.36
183_K	199_I	0.536	0.36
602_K	605_K	0.536	0.36
146_V	549_K	0.536	0.36
641_P	657_L	0.535	0.36
219_S	766_S	0.535	0.36
459_N	635_Q	0.535	0.36
312_L	443_R	0.535	0.36
503_H	638_D	0.535	0.36
771_E	776_G	0.534	0.36
752_K	777_S	0.533	0.36
188_T	450_Y	0.533	0.36
39_S	298_D	0.532	0.36
66_G	98_A	0.532	0.36
186_S	717_Y	0.532	0.36
564_K	762_R	0.531	0.36
259_T	590_I	0.529	0.36
93_S	133_E	0.529	0.36
338_T	400_V	0.529	0.36
78_A	262_Y	0.529	0.36
652_Q	673_K	0.528	0.36
712_L	782_V	0.528	0.36
389_L	494_I	0.528	0.36
702_K	705_H	0.528	0.36
716_R	754_V	0.527	0.35
388_S	474_T	0.527	0.35
717_Y	724_V	0.527	0.35
496_K	611_N	0.527	0.35
356_Q	369_A	0.526	0.35
379_I	399_I	0.525	0.35
697_T	710_L	0.525	0.35
380_G	423_P	0.525	0.35
614_K	754_V	0.525	0.35
67_G	95_L	0.524	0.35
327_D	461_E	0.524	0.35
645_V	781_V	0.523	0.35
247_E	470_F	0.523	0.35
282_K	412_V	0.523	0.35
414_F	512_M	0.523	0.35
11_F	35_K	0.523	0.35
612_A	615_R	0.522	0.35
770_G	783_E	0.522	0.35
584_M	588_E	0.522	0.35
693_E	698_A	0.522	0.35
98_A	273_L	0.522	0.35
82_S	256_T	0.522	0.35
24_S	280_F	0.521	0.35
75_L	79_E	0.521	0.35
665_W	677_K	0.521	0.35
86_P	248_I	0.521	0.35
344_T	468_V	0.520	0.35
27_G	31_L	0.520	0.35
236_S	405_Q	0.520	0.35
358_G	426_G	0.520	0.35
42_E	476_S	0.520	0.35
183_K	204_E	0.520	0.35
52_E	468_V	0.519	0.35
414_F	444_V	0.519	0.35
477_P	487_G	0.518	0.35
80_I	559_I	0.518	0.35
146_V	689_E	0.518	0.35
712_L	723_R	0.518	0.35
664_E	679_K	0.518	0.35
742_I	770_G	0.518	0.35
294_P	362_P	0.517	0.35
764_V	784_L	0.516	0.34
504_I	528_Q	0.516	0.34
144_G	776_G	0.515	0.34
378_D	423_P	0.515	0.34
78_A	132_L	0.515	0.34
215_D	242_V	0.515	0.34
336_P	713_R	0.515	0.34
102_M	130_S	0.515	0.34
202_K	205_Y	0.514	0.34
404_E	496_K	0.514	0.34
663_N	677_K	0.514	0.34
121_Q	528_Q	0.514	0.34
219_S	651_G	0.514	0.34
121_Q	473_E	0.514	0.34
396_M	762_R	0.514	0.34
186_S	716_R	0.514	0.34
44_K	299_T	0.513	0.34
367_S	591_I	0.512	0.34
399_I	433_I	0.512	0.34
598_K	764_V	0.512	0.34
43_I	50_V	0.512	0.34
254_V	408_E	0.512	0.34
708_L	738_R	0.512	0.34
95_L	468_V	0.512	0.34
536_E	541_E	0.511	0.34
290_K	314_P	0.511	0.34
334_T	400_V	0.510	0.34
472_I	505_I	0.510	0.34
336_P	389_L	0.510	0.34
29_E	626_S	0.509	0.34
624_E	628_K	0.509	0.34
36_P	385_I	0.509	0.34
699_V	738_R	0.509	0.34
721_L	760_N	0.509	0.34
338_T	469_E	0.508	0.34
703_D	756_D	0.508	0.34
168_V	173_E	0.508	0.34
52_E	64_P	0.508	0.34
684_I	690_P	0.508	0.34
17_Q	288_A	0.508	0.34
224_F	740_S	0.507	0.34
128_T	406_V	0.506	0.34
147_L	488_R	0.505	0.33
610_I	617_E	0.505	0.33
217_S	422_D	0.505	0.33
343_V	395_H	0.504	0.33
338_T	478_T	0.504	0.33
654_G	667_V	0.504	0.33
148_D	667_V	0.503	0.33
47_L	190_V	0.503	0.33
388_S	494_I	0.503	0.33
119_I	231_V	0.503	0.33
48_D	285_Y	0.503	0.33
745_K	778_G	0.503	0.33
236_S	365_E	0.503	0.33
151_S	247_E	0.502	0.33
422_D	474_T	0.501	0.33
437_V	441_N	0.501	0.33
392_F	402_I	0.501	0.33
739_V	764_V	0.501	0.33
242_V	312_L	0.501	0.33
131_D	134_R	0.501	0.33
553_E	573_E	0.501	0.33
24_S	56_I	0.501	0.33
86_P	144_G	0.501	0.33
244_E	354_M	0.501	0.33
342_T	490_N	0.501	0.33
646_K	684_I	0.501	0.33
50_V	53_A	0.500	0.33
217_S	381_D	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wb9A	2	0.6293	100	0.606	Contact Map
3thxB	1	0.6777	100	0.628	Contact Map
3thxA	1	0.7134	100	0.635	Contact Map
2o8bB	1	0.6408	100	0.659	Contact Map
1ewqA	2	0.6178	100	0.667	Contact Map
4od6A	1	0.1032	100	0.889	Contact Map
2zqeA	1	0.1006	100	0.89	Contact Map
4hseA	1	0.4293	99.9	0.891	Contact Map
3qd7X	1	0.158	99.9	0.897	Contact Map
2d9iA	1	0.1006	99.8	0.919	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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